Dr Devanshi Seth
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Clinical Senior Lecturer
C39 - Royal Prince Alfred Hospital |
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Themes | Biographical details | Research interests | Grants | PhD & Masters' project opportunities | Honours project opportunities | Keywords | International links
Biographical details
Dr Seth, BSc (Hons), MSc (Agriculture), MPH, PhD (Genetics), is a Principal Scientist and Clinical Senior Lecturer at the (i) Drug Health Services (DHS), (ii) Centenary Institute (CI) at RPAH; and at the University of Sydney (USYD), Clinical and Addiction Medicine. Dr Devanshi Seth has more than 25 years of training and experience as Molecular Biologist in Biotechnology industry and more recently in Public Health, with 10 years of contribution towards alcohol research. Dr Seth has several publications in peer reviewed high impact journals in this area. Her work is recognised internationally through invitations to chair and present at international meetings and has generated several national and international collaborations. She also has long term collaboration with Prof Geoff McCaughan, Director AW Morrow Gastroenterology & Liver Clinic, RPAH and Prof Paul Haber, Medical Director, DHS, Sydney South West Area Health Service (SSWAHS). [More...]
Research interests
Dr Devanshi Seth has an international profile in alcohol research: to understand the molecular pathogenesis, genetics and associated risk factors, prevention and treatment of alcoholic liver disease (ALD) through novel therapeutic agents.
Areas of research: Clinical; in vitro and in vivo models of alcohol; Chronic Alcohol; Alcohol related tissue injury; Alcoholism/Addiction; Liver; Cirrhosis/Fibrosis
Opportunities for Honours and PhD: All current research listed above have opportunity for students as honours and/or PhD projects.
Current national competitive grants*
2011
Genetic risk factors for alcoholic cirrhosis - genome wide case control study
Seth D, Haber P, Nalpas B, Stickel F, Day C, Lumeng L, Morgan T, Whitfield J
NIH Research Support ($525,920 over 5 years)
* Grants administered through the University of Sydney
PhD and Masters' project opportunities
Role of Annexin A2 in the regulation of fibrinolysis in alcohol induced liver inhury
Significance of Osteopontin and its splice variants in alcoholic liver disease +
+ indicates the opportunity is full and unavailable.
Honours project opportunities
To investigate Secreted phosphoprotein 1 (SPP1) mediated liver fibrogenesis in alcoholic liver injury
To investigate the mechanism/s of SPP1 action in liver injury model of alcohol and high fat diet using SPP1 knockout animals
Identification of epigenetic factors in excessive alcohol drinkers with and without liver disease by miRNA profiling
International links
Switzerland. (University of Bern, Switzerland) Felix Stickel, M.D. is an Associate Professor and GI specialist at the University of Heidelberg and University of Eirlangen, Germany and Head, Dept. of Visceral Surgery and Medicine, University of Bern. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
United States. (University of California-Irvine
VA Medical Center, Long Beach CA) Timothy R, MORGAN, MD is Professor of Medicine, University of California, Irvine and Chief, Hepatology at the VA Medical Centre. He is the lead US Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
France. (University Paris XII, France) Bertrand Nalpas, M.D, PhD, is Director of research at the University Paris VII, France. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
Germany. (Salem Medical Center, Heidelberg
Centre of Alcohol Research Liver Disease and Nutrition, University of Heidelberg) Helmut Karl Seitz, M.D., PhD, AGAF is Professor, Medical Director, Department of Medicine, Salem Medical Center, Heidelberg;
Head, Centre of Alcohol Research Liver Disease and Nutrition.
He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
United States. (University of California, LA
Indiana school of Medicine, Indianpolis) Prof Tatiana Foroud, B.s, M.S, PhD is Professor of Medical & Molecular Genetics. She is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Dr Seth and Prof Foroud have jointly organised symposium on GWAS at the ISBRA 2008 meeting..
United States. (Indiana University, Bloomington, IN) Lawrence Lumeng, M.D. is a Professor, Physician/Scientist at the Indiana University, Bloomington, IN. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011..
Australia. (Queensland Institute of Medical Research, Brisbane) John B Whitfield, BSc, MSC, PhD, MRCPath, FRCPath is the Director a Senior Principal Research Fellow at the Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Drs Whitfield and Seth have had ~8 years of collaboration and held joint grants during this period..
United Kingdom. (University of Newcastle, UK) DAY, Christopher Paul, MD, MRCP, PhD, FRCP is Pro Vice Chancellor of Medical Sciences & Professor of Liver Medicine at the University of Newcastle, UK. He is one of the Principal Investigators and collaborator in the GenomALC Consortium, a 5-year multi-national project "To identify genetic risk factors that predispose some heavy drinkers to develop cirrhosis" supported by the National Institute of Health (NIH) / National Institute on Alcohol Abuse and Alcoholism (NIAAA), due to commence 2011. Prof Day and Dr Seth have also published together recently in Hepatology..