Dr Elisha Hamilton

Lab Manager
Medicine, Northern Clinical School

Telephone +61 2 99264917
Fax +61 2 99014097

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Biographical details

First working as a research assistant and then as a PhD student at North Shore Heart Research Group, Dr Hamilton was awarded her PhD in 2011. She holds the position of Laboratory Manager/Scientist. Her experience in cellular physiology is invaluable. She has established protocols for the isolation cardiac myocytes used in molecular and cellular electrophysiology experiments and has extensive experience in practical aspects of the whole cell patch clamp technique.

Dr Hamilton completed her undergraduate studies at the University of Western Australia where she was awarded with first class Honours for her project in skeletal muscle physiology (2001). She moved into asthma and allergy research as a Research Assistant until 2002, investigating pulmonary neuroendocrine cells and fine tuning her skills in fluorescent and confocal microscopy. In 2003, Dr Hamilton joined the North Shore Heart Research Group and became an integral part of the team with her proficiencies in the whole cell patch clamp technique. Generously supported by a University of Sydney Postgraduate Award and a Northern Clinical School / Ramsay Healthcare PhD top-up scholarship, Dr Hamilton embarked in a PhD in 2007 investigating the molecular and signaling mechanisms involved in ANP regulation of the cardiac Na+-K+pump. She was awarded her PhD in April 2011.

After taking 12 months maternity leave, Dr Hamilton returned to Prof Rasmussen’s laboratory in June 2012 as the Laboratory Manager.

Dr Hamilton has contributed to publications in high impact journals such as Circulation Research, Journal of Biological Chemistry and the Journal of Physiology (London). She has fifteen peer-reviewed publications in total. Dr Hamilton has presented various abstracts at international meetings including Denmark and the United States of America. She was also a finalist in the Student Investigator Award at the 2009 Australian meeting of the International Society for Heart Research.

Selected grants

2014

  • PDE5 inhibitor/beta 3 agonist combination therapy in heart failure; Rasmussen H, Hamilton E, Liu C; Heart Research Australia/Research Support.

2013

  • Reversing oxidative inhibition of the Na+-K+ pump by ASP9531: implications for heart failure therapy; Liu C, Hamilton E; North Shore Heart Research Foundation/Research Support.

2011

  • Natruretic peptide-induced oxidative modification of the Na-K pump; Hamilton E; North Shore Heart Research Foundation/Research Support.

Selected publications

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Journals

  • Liu, C., Karimi Galougahi, K., Weisbrod, R., Hansen, T., Ravaie, R., Nunez, A., Liu, Y., Fry, N., Garcia, A., Hamilton, E., Figtree, G., et al (2013). Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction. Free Radical Biology and Medicine, 65(2013), 563-572. [More Information]
  • Karimi Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Karimi Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]
  • Hamilton, E., Figtree, G., Rasmussen, H. (2011). Consideration of natriuretic peptide receptor C. Circulation Research, 108(4), e4-e5. [More Information]
  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]
  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]
  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]
  • William, M., Hamilton, E., Bundgaard, H., Garcia, A., Chia, K., Figtree, G., Rasmussen, H. (2008). Natriuretic peptides stimulate the cardiac sodium pump via NPR-C coupled NOS activation. American Journal of Physiology: Cell Physiology, 294(4), C1067-C1073. [More Information]
  • White, C., Hamilton, E., Garcia, A., Wang, D., Chia, K., Figtree, G., Rasmussen, H. (2008). Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. American Journal of Physiology: Cell Physiology, 294, C572-C578. [More Information]
  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2007). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292, C1070-C1077.
  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2006). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292(3), C1070-C1077. [More Information]
  • William, M., Vien, J., Hamilton, E., Garcia, A., Bundgaard, H., Clarke, R., Rasmussen, H. (2005). The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes. The Journal of Physiology, 565.3(3), 815-825. [More Information]

Conferences

  • White, C., Hamilton, E., Garcia, A., Rasmussen, H. (2006). PKA inhibits the Na+-K+ pump in cadiac myocytes via superoxide. 30th Annual Meeting of the Australiasian Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press.
  • Hamilton, E., Garcia, A., William, M., White, C., Franzin, C., Marassi, F., Rasmussen, H. (2005). Phospholemman enhances the sensitivity of the rabbit ventricular myocyte Na+-K+ pump to intracellular Na+. Biophysical Society 49th Annual Meeting, Bethesda, MD: Biophysical Society.

2013

  • Liu, C., Karimi Galougahi, K., Weisbrod, R., Hansen, T., Ravaie, R., Nunez, A., Liu, Y., Fry, N., Garcia, A., Hamilton, E., Figtree, G., et al (2013). Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction. Free Radical Biology and Medicine, 65(2013), 563-572. [More Information]
  • Karimi Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Karimi Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]

2012

  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]

2011

  • Hamilton, E., Figtree, G., Rasmussen, H. (2011). Consideration of natriuretic peptide receptor C. Circulation Research, 108(4), e4-e5. [More Information]
  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]

2010

  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]

2009

  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]

2008

  • William, M., Hamilton, E., Bundgaard, H., Garcia, A., Chia, K., Figtree, G., Rasmussen, H. (2008). Natriuretic peptides stimulate the cardiac sodium pump via NPR-C coupled NOS activation. American Journal of Physiology: Cell Physiology, 294(4), C1067-C1073. [More Information]
  • White, C., Hamilton, E., Garcia, A., Wang, D., Chia, K., Figtree, G., Rasmussen, H. (2008). Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. American Journal of Physiology: Cell Physiology, 294, C572-C578. [More Information]

2007

  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2007). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292, C1070-C1077.

2006

  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2006). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292(3), C1070-C1077. [More Information]
  • White, C., Hamilton, E., Garcia, A., Rasmussen, H. (2006). PKA inhibits the Na+-K+ pump in cadiac myocytes via superoxide. 30th Annual Meeting of the Australiasian Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press.

2005

  • Hamilton, E., Garcia, A., William, M., White, C., Franzin, C., Marassi, F., Rasmussen, H. (2005). Phospholemman enhances the sensitivity of the rabbit ventricular myocyte Na+-K+ pump to intracellular Na+. Biophysical Society 49th Annual Meeting, Bethesda, MD: Biophysical Society.
  • William, M., Vien, J., Hamilton, E., Garcia, A., Bundgaard, H., Clarke, R., Rasmussen, H. (2005). The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes. The Journal of Physiology, 565.3(3), 815-825. [More Information]

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