Dr Damian Holsinger
Lecturer in Neuroscience
M02 - Mallet Street Campus
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Damian Holsinger began investigating molecular mechanisms underlying Alzheimer's disease in 1997. In 2002 he made the seminal discovery that levels of the pivotal AD-related enzyme, BACE1, were increased in the brain of patients (Annals of Neurology, 51:783-786). These findings have been widely accepted in the field (250 citations) and have led to a concentrated focus on this enzyme as a therapeutic avenue for the treatment of Alzheimer?s disease. In 2006, Damian accepted a position as Lecturer in Neuroscience at The University of Sydney and founded the Laboratory of Molecular Neuroscience at the Brain & Mind Research Institute in 2007. He continues to investigate molecular mechanisms underlying neurodegenerative diseases with a particular focus on BACE1.
Research interests surround the understanding of mechanisms by which complex neurological disorders arise and methods of treating these diseases.