Dr Justine Graham

Research Only Academic Level B
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone 02 98456954

Map

Selected grants

2015

  • Role of progesterone in normal breast and its convergence with estrogen action in breast cancer; Clarke C, Hilton H, Graham J; Cancer Council New South Wales/Research Project Grants.

2014

  • NanoString nCounter Platform; deFazio A, Alexander I, Booth D, Byrne J, Christodoulou J, Clarke C, Cunningham A, George J, Graham J, Harman A, Liddle C, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Chromatin context of progesterone transcriptional activity in normal and cancer cells; Clarke C, Graham J; Worldwide Cancer Research/Research Support.
  • Determinants of genomic binding of the progesterone receptor in endocrine target cells; Clarke C, Graham J; Cancer Council New South Wales/Research Project Grants.

2011

  • Progesterone regulation of epithelial expansion in the normal human breast; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Progesterone signalling in normal and malignant breast relies on chromosomal positioning of progesterone receptor; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Illumina Automated Beadstation 500GXDW; Graham J; Cancer Institute New South Wales/Research Grants Program - Category 2.
  • Impact of progesterone receptor submuclear localisation on progesterone action in endocrine target cells; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Cell architectural determinants of transcriptional disruption in breast cancer; Clarke C, Graham J; National Breast Cancer Foundation/Concept Awards.

2004

  • Mutant and variant progesterone receptors in breast cancer; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Progestin regulation of gene expression pathways in human breast cancer; Graham J, Clarke C; Cure Cancer Australia Foundation/Research Support.

2002

  • Progestin regulation of gene expression pathways in human breast cancer; Graham J; DVC Research/Research and Development Scheme: Research and Development (R&D).

2000

  • Microarray scanners and DNA clones; Graham J; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

Selected publications

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Book Chapters

  • Hilton, H., Graham, J., Clarke, C. (2012). Estrogen and Progestin Stimulation of Breast Proliferation. In R. Paul Robinson (Eds.), Translational Endocrinology & Metabolism: Breast Cancer Update, (pp. 1-28). Maryland, United States: The Endocrine Society.

Journals

  • Khushi, M., Liddle, C., Clarke, C., Graham, J. (2014). Binding Sites Analyser (BiSA): Software for Genomic Binding Sites Archiving and Overlap Analysis. PloS One, 9(2), 1-12. [More Information]
  • Doan, T., Eriksson, N., Graham, J., Funder, J., Simpson, E., Kuczek, E., Clyne, C., Leedman, P., Tilley, W., Fuller, P., Clarke, C., et al (2014). Breast cancer prognosis predicted by nuclear receptor-coregulator networks. Molecular Oncology, 8(5), 998-1013. [More Information]
  • Hilton, H., Santucci, N., Silvestri, A., Kantimm, S., Huschtscha, L., Graham, J., Clarke, C. (2014). Progesterone stimulates progenitor cells in normal human breast and breast cancer cells. Breast Cancer Research and Treatment, 143(3), 423-433. [More Information]
  • Hilton, H., Kantimm, S., Graham, J., Clarke, C. (2013). Changed lineage composition is an early event in breast carcinogenesis. Histology and histopathology, 28(9), 1197-1204. [More Information]
  • Knower, K., Chand, A., Eriksson, N., Takagi, K., Miki, Y., Sasano, H., Visvader, J., Lindeman, G., Funder, J., Fuller, P., Graham, J., Clarke, C., et al (2013). Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Research and Treatment, 142(1), 211-223. [More Information]
  • Khushi, M., Edwards, G., de Marcos, D., Carpenter, J., Graham, J., Clarke, C. (2013). Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information. Diagnostic Pathology, 8(1), 1-7. [More Information]
  • Webster, L., Provan, P., Graham, J., Byth Wilson, K., Walker, R., Davis, S., Salisbury, E., Morey, A., Ward, R., Hawkins, N., Clarke, C., Balleine, R., et al (2013). Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33. Pathology, 45(7), 629-636. [More Information]
  • Muscat, G., Eriksson, N., Byth Wilson, K., Loi, S., Graham, D., Jindal, S., Davis, M., Clyne, C., Funder, J., Simpson, E., Kuczek, E., Clarke, C., et al (2013). Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer. Molecular Endocrinology, 27(2), 350-365. [More Information]
  • Clarke, C., Graham, J. (2012). Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes. PloS One, 7(4), 1-14. [More Information]
  • Graham, J., Clarke, C. (2012). Preview: MCE special issue on molecular mechanisms of action in progesterone signalling. Molecular And Cellular Endocrinology, 357(1/2), 1-3. [More Information]
  • Hilton, H., Graham, J., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, L., Mote, P., Clarke, C. (2012). Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast. Molecular And Cellular Endocrinology, 361(1-2), 191-201. [More Information]
  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology, 24(7), 1380-1392. [More Information]
  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Graham, J., Mote, P., Salagame, U., Balleine, R., Huschtscha-Holliday, L., Clarke, C. (2009). Hormone-Responsive Model of Primary Human Breast Epithelium. Journal of Mammary Gland Biology and Neoplasia, 14(4), 367-379. [More Information]
  • Graham, J., Hanson, A., Croft, A., Fox, A., Clarke, C. (2009). Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci. The F A S E B Journal, 23(doi: 10.1096/fj.08-113639), 546-556. [More Information]
  • Scarpin, K., Graham, J., Mote, P., Clarke, C. (2009). Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nuclear Receptor Signaling, 7(10.1621/nrs.07009), e009 - 1-e009 - 13. [More Information]
  • Mote, P., Graham, J., Clarke, C. (2007). Progesterone receptor isoforms in normal and malignant breast. Ernst Schering Research Foundation Workshop, (1), 77-107. [More Information]
  • Arnett-Mansfield, R., Graham, J., Hanson, A., Mote, P., Gompel, A., Scurr, L., Gava, N., deFazio, A., Clarke, C. (2006). Focal subnuclear distribution of progesterone receptor is ligand-dependent and associated with transcriptional activity. Molecular Endocrinology, 21(1), 14-29. [More Information]
  • Chadli, A., Graham, J., Abel, M., Jackson, T., Gordon, D., Wood, W., Felts, S., Horwitz, K., Toft, D. (2006). GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Molecular and Cellular Biology, 26(5), 1722-1730. [More Information]
  • Cowell, L., Graham, J., Bouton, A., Clarke, C., O'Neill, G. (2006). Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene, 25(58), 7597-7607. [More Information]
  • Graham, J., Yager, M., Hill, H., Byth Wilson, K., O'Neill, G., Clarke, C. (2005). Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Molecular Endocrinology, 19(11), 2713-2735. [More Information]
  • McGowan, E., Weinberger, R., Graham, J., Hill, H., Hughes, J., O'Neill, G., Clarke, C. (2003). Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. Journal of Molecular Endocrinology, 31(2), 241-253.
  • Graham, J., Clarke, C. (2002). Progesterone receptors - animal models and cell signaling in breast cancer: expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Research, 4(5), 187-190.

2014

  • Khushi, M., Liddle, C., Clarke, C., Graham, J. (2014). Binding Sites Analyser (BiSA): Software for Genomic Binding Sites Archiving and Overlap Analysis. PloS One, 9(2), 1-12. [More Information]
  • Doan, T., Eriksson, N., Graham, J., Funder, J., Simpson, E., Kuczek, E., Clyne, C., Leedman, P., Tilley, W., Fuller, P., Clarke, C., et al (2014). Breast cancer prognosis predicted by nuclear receptor-coregulator networks. Molecular Oncology, 8(5), 998-1013. [More Information]
  • Hilton, H., Santucci, N., Silvestri, A., Kantimm, S., Huschtscha, L., Graham, J., Clarke, C. (2014). Progesterone stimulates progenitor cells in normal human breast and breast cancer cells. Breast Cancer Research and Treatment, 143(3), 423-433. [More Information]

2013

  • Hilton, H., Kantimm, S., Graham, J., Clarke, C. (2013). Changed lineage composition is an early event in breast carcinogenesis. Histology and histopathology, 28(9), 1197-1204. [More Information]
  • Knower, K., Chand, A., Eriksson, N., Takagi, K., Miki, Y., Sasano, H., Visvader, J., Lindeman, G., Funder, J., Fuller, P., Graham, J., Clarke, C., et al (2013). Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Research and Treatment, 142(1), 211-223. [More Information]
  • Khushi, M., Edwards, G., de Marcos, D., Carpenter, J., Graham, J., Clarke, C. (2013). Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information. Diagnostic Pathology, 8(1), 1-7. [More Information]
  • Webster, L., Provan, P., Graham, J., Byth Wilson, K., Walker, R., Davis, S., Salisbury, E., Morey, A., Ward, R., Hawkins, N., Clarke, C., Balleine, R., et al (2013). Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33. Pathology, 45(7), 629-636. [More Information]
  • Muscat, G., Eriksson, N., Byth Wilson, K., Loi, S., Graham, D., Jindal, S., Davis, M., Clyne, C., Funder, J., Simpson, E., Kuczek, E., Clarke, C., et al (2013). Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer. Molecular Endocrinology, 27(2), 350-365. [More Information]

2012

  • Hilton, H., Graham, J., Clarke, C. (2012). Estrogen and Progestin Stimulation of Breast Proliferation. In R. Paul Robinson (Eds.), Translational Endocrinology & Metabolism: Breast Cancer Update, (pp. 1-28). Maryland, United States: The Endocrine Society.
  • Clarke, C., Graham, J. (2012). Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes. PloS One, 7(4), 1-14. [More Information]
  • Graham, J., Clarke, C. (2012). Preview: MCE special issue on molecular mechanisms of action in progesterone signalling. Molecular And Cellular Endocrinology, 357(1/2), 1-3. [More Information]
  • Hilton, H., Graham, J., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, L., Mote, P., Clarke, C. (2012). Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast. Molecular And Cellular Endocrinology, 361(1-2), 191-201. [More Information]

2010

  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology, 24(7), 1380-1392. [More Information]

2009

  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Graham, J., Mote, P., Salagame, U., Balleine, R., Huschtscha-Holliday, L., Clarke, C. (2009). Hormone-Responsive Model of Primary Human Breast Epithelium. Journal of Mammary Gland Biology and Neoplasia, 14(4), 367-379. [More Information]
  • Graham, J., Hanson, A., Croft, A., Fox, A., Clarke, C. (2009). Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci. The F A S E B Journal, 23(doi: 10.1096/fj.08-113639), 546-556. [More Information]
  • Scarpin, K., Graham, J., Mote, P., Clarke, C. (2009). Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nuclear Receptor Signaling, 7(10.1621/nrs.07009), e009 - 1-e009 - 13. [More Information]

2007

  • Mote, P., Graham, J., Clarke, C. (2007). Progesterone receptor isoforms in normal and malignant breast. Ernst Schering Research Foundation Workshop, (1), 77-107. [More Information]

2006

  • Arnett-Mansfield, R., Graham, J., Hanson, A., Mote, P., Gompel, A., Scurr, L., Gava, N., deFazio, A., Clarke, C. (2006). Focal subnuclear distribution of progesterone receptor is ligand-dependent and associated with transcriptional activity. Molecular Endocrinology, 21(1), 14-29. [More Information]
  • Chadli, A., Graham, J., Abel, M., Jackson, T., Gordon, D., Wood, W., Felts, S., Horwitz, K., Toft, D. (2006). GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Molecular and Cellular Biology, 26(5), 1722-1730. [More Information]
  • Cowell, L., Graham, J., Bouton, A., Clarke, C., O'Neill, G. (2006). Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene, 25(58), 7597-7607. [More Information]

2005

  • Graham, J., Yager, M., Hill, H., Byth Wilson, K., O'Neill, G., Clarke, C. (2005). Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Molecular Endocrinology, 19(11), 2713-2735. [More Information]

2003

  • McGowan, E., Weinberger, R., Graham, J., Hill, H., Hughes, J., O'Neill, G., Clarke, C. (2003). Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. Journal of Molecular Endocrinology, 31(2), 241-253.

2002

  • Graham, J., Clarke, C. (2002). Progesterone receptors - animal models and cell signaling in breast cancer: expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Research, 4(5), 187-190.

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