Professor David Little
C29 - Children's Hospital Westmead
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Dr Little commenced at the University of Sydney based at the Children’s Hospital, Westmead, when it opened in November 1995. In 1998 he began researching the role of bisphosphonates in distraction osteogenesis and in 1999 officially founded Orthopaedic Research and Biotechnology at CHW, which he heads.
In 2005 Dr Little was awarded his PhD on bisphosphonates in distraction osteogenesis. He has initiated further research on osteonecrosis, fracture healing and the interaction of the anabolic and catabolic responses in bone repair. Current focuses include improving bone healing outcomes in neurofibromatosis, and using muscle for in vivo bone tissue engineering.
Dr Little remains active clinically and is now working on translating pre-clinical work on bone repair to clinical practice.
Current national competitive grants*
Pre-clinical validation of a novel implant for bone tissue engineering
Little D, Cooper-White J, Ruys A, Schindeler A
NHMRC Project Grants ($421,175 over 3 years)
The role of muscle and the application of muscle-cell therapies in bone repair
Little D, Schindeler A, Hamrick M
National Health and Medical Research Council Project Grant ($423,786 over 3 years)
Novel therapeutic interventions for the orthopaedic complications of Neurofibromatosis type 1 (NF1)
Little D, Alexander I, Schindeler A
National Health and Medical Research Council Project Grant ($606,732 over 3 years)
A randomised controlled trial to evaluate the effectiveness of zoledronate therapy in osteonecrosis of the hip
March L, Little D, Buchbinder R, Sambrook P
NHMRC Project Grant ($511,426 over 5 years)
Bisphosphonate Treatment of childhood femoral head avascular necrosis due to Perthes disease
Cowell C, Little D, Munns C, Foster B, Zacharin M
NHMRC Project Grant ($1,305,625 over 5 years)
* Grants administered through the University of Sydney
PhD and Masters' project opportunities
Sweden. (Universtiy of Lund) A/Prof Magnus Tagil
Combined research projects
Exchange visits and presentations
Future student exchange.