Dr Elizabeth Clarke

Senior Research Fellow
Kolling Institute of Medical Research, Northern Clinical School

Telephone 9926 4821

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Biographical details

Dr Clarke has a background in Mechanical (Biomedical) Engineering and Neuroscience. Her PhD research investigated biomechanics of paediatric spine and spinal cord injury.

Research interests

Dr Clarke's broad research interest is musculoskeletal biomechanics. Her research investigates age-related changes in tissue and joint biomechanics, and how these changes affect injury and disease (mechanisms, thresholds and recovery). She also researches how musculoskeletal pathologies affect tissue and joint biomechanics, and how tissue and joint biomechanics affect musculoskeletal pathologies.

Dr Clarke's specific research projects include spine/spinal cord biomechanics, paediatric and elderly injury biomechanics, tendinopathy, ligament injury, osteoarthritis, and clinical imaging biomechanics. These programs involve the use of established animal models as well as emerging, non-invasive technologies for in vivo human studies.

Teaching and supervision

Dr Clarke has taught the Biomechanics component of 'Biomechanics and Biomaterials'; a fourth year elective course in the Engineering Faculty, School of Aerospace, Mechanical and Mechatronic Engineering.

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

Selected grants

2013

  • Safe transport for low birth-weight babies; Clarke E, Sinn J; Royal North Shore Hospital/Staff Specialist Trust Fund.

2012

  • Nonlinear viscoelastic properties of paediatric soft tissues throughout development; Bilston L, Cheng S, Clarke E, Sinkus R; Australian Research Council (ARC)/Discovery Projects (DP).

2010

  • Effects of growth and ageing on mechanical property of human muscles; Clarke E; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Book Chapters

  • Clarke, E. (2011). Spinal Cord Mechanical Properties. In Lynne E. Bilston (Eds.), Neural Tissue Biomechanics, (pp. 25-40). Heidelberg, Germany: Springer.
  • Bilston, L., Clarke, E., Cheng, S. (2009). Brain tissue mechanical properties – making sense of 5 decades of test data. In Amit Gefen (Eds.), The Pathomechanics of Tissue Injury and Disease, and the Mechanophysiology of Healing, (pp. 1-18). Kerala, India: Research Signpost.

Journals

  • Keay, L., Coxon, K., Brown, J., Clarke, E., Bundy, A., Ivers, R., Lo, S., Boufous, S. (2013). A randomized trial to evaluate the effectiveness of an individual, education-based safe transport program for drivers aged 75 years and older. BMC Public Health, 13, 1-8. [More Information]
  • Clarke, E., Stoodley, M., Bilston, L. (2013). Changes in temporal flow characteristics of CSF in Chiari malformation Type I with and without syringomyelia: implications for theory of syrinx development. Journal of Neurosurgery, 118(5), 1135-1140. [More Information]
  • Clarke, E., Fletcher, D., Stoodley, M., Bilston, L. (2013). Computational fluid dynamics modelling of cerebrospinal fluid pressure in Chiari malformation and syringomyelia. Journal of Biomechanics, 46(11), 1801-1809. [More Information]
  • Lau, N., Gorrie, C., Chia, J., Bilston, L., Clarke, E. (2013). Severity of spinal cord injury in adult and infant rats following vertebral dislocation depends on displacement but not speed. Journal of Neurotrauma, 30(15), 1361-1373. [More Information]
  • Meredith, L., Brown, J., Clarke, E., Coxon, K., Boufous, S., Ivers, R., Keay, L. (2013). Validation of an in-vehicle monitoring device for measuring driving exposure and deceleration events. Journal of the Australasian College of Road Safety, 24(1), 42-50.
  • Kwah, L., Herbert, R., Harvey, L., Diong, J., Clarke, J., Martin, J., Clarke, E., Hoang, P., Bilston, L., Gandevia, S. (2012). Passive Mechanical Properties of Gastrocnemius Muscles of People With Ankle Contracture After Stroke. Archives of Physical Medicine and Rehabilitation, 93(7), 1185-1190. [More Information]
  • Diong, J., Herbert, R., Harvey, L., Kwah, L., Clarke, J., Hoang, P., Martin, J., Clarke, E., Bilston, L., Gandevia, S. (2012). Passive mechanical properties of the gastrocnemius after spinal cord injury. Muscle and Nerve, 46(2), 237-245. [More Information]
  • Herbert, R., Clarke, J., Kwah, L., Diong, J., Martin, J., Clarke, E., Bilston, L., Gandevia, S. (2011). In vivo passive mechanical behaviour of muscle fascicles and tendons in human gastrocnemius muscle-tendon units. The Journal of Physiology, 589(21), 5257-5267. [More Information]
  • Clarke, E., Cheng, S., Green, M., Sinkus, R., Bilston, L. (2011). Using static preload with magnetic resonance elastography to estimate large strain viscoelastic properties of bovine liver. Journal of Biomechanics, 44(13), 2461-2465. [More Information]
  • Boughton, P., Merhebi, J., Kim, C., Roger, G., Diwan, A., Clarke, E., Maddock (nee Amanat), N., Ho, R., Ruys, A. (2010). An Interlocking Ligamentous Spinal Disk Arthroplasty with Neural Network Infrastructure. Journal of Biomimetics, Biomaterials, and Tissue Engineering, 7, 55-79. [More Information]
  • Clarke, E., Martin, J., Herbert, R. (2010). Assumption of a 'gravity only region' for gravity correction of passive joint moment data may be problematic [Letter to the Editor]. Journal of Biomechanics, 43(13), 2653-2655. [More Information]
  • Bilston, L., Clarke, E., Brown, J. (2010). Spinal injury in car crashes: crash factors and the effects of occupant age. Injury Prevention, Online, 1-5. [More Information]
  • Cheng, S., Clarke, E., Bilston, L. (2009). The effects of preconditioning strain on measured tissue properties. Journal of Biomechanics, 42(9), 1360-1362. [More Information]
  • Clarke, E., Cheng, S., Bilston, L. (2009). The mechanical properties of neonatal rat spinal cord in vitro, and comparisons with adult. Journal of Biomechanics, 42(10), 1397-1402. [More Information]
  • Clarke, E., Choo, A., Liu, J., Lam, C., Bilston, L., Tetzlaff, W., Oxland, T. (2008). Anterior fracture-dislocation is more severe than lateral: A biomechanical and neuropathological comparison in rat thoracolumbar spine. Journal of Neurotrauma, 25(4), 371-383. [More Information]
  • Clarke, E., Bilston, L. (2008). Contrasting Biomechanics and Neuropathology of Spinal Cord Injury in Neonatal and Adult Rats following Vertebral Dislocation. Journal of Neurotrauma, 25(7), 817-832. [More Information]
  • Cheng, S., Clarke, E., Bilston, L. (2008). Rheological properties of the tissues of the central nervous system: A review. Medical Engineering and Physics, 30(10), 1318-1337. [More Information]
  • Clarke, E., Appleyard, R., Bilston, L. (2007). Immature sheep spines are more flexible than mature spines: an in vitro biomechanical study. Spine, 32(26), 2970-2979. [More Information]
  • Clarke, E., McNulty, P., Macefield, V., Bilston, L. (2007). Mechanically Evoked Sensory and Motor Responses to Dynamic Compression of the Ulnar Nerve. Muscle and Nerve, 35(3), 303-311. [More Information]
  • Clarke, E., McNulty, P., Macefield, V., Bilston, L. (2006). Mechanically evoked sensory and motor responses to dynamic compression of the ulnar nerve. Muscle and Nerve, 35(3), 303-311. [More Information]
  • Behrend, O., Dickson, B., Clarke, E., Jin, C., Carlile, S. (2004). Neural Responses To Free Field And Virtual Acoustic Stimulation In The Inferior Colliculus Of The Guinea Pig. Journal of Neurophysiology, 92(5), 3014-3029. [More Information]

Conferences

  • Tan, K., Cheng, S., Clarke, E., Green, M., Sinkus, R., Bilston, L. (2012). Combining rheometry and elastography to understand large deformation soft tissue properties. 2012 International Research Council on the Biomechanics of Injury Conference, IRCOBI 2012, Dublin.

2013

  • Keay, L., Coxon, K., Brown, J., Clarke, E., Bundy, A., Ivers, R., Lo, S., Boufous, S. (2013). A randomized trial to evaluate the effectiveness of an individual, education-based safe transport program for drivers aged 75 years and older. BMC Public Health, 13, 1-8. [More Information]
  • Clarke, E., Stoodley, M., Bilston, L. (2013). Changes in temporal flow characteristics of CSF in Chiari malformation Type I with and without syringomyelia: implications for theory of syrinx development. Journal of Neurosurgery, 118(5), 1135-1140. [More Information]
  • Clarke, E., Fletcher, D., Stoodley, M., Bilston, L. (2013). Computational fluid dynamics modelling of cerebrospinal fluid pressure in Chiari malformation and syringomyelia. Journal of Biomechanics, 46(11), 1801-1809. [More Information]
  • Lau, N., Gorrie, C., Chia, J., Bilston, L., Clarke, E. (2013). Severity of spinal cord injury in adult and infant rats following vertebral dislocation depends on displacement but not speed. Journal of Neurotrauma, 30(15), 1361-1373. [More Information]
  • Meredith, L., Brown, J., Clarke, E., Coxon, K., Boufous, S., Ivers, R., Keay, L. (2013). Validation of an in-vehicle monitoring device for measuring driving exposure and deceleration events. Journal of the Australasian College of Road Safety, 24(1), 42-50.

2012

  • Tan, K., Cheng, S., Clarke, E., Green, M., Sinkus, R., Bilston, L. (2012). Combining rheometry and elastography to understand large deformation soft tissue properties. 2012 International Research Council on the Biomechanics of Injury Conference, IRCOBI 2012, Dublin.
  • Kwah, L., Herbert, R., Harvey, L., Diong, J., Clarke, J., Martin, J., Clarke, E., Hoang, P., Bilston, L., Gandevia, S. (2012). Passive Mechanical Properties of Gastrocnemius Muscles of People With Ankle Contracture After Stroke. Archives of Physical Medicine and Rehabilitation, 93(7), 1185-1190. [More Information]
  • Diong, J., Herbert, R., Harvey, L., Kwah, L., Clarke, J., Hoang, P., Martin, J., Clarke, E., Bilston, L., Gandevia, S. (2012). Passive mechanical properties of the gastrocnemius after spinal cord injury. Muscle and Nerve, 46(2), 237-245. [More Information]

2011

  • Herbert, R., Clarke, J., Kwah, L., Diong, J., Martin, J., Clarke, E., Bilston, L., Gandevia, S. (2011). In vivo passive mechanical behaviour of muscle fascicles and tendons in human gastrocnemius muscle-tendon units. The Journal of Physiology, 589(21), 5257-5267. [More Information]
  • Clarke, E. (2011). Spinal Cord Mechanical Properties. In Lynne E. Bilston (Eds.), Neural Tissue Biomechanics, (pp. 25-40). Heidelberg, Germany: Springer.
  • Clarke, E., Cheng, S., Green, M., Sinkus, R., Bilston, L. (2011). Using static preload with magnetic resonance elastography to estimate large strain viscoelastic properties of bovine liver. Journal of Biomechanics, 44(13), 2461-2465. [More Information]

2010

  • Boughton, P., Merhebi, J., Kim, C., Roger, G., Diwan, A., Clarke, E., Maddock (nee Amanat), N., Ho, R., Ruys, A. (2010). An Interlocking Ligamentous Spinal Disk Arthroplasty with Neural Network Infrastructure. Journal of Biomimetics, Biomaterials, and Tissue Engineering, 7, 55-79. [More Information]
  • Clarke, E., Martin, J., Herbert, R. (2010). Assumption of a 'gravity only region' for gravity correction of passive joint moment data may be problematic [Letter to the Editor]. Journal of Biomechanics, 43(13), 2653-2655. [More Information]
  • Bilston, L., Clarke, E., Brown, J. (2010). Spinal injury in car crashes: crash factors and the effects of occupant age. Injury Prevention, Online, 1-5. [More Information]

2009

  • Bilston, L., Clarke, E., Cheng, S. (2009). Brain tissue mechanical properties – making sense of 5 decades of test data. In Amit Gefen (Eds.), The Pathomechanics of Tissue Injury and Disease, and the Mechanophysiology of Healing, (pp. 1-18). Kerala, India: Research Signpost.
  • Cheng, S., Clarke, E., Bilston, L. (2009). The effects of preconditioning strain on measured tissue properties. Journal of Biomechanics, 42(9), 1360-1362. [More Information]
  • Clarke, E., Cheng, S., Bilston, L. (2009). The mechanical properties of neonatal rat spinal cord in vitro, and comparisons with adult. Journal of Biomechanics, 42(10), 1397-1402. [More Information]

2008

  • Clarke, E., Choo, A., Liu, J., Lam, C., Bilston, L., Tetzlaff, W., Oxland, T. (2008). Anterior fracture-dislocation is more severe than lateral: A biomechanical and neuropathological comparison in rat thoracolumbar spine. Journal of Neurotrauma, 25(4), 371-383. [More Information]
  • Clarke, E., Bilston, L. (2008). Contrasting Biomechanics and Neuropathology of Spinal Cord Injury in Neonatal and Adult Rats following Vertebral Dislocation. Journal of Neurotrauma, 25(7), 817-832. [More Information]
  • Cheng, S., Clarke, E., Bilston, L. (2008). Rheological properties of the tissues of the central nervous system: A review. Medical Engineering and Physics, 30(10), 1318-1337. [More Information]

2007

  • Clarke, E., Appleyard, R., Bilston, L. (2007). Immature sheep spines are more flexible than mature spines: an in vitro biomechanical study. Spine, 32(26), 2970-2979. [More Information]
  • Clarke, E., McNulty, P., Macefield, V., Bilston, L. (2007). Mechanically Evoked Sensory and Motor Responses to Dynamic Compression of the Ulnar Nerve. Muscle and Nerve, 35(3), 303-311. [More Information]

2006

  • Clarke, E., McNulty, P., Macefield, V., Bilston, L. (2006). Mechanically evoked sensory and motor responses to dynamic compression of the ulnar nerve. Muscle and Nerve, 35(3), 303-311. [More Information]

2004

  • Behrend, O., Dickson, B., Clarke, E., Jin, C., Carlile, S. (2004). Neural Responses To Free Field And Virtual Acoustic Stimulation In The Inferior Colliculus Of The Guinea Pig. Journal of Neurophysiology, 92(5), 3014-3029. [More Information]

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