Dr Edmund Lau

Clinical Senior Lecturer
Medicine: Central Clinical School

Telephone 9515 8195
Fax 9515 8196

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Biographical details

Dr Edmund Lau is a respiratory and sleep physician and currently holds appointments as Staff Specialist at the Royal Prince Alfred Hospital and Senior Lecturer at the University of Sydney. He has a PhD in pulmonary vascular medicine and previously worked at the French National Referral Centre for Pulmonary Hypertension prior to returning to Australia.

Research interests

Main research theme focuses on a devastating disease known as pulmonary arterial hypertension (PAH), which causes blockage of the small blood vessels of the lungs. Areas of research in PAH encompass:
  1. Epidemiological studies with the Australian and New Zealand Pulmonary Hypertension Registry,
  2. Functional imaging of the right ventricle-pulmonary circulation,
  3. Exercise physiology of the pulmonary circulation,
  4. Novel therapies for PAH.
Research collaboration includes the Department of Cardiology and Department of Radiology at Royal Prince Alfred Hospital, and ongoing international collaboration with the French National Referral Centre. Apart from his interest in pulmonary hypertension, Dr Lau has also published in the fields of sleep, asthma, and cystic fibrosis. Dr Lau was the recipient of the Ann Woolcock Young Investigator Award in 2013 and has published in high impact journals such as Circulation, European Heart Journal and European Respiratory Journal. He has participated as member of a Task Force Group on the pulmonary circulation for the European Respiratory Society and is on the editorial board of the European Respiratory Review. He is executive board member of the Pulmonary Hypertension Society of Australia and New Zealand (PHSANZ) and is the medical director of PHSANZ Registry.

Current projects

Honors and PhD projects opportunities are available

Awards and honours

Ann Woolcock Young Investigator Winner TSANZ 2013

RPAH Cardiologists' Prize for Best Clinical Paper 2012

University of NSW Dean's Recommendation for University High Achiever 2002

Australian Student Prize 1996

International links

Belgium

(Professor Robert Naeije, Erasme Hospital, Brussels) Right ventricular response to stress in pulmonary arterial hypertension

France

(Professor Denis Chemla, University of Paris-Sud) Haemodynamics of pulmonary circulation; exercise response in pulmonary vascular disease

France

(Professor Marc Humbert, INSERM UMR_S999) Translational and clinical research in pulmonary arterial hypertension

Selected grants

2015

  • Crybiopsy versus Surgical Lung Biopsy for Diagnosis of Interstitial Lung Diseases; Lau E; University of Sydney/Kickstart Grants Program.

2014

  • Signature olfactive de lhypertension arterielle pulmonaire detectee dans les exhalats pulmonaires par un nez artificiel : de la preuve de concept a la validation; Lau E; Fondation du Souffle/Postdocoral Fellowship.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Lau, E., Thakkar, V. (2016). Connective tissue disease-related pulmonary arterial hypertension. Best Practice & Research: Clinical Rheumatology, 30(1), 22-38. [More Information]
  • Godinas, L., Lau, E., Chemla, D., Lador, F., Savale, L., Montani, D., Jais, X., Sitbon, O., Simonneau, G., Humbert, M., et al (2016). Diagnostic concordance of different criteria for exercise pulmonary hypertension in subjects with normal resting pulmonary artery pressure. European Respiratory Journal, 48(1), 254-257. [More Information]
  • Lau, E., Chemla, D., Whyte, K., Kovacs, G., Olschewski, H., Herve, P. (2016). Does exercise pulmonary hypertension exist? Current Opinion in Pulmonary Medicine, 22(5), 400-407. [More Information]
  • Troy, L., Young, I., Lau, E., Corte, T. (2016). Exercise pathophysiology and the role of oxygen therapy in idiopathic interstitial pneumonia. Respirology, 21(6), 1005-1014. [More Information]
  • Chia, E., Lau, E., Xuan, W., Celermajer, D., Thomas, L. (2016). Exercise testing can unmask right ventricular dysfunction in systemic sclerosis patients with normal resting pulmonary artery pressure. International Journal of Cardiology, 204, 179-186. [More Information]
  • Girerd, B., Montani, D., Jais, X., Eyries, M., Yaici, A., Sztrymf, B., Savale, L., Parent, F., Coulet, F., Lau, E., et al (2016). Genetic counselling in a national referral centre for pulmonary hypertension. European Respiratory Journal, 47(2), 541-552. [More Information]
  • Lau, E., Chemla, D., Godinas, L., Zhu, K., Sitbon, O., Savale, L., Montani, D., Jais, X., Celermajer, D., Simonneau, G., et al (2016). Loss of Vascular Distensibility During Exercise is an Early Hemodynamic Marker of Pulmonary Vascular Disease. Chest, 149(2), 353-361. [More Information]
  • Godinas, L., Amar, D., Montani, D., Lau, E., Jais, X., Savale, L., Jevnikar, M., Sitbon, O., Simonneau, G., Humbert, M., et al (2016). Lung capillary blood volume and membrane diffusion in precapillary pulmonary hypertension. Journal Of Heart And Lung Transplantation, 35(5), 647-656. [More Information]
  • Lau, E., Naeije, R. (2016). Provocative testing of the pulmonary circulation: advances and unresolved issues. European Respiratory Journal, 48(1), 18-20. [More Information]
  • Montani, D., Lau, E., Dorfmuller, P., Girerd, B., Jais, X., Savale, L., Perros, F., Nossent, E., Garcia, G., Parent, F., et al (2016). Pulmonary veno-occlusive disease. European Respiratory Journal, 47(5), 1518-1534. [More Information]
  • Lau, E., Godinas, L., Sitbon, O., Montani, D., Savale, L., Jais, X., Lador, F., Gunther, S., Celermajer, D., Simonneau, G., et al (2016). Resting pulmonary artery pressure of 21-24 mmHg predicts abnormal exercise haemodynamics. European Respiratory Journal, 47(5), 1436-1444. [More Information]
  • Arnott, C., Boehm, C., Lau, E., Celermajer, D. (2016). Survival outcomes in severe congenital versus non-congenital pulmonary hypertension. Heart Asia, 8(1), 3-7. [More Information]
  • Lau, E., Humbert, M. (2015). A Critical Appraisal of the Updated 2014 Nice Pulmonary Hypertension Classification System. Canadian Journal of Cardiology, 31(4), 367-374. [More Information]
  • Lau, E., Humbert, M. (2015). A Critical Appraisal of the Updated 2014 Nice Pulmonary Hypertension Classification System. Canadian Journal of Cardiology, 31(4), 367-374. [More Information]
  • Herve, P., Lau, E., Sitbon, O., Savale, L., Montani, D., Godinas, L., Lador, F., Jais, X., Parent, F., Gunther, S., et al (2015). Criteria for diagnosis of exercise pulmonary hypertension. European Respiratory Journal, 46(3), 728-737. [More Information]
  • Ge, Q., Zeng, Q., Tjin, G., Lau, E., Black, J., Oliver, B., Burgess, J. (2015). Differential deposition of fibronectin by asthmatic bronchial epithelial cells. AJP: Lung Cellular and Molecular Physiology, 309(10), L1093-L1192. [More Information]
  • Sharma, T., Lau, E., Choudhary, P., Torzillo, P., Munoz, P., Simmons, L., Naeije, R., Celermajer, D. (2015). Dobutamine stress for evaluation of right ventricular reserve in pulmonary arterial hypertension. European Respiratory Journal, 45(3), 700-708. [More Information]
  • Lau, E., Humbert, M., Celermajer, D. (2015). Early detection of pulmonary arterial hypertension. Nature Reviews Cardiology, 12(3), 143-155. [More Information]
  • Chemla, D., Lau, E., Papelier, Y., Attal, P., Herve, P. (2015). Pulmonary vascular resistance and compliance relationship in pulmonary hypertension. European Respiratory Journal, 46(4), 1178-1189. [More Information]
  • Harari, S., Lau, E., Tamura, Y., Cottin, V., Simonneau, G., Humbert, M. (2015). Rare (pulmonary) disease day: "feeding the breath, energy for life!". European Respiratory Journal, 45(2), 297-300. [More Information]
  • Gunther, S., Sztrymf, B., Savale, L., Lau, E., Montani, D., Herve, P., Lador, F., Jais, X., Parent, F., Simonneau, G., et al (2015). Relation between left ventricular ejection time and pulmonary hemodynamics in pulmonary hypertension. International Journal of Cardiology, 184(1), 763-765. [More Information]
  • Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G., Humbert, M. (2015). Response to Letter Regarding Article, "Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension". Circulation, 132(12), e154. [More Information]
  • Lau, E., Tamura, Y., McGoon, M., Sitbon, O. (2015). The 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: a practical chronicle of progress. European Respiratory Journal, 46(4), 879-882. [More Information]
  • Lau, E., Celermajer, D., Naeije, R. (2015). The emerging role of the contractile and vascular reserves in pulmonary arterial hypertension. European Respiratory Journal, 45(6), 1758-1759. [More Information]
  • Marc, H., Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G. (2014). Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension. Circulation, 130(24), 2189-2208. [More Information]
  • Lau, E., Abelson, D., Dwyer, N., Yu, Y., Ng, M., Celermajer, D. (2014). Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis. European Respiratory Journal, 43(6), 1804-1807. [More Information]
  • Lau, E., Vanderpool, R., Choudhary, P., Simmons, L., Corte, T., Argiento, P., DAlto, M., Naeije, R., Celermajer, D. (2014). Dobutamine Stress Echocardiography for the Assessment of Pressure-Flow Relationships of the Pulmonary Circulation. Chest, 146(4), 959-966. [More Information]
  • Lau, E., Celermajer, D. (2014). Protecting our children from environmental tobacco smoke: one of our great healthcare challenges. European Heart Journal, 35(36), 2452-2453. [More Information]
  • Lau, E., Bailey, D., Bailey, E., Torzillo, P., Roach, P., Schembri, G., Corte, T., Celermajer, D. (2014). Pulmonary hypertension leads to a loss of gravity dependent redistribution of regional lung perfusion: a SPECT/CT study. Heart, 100(1), 47-53. [More Information]
  • Lau, E., Morgan, P., Belousova, E., Toelle, B., Ayer, J., Celermajer, D., Marks, G. (2013). Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study. European Respiratory Journal, 41(5), 1234-1237. [More Information]
  • Lau, E., Jaijee, S., Melehan, K., Wong, K., Yee, B., Grunstein, R., Celermajer, D. (2013). Prevalence of patent foramen ovale and its impact on oxygen desaturation in obstructive sleep apnea. International Journal of Cardiology, 165(1), 35-40. [More Information]
  • Lau, E., McCaughan, G., Torzillo, P. (2012). A case of portopulmonary hypertension spanning 18 years: successful use of bosentan for progressive disease after two liver transplantations. Internal Medicine Journal, 42(5), 600-601. [More Information]
  • Lau, E., Iyer, N., Ilsar, R., Bailey, B., Adams, M., Celermajer, D. (2012). Abnormal Pulmonary Artery Stiffness in Pulmonary Arterial Hypertension: In Vivo Study with Intravascular Ultrasound. PloS One, 7(3), 1-6. [More Information]
  • Lau, E., Cooper, W., Bye, P., Yan, K. (2011). Difficult asthma and Churg-Strauss-like syndrome: A cautionary tale. Respirology, 16(1), 180-181. [More Information]
  • Lau, E., Manes, A., Celermajer, D., Galie, N. (2011). Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. European Heart Journal, 32(20), 2489-2498. [More Information]
  • Bye, P., Lau, E., Elkins, M. (2011). Pharmacological airway clearance strategies in bronchiectasis. European Respiratory Monograph, , 239-247.
  • Lau, E., Barnes, D., Moriarty, C., Ogle, R., Dentice, R., Civitico, J., Avedello, A., Torzillo, P., Bye, P. (2011). Pregnancy outcomes in the current era of cystic fibrosis care: A 15-year experience. Australian and New Zealand Journal of Obstetrics and Gynaecology, 51(3), 220-224. [More Information]
  • Iyer, N., Lau, E., Ilsar, R., Celermajer, D. (2011). Treatment responsiveness in pulmonary arterial hypertension-Preliminary report on serial intra-arterial Doppler flow velocity waveform measurements. International Journal of Cardiology, 153(2), 219-221. [More Information]
  • Lau, E., Yee, B., Grunstein, R., Celermajer, D. (2010). Patent foramen ovale and obstructive sleep apnea: A new association? Sleep Medicine Reviews, 14(6), 391-395. [More Information]

2016

  • Lau, E., Thakkar, V. (2016). Connective tissue disease-related pulmonary arterial hypertension. Best Practice & Research: Clinical Rheumatology, 30(1), 22-38. [More Information]
  • Godinas, L., Lau, E., Chemla, D., Lador, F., Savale, L., Montani, D., Jais, X., Sitbon, O., Simonneau, G., Humbert, M., et al (2016). Diagnostic concordance of different criteria for exercise pulmonary hypertension in subjects with normal resting pulmonary artery pressure. European Respiratory Journal, 48(1), 254-257. [More Information]
  • Lau, E., Chemla, D., Whyte, K., Kovacs, G., Olschewski, H., Herve, P. (2016). Does exercise pulmonary hypertension exist? Current Opinion in Pulmonary Medicine, 22(5), 400-407. [More Information]
  • Troy, L., Young, I., Lau, E., Corte, T. (2016). Exercise pathophysiology and the role of oxygen therapy in idiopathic interstitial pneumonia. Respirology, 21(6), 1005-1014. [More Information]
  • Chia, E., Lau, E., Xuan, W., Celermajer, D., Thomas, L. (2016). Exercise testing can unmask right ventricular dysfunction in systemic sclerosis patients with normal resting pulmonary artery pressure. International Journal of Cardiology, 204, 179-186. [More Information]
  • Girerd, B., Montani, D., Jais, X., Eyries, M., Yaici, A., Sztrymf, B., Savale, L., Parent, F., Coulet, F., Lau, E., et al (2016). Genetic counselling in a national referral centre for pulmonary hypertension. European Respiratory Journal, 47(2), 541-552. [More Information]
  • Lau, E., Chemla, D., Godinas, L., Zhu, K., Sitbon, O., Savale, L., Montani, D., Jais, X., Celermajer, D., Simonneau, G., et al (2016). Loss of Vascular Distensibility During Exercise is an Early Hemodynamic Marker of Pulmonary Vascular Disease. Chest, 149(2), 353-361. [More Information]
  • Godinas, L., Amar, D., Montani, D., Lau, E., Jais, X., Savale, L., Jevnikar, M., Sitbon, O., Simonneau, G., Humbert, M., et al (2016). Lung capillary blood volume and membrane diffusion in precapillary pulmonary hypertension. Journal Of Heart And Lung Transplantation, 35(5), 647-656. [More Information]
  • Lau, E., Naeije, R. (2016). Provocative testing of the pulmonary circulation: advances and unresolved issues. European Respiratory Journal, 48(1), 18-20. [More Information]
  • Montani, D., Lau, E., Dorfmuller, P., Girerd, B., Jais, X., Savale, L., Perros, F., Nossent, E., Garcia, G., Parent, F., et al (2016). Pulmonary veno-occlusive disease. European Respiratory Journal, 47(5), 1518-1534. [More Information]
  • Lau, E., Godinas, L., Sitbon, O., Montani, D., Savale, L., Jais, X., Lador, F., Gunther, S., Celermajer, D., Simonneau, G., et al (2016). Resting pulmonary artery pressure of 21-24 mmHg predicts abnormal exercise haemodynamics. European Respiratory Journal, 47(5), 1436-1444. [More Information]
  • Arnott, C., Boehm, C., Lau, E., Celermajer, D. (2016). Survival outcomes in severe congenital versus non-congenital pulmonary hypertension. Heart Asia, 8(1), 3-7. [More Information]

2015

  • Lau, E., Humbert, M. (2015). A Critical Appraisal of the Updated 2014 Nice Pulmonary Hypertension Classification System. Canadian Journal of Cardiology, 31(4), 367-374. [More Information]
  • Lau, E., Humbert, M. (2015). A Critical Appraisal of the Updated 2014 Nice Pulmonary Hypertension Classification System. Canadian Journal of Cardiology, 31(4), 367-374. [More Information]
  • Herve, P., Lau, E., Sitbon, O., Savale, L., Montani, D., Godinas, L., Lador, F., Jais, X., Parent, F., Gunther, S., et al (2015). Criteria for diagnosis of exercise pulmonary hypertension. European Respiratory Journal, 46(3), 728-737. [More Information]
  • Ge, Q., Zeng, Q., Tjin, G., Lau, E., Black, J., Oliver, B., Burgess, J. (2015). Differential deposition of fibronectin by asthmatic bronchial epithelial cells. AJP: Lung Cellular and Molecular Physiology, 309(10), L1093-L1192. [More Information]
  • Sharma, T., Lau, E., Choudhary, P., Torzillo, P., Munoz, P., Simmons, L., Naeije, R., Celermajer, D. (2015). Dobutamine stress for evaluation of right ventricular reserve in pulmonary arterial hypertension. European Respiratory Journal, 45(3), 700-708. [More Information]
  • Lau, E., Humbert, M., Celermajer, D. (2015). Early detection of pulmonary arterial hypertension. Nature Reviews Cardiology, 12(3), 143-155. [More Information]
  • Chemla, D., Lau, E., Papelier, Y., Attal, P., Herve, P. (2015). Pulmonary vascular resistance and compliance relationship in pulmonary hypertension. European Respiratory Journal, 46(4), 1178-1189. [More Information]
  • Harari, S., Lau, E., Tamura, Y., Cottin, V., Simonneau, G., Humbert, M. (2015). Rare (pulmonary) disease day: "feeding the breath, energy for life!". European Respiratory Journal, 45(2), 297-300. [More Information]
  • Gunther, S., Sztrymf, B., Savale, L., Lau, E., Montani, D., Herve, P., Lador, F., Jais, X., Parent, F., Simonneau, G., et al (2015). Relation between left ventricular ejection time and pulmonary hemodynamics in pulmonary hypertension. International Journal of Cardiology, 184(1), 763-765. [More Information]
  • Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G., Humbert, M. (2015). Response to Letter Regarding Article, "Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension". Circulation, 132(12), e154. [More Information]
  • Lau, E., Tamura, Y., McGoon, M., Sitbon, O. (2015). The 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: a practical chronicle of progress. European Respiratory Journal, 46(4), 879-882. [More Information]
  • Lau, E., Celermajer, D., Naeije, R. (2015). The emerging role of the contractile and vascular reserves in pulmonary arterial hypertension. European Respiratory Journal, 45(6), 1758-1759. [More Information]

2014

  • Marc, H., Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G. (2014). Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension. Circulation, 130(24), 2189-2208. [More Information]
  • Lau, E., Abelson, D., Dwyer, N., Yu, Y., Ng, M., Celermajer, D. (2014). Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis. European Respiratory Journal, 43(6), 1804-1807. [More Information]
  • Lau, E., Vanderpool, R., Choudhary, P., Simmons, L., Corte, T., Argiento, P., DAlto, M., Naeije, R., Celermajer, D. (2014). Dobutamine Stress Echocardiography for the Assessment of Pressure-Flow Relationships of the Pulmonary Circulation. Chest, 146(4), 959-966. [More Information]
  • Lau, E., Celermajer, D. (2014). Protecting our children from environmental tobacco smoke: one of our great healthcare challenges. European Heart Journal, 35(36), 2452-2453. [More Information]
  • Lau, E., Bailey, D., Bailey, E., Torzillo, P., Roach, P., Schembri, G., Corte, T., Celermajer, D. (2014). Pulmonary hypertension leads to a loss of gravity dependent redistribution of regional lung perfusion: a SPECT/CT study. Heart, 100(1), 47-53. [More Information]

2013

  • Lau, E., Morgan, P., Belousova, E., Toelle, B., Ayer, J., Celermajer, D., Marks, G. (2013). Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study. European Respiratory Journal, 41(5), 1234-1237. [More Information]
  • Lau, E., Jaijee, S., Melehan, K., Wong, K., Yee, B., Grunstein, R., Celermajer, D. (2013). Prevalence of patent foramen ovale and its impact on oxygen desaturation in obstructive sleep apnea. International Journal of Cardiology, 165(1), 35-40. [More Information]

2012

  • Lau, E., McCaughan, G., Torzillo, P. (2012). A case of portopulmonary hypertension spanning 18 years: successful use of bosentan for progressive disease after two liver transplantations. Internal Medicine Journal, 42(5), 600-601. [More Information]
  • Lau, E., Iyer, N., Ilsar, R., Bailey, B., Adams, M., Celermajer, D. (2012). Abnormal Pulmonary Artery Stiffness in Pulmonary Arterial Hypertension: In Vivo Study with Intravascular Ultrasound. PloS One, 7(3), 1-6. [More Information]

2011

  • Lau, E., Cooper, W., Bye, P., Yan, K. (2011). Difficult asthma and Churg-Strauss-like syndrome: A cautionary tale. Respirology, 16(1), 180-181. [More Information]
  • Lau, E., Manes, A., Celermajer, D., Galie, N. (2011). Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. European Heart Journal, 32(20), 2489-2498. [More Information]
  • Bye, P., Lau, E., Elkins, M. (2011). Pharmacological airway clearance strategies in bronchiectasis. European Respiratory Monograph, , 239-247.
  • Lau, E., Barnes, D., Moriarty, C., Ogle, R., Dentice, R., Civitico, J., Avedello, A., Torzillo, P., Bye, P. (2011). Pregnancy outcomes in the current era of cystic fibrosis care: A 15-year experience. Australian and New Zealand Journal of Obstetrics and Gynaecology, 51(3), 220-224. [More Information]
  • Iyer, N., Lau, E., Ilsar, R., Celermajer, D. (2011). Treatment responsiveness in pulmonary arterial hypertension-Preliminary report on serial intra-arterial Doppler flow velocity waveform measurements. International Journal of Cardiology, 153(2), 219-221. [More Information]

2010

  • Lau, E., Yee, B., Grunstein, R., Celermajer, D. (2010). Patent foramen ovale and obstructive sleep apnea: A new association? Sleep Medicine Reviews, 14(6), 391-395. [More Information]

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