Associate Professor Edna Hardeman

Adjunct Associate Professor
Medicine, Children's Medical Research Institute

Telephone 02 8865 2913
Fax 02 687 2120

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Research interests

Associate Professor Edna Hardeman is an internationally recognised expert in muscle biology and disease and more recently researches the neurodevelopmental disorder Williams Syndrome.

Selected grants

2009

  • Mouse models for the identification of factors involved in muscle adaptation; Hardeman E, Palmer S; Australian Research Council (ARC)/Discovery Projects (DP).
  • A novel actin filament population regulates glucose transport in skeletal muscle; Gunning P, Hardeman E, Kee A; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • The influence of alpha actinins on human performance in health and disease; North K, Hardeman E, Gunning P, Head S, Yang N; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Confocal microscope for cancer research in the northern hub; Robinson P, Gunning P, Hardeman E, Henderson B, Bendall L, Chircop (nee Fabbro) M; Cancer Institute New South Wales/Research Grant.

2005

  • Novel Features And Mechanisms Of Congenital Myopathies; Hardeman E, Hardeman E, North K; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • The influence of alpha actinins on human performance; Yang N, North K, Gunning P, Hardeman E; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Nguyen, M., Hardeman, E. (2008). Mouse Models for Thin Filament Disease. In Nigel G. Laing (Eds.), The Sarcomere and Skeletal Muscle Disease, (pp. 66-77). New York: Springer Science + Business Media.

Journals

  • Lee, A., Anderson, J., Joya, J., Head, S., Pather, N., Kee, A., Gunning, P., Hardeman, E. (2013). Aged skeletal muscle retains the ability to fully regenerate functional architecture. Bioarchitecture, 3(2), 25-37.
  • Lindqvist, J., Cheng, A., Renaud, G., Hardeman, E., Ochala, J. (2013). Distinct Underlying Mechanisms of Limb and Respiratory Muscle Fiber Weaknesses in Nemaline Myopathy. Journal of Neuropathology and Experimental Neurology, 72(6), 472-481. [More Information]
  • Schevzov, G., Fath, T., Vrhoski, B., Vlahovich, N., Rajan, S., Hook, J., Joya, J., Lemckert, F., Puttur, F., Lin, J., Hardeman, E., O'Neill, G., Gunning, P., et al (2008). Divergent regulation of the sarcomere and the cytoskeleton. Journal of Biological Chemistry, 283(1), 275-283. [More Information]
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008). The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology, 149(5), 2403-2410. [More Information]
  • Gunning, P., O'Neill, G., Hardeman, E. (2008). Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space. Physiological Reviews, 88(1), 1-35. [More Information]
  • MacArthur, D., Seto, J., Raftery, J., Quinlan (nee Edwards), K., Huttley, G., Hook, J., Lemckert, F., Kee, A., Edwards, M., Berman, Y., Hardeman, E., Gunning, P., Yang, N., North, K., et al (2007). Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nature Genetics, 39(10), 1261-1265. [More Information]
  • Domazetovska, A., Ilkovski, B., Cooper, S., Ghoddusi, M., Hardeman, E., Minamide, L., Gunning, P., Bamburg, J., North, K. (2007). Mechanisms underlying intranuclear rod formation. Brain, 130(12), 3275-3284. [More Information]
  • Vlahovich, N., Schevzov, G., Nair-Shalliker, V., Ilkovski, B., Artap, S., Joya, J., Kee, A., North, K., Gunning, P., Hardeman, E. (2007). Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle. Cell Motility and the Cytoskeleton, 65(online 29 Oct 2007), 73-85. [More Information]
  • Chen, W., Ruell, P., Ghoddusi, M., Kee, A., Hardeman, E., Hoffman, K., Thompson, M. (2007). Ultrastructural changes and sarcoplasmic reticulum Ca2+ regulation in red vastus muscle following eccentric exercise in the rat. Experimental Physiology, 92(2), 437-447. [More Information]
  • MacArthur, D., Yang, N., Seto, J., Raftery, J., Kee, A., Hardeman, E., Gunning, P., North, K. (2006). A gene for speed: the ACTN3 R577X polymorphism influences muscle performance. Neuromuscular Disorders, 16(Supplement 1), S59-S59.
  • Butler, T., Au, C., Yang, B., Egan, J., Tan, Y., Hardeman, E., North, K., Verkman, A., Winlaw, D. (2006). Cardiac aquaporin expression in humans, rats, and mice. American Journal of Physiology: Heart and Circulatory Physiology, 291(2), H705-H713. [More Information]
  • Palmer, S., Tay, E., Santucci, N., Bach, C., Hook, J., Lemckert, F., Jamieson, R., Gunning, P., Hardeman, E. (2006). Expression of Gtf2ird1, the Williams syndrome-associated gene, during mouse development. Gene Expression Patterns, 7, 396-404. [More Information]
  • McGrath, M., Cottle, D., Nguyen, M., Dyson, J., Coghill, I., Robinson, P., Holdsworth, M., Cowling, B., Hardeman, E., Mitchell, C., et al (2006). Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly. Journal of Biological Chemistry, 281(11), 7666-7683. [More Information]
  • Issa, L., Palmer, S., Guven, K., Santucci, N., Hodgson, V., Popovic, K., Joya, J., Hardeman, E. (2006). MusTRD can regulate postnatal fiber-specific expression. Developmental Biology, 293(1), 104-115. [More Information]
  • Sanoudou, D., Corbett, M., Han, M., Ghoddusi, M., Nguyen, M., Vlahovich, N., Hardeman, E., Beggs, A. (2006). Skeletal muscle repair in a mouse model of nemaline myopathy. Human Molecular Genetics, 15(17), 2603-2612.
  • Chen, W., Ruell, P., Ghoddusi, M., Kee, A., Hardeman, E., Hoffman, K., Thompson, M. (2006). Ultrastructural changes and SR Ca2+ regulation in red vastus muscle following eccentric exercise in the rat. Experimental Physiology, 294(5), 1628-1637. [More Information]
  • Domazetovska, A., Ilkovski, B., Cooper, S., Valova, V., Lemckert, F., Hook, J., Hardeman, E., Robinson, P., Yang, N., Gunning, P., North, K. (2006). Unravelling the thin filament: mechanisms of weakness in inherited muscle disease. Neuromuscular Disorders, 16(Sup. 1), S60-S61.
  • Corbett, M., Akkari, A., Domazetovska, A., Cooper, S., North, K., Laing, N., Gunning, P., Hardeman, E. (2005). An alphaTropomyosin mutation alters dimer preference in nemaline myopathy. Annals of Neurology, 57(1), 42-49. [More Information]
  • Schevzov, G., Bryce, N., Almonte-Baldonado, R., Joya, J., Lin, J., Hardeman, E., Weinberger, R., Gunning, P. (2005). Specific Features of Neuronal Size and Shape Are Regulated by Tropomyosin Isoforms. Molecular Biology of the Cell, 16(7), 3425-3437. [More Information]
  • Gunning, P., Schevzov, G., Kee, A., Hardeman, E. (2005). Tropomyosin isoforms: divining rods for actin cytoskeleton function. Trends in Cell Biology, 15(6), 333-341. [More Information]
  • Allen, D., Hardeman, E., North, K., Alexander, I., Cooper, S., Maxwell, A., Kizana, E., Ghoddusi, M. (2004). C2C12 Co-Culture On A Fibroblast Substratum Enables Sustained Survival Of Contractile, Highly Differentiated Myotubes With Peripheral Nuclei And Adult Fast Myosin Expression. Cell Motility and the Cytoskeleton, 58(3), 200-211. [More Information]
  • Joya, J., Kee, A., Nair-Shalliker, V., Ghoddusi, M., Nguyen, M., Luther, P., Hardeman, E. (2004). Muscle Weakness In A Mouse Model Of Nemaline Myopathy Can Be Reversed With Exercise And Reveals A Novel Myofiber Repair Mechanism. Human Molecular Genetics, 13(21), 2633-2645.
  • Nair-Shalliker, V., Kee, A., Joya, J., Lucas, C., Hoh, J., Hardeman, E. (2004). Myofiber Adaptational Response To Exercise In A Mouse Model Of Nemaline Myopathy. Muscle and Nerve, 30(4), 470-480. [More Information]
  • Kee, A., Schevzov, G., Nair-Shalliker, V., Robinson, C., Vrhovski, B., Ghoddusi, M., Qiu, M., Lin, J., Weinberger, R., Gunning, P., Hardeman, E. (2004). Sorting Of A Nonmuscle Tropomyosin To A Novel Cytoskeletal Compartment In Skeletal Muscle Results In Muscular Dystrophy. The Journal of Cell Biology, 166(5), 685-696.
  • Polly, P., Haddadi, L., Issa, L., Subramaniam, N., Palmer, S., Tay, E., Hardeman, E. (2003). hMusTRD1α1 represses MEF2 activation of the Troponin I slow enhancer. Journal of Biological Chemistry, 278(38), 36603-36619.
  • Tay, E., Guven, K., Subramaniam, N., Polly, P., Issa, L., Gunning, P., Hardeman, E. (2003). Regulation of alternative splicing of Gtf2ird1 and its impact on slow muscle proomoter activity. Biochemical Journal, 374(2), 359-367.
  • de Haan, A., van der Vliet, M., Gommans, I., Hardeman, E., van Engelen, B. (2002). Skeletal muscle of mice with a mutation in slow alpha-tropomyosin is weaker at lower lengths. Neuromuscular Disorders, 12(10), 952-957.
  • Corbett, M., Gunning, P., North, K., Hardeman, E., Robinson, C., Dunglison,, G., Yang, N., Joya, J., Stewart, A., Schnell, C. (2001). A mutation in alpha-tropomyosin slow affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy. Human Molecular Genetics, 10, 317-328.
  • Gunning, P., Hardeman, E., Ferguson, V., Brennan, K. (2001). Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle. Journal of Cell Science, 114, 513-524.
  • Gunning, P., Hardeman, E., Ferguson, V., Brennan, K. (2001). Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle. Journal of Cell Science, 114, 513-524.
  • Ilkovski, B., Ryan, M., Gunning, P., Hardeman, E., North, K., Cooper, S., Nowak, K., Yang, N., Schnell, C., Durling, H., et al (2001). Nemaline myopathy caused by mutations in the muscle alpha-skeletal-acting gene. American Journal of Human Genetics, 68, 1333-1343.
  • De Iongh, R., Lovicu, F., Hardeman, E., McAvoy, J., Overbeek, P., Schneider, M., Joya, J. (2001). Requirement for TGFb receptor signalling during terminal lens fiber differentiation. Development (Cambridge), 128, 3995-4010.

2013

  • Lee, A., Anderson, J., Joya, J., Head, S., Pather, N., Kee, A., Gunning, P., Hardeman, E. (2013). Aged skeletal muscle retains the ability to fully regenerate functional architecture. Bioarchitecture, 3(2), 25-37.
  • Lindqvist, J., Cheng, A., Renaud, G., Hardeman, E., Ochala, J. (2013). Distinct Underlying Mechanisms of Limb and Respiratory Muscle Fiber Weaknesses in Nemaline Myopathy. Journal of Neuropathology and Experimental Neurology, 72(6), 472-481. [More Information]

2008

  • Schevzov, G., Fath, T., Vrhoski, B., Vlahovich, N., Rajan, S., Hook, J., Joya, J., Lemckert, F., Puttur, F., Lin, J., Hardeman, E., O'Neill, G., Gunning, P., et al (2008). Divergent regulation of the sarcomere and the cytoskeleton. Journal of Biological Chemistry, 283(1), 275-283. [More Information]
  • Nguyen, M., Hardeman, E. (2008). Mouse Models for Thin Filament Disease. In Nigel G. Laing (Eds.), The Sarcomere and Skeletal Muscle Disease, (pp. 66-77). New York: Springer Science + Business Media.
  • Chang, A., Hook, J., Lemckert, F., McDonald, M., Nguyen, M., Hardeman, E., Little, D., Gunning, P., Reddel, R. (2008). The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology, 149(5), 2403-2410. [More Information]
  • Gunning, P., O'Neill, G., Hardeman, E. (2008). Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space. Physiological Reviews, 88(1), 1-35. [More Information]

2007

  • MacArthur, D., Seto, J., Raftery, J., Quinlan (nee Edwards), K., Huttley, G., Hook, J., Lemckert, F., Kee, A., Edwards, M., Berman, Y., Hardeman, E., Gunning, P., Yang, N., North, K., et al (2007). Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans. Nature Genetics, 39(10), 1261-1265. [More Information]
  • Domazetovska, A., Ilkovski, B., Cooper, S., Ghoddusi, M., Hardeman, E., Minamide, L., Gunning, P., Bamburg, J., North, K. (2007). Mechanisms underlying intranuclear rod formation. Brain, 130(12), 3275-3284. [More Information]
  • Vlahovich, N., Schevzov, G., Nair-Shalliker, V., Ilkovski, B., Artap, S., Joya, J., Kee, A., North, K., Gunning, P., Hardeman, E. (2007). Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle. Cell Motility and the Cytoskeleton, 65(online 29 Oct 2007), 73-85. [More Information]
  • Chen, W., Ruell, P., Ghoddusi, M., Kee, A., Hardeman, E., Hoffman, K., Thompson, M. (2007). Ultrastructural changes and sarcoplasmic reticulum Ca2+ regulation in red vastus muscle following eccentric exercise in the rat. Experimental Physiology, 92(2), 437-447. [More Information]

2006

  • MacArthur, D., Yang, N., Seto, J., Raftery, J., Kee, A., Hardeman, E., Gunning, P., North, K. (2006). A gene for speed: the ACTN3 R577X polymorphism influences muscle performance. Neuromuscular Disorders, 16(Supplement 1), S59-S59.
  • Butler, T., Au, C., Yang, B., Egan, J., Tan, Y., Hardeman, E., North, K., Verkman, A., Winlaw, D. (2006). Cardiac aquaporin expression in humans, rats, and mice. American Journal of Physiology: Heart and Circulatory Physiology, 291(2), H705-H713. [More Information]
  • Palmer, S., Tay, E., Santucci, N., Bach, C., Hook, J., Lemckert, F., Jamieson, R., Gunning, P., Hardeman, E. (2006). Expression of Gtf2ird1, the Williams syndrome-associated gene, during mouse development. Gene Expression Patterns, 7, 396-404. [More Information]
  • McGrath, M., Cottle, D., Nguyen, M., Dyson, J., Coghill, I., Robinson, P., Holdsworth, M., Cowling, B., Hardeman, E., Mitchell, C., et al (2006). Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly. Journal of Biological Chemistry, 281(11), 7666-7683. [More Information]
  • Issa, L., Palmer, S., Guven, K., Santucci, N., Hodgson, V., Popovic, K., Joya, J., Hardeman, E. (2006). MusTRD can regulate postnatal fiber-specific expression. Developmental Biology, 293(1), 104-115. [More Information]
  • Sanoudou, D., Corbett, M., Han, M., Ghoddusi, M., Nguyen, M., Vlahovich, N., Hardeman, E., Beggs, A. (2006). Skeletal muscle repair in a mouse model of nemaline myopathy. Human Molecular Genetics, 15(17), 2603-2612.
  • Chen, W., Ruell, P., Ghoddusi, M., Kee, A., Hardeman, E., Hoffman, K., Thompson, M. (2006). Ultrastructural changes and SR Ca2+ regulation in red vastus muscle following eccentric exercise in the rat. Experimental Physiology, 294(5), 1628-1637. [More Information]
  • Domazetovska, A., Ilkovski, B., Cooper, S., Valova, V., Lemckert, F., Hook, J., Hardeman, E., Robinson, P., Yang, N., Gunning, P., North, K. (2006). Unravelling the thin filament: mechanisms of weakness in inherited muscle disease. Neuromuscular Disorders, 16(Sup. 1), S60-S61.

2005

  • Corbett, M., Akkari, A., Domazetovska, A., Cooper, S., North, K., Laing, N., Gunning, P., Hardeman, E. (2005). An alphaTropomyosin mutation alters dimer preference in nemaline myopathy. Annals of Neurology, 57(1), 42-49. [More Information]
  • Schevzov, G., Bryce, N., Almonte-Baldonado, R., Joya, J., Lin, J., Hardeman, E., Weinberger, R., Gunning, P. (2005). Specific Features of Neuronal Size and Shape Are Regulated by Tropomyosin Isoforms. Molecular Biology of the Cell, 16(7), 3425-3437. [More Information]
  • Gunning, P., Schevzov, G., Kee, A., Hardeman, E. (2005). Tropomyosin isoforms: divining rods for actin cytoskeleton function. Trends in Cell Biology, 15(6), 333-341. [More Information]

2004

  • Allen, D., Hardeman, E., North, K., Alexander, I., Cooper, S., Maxwell, A., Kizana, E., Ghoddusi, M. (2004). C2C12 Co-Culture On A Fibroblast Substratum Enables Sustained Survival Of Contractile, Highly Differentiated Myotubes With Peripheral Nuclei And Adult Fast Myosin Expression. Cell Motility and the Cytoskeleton, 58(3), 200-211. [More Information]
  • Joya, J., Kee, A., Nair-Shalliker, V., Ghoddusi, M., Nguyen, M., Luther, P., Hardeman, E. (2004). Muscle Weakness In A Mouse Model Of Nemaline Myopathy Can Be Reversed With Exercise And Reveals A Novel Myofiber Repair Mechanism. Human Molecular Genetics, 13(21), 2633-2645.
  • Nair-Shalliker, V., Kee, A., Joya, J., Lucas, C., Hoh, J., Hardeman, E. (2004). Myofiber Adaptational Response To Exercise In A Mouse Model Of Nemaline Myopathy. Muscle and Nerve, 30(4), 470-480. [More Information]
  • Kee, A., Schevzov, G., Nair-Shalliker, V., Robinson, C., Vrhovski, B., Ghoddusi, M., Qiu, M., Lin, J., Weinberger, R., Gunning, P., Hardeman, E. (2004). Sorting Of A Nonmuscle Tropomyosin To A Novel Cytoskeletal Compartment In Skeletal Muscle Results In Muscular Dystrophy. The Journal of Cell Biology, 166(5), 685-696.

2003

  • Polly, P., Haddadi, L., Issa, L., Subramaniam, N., Palmer, S., Tay, E., Hardeman, E. (2003). hMusTRD1α1 represses MEF2 activation of the Troponin I slow enhancer. Journal of Biological Chemistry, 278(38), 36603-36619.
  • Tay, E., Guven, K., Subramaniam, N., Polly, P., Issa, L., Gunning, P., Hardeman, E. (2003). Regulation of alternative splicing of Gtf2ird1 and its impact on slow muscle proomoter activity. Biochemical Journal, 374(2), 359-367.

2002

  • de Haan, A., van der Vliet, M., Gommans, I., Hardeman, E., van Engelen, B. (2002). Skeletal muscle of mice with a mutation in slow alpha-tropomyosin is weaker at lower lengths. Neuromuscular Disorders, 12(10), 952-957.

2001

  • Corbett, M., Gunning, P., North, K., Hardeman, E., Robinson, C., Dunglison,, G., Yang, N., Joya, J., Stewart, A., Schnell, C. (2001). A mutation in alpha-tropomyosin slow affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy. Human Molecular Genetics, 10, 317-328.
  • Gunning, P., Hardeman, E., Ferguson, V., Brennan, K. (2001). Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle. Journal of Cell Science, 114, 513-524.
  • Gunning, P., Hardeman, E., Ferguson, V., Brennan, K. (2001). Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle. Journal of Cell Science, 114, 513-524.
  • Ilkovski, B., Ryan, M., Gunning, P., Hardeman, E., North, K., Cooper, S., Nowak, K., Yang, N., Schnell, C., Durling, H., et al (2001). Nemaline myopathy caused by mutations in the muscle alpha-skeletal-acting gene. American Journal of Human Genetics, 68, 1333-1343.
  • De Iongh, R., Lovicu, F., Hardeman, E., McAvoy, J., Overbeek, P., Schneider, M., Joya, J. (2001). Requirement for TGFb receptor signalling during terminal lens fiber differentiation. Development (Cambridge), 128, 3995-4010.

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