Dr Elham Hosseini Beheshti

Postdoctoral Research Associate
Vascular Immunology Unit
Pathology, School Medical Sciences

Member of the Charles Perkins Centre

Telephone +61 9 036 3032

Map

Research interests

Cancer cell biology, Extracellular vesicles, Exosomes, Microvesicles, Oncosomes, Biomarker discovery, Immunopathological disease

Teaching and supervision

Miss Tamkin Ahmadzada-PhD studnet; in collaboration with Prof. Stephen Clarke

Mr. Keenan Whittle-MD Studnet; in collaboration with Prof. Georges Grau

Current projects

Brain endothelium and extracellular vesicles in infectouse pathologies

Vibrational spectroscopiuc characterisation of brain endothelial cell-derived EV in an in vitro model of cerebral malaria

Investigating the role of EV in cancer

EV as biomarkers in malignant pleural mesothelioma

Micro-RNA and the regulation of disease severity in malaria

Awards and honours

Awards:

2017 AINST Research Collaboration Award, University of Sydney

2013-2014 Prostate Cancer Foundation BC, Doctoral Research Fellowship Award for Research in Prostate Cancer

2012-2013 Prostate Cancer Foundation BC, Doctoral Research Fellowship Award for Research in Prostate Cancer

2012 Canadian Institutes of Health Research, Student Travel Award

2011 BC Proteomics Network Biomedical Research Centre, Student Travel Award

2010 Ajaib and Nirmal Sidhoo Charities, Student Travel Award

2010 BC Proteomics Network Biomedical Research Centre, Student Travel Award

2010 Human Proteome Organization, Student Bursary Award

2010 Winner of the best poster and oral presentation award, Experimental Medicine Research day (UBC)

2009 Faculty of Medicine Graduate Award, University of British Columbia

2008 Pharmaceutical Sciences Graduate Entrance Scholarship, University of British Columbia

Honours:

April 2012: Top 5% of doctoral students at University of British Columbia

International links

Canada

(Simon Fraser University) Investigating the effect of lysosomal inhibition on the content and function of TNBC-derived exosomes.

Canada

(University of British Columbia) Investigating the role of extracellular vesicles (EV) in the pathogenesis of protein misfolding in type 2 diabetes.

Selected grants

2017

  • SMS - FDF Support E Bhesthti; Hosseini Beheshti E; Sydney Medical School/Faculty Development Fund (FDF Support).

Selected publications

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Journals

  • Hosseini Beheshti, E., Grau, G. (2018). Extracellular vesicles as mediators of immunopathology in infectious diseases. Immunology and Cell Biology, 96(7), 694-703. [More Information]
  • Cairns, R., Alvarez-Guaita, A., Mart´┐Żnez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]
  • Kharmate, G., Hosseini-Beheshti, E., Caradec, J., Chin, M., Tomlinson Guns, E. (2016). Epidermal Growth Factor Receptor in Prostate Cancer Derived Exosomes. PloS One, 11(5), 1-14. [More Information]
  • Hosseini-Beheshti, E., Choi, W., Weiswald, L., Kharmate, G., Ghaffari, M., Roshan-Moniri, M., Hassona, M., Chan, L., Chin, M., et al (2016). Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment. Oncotarget, 7(12), 14639-14658. [More Information]
  • Minciacchi, V., You, S., Spinelli, C., Morley, S., Zandian, M., Aspuria, P., Cavallini, L., Ciardiello, C., Hosseini-Beheshti, E., et al (2015). Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles. Oncotarget, 6(13), 11327-11341. [More Information]
  • Fokidis, H., Adomat, H., Kharmate, G., Hosseini-Beheshti, E., Tomlinson Guns, E., Soma, K. (2015). Regulation of local steroidogenesis in the brain and in prostate cancer: Lessons learned from interdisciplinary collaboration. Frontiers in Neuroendocrinology, 36, 108-129. [More Information]
  • Pham, S., Deb, S., Ming, D., Adomat, H., Hosseini-Beheshti, E., Zoubeidi, A., Gleave, M., Tomlinson Guns, E. (2014). Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro. Journal of Steroid Biochemistry and Molecular Biology, 144(PB), 436-444. [More Information]
  • Ming, D., Pham, S., Deb, S., Chin, M., Kharmate, G., Adomat, H., Hosseini-Beheshti, E., Locke, J., Tomlinson Guns, E. (2014). Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo. Journal of Steroid Biochemistry and Molecular Biology, 143, 19-28. [More Information]
  • Caradec, J., Kharmate, G., Hosseini-Beheshti, E., Adomat, H., Gleave, M., Tomlinson Guns, E. (2014). Reproducibility and efficiency of serum-derived exosome extraction methods. Clinical Biochemistry, 47(13-14), 1286-1292. [More Information]
  • Hosseini-Beheshti, E., Lund, S., Kitts, D. (2012). Characterization of Antioxidant Capacity from Fruits with Distinct Anthocyanin Biosynthetic Pathways. Journal of Nutrition & Food Sciences, 2(1), 1-10. [More Information]
  • Hosseini-Beheshti, E., Pham, S., Adomat, H., Li, N., Tomlinson Guns, E. (2012). Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Molecular and Cellular Proteomics, 11(10), 863-885. [More Information]

2018

  • Hosseini Beheshti, E., Grau, G. (2018). Extracellular vesicles as mediators of immunopathology in infectious diseases. Immunology and Cell Biology, 96(7), 694-703. [More Information]

2017

  • Cairns, R., Alvarez-Guaita, A., Mart´┐Żnez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]

2016

  • Kharmate, G., Hosseini-Beheshti, E., Caradec, J., Chin, M., Tomlinson Guns, E. (2016). Epidermal Growth Factor Receptor in Prostate Cancer Derived Exosomes. PloS One, 11(5), 1-14. [More Information]
  • Hosseini-Beheshti, E., Choi, W., Weiswald, L., Kharmate, G., Ghaffari, M., Roshan-Moniri, M., Hassona, M., Chan, L., Chin, M., et al (2016). Exosomes confer pro-survival signals to alter the phenotype of prostate cells in their surrounding environment. Oncotarget, 7(12), 14639-14658. [More Information]

2015

  • Minciacchi, V., You, S., Spinelli, C., Morley, S., Zandian, M., Aspuria, P., Cavallini, L., Ciardiello, C., Hosseini-Beheshti, E., et al (2015). Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles. Oncotarget, 6(13), 11327-11341. [More Information]
  • Fokidis, H., Adomat, H., Kharmate, G., Hosseini-Beheshti, E., Tomlinson Guns, E., Soma, K. (2015). Regulation of local steroidogenesis in the brain and in prostate cancer: Lessons learned from interdisciplinary collaboration. Frontiers in Neuroendocrinology, 36, 108-129. [More Information]

2014

  • Pham, S., Deb, S., Ming, D., Adomat, H., Hosseini-Beheshti, E., Zoubeidi, A., Gleave, M., Tomlinson Guns, E. (2014). Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro. Journal of Steroid Biochemistry and Molecular Biology, 144(PB), 436-444. [More Information]
  • Ming, D., Pham, S., Deb, S., Chin, M., Kharmate, G., Adomat, H., Hosseini-Beheshti, E., Locke, J., Tomlinson Guns, E. (2014). Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo. Journal of Steroid Biochemistry and Molecular Biology, 143, 19-28. [More Information]
  • Caradec, J., Kharmate, G., Hosseini-Beheshti, E., Adomat, H., Gleave, M., Tomlinson Guns, E. (2014). Reproducibility and efficiency of serum-derived exosome extraction methods. Clinical Biochemistry, 47(13-14), 1286-1292. [More Information]

2012

  • Hosseini-Beheshti, E., Lund, S., Kitts, D. (2012). Characterization of Antioxidant Capacity from Fruits with Distinct Anthocyanin Biosynthetic Pathways. Journal of Nutrition & Food Sciences, 2(1), 1-10. [More Information]
  • Hosseini-Beheshti, E., Pham, S., Adomat, H., Li, N., Tomlinson Guns, E. (2012). Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes. Molecular and Cellular Proteomics, 11(10), 863-885. [More Information]

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