Dr Emily Blyth

Ludwig Engel Fellow
Medicine, Westmead Clinical School
The Westmead Institute for Medical Research
Haematologist
Department of Haematology
Westmead Hospital


Map

Selected grants

2019

  • A randomized trial of cell therapy for opportunistic infection after allogeneic stem cell transplant; Gottlieb D, Blyth E; Health Administration Corporation/Research Grant.

2016

  • A Phase I Study of PiggyBac CD19 Specific Chimeric Antigen Receptor T-cells for Therapy of Persistent and Relapsed B-cell Leukaemia and Lymphoma Post Allogeneic Stem Cell Transplantation (The CARTELL Study); Micklethwaite K, Dalla-Pozza L, Gottlieb D, O'Brien T, Trahair T, Clancy L, Blyth E, Shaw P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Coadministration of malignancy and infection specific T cells after allogeneic stem cell transplant for acute leukaemia with CD34+ stem cells; Gottlieb D, Micklethwaite K, Blyth E; Cancer Council New South Wales/Research Project Grants.

2015

  • Patient tailored anti-tumour T cells to prevent relapse in patients with acute myeloid leukaemia undergoing allogeneic haemopoietic stem cell transplantation; Blyth E; Royal Australasian College of Physicians/Robert Maple-Brown Research Establishment Fellowship.
  • A trial of tumour antigen targeted donor T cells in high risk acute myeloid leukaemia; Blyth E; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Patient tailored anti-tumour T cells to prevent relapse in patients with acute myeloid leukaemia undergoing allogeneic haemopoietic stem cell transplantation; Blyth E; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

2012

  • Partial Ludwig Engel Memorial Fellowship; Blyth E; Westmead Institute for Medical Research/Ludwig Engel Memorial Fellowship.

2011

  • Autologous cellular therapy for rapid immune reconstitution in patents with CLL receiving immunisuppressive chemotherapy; Gottlieb D, Clancy L, Blyth E, Deo S; The Leukaemia Foundation of Australia Limited/Grants in Aid.

2008

  • The use of cytoxic T cells as immunotherapy for viral infections post allogenic stem cell transplant; Gottlieb D, Blyth E; The Leukaemia Foundation of Australia Limited/Postdoctoral Fellowship.

Selected publications

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Journals

  • Ma, C., Clancy, L., Simms, R., Burgess, J., Deo, S., Blyth, E., Micklethwaite, K., Gottlieb, D. (2018). Adjuvant Peptide Pulsed Dendritic Cell Vaccination in Addition to T Cell Adoptive Immunotherapy for Cytomegalovirus Infection in Allogeneic Hematopoietic Stem Cell Transplantation Recipients. Biology of Blood and Marrow Transplantation, 24(1), 71-77. [More Information]
  • Stern, L., McGuire, H., Avdic, S., Rizzetto, S., Fazekas de St Groth, B., Luciani, F., Slobedman, B., Blyth, E. (2018). Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 9, 1-18. [More Information]
  • Kliman, D., Bilmon, I., Kwan, J., Blyth, E., Micklethwaite, K., Panicker, S., Bhattacharyya, A., Deren, S., Antonenas, V., Huang, G., Gottlieb, D. (2018). Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single-centre case series. Internal Medicine Journal, 48(8), 988-991. [More Information]
  • Kliman, D., Castellano-Gonzalez, G., Withers, B., Street, J., Tegg, E., Mirochnik, O., Lai, J., Clancy, L., Gottlieb, D., Blyth, E. (2018). Ultra-Sensitive Droplet Digital PCR for the Assessment of Microchimerism in Cellular Therapies. Biology of Blood and Marrow Transplantation, 24(5), 1069-1078. [More Information]
  • Sutrave, G., Blyth, E., Gottlieb, D. (2017). Cellular therapy for multiple pathogen infections after hematopoietic stem cell transplant. Cytotherapy, 19(11), 1284-1301. [More Information]
  • Ma, C., Clancy, L., Deo, S., Blyth, E., Micklethwaite, K., Gottlieb, D. (2017). Herpes simplex virus type 1 (HSV-1) specific T-cell generation from HLA-A1- and HLA-A2-positive donors for adoptive immunotherapy. Cytotherapy, 19(1), 107-118. [More Information]
  • Withers, B., Blyth, E., Clancy, L., Yong, A., Fraser, C., Burgess, J., Simms, R., Brown, R., Kliman, D., Dubosq, M., Bishop, D., Sutrave, G., Ma, C., Micklethwaite, K., Gottlieb, D., et al (2017). Long-term control of recurrent or refractory viral infections after allogeneic HSCT with third-party virus-specific T cells. Blood Advances, 1(24), 2193-2205. [More Information]
  • Blyth, E., Withers, B., Clancy, L., Gottlieb, D. (2016). CMV-specific immune reconstitution following allogeneic stem cell transplantation. Virulence, 7(8), 967-980. [More Information]
  • Brennan, Y., Gottlieb, D., Baewer, D., Blyth, E. (2015). A fatal case of acute HHV-6 myocarditis following allogeneic haemopoietic stem cell transplantation. Journal Of Clinical Virology, 72, 82-84. [More Information]
  • Ma, C., Blyth, E., Clancy, L., Simms, R., Burgess, J., Brown, R., Deo, S., Micklethwaite, K., Gottlieb, D. (2015). Addition of varicella zoster virus-specific T cells to cytomegalovirus, Epstein-Barr virus and adenovirus tri-specific T cells as adoptive immunotherapy in patients undergoing allogeneic hematopoietic stem cell transplantation. Cytotherapy, 17(10), 1406-1420. [More Information]
  • Macesic, N., Langsford, D., Nicholls, K., Hughes, P., Gottlieb, D., Clancy, L., Blyth, E., Micklethwaite, K., Withers, B., Majumdar, S., et al (2015). Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient. American Journal Of Transplantation, 15(3), 827-832. [More Information]
  • Bradstock, K., Bilmon, I., Kwan, J., Blyth, E., Micklethwaite, K., Huang, G., Deren, S., Byth Wilson, K., Gottlieb, D. (2015). Influence of Stem Cell Source on Outcomes of Allogeneic Reduced Intensity Conditioning Therapy Transplants Using Haploidentical Related Donors. Biology of Blood and Marrow Transplantation, 21(9), 1641-1645. [More Information]
  • Ramanayake, S., Bilmon, I., Bishop, D., Dubosq, M., Blyth, E., Clancy, L., Gottlieb, D., Micklethwaite, K. (2015). Low-cost generation of Good Manufacturing Practice-grade CD19-specific chimeric antigen receptor-expressing T cells using piggyBac gene transfer and patient-derived materials. Cytotherapy, 17(9), 1251-1267. [More Information]
  • Blyth, E., Clancy, L., Gottlieb, D. (2015). Moving towards pathogen-specific T cells post-stem cell transplant as standard of care. ISBT Science Series, 10(Suppl. 1), 349-356. [More Information]
  • Bradstock, K., Bilmon, I., Kwan, J., Micklethwaite, K., Blyth, E., Deren, S., Bayley, A., Gebski, V., Gottlieb, D. (2015). Single-agent high-dose cyclophosphamide for graft-versus-host disease prophylaxis in human leukocyte antigen-matched reduced-intensity peripheral blood stem cell transplantation results in an unacceptably high rate of severe acute graft-versus-host disease. Biology of Blood and Marrow Transplantation, 21(5), 941-944. [More Information]
  • Clancy, L., Blyth, E., Simms, R., Micklethwaite, K., Ma, C., Burgess, J., Antonenas, V., Shaw, P., Gottlieb, D. (2013). Cytomegalovirus-specific cytotoxic T lymphocytes can be efficiently expanded from granulocyte colony-stimulating factor-mobilized hemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplantation recipients to facilitate immune reconstitution. Biology of Blood and Marrow Transplantation, 19(5), 725-734. [More Information]
  • Blyth, E., Clancy, L., Simms, R., Ma, C., Burgess, J., Deo, S., Byth Wilson, K., Dubosq, M., Shaw, P., Micklethwaite, K., Gottlieb, D. (2013). Donor-derived CMV specific T-cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation. Blood, 121(18), 3745-3758. [More Information]
  • Blyth, E., Deo, S., Clancy, L., Simms, R., Bilmon, I., Micklethwaite, K., Gottlieb, D. (2012). Clinical-grade varicella zoster virus-specific T cells produced for adoptive immunotherapy in hemopoietic stem cell transplant recipients. Cytotherapy, 14(6), 724-732. [More Information]
  • Deo, S., Blyth, E., Clancy, L., Simms, R., Ma, C., Gottlieb, D. (2012). In vitro generation of influenza-specific polyfunctional CD4 + T cells suitable for adoptive immunotherapy. Cytotherapy, 14(2), 182-193. [More Information]
  • Deo, S., Clancy, L., Blyth, E., Meyer, W., Gottlieb, D. (2012). Robust polyfunctional T-helper 1 responses to multiple fungal antigens from a cell population generated using an environmental strain of Aspergillus fumigatus. Cytotherapy, 14(9), 1119-1130. [More Information]
  • Blyth, E., Clancy, L., Simms, R., Deo, S., O'Connell, P., Micklethwaite, K., Gottlieb, D. (2011). BK Virus-Specific T Cells for Use in Cellular Therapy Show Specificity to Multiple Antigens and Polyfunctional Cytokine Responses. Transplantation, 92(10), 1077-1084. [More Information]
  • Micklethwaite, K., Clancy, L., Sandher, U., Hansen, A., Blyth, E., Antonenas, V., Sartor, M., Bradstock, K., Gottlieb, D. (2008). Prophylactic infusion of cytomegalovirus specific cytotoxic T-lymphocytes stimulated with Ad5f35pp65 gene modified dendritic cells following allogeneic haemopoietic stem cell transplantation. Blood, 112(10), 3974-3981. [More Information]

2018

  • Ma, C., Clancy, L., Simms, R., Burgess, J., Deo, S., Blyth, E., Micklethwaite, K., Gottlieb, D. (2018). Adjuvant Peptide Pulsed Dendritic Cell Vaccination in Addition to T Cell Adoptive Immunotherapy for Cytomegalovirus Infection in Allogeneic Hematopoietic Stem Cell Transplantation Recipients. Biology of Blood and Marrow Transplantation, 24(1), 71-77. [More Information]
  • Stern, L., McGuire, H., Avdic, S., Rizzetto, S., Fazekas de St Groth, B., Luciani, F., Slobedman, B., Blyth, E. (2018). Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 9, 1-18. [More Information]
  • Kliman, D., Bilmon, I., Kwan, J., Blyth, E., Micklethwaite, K., Panicker, S., Bhattacharyya, A., Deren, S., Antonenas, V., Huang, G., Gottlieb, D. (2018). Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single-centre case series. Internal Medicine Journal, 48(8), 988-991. [More Information]
  • Kliman, D., Castellano-Gonzalez, G., Withers, B., Street, J., Tegg, E., Mirochnik, O., Lai, J., Clancy, L., Gottlieb, D., Blyth, E. (2018). Ultra-Sensitive Droplet Digital PCR for the Assessment of Microchimerism in Cellular Therapies. Biology of Blood and Marrow Transplantation, 24(5), 1069-1078. [More Information]

2017

  • Sutrave, G., Blyth, E., Gottlieb, D. (2017). Cellular therapy for multiple pathogen infections after hematopoietic stem cell transplant. Cytotherapy, 19(11), 1284-1301. [More Information]
  • Ma, C., Clancy, L., Deo, S., Blyth, E., Micklethwaite, K., Gottlieb, D. (2017). Herpes simplex virus type 1 (HSV-1) specific T-cell generation from HLA-A1- and HLA-A2-positive donors for adoptive immunotherapy. Cytotherapy, 19(1), 107-118. [More Information]
  • Withers, B., Blyth, E., Clancy, L., Yong, A., Fraser, C., Burgess, J., Simms, R., Brown, R., Kliman, D., Dubosq, M., Bishop, D., Sutrave, G., Ma, C., Micklethwaite, K., Gottlieb, D., et al (2017). Long-term control of recurrent or refractory viral infections after allogeneic HSCT with third-party virus-specific T cells. Blood Advances, 1(24), 2193-2205. [More Information]

2016

  • Blyth, E., Withers, B., Clancy, L., Gottlieb, D. (2016). CMV-specific immune reconstitution following allogeneic stem cell transplantation. Virulence, 7(8), 967-980. [More Information]

2015

  • Brennan, Y., Gottlieb, D., Baewer, D., Blyth, E. (2015). A fatal case of acute HHV-6 myocarditis following allogeneic haemopoietic stem cell transplantation. Journal Of Clinical Virology, 72, 82-84. [More Information]
  • Ma, C., Blyth, E., Clancy, L., Simms, R., Burgess, J., Brown, R., Deo, S., Micklethwaite, K., Gottlieb, D. (2015). Addition of varicella zoster virus-specific T cells to cytomegalovirus, Epstein-Barr virus and adenovirus tri-specific T cells as adoptive immunotherapy in patients undergoing allogeneic hematopoietic stem cell transplantation. Cytotherapy, 17(10), 1406-1420. [More Information]
  • Macesic, N., Langsford, D., Nicholls, K., Hughes, P., Gottlieb, D., Clancy, L., Blyth, E., Micklethwaite, K., Withers, B., Majumdar, S., et al (2015). Adoptive T cell immunotherapy for treatment of ganciclovir-resistant cytomegalovirus disease in a renal transplant recipient. American Journal Of Transplantation, 15(3), 827-832. [More Information]
  • Bradstock, K., Bilmon, I., Kwan, J., Blyth, E., Micklethwaite, K., Huang, G., Deren, S., Byth Wilson, K., Gottlieb, D. (2015). Influence of Stem Cell Source on Outcomes of Allogeneic Reduced Intensity Conditioning Therapy Transplants Using Haploidentical Related Donors. Biology of Blood and Marrow Transplantation, 21(9), 1641-1645. [More Information]
  • Ramanayake, S., Bilmon, I., Bishop, D., Dubosq, M., Blyth, E., Clancy, L., Gottlieb, D., Micklethwaite, K. (2015). Low-cost generation of Good Manufacturing Practice-grade CD19-specific chimeric antigen receptor-expressing T cells using piggyBac gene transfer and patient-derived materials. Cytotherapy, 17(9), 1251-1267. [More Information]
  • Blyth, E., Clancy, L., Gottlieb, D. (2015). Moving towards pathogen-specific T cells post-stem cell transplant as standard of care. ISBT Science Series, 10(Suppl. 1), 349-356. [More Information]
  • Bradstock, K., Bilmon, I., Kwan, J., Micklethwaite, K., Blyth, E., Deren, S., Bayley, A., Gebski, V., Gottlieb, D. (2015). Single-agent high-dose cyclophosphamide for graft-versus-host disease prophylaxis in human leukocyte antigen-matched reduced-intensity peripheral blood stem cell transplantation results in an unacceptably high rate of severe acute graft-versus-host disease. Biology of Blood and Marrow Transplantation, 21(5), 941-944. [More Information]

2013

  • Clancy, L., Blyth, E., Simms, R., Micklethwaite, K., Ma, C., Burgess, J., Antonenas, V., Shaw, P., Gottlieb, D. (2013). Cytomegalovirus-specific cytotoxic T lymphocytes can be efficiently expanded from granulocyte colony-stimulating factor-mobilized hemopoietic progenitor cell products ex vivo and safely transferred to stem cell transplantation recipients to facilitate immune reconstitution. Biology of Blood and Marrow Transplantation, 19(5), 725-734. [More Information]
  • Blyth, E., Clancy, L., Simms, R., Ma, C., Burgess, J., Deo, S., Byth Wilson, K., Dubosq, M., Shaw, P., Micklethwaite, K., Gottlieb, D. (2013). Donor-derived CMV specific T-cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation. Blood, 121(18), 3745-3758. [More Information]

2012

  • Blyth, E., Deo, S., Clancy, L., Simms, R., Bilmon, I., Micklethwaite, K., Gottlieb, D. (2012). Clinical-grade varicella zoster virus-specific T cells produced for adoptive immunotherapy in hemopoietic stem cell transplant recipients. Cytotherapy, 14(6), 724-732. [More Information]
  • Deo, S., Blyth, E., Clancy, L., Simms, R., Ma, C., Gottlieb, D. (2012). In vitro generation of influenza-specific polyfunctional CD4 + T cells suitable for adoptive immunotherapy. Cytotherapy, 14(2), 182-193. [More Information]
  • Deo, S., Clancy, L., Blyth, E., Meyer, W., Gottlieb, D. (2012). Robust polyfunctional T-helper 1 responses to multiple fungal antigens from a cell population generated using an environmental strain of Aspergillus fumigatus. Cytotherapy, 14(9), 1119-1130. [More Information]

2011

  • Blyth, E., Clancy, L., Simms, R., Deo, S., O'Connell, P., Micklethwaite, K., Gottlieb, D. (2011). BK Virus-Specific T Cells for Use in Cellular Therapy Show Specificity to Multiple Antigens and Polyfunctional Cytokine Responses. Transplantation, 92(10), 1077-1084. [More Information]

2008

  • Micklethwaite, K., Clancy, L., Sandher, U., Hansen, A., Blyth, E., Antonenas, V., Sartor, M., Bradstock, K., Gottlieb, D. (2008). Prophylactic infusion of cytomegalovirus specific cytotoxic T-lymphocytes stimulated with Ad5f35pp65 gene modified dendritic cells following allogeneic haemopoietic stem cell transplantation. Blood, 112(10), 3974-3981. [More Information]

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