Dr Daohai Zhang
D06 - Blackburn Building
Dr Zhang started his postdoctoral training in molecular /structural biology inTemasek Life Sciences Laboratory, Singapore, in 1999. After 3 years' postdoc training, he joined the Dept. of Pathology at the National University of Singapore (NUS) where he setup and led the Cancer Proteomics and Tissue Microarray Group for biomarker discovery and validation. In 2004, he was appointed as Scientific Officer (Senior) in National University Hospital of Singapore, to run a Research and Development Lab in clinical proteomics, and to supervise/train junior medical technologists and junior pathologist in molecular diagnosis and cell biology. Later in 2005, he was promoted to Assistant Professor in the Dept. of Pathology to lead a research group on breast cancer cell biology until he moved to Sydney in 2010. Currently, Dr Zhangis working as Research Fellow in the Dept. of Pathology at the University of Sydney. He is supervising/mentoring Ph.D and Honours students in cancer cell biology and therapeutics.
1. Epithelial-mesenchymal transition and breast cancer stem cells
2. Endoplasmic reticulum stress and autophagy in breast and prostatee cancer cell survival and apoptosis
3. Molecular mechanisms of breast cancer cell dormancy and chemo- / radio-resistance
4, Nanotherapy of breast cancer stem cells and circulating tumour cells.
Current research projects
1.Molecular mechanisms of ERp29 in regulating epithelial-mesenchymal reverse transition and cell polarity in mammary epithelial cells.
2. Role of ERp29 and NDRG1 in ER stress and autophagy signalling
3. Nanotechnology-based therapy targeting CD44+ breast cancer stem cells (oversea collaboration)
Previous teaching and supervision experience include:
1. Clinical proteomics
2. Cancer cell biology
3. Molecuar pathology
4. Molecular diagnosis of solid tumour