Dr Damian Holsinger
Lecturer in Neuroscience
M02 - Mallet Street Campus
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Damian Holsinger began investigating molecular mechanisms underlying Alzheimer's disease in 1997. In 2002 he made the seminal discovery that levels of the pivotal AD-related enzyme, BACE1, were increased in the brain of patients (Annals of Neurology, 51:783-786). These findings have been widely accepted in the field (325 citations) and have led to a concentrated focus on this enzyme as a therapeutic avenue for the treatment of Alzheimer's disease. In 2006, Damian accepted a position as Lecturer in Neuroscience at The University of Sydney and founded the Laboratory of Molecular Neuroscience at the Brain & Mind Research Institute in 2007. He continues to investigate molecular mechanisms underlying neurodegenerative diseases with a particular focus on BACE1.[Hide detail]
Research interests surround the understanding of mechanisms by which complex neurological disorders arise and methods of treating these diseases.
Neuroanatomy, Neurophysiology, Neuropathology, Neuroplasticity, Neuromolecular Medicine, Molecular Biology, Molceular and Cellular Neuroscience