Dr Fiona McKay

ARC Post-doctoral Fellow
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 8738
Fax +61 2 9891 3889

Map

Selected grants

2013

  • Clinical implications of IL7R genotype: from disease risk to disease management; Stewart G, Booth D, Gottlieb D, McKay F, Vucic S, Rajasuriar R; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • The biologic and clinical implications of IL7Ra genotype in multiple sclerosis; Stewart G, Booth D, McKay F; Multiple Sclerosis Research Australia/Investigator Project Grants.

2011

  • Genotyping to identify causes of disease and to personalise therapeutic management; McKay F; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2009

  • Functional Genomics to Predict and Enhance Response to Interferon; George J, Suppiah V, Kingston D, Bahlo M, Yang J, McKay F, Booth D, Stewart G, Bahlo M; Australian Research Council (ARC)/Linkage Projects (LP).

2006

  • Molecular response to interferon beta treatment in multiple sclerosis; Arthur J, Stewart G, Heard R, Booth D, Sedger L, Booth D, Stewart G, Heard R; Australian Research Council (ARC)/Linkage Projects (LP).

Selected publications

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Journals

  • Parnell, G., Gatt, P., McKay, F., Schibeci, S., Krupa, M., Powell, J., Visscher, P., Montgomery, G., Lechner-Scott, J., Broadley, S., Liddle, C., Vucic, S., Stewart, G., Booth, D., et al (2014). Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season. Multiple Sclerosis Journal, 20(6), 675-685. [More Information]
  • Parnell, G., Gatt, P., Krupa, M., Dorothee, N., McKay, F., Schibeci, S., Batten, M., Baranzini, S., Henderson, A., Barnett, M., Vucic, S., Stewart, G., Booth, D., et al (2014). The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clinical Immunology, 151(1), 16-24. [More Information]
  • McKay, F., Hoe, E., Parnell, G., Gatt, P., Schibeci, S., Stewart, G., Booth, D. (2013). IL7Ralpha Expression and Upregulation by IFNbeta in Dendritic Cell Subsets Is Haplotype-Dependent. PLoS One, 8(10), 1-10. [More Information]
  • Riveros, C., Mellor, D., Gandhi, K., McKay, F., Cox, M., Berretta, R., Vaezpour, S., Inostroza-Ponta, M., Broadley, S., Heard, R., Vucic, S., Stewart, G., Booth, D., et al (2010). A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis. PLoS One, 5(12), e14176-1-e14176-28. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Gandhi, K., Heard, R., Stewart, G., Booth, D. (2010). Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. Journal of Immunology, 184(5), 2512-2517. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2010). Interleukin 7 Receptor Alpha Chain (IL-7Ralpha) Haplotypes Vary in Their Influence on Multiple Sclerosis Susceptibility and Response to Interferon Beta. Journal of Interferon and Cytokine Research, 30(5), 291-298. [More Information]
  • Gandhi, K., McKay, F., Diefenbach, E., Crossett, B., Schibeci, S., Heard, R., Stewart, G., Booth, D., Arthur, J. (2010). Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis. PLoS One, 5(5), e10484 - 1-e10484 - 9. [More Information]
  • McKay, F., Maamary, P., Sanderson-Smith, M., Aziz, R., Hollands, M., Hollands, A., Cole, J., McArthur, J., Kirk, J., Cork, A., et al (2010). Parameters Governing Invasive Disease Propensity of Non-M1 Serotype Group A Streptococci. Journal of Innate Immunity, 596(606), 596-606. [More Information]
  • Gandhi, K., McKay, F., Cox, M., Riveros, C., Armstrong, N., Heard, R., Vucic, S., Williams, D., Stankovich, J., Brown, M., Stewart, G., Booth, D., et al (2010). The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Human Molecular Genetics, 19(11), 2134-2143. [More Information]
  • McArthur, J., McKay, F., Ramachandran, V., Shyam, P., Cork, A., Sanderson-Smith, M., Cole, J., Ringdahl, U., Sjoebring, U., Ranson, M., et al (2008). Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation. The F A S E B Journal, 22(9), 3146-3153. [More Information]
  • Gandhi, K., McKay, F., Schibeci, S., Arthur, J., Heard, R., Stewart, G., Booth, D. (2008). BAFF is a Biological Response Marker to IFN-beta Treatment in Multiple Sclerosis. Journal of Interferon and Cytokine Research, 28(9), 529-540. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2008). CD127 immunophenotyping suggests altered CD4(+) T cell regulation in primary progressive multiple sclerosis. Journal of Autoimmunity, 31(1), 52-58. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2007). Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes and Immunity, 9((accepted 6 September, 2007)), 1-6. [More Information]
  • McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2006). Analysis of neutralizing antibodies to therapeutic interferon-beta in multiple sclerosis patients: a comparison of three methods in a large Australasian cohort. Journal of Immunological Methods, 310(1-2), 20-29. [More Information]
  • Cole, J., McArthur, J., McKay, F., Sanderson-Smith, M., Cork, A., Ranson, M., Rohde, M., Itzek, A., Sun, H., Ginsburg, D., et al (2006). Trigger for group A streptococcal M1T1 invasive disease. The F A S E B Journal, 20(10), E1139-E1145. [More Information]
  • Walker, M., McArthur, J., McKay, F., Ranson, M. (2005). Is plasminogen deployed as a Streptococcus pyogenes virulence factor? Trends in Microbiology, 13(7), 308-313. [More Information]
  • McKay, F., McArthur, J., Sanderson-Smith, M., Gardam, S., Currie, B., Sriprakash, K., Fagan, P., Towers, R., Batzloff, M., Chhatwal, G., et al (2004). Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection. Infection and Immunity.
  • Sanderson-Smith, M., McKay, F., Ranson, M., Walker, M. (2004). Subversion of the plasminogen activation system by Streptococcus pyogenes:mounting evidence to implicate the human protease plasmin in disease processes. Current Trends In Microbiology, 1, 75-85.

2014

  • Parnell, G., Gatt, P., McKay, F., Schibeci, S., Krupa, M., Powell, J., Visscher, P., Montgomery, G., Lechner-Scott, J., Broadley, S., Liddle, C., Vucic, S., Stewart, G., Booth, D., et al (2014). Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season. Multiple Sclerosis Journal, 20(6), 675-685. [More Information]
  • Parnell, G., Gatt, P., Krupa, M., Dorothee, N., McKay, F., Schibeci, S., Batten, M., Baranzini, S., Henderson, A., Barnett, M., Vucic, S., Stewart, G., Booth, D., et al (2014). The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clinical Immunology, 151(1), 16-24. [More Information]

2013

  • McKay, F., Hoe, E., Parnell, G., Gatt, P., Schibeci, S., Stewart, G., Booth, D. (2013). IL7Ralpha Expression and Upregulation by IFNbeta in Dendritic Cell Subsets Is Haplotype-Dependent. PLoS One, 8(10), 1-10. [More Information]

2010

  • Riveros, C., Mellor, D., Gandhi, K., McKay, F., Cox, M., Berretta, R., Vaezpour, S., Inostroza-Ponta, M., Broadley, S., Heard, R., Vucic, S., Stewart, G., Booth, D., et al (2010). A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis. PLoS One, 5(12), e14176-1-e14176-28. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Gandhi, K., Heard, R., Stewart, G., Booth, D. (2010). Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. Journal of Immunology, 184(5), 2512-2517. [More Information]
  • Hoe, E., McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2010). Interleukin 7 Receptor Alpha Chain (IL-7Ralpha) Haplotypes Vary in Their Influence on Multiple Sclerosis Susceptibility and Response to Interferon Beta. Journal of Interferon and Cytokine Research, 30(5), 291-298. [More Information]
  • Gandhi, K., McKay, F., Diefenbach, E., Crossett, B., Schibeci, S., Heard, R., Stewart, G., Booth, D., Arthur, J. (2010). Novel approaches to detect serum biomarkers for clinical response to interferon-beta treatment in multiple sclerosis. PLoS One, 5(5), e10484 - 1-e10484 - 9. [More Information]
  • McKay, F., Maamary, P., Sanderson-Smith, M., Aziz, R., Hollands, M., Hollands, A., Cole, J., McArthur, J., Kirk, J., Cork, A., et al (2010). Parameters Governing Invasive Disease Propensity of Non-M1 Serotype Group A Streptococci. Journal of Innate Immunity, 596(606), 596-606. [More Information]
  • Gandhi, K., McKay, F., Cox, M., Riveros, C., Armstrong, N., Heard, R., Vucic, S., Williams, D., Stankovich, J., Brown, M., Stewart, G., Booth, D., et al (2010). The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Human Molecular Genetics, 19(11), 2134-2143. [More Information]

2008

  • McArthur, J., McKay, F., Ramachandran, V., Shyam, P., Cork, A., Sanderson-Smith, M., Cole, J., Ringdahl, U., Sjoebring, U., Ranson, M., et al (2008). Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation. The F A S E B Journal, 22(9), 3146-3153. [More Information]
  • Gandhi, K., McKay, F., Schibeci, S., Arthur, J., Heard, R., Stewart, G., Booth, D. (2008). BAFF is a Biological Response Marker to IFN-beta Treatment in Multiple Sclerosis. Journal of Interferon and Cytokine Research, 28(9), 529-540. [More Information]
  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2008). CD127 immunophenotyping suggests altered CD4(+) T cell regulation in primary progressive multiple sclerosis. Journal of Autoimmunity, 31(1), 52-58. [More Information]

2007

  • McKay, F., Swain, L., Schibeci, S., Rubio, J., Kilpatrick, T., Heard, R., Stewart, G., Booth, D. (2007). Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes and Immunity, 9((accepted 6 September, 2007)), 1-6. [More Information]

2006

  • McKay, F., Schibeci, S., Heard, R., Stewart, G., Booth, D. (2006). Analysis of neutralizing antibodies to therapeutic interferon-beta in multiple sclerosis patients: a comparison of three methods in a large Australasian cohort. Journal of Immunological Methods, 310(1-2), 20-29. [More Information]
  • Cole, J., McArthur, J., McKay, F., Sanderson-Smith, M., Cork, A., Ranson, M., Rohde, M., Itzek, A., Sun, H., Ginsburg, D., et al (2006). Trigger for group A streptococcal M1T1 invasive disease. The F A S E B Journal, 20(10), E1139-E1145. [More Information]

2005

  • Walker, M., McArthur, J., McKay, F., Ranson, M. (2005). Is plasminogen deployed as a Streptococcus pyogenes virulence factor? Trends in Microbiology, 13(7), 308-313. [More Information]

2004

  • McKay, F., McArthur, J., Sanderson-Smith, M., Gardam, S., Currie, B., Sriprakash, K., Fagan, P., Towers, R., Batzloff, M., Chhatwal, G., et al (2004). Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection. Infection and Immunity.
  • Sanderson-Smith, M., McKay, F., Ranson, M., Walker, M. (2004). Subversion of the plasminogen activation system by Streptococcus pyogenes:mounting evidence to implicate the human protease plasmin in disease processes. Current Trends In Microbiology, 1, 75-85.

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