Associate Professor Elena Bagley

Senior Lecturer
Pharmacology, School of Medical Sciences

Telephone +61 2 9351 4895

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Biographical details

Dr Bagley is a senior lecturer in the Discipline of Pharmacology.

Dr Bagley completed a PhD at The University of Sydney in 2001. She was a C.J Martin Fellow from 2001 to 2006. During this time she was a postdoctoral fellow in the laboratory of Professor Gary Westbrook at the Vollum Institute (Oregon, USA) and at the Pain Management Research Institute (University of Sydney).

Dr Bagley began developing her research laboratory at the Brain and Mind Institute (2010-2011) and then moved to Pharmacology in 2011.

Research interests

The laboratory primarily focuses on synapses, which are the point of communication between brain cells. We are interested in normal synaptic function and synapse dysfuntion. Synaptic dysfunction is emerging as a key player in many brain disorders. We use patch-clamp electrophysiology in brain slices, immunohistochemistry and biochemical assays to study synaptic properties and synaptic plasticity that may participate in physiological or pathophysiological processes. Of particular interest are the synaptic changes or plasticity that may be responsible for chronic pain states, neurodevelopmental problems and drug addiction. We also use behavioural assays to try to understand the role of these synaptic changes in the whole animal.

Current projects

Undergraduate, honours and postgraduate research projects are available and would focus on one of two major research programmes in my laborator.

1. How endogenous opioids affect amygdala function- with a particular focus on how they participate in anxiety disorders.

2. Pain induced synaptic plasticity in neural circuits involved in the emotional aspects of pain and endogneous analgesia.

Please contact me for more details or to arrange a visit to my lab.

International links

United States

(Oregon Health & Sciences University) Dr Sue Aicher and I collaborate on location and role endogenous opioids in the Amygdala

Selected grants

2015

  • How the midbrain assembles fear; Bagley E; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Endogenous opioids and anxiety; Bagley E; DVC Research/Thompson Fellowships.

2013

  • Endogenous opioids in the amygdala.; Bagley E, McNally G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Role of GAT-1 transporter channels in opioid dependence; Christie M, Chieng B, Bagley E; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Research Infrastructure (Major Equipment) Scheme 2008; Ittner L, Goetz J, Christie M, Bennett M, Kassiou M, Connor M, Holsinger D, Bagley E; Faculty of Medicine/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Real-time cellular imaging system; Connor M, Keast J, Vaughan C, Christie M, Osborne P, Bagley E, Sue C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • Stimulus induced synaptic plasticity in the amygdala.; Bagley E, Christie M; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Molecular mechanisms underlying functional maturation of hippocampal neurons; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

Selected publications

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Book Chapters

  • Keogh, J., Bagley, E. (2004). Neonatal Encephalopathy. In Virginia Moyer and Elizabeth Elliott (Eds.), Evidence Based Paediatrics and Child Health, (pp. 499-508). USA: Blackwell Publishers.

Journals

  • Bagley, E. (2014). Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment. Frontiers in Pharmacology, 5, 148. [More Information]
  • Bagley, E., Westbrook, G. (2012). Short-term field stimulation mimics synaptic maturation of hippocampal synapses. The Journal of Physiology, 590(7), 1641-1654. [More Information]
  • Bagley, E., Hacker, J., Chefer, V., Mallet, C., McNally, G., Chieng, B., Perroud, J., Shippenberg, T., Christie, M. (2011). Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nature Neuroscience, 14(12), 1548-1554. [More Information]
  • Thomas, C., Krupp, J., Bagley, E., Bauzon, R., Heinemann, S., Vissel, B., Westbrook, G. (2006). Probing N-methyl-D-aspartate receptor desensitization with the substituted-cysteine accessibility method. Molecular Pharmacology, 69(4), 1296-1303. [More Information]
  • Bagley, E., Gerke, M., Vaughan, C., Hack, S., Christie, M. (2005). GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron, 45(3), 433-445. [More Information]
  • Hack, S., Bagley, E., Chieng, B., Christie, M. (2005). Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. The Journal of Neuroscience, 25(12), 3192-3198. [More Information]
  • Bagley, E., Chieng, B., Christie, M., Connor, M. (2005). Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. British Journal of Pharmacology, 146(1), 68-76. [More Information]
  • Connor, M., Bagley, E., Mitchell, V., Ingram, S., Christie, M., Humphrey, P., Vaughan, C. (2004). Cellular Actions Of Somatostatin On Rat Periaqueductal Grey Neurons In Vitro. British Journal of Pharmacology, 142(8), 1273-1280.
  • Vaughan, C., Bagley, E., Drew, G., Schuller, A., Pintar, J., Hack, S., Christie, M. (2003). Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. British Journal of Pharmacology, 139(2), 362-367.

Conferences

  • Christie, M., Bagley, E., Hacker, J., Chieng, B. (2006). GABA transporters in drug dependence: Neuronal or glial. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.

2014

  • Bagley, E. (2014). Opioid and GABAB receptors differentially couple to an adenylyl cyclase/protein kinase A downstream effector after chronic morphine treatment. Frontiers in Pharmacology, 5, 148. [More Information]

2012

  • Bagley, E., Westbrook, G. (2012). Short-term field stimulation mimics synaptic maturation of hippocampal synapses. The Journal of Physiology, 590(7), 1641-1654. [More Information]

2011

  • Bagley, E., Hacker, J., Chefer, V., Mallet, C., McNally, G., Chieng, B., Perroud, J., Shippenberg, T., Christie, M. (2011). Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors. Nature Neuroscience, 14(12), 1548-1554. [More Information]

2006

  • Christie, M., Bagley, E., Hacker, J., Chieng, B. (2006). GABA transporters in drug dependence: Neuronal or glial. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Thomas, C., Krupp, J., Bagley, E., Bauzon, R., Heinemann, S., Vissel, B., Westbrook, G. (2006). Probing N-methyl-D-aspartate receptor desensitization with the substituted-cysteine accessibility method. Molecular Pharmacology, 69(4), 1296-1303. [More Information]

2005

  • Bagley, E., Gerke, M., Vaughan, C., Hack, S., Christie, M. (2005). GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron, 45(3), 433-445. [More Information]
  • Hack, S., Bagley, E., Chieng, B., Christie, M. (2005). Induction of delta-opioid receptor function in the midbrain after chronic morphine treatment. The Journal of Neuroscience, 25(12), 3192-3198. [More Information]
  • Bagley, E., Chieng, B., Christie, M., Connor, M. (2005). Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine. British Journal of Pharmacology, 146(1), 68-76. [More Information]

2004

  • Connor, M., Bagley, E., Mitchell, V., Ingram, S., Christie, M., Humphrey, P., Vaughan, C. (2004). Cellular Actions Of Somatostatin On Rat Periaqueductal Grey Neurons In Vitro. British Journal of Pharmacology, 142(8), 1273-1280.
  • Keogh, J., Bagley, E. (2004). Neonatal Encephalopathy. In Virginia Moyer and Elizabeth Elliott (Eds.), Evidence Based Paediatrics and Child Health, (pp. 499-508). USA: Blackwell Publishers.

2003

  • Vaughan, C., Bagley, E., Drew, G., Schuller, A., Pintar, J., Hack, S., Christie, M. (2003). Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. British Journal of Pharmacology, 139(2), 362-367.

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