Dr Eddy Kizana

Senior Lecturer
Medicine, Westmead Clinical School

Telephone +61 2 9845 6795
Fax +61 2 9846 8323

Website Honours in Medical Sciences at Westmead

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Current research students

Project title Research student
Role of angiogenic factors and circulating monocytes in the pathogenesis of preeclampsia and intrauterine fetal growth restriction Thushari Indika ALAHAKOON
SOMATIC GENE TRANSFER OF HTBX18 TO INDUCE BIOLOGICAL PACEMAKER FUNCTIONALITY IN OVINE HEARTS WITH REDUCED PACEMAKING ABILITY Melad FARRAHA
Platelet Derived Growth Factor Mediated Activation and Rejuvenation of Endogenous Cardiac Stem Cells. Sujitha THAVAPALACHANDRAN

Selected grants

2017

  • Pluripotent Stem Cell Derived Cardiomyocytes: Improving Electrical Stability and Quantifying Functional Improvements; Chong J, Murry C, Kovoor P, Kizana E, Grieve S, Elliott D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Preclinical Assessment of Gene Therapy for Ventricular Arrhythmia; Kizana E, Hajjar R, Chong J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A new paradigm in redox-mediated cardiac fibrosis; Figtree G, Blaxall B, Kizana E, Xie Z, hayward C, Gentle C; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • Clinical Translation of Human Pluripotent Stem Cells for Heart Failure (Catalyst funding for University of Washington Collaboration).; Chong J, Kizana E, Murry C; DVC International/IPDF Grant.

2014

  • WAVE 20/50 Bioreactor and C5 Cell Disruptor; Chircop (nee Fabbro) M, Kizana E, Robinson P, Diefenbach R, Bryan T, Gottlieb D, Micklethwaite K, Alexander I; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Gene Therapy for Ventricular Arrhythmias; Kizana E, Kovoor P, Bhindi R; National Heart Foundation of Australia/Grants-in-Aid.

2008

  • The Role of Connexin40 in the Pathogenesis of Atrial Fibrillation Probed by Targeted In Vivo Gene Transfer; Kizana E; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Farraha, M., Chong, J., Kizana, E. (2016). Therapeutic Prospects of Gene Therapy for Atrial Fibrillation. Heart, Lung and Circulation, 25(8), 808-813. [More Information]
  • Nalliah, C., Lim, T., Kizana, E., Qian, P., Kovoor, P., Thiagalingam, A., Ross, D., Thomas, S. (2015). Clinical significance of early atrial arrhythmia type and timing after single ring isolation of the pulmonary veins. Europace, 17(7), 1038-1044. [More Information]
  • Nalliah, C., Lim, T., Bhaskaran, A., Kizana, E., Kovoor, P., Thomas, L., Ross, D., Thomas, S. (2015). Posterior left atrial isolation for atrial fibrillation in left ventricular diastolic impairment is associated with better arrhythmia free survival. International Journal of Cardiology, 184(1), 674-679. [More Information]
  • Chik, W., Chan, J., Ross, D., Wagstaff, J., Kizana, E., Thiagalingam, A., Kovoor, P., Thomas, S. (2014). Atrial Tachycardias Utilizing the Ligament of Marshall Region Following Single Ring Pulmonary Vein Isolation for Atrial Fibrillation. Pacing And Clinical Electrophysiology, 37(9), 1149-1158. [More Information]
  • Al Raisi, S., Pouliopoulos, J., Barry, M., Swinnen, J., Thiagalingam, A., Thomas, S., Sivagangabalan, G., Chow, C., Chong, J., Kizana, E., Kovoor, P. (2014). Evaluation of lesion and thermodynamic characteristics of Symplicity and EnligHTN renal denervation systems in a phantom renal artery model. EuroIntervention, 10(2), 277-284. [More Information]
  • Pouliopoulos, J., Chik, W., Kanthan, A., Sivagangabalan, G., Barry, M., Fahmy, P., Midekin, C., Lu, J., Kizana, E., Thomas, S., Thiagalingam, A., Kovoor, P. (2013). Intramyocardial Adiposity After Myocardial Infarction: New Implications of a Substrate for Ventricular Tachycardia. Circulation, 128(21), 2296-2308. [More Information]
  • Barth, A., Zhang, Y., Li, T., Smith, R., Chimenti, I., Terrovitis, I., Davis, D., Kizana, E., Ho, A., O'Rourke, B., et al (2012). Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab. Stem Cells: the international journal of cell differentiation and proliferation, 1(4), 289-297. [More Information]
  • Barile, L., Cerisoli, F., Frati, G., Gaetani, R., Chimenti, I., Forte, E., Cassinelli, L., Spinardi, L., Altomare, C., Kizana, E., et al (2011). Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart. Journal of Cellular and Molecular Medicine, 15(1), 63-71. [More Information]
  • Cunningham, S., Kok, C., Dane, A., Carpenter, K., Kizana, E., Kuchel, P., Alexander, I. (2011). Induction and Prevention of Severe Hyperammonemia in the spf(ash) Mouse Model of Ornithine Transcarbamylase Deficiency Using shRNA and rAAV-mediated Gene Delivery. Molecular Therapy, 19(5), 854-859. [More Information]
  • Kho, C., Lee, A., Jeong, D., Oh, J., Chaanine, A., Kizana, E., Park, W., Hajjar, R. (2011). SUMO1-dependent modulation of SERCA2a in heart failure. Nature, 477(7366), 601-605. [More Information]
  • Davis, D., Kizana, E., Terrovitis, J., Barth, A., Zhang, Y., Smith, R., Miake, J., Marban, E. (2010). Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. Journal of Molecular and Cellular Cardiology, 49(2), 312-321. [More Information]
  • Rossello, R., Wang, Z., Kizana, E., Krebsbach, P., Kohn, D. (2009). Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(32), 13219-13224. [More Information]
  • Sekar, R., Kizana, E., Cho, H., Molitoris, J., Hesketh, G., Eaton, B., Marban, E., Tung, L. (2009). IK1 Heterogeneity Affects Genesis and Stability of Spiral Waves in Cardiac Myocyte Monolayers. Circulation Research, 104, 355-364. [More Information]
  • Kizana, E., Cingolani, E., Marban, E. (2009). Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells. Gene Therapy (Basingstoke), 16(9), 1163-1168. [More Information]
  • Mahairaki, V., Xu, L., Farah, M., Hatfield, G., Kizana, E., Marban, E., Koliatsos, V. (2009). Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interference. Journal of Neuroscience Methods, 179(2), 292-299. [More Information]
  • Chang, K., Barth, A., Sasano, T., Kizana, E., Kashiwakura, Y., Zhang, Y., Foster, D., Marbán, E. (2008). CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(11), 4477-4482. [More Information]
  • Terrovitis, J., Kwok, K., Lautamäki, R., Engles, J., Barth, A., Kizana, E., Miake, J., Leppo, M., Fox, J., Seidel, J., et al (2008). Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. Journal of the American College of Cardiology, 52(20), 1652-1660. [More Information]
  • Barth, A., Kizana, E., Smith, R., Terrovitis, J., Dong, P., Leppo, M., Zhang, Y., Miake, J., Olson, E., Schneider, J., et al (2008). Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report cardiogenic differentiation in stem cells. Molecular Therapy, 16(5), 957-964. [More Information]
  • Terrovitis, J., Stuber, M., Youssef, A., Preece, S., Leppo, M., Kizana, E., Schar, M., Gerstenblith, G., Weiss, R., Marbán, E., et al (2008). Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation (Baltimore), 117(12), 1555-1562. [More Information]
  • Cingolani, E., Ramirez-Correa, G., Kizana, E., Murata, M., Cho, H., Marbán, E. (2007). Gene therapy to inhibit the calcium channel beta subunit: physiological consequences and pathophysiological effects in models of cardiac hypertrophy. Circulation Research, 101(2), 166-175. [More Information]
  • Sekar, R., Kizana, E., Smith, R., Barth, A., Zhang, Y., Marban, E., Tung, L. (2007). Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity. American Journal of Physiology: Heart and Circulatory Physiology, 293(5), H2757-H2770. [More Information]
  • Kizana, E. (2007). Therapeutic prospects of cardiac gene transfer. Heart, Lung and Circulation, 16(3), 180-184. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006). Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene Therapy (Basingstoke), 13(22), 1611-1615. [More Information]
  • Kizana, E., Ginn, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation, 111(4), 394-398. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Thomas, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts Modulate Cardiomyocyte Excitability: Insights from Fibroblasts with Genetically Altered Connexin43 Expression. Journal of Gene Medicine, 7(point P8 on page 1127), 1127-1127.
  • Allen, D., Hardeman, E., North, K., Alexander, I., Cooper, S., Maxwell, A., Kizana, E., Ghoddusi, M. (2004). C2C12 Co-Culture On A Fibroblast Substratum Enables Sustained Survival Of Contractile, Highly Differentiated Myotubes With Peripheral Nuclei And Adult Fast Myosin Expression. Cell Motility and the Cytoskeleton, 58(3), 200-211. [More Information]
  • del Monte, F., Kizana, E., Tabchy, A., Hajjar, R. (2004). Targeted gene transfer in heart failure: Implications for novel gene identification. Current Opinion in Molecular Therapeutics, 6(4), 381-394. [More Information]

2016

  • Farraha, M., Chong, J., Kizana, E. (2016). Therapeutic Prospects of Gene Therapy for Atrial Fibrillation. Heart, Lung and Circulation, 25(8), 808-813. [More Information]

2015

  • Nalliah, C., Lim, T., Kizana, E., Qian, P., Kovoor, P., Thiagalingam, A., Ross, D., Thomas, S. (2015). Clinical significance of early atrial arrhythmia type and timing after single ring isolation of the pulmonary veins. Europace, 17(7), 1038-1044. [More Information]
  • Nalliah, C., Lim, T., Bhaskaran, A., Kizana, E., Kovoor, P., Thomas, L., Ross, D., Thomas, S. (2015). Posterior left atrial isolation for atrial fibrillation in left ventricular diastolic impairment is associated with better arrhythmia free survival. International Journal of Cardiology, 184(1), 674-679. [More Information]

2014

  • Chik, W., Chan, J., Ross, D., Wagstaff, J., Kizana, E., Thiagalingam, A., Kovoor, P., Thomas, S. (2014). Atrial Tachycardias Utilizing the Ligament of Marshall Region Following Single Ring Pulmonary Vein Isolation for Atrial Fibrillation. Pacing And Clinical Electrophysiology, 37(9), 1149-1158. [More Information]
  • Al Raisi, S., Pouliopoulos, J., Barry, M., Swinnen, J., Thiagalingam, A., Thomas, S., Sivagangabalan, G., Chow, C., Chong, J., Kizana, E., Kovoor, P. (2014). Evaluation of lesion and thermodynamic characteristics of Symplicity and EnligHTN renal denervation systems in a phantom renal artery model. EuroIntervention, 10(2), 277-284. [More Information]

2013

  • Pouliopoulos, J., Chik, W., Kanthan, A., Sivagangabalan, G., Barry, M., Fahmy, P., Midekin, C., Lu, J., Kizana, E., Thomas, S., Thiagalingam, A., Kovoor, P. (2013). Intramyocardial Adiposity After Myocardial Infarction: New Implications of a Substrate for Ventricular Tachycardia. Circulation, 128(21), 2296-2308. [More Information]

2012

  • Barth, A., Zhang, Y., Li, T., Smith, R., Chimenti, I., Terrovitis, I., Davis, D., Kizana, E., Ho, A., O'Rourke, B., et al (2012). Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab. Stem Cells: the international journal of cell differentiation and proliferation, 1(4), 289-297. [More Information]

2011

  • Barile, L., Cerisoli, F., Frati, G., Gaetani, R., Chimenti, I., Forte, E., Cassinelli, L., Spinardi, L., Altomare, C., Kizana, E., et al (2011). Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart. Journal of Cellular and Molecular Medicine, 15(1), 63-71. [More Information]
  • Cunningham, S., Kok, C., Dane, A., Carpenter, K., Kizana, E., Kuchel, P., Alexander, I. (2011). Induction and Prevention of Severe Hyperammonemia in the spf(ash) Mouse Model of Ornithine Transcarbamylase Deficiency Using shRNA and rAAV-mediated Gene Delivery. Molecular Therapy, 19(5), 854-859. [More Information]
  • Kho, C., Lee, A., Jeong, D., Oh, J., Chaanine, A., Kizana, E., Park, W., Hajjar, R. (2011). SUMO1-dependent modulation of SERCA2a in heart failure. Nature, 477(7366), 601-605. [More Information]

2010

  • Davis, D., Kizana, E., Terrovitis, J., Barth, A., Zhang, Y., Smith, R., Miake, J., Marban, E. (2010). Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. Journal of Molecular and Cellular Cardiology, 49(2), 312-321. [More Information]

2009

  • Rossello, R., Wang, Z., Kizana, E., Krebsbach, P., Kohn, D. (2009). Connexin 43 as a signaling platform for increasing the volume and spatial distribution of regenerated tissue. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(32), 13219-13224. [More Information]
  • Sekar, R., Kizana, E., Cho, H., Molitoris, J., Hesketh, G., Eaton, B., Marban, E., Tung, L. (2009). IK1 Heterogeneity Affects Genesis and Stability of Spiral Waves in Cardiac Myocyte Monolayers. Circulation Research, 104, 355-364. [More Information]
  • Kizana, E., Cingolani, E., Marban, E. (2009). Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells. Gene Therapy (Basingstoke), 16(9), 1163-1168. [More Information]
  • Mahairaki, V., Xu, L., Farah, M., Hatfield, G., Kizana, E., Marban, E., Koliatsos, V. (2009). Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interference. Journal of Neuroscience Methods, 179(2), 292-299. [More Information]

2008

  • Chang, K., Barth, A., Sasano, T., Kizana, E., Kashiwakura, Y., Zhang, Y., Foster, D., Marbán, E. (2008). CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(11), 4477-4482. [More Information]
  • Terrovitis, J., Kwok, K., Lautamäki, R., Engles, J., Barth, A., Kizana, E., Miake, J., Leppo, M., Fox, J., Seidel, J., et al (2008). Ectopic expression of the sodium-iodide symporter enables imaging of transplanted cardiac stem cells in vivo by single-photon emission computed tomography or positron emission tomography. Journal of the American College of Cardiology, 52(20), 1652-1660. [More Information]
  • Barth, A., Kizana, E., Smith, R., Terrovitis, J., Dong, P., Leppo, M., Zhang, Y., Miake, J., Olson, E., Schneider, J., et al (2008). Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report cardiogenic differentiation in stem cells. Molecular Therapy, 16(5), 957-964. [More Information]
  • Terrovitis, J., Stuber, M., Youssef, A., Preece, S., Leppo, M., Kizana, E., Schar, M., Gerstenblith, G., Weiss, R., Marbán, E., et al (2008). Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation (Baltimore), 117(12), 1555-1562. [More Information]

2007

  • Cingolani, E., Ramirez-Correa, G., Kizana, E., Murata, M., Cho, H., Marbán, E. (2007). Gene therapy to inhibit the calcium channel beta subunit: physiological consequences and pathophysiological effects in models of cardiac hypertrophy. Circulation Research, 101(2), 166-175. [More Information]
  • Sekar, R., Kizana, E., Smith, R., Barth, A., Zhang, Y., Marban, E., Tung, L. (2007). Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity. American Journal of Physiology: Heart and Circulatory Physiology, 293(5), H2757-H2770. [More Information]
  • Kizana, E. (2007). Therapeutic prospects of cardiac gene transfer. Heart, Lung and Circulation, 16(3), 180-184. [More Information]

2006

  • Kizana, E., Ginn, S., Smyth, C., Boyd, A., Thomas, S., Allen, D., Ross, D., Alexander, I. (2006). Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy. Gene Therapy (Basingstoke), 13(22), 1611-1615. [More Information]

2005

  • Kizana, E., Ginn, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling. Circulation, 111(4), 394-398. [More Information]
  • Kizana, E., Ginn, S., Smyth, C., Thomas, S., Allen, D., Ross, D., Alexander, I. (2005). Fibroblasts Modulate Cardiomyocyte Excitability: Insights from Fibroblasts with Genetically Altered Connexin43 Expression. Journal of Gene Medicine, 7(point P8 on page 1127), 1127-1127.

2004

  • Allen, D., Hardeman, E., North, K., Alexander, I., Cooper, S., Maxwell, A., Kizana, E., Ghoddusi, M. (2004). C2C12 Co-Culture On A Fibroblast Substratum Enables Sustained Survival Of Contractile, Highly Differentiated Myotubes With Peripheral Nuclei And Adult Fast Myosin Expression. Cell Motility and the Cytoskeleton, 58(3), 200-211. [More Information]
  • del Monte, F., Kizana, E., Tabchy, A., Hajjar, R. (2004). Targeted gene transfer in heart failure: Implications for novel gene identification. Current Opinion in Molecular Therapeutics, 6(4), 381-394. [More Information]

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