Dr Donna Lai

Senior Lecturer
Bosch Institute, School of Medical Sciences

Telephone 9351 8787/9351 4576
Fax 9351 8400/9114 0520

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Research interests

I am interested in developing innovative molecular biology techniques to tackle complex real-world problems in biomedical research in particular: 1) detecting altered gene expression directly related to cardiac sinoatrial node ageing and heart failure; 2) identifying the signalling pathways participating in the response to glucocorticoids treatment in advanced diabetic retinopathy.

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.

2012

  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

Selected publications

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Journals

  • Lui, W., Zhang, X., Song, C., Bao, B., Lai, D., Mou, J., Jiang, T., Wang, N. (2014). Expression and characterization of a soluble VEGF receptor 2 protein. Cell & Bioscience, 4(1), 1-10. [More Information]
  • Zhang, X., Lai, D., Bao, B., Hambly, B., Gillies, M. (2013). Triamcinolone Acetonide Inhibits p38MAPK Activation and Neuronal Apoptosis in Early Diabetic Retinopathy. Current Molecular Medicine, 13(6), 946-958. [More Information]
  • Desbonnet, L., O'Tuathaigh, C., Clarke, G., O'Leary, C., Petit, E., Clarke, N., Tighe, O., Lai, D., Harvey, R., Cryan, J., et al (2012). Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene x environment interaction. Brain, Behavior, and Immunity, 26(4), 660-671. [More Information]
  • Ju, Y., Liu, J., Lee, B., Lai, D., Woodcock, E., Lei, M., Cannell, M., Allen, D. (2011). Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node. Circulation Research, 109(8), 848-857. [More Information]
  • He, Z., Lai, D., Wakelin, L. (2010). [Co(III)(cyclen)Cl(2)]Cl is selectively cytotoxic to human leukaemia cells. European Journal of Pharmacology, 637(1-3), 11-15. [More Information]
  • Duffy, L., Cappas, E., Lai, D., Boucher, A., Karl, T. (2010). Cognition in Transmembrane Domain Neuregulin 1 Mutant Mice. Neuroscience, 170(3), 800-807. [More Information]
  • Walsh, J., Tighe, O., Lai, D., Harvey, R., Karayiorgou, M., Gogos, J., Waddington, J., O'Tuathaigh, C. (2010). Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1. Brain Research, 1348 (C), 114-119. [More Information]
  • Lai, D., Liu, X., Forrai, A., Wolstein, O., Michalicek, J., Ahmed, I., Garratt, A., Birchmeier, C., Zhou, M., Hartley, L., et al (2010). Neuregulin 1 Sustains the Gene Regulatory Network in Both Trabecular and Nontrabecular Myocardium. Circulation Research, 107(6), 715-727. [More Information]
  • O'Tuathaigh, C., Harte, M., O'Leary, C., O'Sullivan, G., Blau, C., Lai, D., Harvey, R., Tighe, O., Fagan, A., Kerskens, C., et al (2010). Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice. European Journal of Neuroscience, 31(2), 349-358. [More Information]
  • Tomiyama, K., O'Tuathaigh, C., O'Sullivan, G., Kinsella, A., Lai, D., Harvey, R., Tighe, O., Croke, D., Koshikawa, N., Waddington, J. (2009). Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 ‘knockout’ mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33, 330-333. [More Information]
  • O'Tuathaigh, C., O'Connor, A., O'Sullivan, G., Lai, D., Harvey, R., Croke, D., Waddington, J. (2008). Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous ‘knockout’ of the schizophrenia risk gene neuregulin-1. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(2), 462-466. [More Information]
  • Zhang, X., Bao, B., Lai, D., Rapkins, R., Gillies, M. (2008). Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier through Differential Regulation of VEGF-A and its Receptors in Early Diabetic Rat Retinas. Diabetes, 57(4), 1026-1033. [More Information]
  • Ju, Y., Chu, Y., Chaulet, H., Lai, D., Gervasio, O., Graham, R., Cannell, M., Allen, D. (2007). Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node. Circulation Research, 100(11), 1605-1614. [More Information]
  • Liu, X., Gu, X., Li, Z., Li, X., Li, H., Chang, J., Chen, P., Jin, J., Xi, B., Chen, D., Lai, D., et al (2006). Neuregulin-1/erbB-Activation Improves Cardiac Function and Survival in Models of Ischemic, Dilated, and Viral Cardiomyopathy. Journal of the American College of Cardiology, 48(7), 1438-1447. [More Information]
  • Kirk, E., Hyun, C., Thomson, P., Lai, D., Castro, M., Biben, C., Buckley, M., Martin, I., Moran, C., Harvey, R. (2006). Quantitative Trait Loci Modifying Cardiac Atrial Septal Morphology and Risk of Patent Foramen Ovale in the Mouse. Circulation Research, 98(5), 651-658. [More Information]
  • Stennard, F., Costa, M., Lai, D., Biben, C., Furtado, M., Solloway, M., McCulley, D., Leimena, C., Preis, J., Dunwoodie, S., et al (2005). Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development (Cambridge), 132(10), 2451-2462. [More Information]
  • Linhares, V., Almeida, N., Menezes, D., Elliott, D., Lai, D., Beyer, E., Campos de Carvalho, A., Costa, M. (2004). Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5. Cardiovascular Research, 64(3), 402-411. [More Information]
  • Stennard, F., Costa, M., Elliott, D., Rankin, S., Haast, S., Lai, D., McDonald, L., Niederreither, K., Dolle, P., Bruneau, B., et al (2003). Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Developmental Biology, 262(2), 206-224.

2014

  • Lui, W., Zhang, X., Song, C., Bao, B., Lai, D., Mou, J., Jiang, T., Wang, N. (2014). Expression and characterization of a soluble VEGF receptor 2 protein. Cell & Bioscience, 4(1), 1-10. [More Information]

2013

  • Zhang, X., Lai, D., Bao, B., Hambly, B., Gillies, M. (2013). Triamcinolone Acetonide Inhibits p38MAPK Activation and Neuronal Apoptosis in Early Diabetic Retinopathy. Current Molecular Medicine, 13(6), 946-958. [More Information]

2012

  • Desbonnet, L., O'Tuathaigh, C., Clarke, G., O'Leary, C., Petit, E., Clarke, N., Tighe, O., Lai, D., Harvey, R., Cryan, J., et al (2012). Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene x environment interaction. Brain, Behavior, and Immunity, 26(4), 660-671. [More Information]

2011

  • Ju, Y., Liu, J., Lee, B., Lai, D., Woodcock, E., Lei, M., Cannell, M., Allen, D. (2011). Distribution and Functional Role of Inositol 1,4,5-trisphosphate Receptors in Mouse Sinoatrial Node. Circulation Research, 109(8), 848-857. [More Information]

2010

  • He, Z., Lai, D., Wakelin, L. (2010). [Co(III)(cyclen)Cl(2)]Cl is selectively cytotoxic to human leukaemia cells. European Journal of Pharmacology, 637(1-3), 11-15. [More Information]
  • Duffy, L., Cappas, E., Lai, D., Boucher, A., Karl, T. (2010). Cognition in Transmembrane Domain Neuregulin 1 Mutant Mice. Neuroscience, 170(3), 800-807. [More Information]
  • Walsh, J., Tighe, O., Lai, D., Harvey, R., Karayiorgou, M., Gogos, J., Waddington, J., O'Tuathaigh, C. (2010). Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1. Brain Research, 1348 (C), 114-119. [More Information]
  • Lai, D., Liu, X., Forrai, A., Wolstein, O., Michalicek, J., Ahmed, I., Garratt, A., Birchmeier, C., Zhou, M., Hartley, L., et al (2010). Neuregulin 1 Sustains the Gene Regulatory Network in Both Trabecular and Nontrabecular Myocardium. Circulation Research, 107(6), 715-727. [More Information]
  • O'Tuathaigh, C., Harte, M., O'Leary, C., O'Sullivan, G., Blau, C., Lai, D., Harvey, R., Tighe, O., Fagan, A., Kerskens, C., et al (2010). Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice. European Journal of Neuroscience, 31(2), 349-358. [More Information]

2009

  • Tomiyama, K., O'Tuathaigh, C., O'Sullivan, G., Kinsella, A., Lai, D., Harvey, R., Tighe, O., Croke, D., Koshikawa, N., Waddington, J. (2009). Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 ‘knockout’ mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33, 330-333. [More Information]

2008

  • O'Tuathaigh, C., O'Connor, A., O'Sullivan, G., Lai, D., Harvey, R., Croke, D., Waddington, J. (2008). Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous ‘knockout’ of the schizophrenia risk gene neuregulin-1. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(2), 462-466. [More Information]
  • Zhang, X., Bao, B., Lai, D., Rapkins, R., Gillies, M. (2008). Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier through Differential Regulation of VEGF-A and its Receptors in Early Diabetic Rat Retinas. Diabetes, 57(4), 1026-1033. [More Information]

2007

  • Ju, Y., Chu, Y., Chaulet, H., Lai, D., Gervasio, O., Graham, R., Cannell, M., Allen, D. (2007). Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node. Circulation Research, 100(11), 1605-1614. [More Information]

2006

  • Liu, X., Gu, X., Li, Z., Li, X., Li, H., Chang, J., Chen, P., Jin, J., Xi, B., Chen, D., Lai, D., et al (2006). Neuregulin-1/erbB-Activation Improves Cardiac Function and Survival in Models of Ischemic, Dilated, and Viral Cardiomyopathy. Journal of the American College of Cardiology, 48(7), 1438-1447. [More Information]
  • Kirk, E., Hyun, C., Thomson, P., Lai, D., Castro, M., Biben, C., Buckley, M., Martin, I., Moran, C., Harvey, R. (2006). Quantitative Trait Loci Modifying Cardiac Atrial Septal Morphology and Risk of Patent Foramen Ovale in the Mouse. Circulation Research, 98(5), 651-658. [More Information]

2005

  • Stennard, F., Costa, M., Lai, D., Biben, C., Furtado, M., Solloway, M., McCulley, D., Leimena, C., Preis, J., Dunwoodie, S., et al (2005). Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development (Cambridge), 132(10), 2451-2462. [More Information]

2004

  • Linhares, V., Almeida, N., Menezes, D., Elliott, D., Lai, D., Beyer, E., Campos de Carvalho, A., Costa, M. (2004). Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5. Cardiovascular Research, 64(3), 402-411. [More Information]

2003

  • Stennard, F., Costa, M., Elliott, D., Rankin, S., Haast, S., Lai, D., McDonald, L., Niederreither, K., Dolle, P., Bruneau, B., et al (2003). Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Developmental Biology, 262(2), 206-224.

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