Dr Edmund Lau

Clinical Senior Lecturer
Medicine: Central Clinical School

Telephone 9515 8613

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Biographical details

Dr Edmund Lau is a respiratory and sleep physician and currently holds appointments as Staff Specialist at the Royal Prince Alfred Hospital and Senior Lecturer at the University of Sydney. He has a PhD in pulmonary vascular disease and has completed a post-doctoralresearch fellowshipat the French National Referral Centre for Pulmonary Hypertension.

Research interests

Dr Lau'smain research focuses on a devastating disease known as pulmonary arterial hypertension (PAH), which causes blockage of the small blood vessels of the lungs and eventually leads to severe right heart failure. His research in PAH encompasses (1) epidemiological studies via collaboration with the Australian and New Zealand Pulmonary Hypertension Registry, (2) advanced invasive haemodynamic evaluation and novel functional imaging of the pulmonary artery-right ventricle unit, (3)exercise pathophysiology in pulmonary hypertension, (4) evidence-based evaluation of PAH therapies.
Edmund has research collaboration with the Department of Cardiology at Royal Prince Alfred Hospital, and ongoing international collaboration with leading PAH centres in France and Belgium. Apart fromhis interest in pulmonary hypertension, Edmund has also published in the fields of sleep, asthma, and cystic fibrosis. Edmund was the recipient of the Ann Woolcock Young Investigator Award in 2013 and has published in high impact journals such as Circulation, European Heart Journal and European Respiratory Journal. He has participated as member of Task Force Group on the pulmonary circulation for the European Respiratory Society and is on the editorial board of the European Respiratory Review.

Current projects

Honors and PhD projects are available

Awards and honours

Ann Woolcock Young Investigator Winner TSANZ 2013

RPAH Cardiologists' Prize for Best Clinical Paper 2012

University of NSW Dean's Recommendation for University High Achiever 2002

Australian Student Prize 1996

International links

Belgium

(Professor Robert Naeije, Erasme Hospital, Brussels) Right ventricular response to stress in pulmonary arterial hypertension

France

(Professor Denis Chemla, University of Paris-Sud) Haemodynamics of pulmonary circulation; exercise response in pulmonary vascular disease

France

(Professor Marc Humbert, INSERM UMR_S999) Translational and clinical research in pulmonary arterial hypertension

Selected grants

2015

  • Crybiopsy versus Surgical Lung Biopsy for Diagnosis of Interstitial Lung Diseases; Lau E; University of Sydney/Kickstart Grants Program.

2014

  • Signature olfactive de lhypertension arterielle pulmonaire detectee dans les exhalats pulmonaires par un nez artificiel : de la preuve de concept a la validation; Lau E; Fondation du Souffle/Postdocoral Fellowship.

Selected publications

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Journals

  • Chia, E., Lau, E., Xuan, W., Celermajer, D., Thomas, L. (2016). Exercise testing can unmask right ventricular dysfunction in systemic sclerosis patients with normal resting pulmonary artery pressure. International Journal of Cardiology, 204, 179-186. [More Information]
  • Girerd, B., Montani, D., Jais, X., Eyries, M., Yaici, A., Sztrymf, B., Savale, L., Parent, F., Coulet, F., Lau, E., et al (2016). Genetic counselling in a national referral centre for pulmonary hypertension. European Respiratory Journal, 47(2), 541-552. [More Information]
  • Lau, E., Humbert, M. (2015). A Critical Appraisal of the Updated 2014 Nice Pulmonary Hypertension Classification System. Canadian Journal of Cardiology, 31(4), 367-374. [More Information]
  • Herve, P., Lau, E., Sitbon, O., Savale, L., Montani, D., Godinas, L., Lador, F., Jais, X., Parent, F., Gunther, S., et al (2015). Criteria for diagnosis of exercise pulmonary hypertension. European Respiratory Journal, 46(3), 728-737. [More Information]
  • Ge, Q., Zeng, Q., Tjin, G., Lau, E., Black, J., Oliver, B., Burgess, J. (2015). Differential deposition of fibronectin by asthmatic bronchial epithelial cells. AJP: Lung Cellular and Molecular Physiology, 309(10), L1093-L1192. [More Information]
  • Sharma, T., Lau, E., Choudhary, P., Torzillo, P., Munoz, P., Simmons, L., Naeije, R., Celermajer, D. (2015). Dobutamine stress for evaluation of right ventricular reserve in pulmonary arterial hypertension. European Respiratory Journal, 45(3), 700-708. [More Information]
  • Lau, E., Humbert, M., Celermajer, D. (2015). Early detection of pulmonary arterial hypertension. Nature Reviews Cardiology, 12(3), 143-155. [More Information]
  • Chemla, D., Lau, E., Papelier, Y., Attal, P., Herve, P. (2015). Pulmonary vascular resistance and compliance relationship in pulmonary hypertension. European Respiratory Journal, 46(4), 1178-1189. [More Information]
  • Harari, S., Lau, E., Tamura, Y., Cottin, V., Simonneau, G., Humbert, M. (2015). Rare (pulmonary) disease day: "feeding the breath, energy for life!". European Respiratory Journal, 45(2), 297-300. [More Information]
  • Gunther, S., Sztrymf, B., Savale, L., Lau, E., Montani, D., Herve, P., Lador, F., Jais, X., Parent, F., Simonneau, G., et al (2015). Relation between left ventricular ejection time and pulmonary hemodynamics in pulmonary hypertension. International Journal of Cardiology, 184(1), 763-765. [More Information]
  • Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G., Humbert, M. (2015). Response to Letter Regarding Article, "Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension". Circulation, 132(12), e154. [More Information]
  • Lau, E., Tamura, Y., McGoon, M., Sitbon, O. (2015). The 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: a practical chronicle of progress. European Respiratory Journal, 46(4), 879-882. [More Information]
  • Lau, E., Celermajer, D., Naeije, R. (2015). The emerging role of the contractile and vascular reserves in pulmonary arterial hypertension. European Respiratory Journal, 45(6), 1758-1759. [More Information]
  • Marc, H., Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G. (2014). Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension. Circulation, 130(24), 2189-2208. [More Information]
  • Lau, E., Abelson, D., Dwyer, N., Yu, Y., Ng, M., Celermajer, D. (2014). Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis. European Respiratory Journal, 43(6), 1804-1807. [More Information]
  • Lau, E., Vanderpool, R., Choudhary, P., Simmons, L., Corte, T., Argiento, P., DAlto, M., Naeije, R., Celermajer, D. (2014). Dobutamine Stress Echocardiography for the Assessment of Pressure-Flow Relationships of the Pulmonary Circulation. Chest, 146(4), 959-966. [More Information]
  • Lau, E., Celermajer, D. (2014). Protecting our children from environmental tobacco smoke: one of our great healthcare challenges. European Heart Journal, 35(36), 2452-2453. [More Information]
  • Lau, E., Bailey, D., Bailey, E., Torzillo, P., Roach, P., Schembri, G., Corte, T., Celermajer, D. (2014). Pulmonary hypertension leads to a loss of gravity dependent redistribution of regional lung perfusion: a SPECT/CT study. Heart, 100(1), 47-53. [More Information]
  • Lau, E., Morgan, P., Belousova, E., Toelle, B., Ayer, J., Celermajer, D., Marks, G. (2013). Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study. European Respiratory Journal, 41(5), 1234-1237. [More Information]
  • Lau, E., Jaijee, S., Melehan, K., Wong, K., Yee, B., Grunstein, R., Celermajer, D. (2013). Prevalence of patent foramen ovale and its impact on oxygen desaturation in obstructive sleep apnea. International Journal of Cardiology, 165(1), 35-40. [More Information]
  • Lau, E., McCaughan, G., Torzillo, P. (2012). A case of portopulmonary hypertension spanning 18 years: successful use of bosentan for progressive disease after two liver transplantations. Internal Medicine Journal, 42(5), 600-601. [More Information]
  • Lau, E., Iyer, N., Ilsar, R., Bailey, B., Adams, M., Celermajer, D. (2012). Abnormal Pulmonary Artery Stiffness in Pulmonary Arterial Hypertension: In Vivo Study with Intravascular Ultrasound. PloS One, 7(3), 1-6. [More Information]
  • Lau, E., Cooper, W., Bye, P., Yan, K. (2011). Difficult asthma and Churg-Strauss-like syndrome: A cautionary tale. Respirology, 16(1), 180-181. [More Information]
  • Lau, E., Manes, A., Celermajer, D., Galie, N. (2011). Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. European Heart Journal, 32(20), 2489-2498. [More Information]
  • Bye, P., Lau, E., Elkins, M. (2011). Pharmacological airway clearance strategies in bronchiectasis. European Respiratory Monograph, , 239-247.
  • Lau, E., Barnes, D., Moriarty, C., Ogle, R., Dentice, R., Civitico, J., Avedello, A., Torzillo, P., Bye, P. (2011). Pregnancy outcomes in the current era of cystic fibrosis care: A 15-year experience. Australian and New Zealand Journal of Obstetrics and Gynaecology, 51(3), 220-224. [More Information]
  • Iyer, N., Lau, E., Ilsar, R., Celermajer, D. (2011). Treatment responsiveness in pulmonary arterial hypertension-Preliminary report on serial intra-arterial Doppler flow velocity waveform measurements. International Journal of Cardiology, 153(2), 219-221. [More Information]
  • Lau, E., Yee, B., Grunstein, R., Celermajer, D. (2010). Patent foramen ovale and obstructive sleep apnea: A new association? Sleep Medicine Reviews, 14(6), 391-395. [More Information]

2016

  • Chia, E., Lau, E., Xuan, W., Celermajer, D., Thomas, L. (2016). Exercise testing can unmask right ventricular dysfunction in systemic sclerosis patients with normal resting pulmonary artery pressure. International Journal of Cardiology, 204, 179-186. [More Information]
  • Girerd, B., Montani, D., Jais, X., Eyries, M., Yaici, A., Sztrymf, B., Savale, L., Parent, F., Coulet, F., Lau, E., et al (2016). Genetic counselling in a national referral centre for pulmonary hypertension. European Respiratory Journal, 47(2), 541-552. [More Information]

2015

  • Lau, E., Humbert, M. (2015). A Critical Appraisal of the Updated 2014 Nice Pulmonary Hypertension Classification System. Canadian Journal of Cardiology, 31(4), 367-374. [More Information]
  • Herve, P., Lau, E., Sitbon, O., Savale, L., Montani, D., Godinas, L., Lador, F., Jais, X., Parent, F., Gunther, S., et al (2015). Criteria for diagnosis of exercise pulmonary hypertension. European Respiratory Journal, 46(3), 728-737. [More Information]
  • Ge, Q., Zeng, Q., Tjin, G., Lau, E., Black, J., Oliver, B., Burgess, J. (2015). Differential deposition of fibronectin by asthmatic bronchial epithelial cells. AJP: Lung Cellular and Molecular Physiology, 309(10), L1093-L1192. [More Information]
  • Sharma, T., Lau, E., Choudhary, P., Torzillo, P., Munoz, P., Simmons, L., Naeije, R., Celermajer, D. (2015). Dobutamine stress for evaluation of right ventricular reserve in pulmonary arterial hypertension. European Respiratory Journal, 45(3), 700-708. [More Information]
  • Lau, E., Humbert, M., Celermajer, D. (2015). Early detection of pulmonary arterial hypertension. Nature Reviews Cardiology, 12(3), 143-155. [More Information]
  • Chemla, D., Lau, E., Papelier, Y., Attal, P., Herve, P. (2015). Pulmonary vascular resistance and compliance relationship in pulmonary hypertension. European Respiratory Journal, 46(4), 1178-1189. [More Information]
  • Harari, S., Lau, E., Tamura, Y., Cottin, V., Simonneau, G., Humbert, M. (2015). Rare (pulmonary) disease day: "feeding the breath, energy for life!". European Respiratory Journal, 45(2), 297-300. [More Information]
  • Gunther, S., Sztrymf, B., Savale, L., Lau, E., Montani, D., Herve, P., Lador, F., Jais, X., Parent, F., Simonneau, G., et al (2015). Relation between left ventricular ejection time and pulmonary hemodynamics in pulmonary hypertension. International Journal of Cardiology, 184(1), 763-765. [More Information]
  • Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G., Humbert, M. (2015). Response to Letter Regarding Article, "Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension". Circulation, 132(12), e154. [More Information]
  • Lau, E., Tamura, Y., McGoon, M., Sitbon, O. (2015). The 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: a practical chronicle of progress. European Respiratory Journal, 46(4), 879-882. [More Information]
  • Lau, E., Celermajer, D., Naeije, R. (2015). The emerging role of the contractile and vascular reserves in pulmonary arterial hypertension. European Respiratory Journal, 45(6), 1758-1759. [More Information]

2014

  • Marc, H., Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G. (2014). Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension. Circulation, 130(24), 2189-2208. [More Information]
  • Lau, E., Abelson, D., Dwyer, N., Yu, Y., Ng, M., Celermajer, D. (2014). Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis. European Respiratory Journal, 43(6), 1804-1807. [More Information]
  • Lau, E., Vanderpool, R., Choudhary, P., Simmons, L., Corte, T., Argiento, P., DAlto, M., Naeije, R., Celermajer, D. (2014). Dobutamine Stress Echocardiography for the Assessment of Pressure-Flow Relationships of the Pulmonary Circulation. Chest, 146(4), 959-966. [More Information]
  • Lau, E., Celermajer, D. (2014). Protecting our children from environmental tobacco smoke: one of our great healthcare challenges. European Heart Journal, 35(36), 2452-2453. [More Information]
  • Lau, E., Bailey, D., Bailey, E., Torzillo, P., Roach, P., Schembri, G., Corte, T., Celermajer, D. (2014). Pulmonary hypertension leads to a loss of gravity dependent redistribution of regional lung perfusion: a SPECT/CT study. Heart, 100(1), 47-53. [More Information]

2013

  • Lau, E., Morgan, P., Belousova, E., Toelle, B., Ayer, J., Celermajer, D., Marks, G. (2013). Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study. European Respiratory Journal, 41(5), 1234-1237. [More Information]
  • Lau, E., Jaijee, S., Melehan, K., Wong, K., Yee, B., Grunstein, R., Celermajer, D. (2013). Prevalence of patent foramen ovale and its impact on oxygen desaturation in obstructive sleep apnea. International Journal of Cardiology, 165(1), 35-40. [More Information]

2012

  • Lau, E., McCaughan, G., Torzillo, P. (2012). A case of portopulmonary hypertension spanning 18 years: successful use of bosentan for progressive disease after two liver transplantations. Internal Medicine Journal, 42(5), 600-601. [More Information]
  • Lau, E., Iyer, N., Ilsar, R., Bailey, B., Adams, M., Celermajer, D. (2012). Abnormal Pulmonary Artery Stiffness in Pulmonary Arterial Hypertension: In Vivo Study with Intravascular Ultrasound. PloS One, 7(3), 1-6. [More Information]

2011

  • Lau, E., Cooper, W., Bye, P., Yan, K. (2011). Difficult asthma and Churg-Strauss-like syndrome: A cautionary tale. Respirology, 16(1), 180-181. [More Information]
  • Lau, E., Manes, A., Celermajer, D., Galie, N. (2011). Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. European Heart Journal, 32(20), 2489-2498. [More Information]
  • Bye, P., Lau, E., Elkins, M. (2011). Pharmacological airway clearance strategies in bronchiectasis. European Respiratory Monograph, , 239-247.
  • Lau, E., Barnes, D., Moriarty, C., Ogle, R., Dentice, R., Civitico, J., Avedello, A., Torzillo, P., Bye, P. (2011). Pregnancy outcomes in the current era of cystic fibrosis care: A 15-year experience. Australian and New Zealand Journal of Obstetrics and Gynaecology, 51(3), 220-224. [More Information]
  • Iyer, N., Lau, E., Ilsar, R., Celermajer, D. (2011). Treatment responsiveness in pulmonary arterial hypertension-Preliminary report on serial intra-arterial Doppler flow velocity waveform measurements. International Journal of Cardiology, 153(2), 219-221. [More Information]

2010

  • Lau, E., Yee, B., Grunstein, R., Celermajer, D. (2010). Patent foramen ovale and obstructive sleep apnea: A new association? Sleep Medicine Reviews, 14(6), 391-395. [More Information]

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