Dr Fiona Simpson

Clinical Senior Lecturer
Intensive Care Medicine, Northern Clinical School

Telephone +61 2 9463 2633
Fax +61 2 9463 2057

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Selected grants

2016

  • Prophylactic early parenteral nutrition in patients undergoing hematopoietic cell transplantation: A multi-centre randomised controlled trial.; Doig G, Simpson F, Ward C, Laviano A; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Management of refeeding syndrome in critical illness: An AuSPEN endorsed multi-centre clinical trial; Doig G, Simpson F, Caterson I, Davies A, McLean A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Nephro-protective effects of L-amino acids in critically ill patients: A multi-centre randomised controlled trial; Doig G, Pollock C, Reade M, Davies A, Simpson F; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • The effects of amoni acid supplementation in critically ill patients at high risk of clinically significant renal dysfunction: A Phase II randomised controlled trial; Doig G, Simpson F, Bellomo R; Baxter Healthcare Pty Limited/Research Support.

2006

  • Early parenteral nutrition versus standard care in the critically ill patient: A Level 1 randomised controlled trial; Doig G, Cooper D, Finfer F, Cooper D, Finfer S, Simpson F; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Doig, G., Simpson, F., Heighes, P. (2015). Mortality in Intensive Care and the Role of Enteral Nutrition in Trauma Patients. In Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel (Eds.), Diet and Nutrition in Critical Care, (pp. 1333-1338). New York: Springer Science+Business Media. [More Information]
  • Doig, G., Simpson, F. (2009). Parenteral Nutrition. In C Ronco, R Bellomo, J Kellum (Eds.), Critical Care Nephrology (2nd Ed.), (pp. 751-756). United Kingdom: W B Saunders.

Journals

  • Doig, G., Simpson, F. (2015). CALORIES trial offers confirmatory evidence that parenteral nutrition does not cause infectious complications in critically ill patients. Evidence-Based Medicine, 20(2), 60-60. [More Information]
  • Doig, G., Simpson, F., Bellomo, R., Heighes, P., Sweetman, E., Chesher, D., Pollock, C., Davies, A., Botha, J., Harrigan, P., et al (2015). Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial. Intensive Care Medicine, 41(7), 1197-1208. [More Information]
  • Simpson, F., Doig, G. (2015). Physical Assessment and Anthropometric Measures for Use in Clinical Research Conducted in Critically Ill Patient Populations: An Analytic Observational Study. Journal of Parenteral and Enteral Nutrition, 39(3), 313-321. [More Information]
  • Doig, G., Simpson, F., Heighes, P., Bellomo, R., Chesher, D., Caterson, I., Reade, M., Harrigan, P. (2015). Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: A randomised, parallel-group, multicentre, single-blind controlled trial. The Lancet Respiratory Medicine, 3(12), 943-952. [More Information]
  • Doig, G., Simpson, F. (2014). Hydroxyethyl starch 130/0.42 for bolus resuscitation in severe sepsis: long-term follow-up, confidence intervals and clinically important differences in outcomes. Intensive Care Medicine, 40(7), 1036-1038. [More Information]
  • Doig, G., Simpson, F. (2014). Understanding clinical trials: emerging methodological issues. Intensive Care Medicine, 40(11), 1755-1757. [More Information]
  • Doig, G., Chevrou-Severac, H., Simpson, F. (2013). Early enteral nutrition in critical illness: a full economic analysis using US costs. ClinicoEconomics and Outcome Research, 5, 429-436. [More Information]
  • Doig, G., Simpson, F. (2013). Early parenteral nutrition in critical illness--reply. JAMA, 310(11), 1184-1184. [More Information]
  • Doig, G., Simpson, F. (2013). Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a full economic analysis of a multicenter randomized controlled trial based on US costs. ClinicoEconomics and Outcome Research, 5, 369-379. [More Information]
  • Doig, G., Simpson, F., Sweetman, E., Finfer, S., Cooper, J., Heighes, P., Davies, A., O'Leary, M., Solano, T., Peake, S. (2013). Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA, 309(20), 2130-2138. [More Information]
  • Doig, G., Heighes, P., Simpson, F., Sweetman, E. (2011). Early enteral nutrition reduces mortality in trauma patients requiring intensive care: A meta-analysis of randomised controlled trials. Injury, 42(1), 50-56. [More Information]
  • Simpson, F., Sweetman, E., Doig, G. (2010). A systematic review of techniques and interventions for improving adherence to inclusion and exclusion criteria during enrolment into randomised controlled trials. Trials, 11(17), 17-1-17-7. [More Information]
  • Heighes, P., Doig, G., Sweetman, E., Simpson, F. (2010). An overview of evidence from systematic reviews evaluating early enteral nutrition in critically ill patients: more convincing evidence is needed. Anaesthesia and Intensive Care, 38(1), 167-174. [More Information]
  • Doig, G., Simpson, F. (2010). Early enteral nutrition in critically ill patients: authors' response. Intensive Care Medicine, 36, 1089-1090. [More Information]
  • Doig, G., Heighes, P., Simpson, F., Sweetman, E., Davies, A. (2009). Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta-analysis of randomised controlled trials. Intensive Care Medicine, 35(12), 2018-2027. [More Information]
  • Doig, G., Simpson, F., Sweetman, E. (2009). Evidence-based nutrition support in the intensive care unit: an update on reported trial quality. Current Opinion In Clinical Nutrition And Metabolic Care, 12(2), 201-206. [More Information]
  • Doig, G., Simpson, F., Finfer, S., Delaney, A., Davies, A., Miotchell, I., Dobb, G. (2008). Effect of Evidence-Based Feeding Guidelines on Mortality of Critically Ill Adults. JAMA: The Journal of the American Medical Association, 300(23), 2731-2741. [More Information]
  • Simpson, F., Doig, G. (2007). The relative effectiveness of practice change interventions in overcoming common barriers to change: a survey of 14 hospitals with experience implementing evidence-based guidelines. Journal of Evaluation in Clinical Practice, 13(5), 709-715. [More Information]
  • Doig, G., Simpson, F. (2006). Early enteral nutrition in the critically ill: do we need more evidence or better evidence? Current Opinion in Critical Care. [More Information]
  • Doig, G., Simpson, F. (2006). With caveats, varying the block size can adequately conceal the allocation sequence: authors' response. Journal of Critical Care, 21(2), 229-30. [More Information]
  • Doig, G., Simpson, F., Delaney, A. (2005). A review of the true methodological quality of nutritional support trials conducted in the critically ill: time for improvement. Anesthesia and Analgesia, 100(2), 527-33. [More Information]
  • Simpson, F., Doig, G. (2005). Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intensive Care Medicine, 31(1), 12-23. [More Information]
  • Doig, G., Simpson, F. (2005). Randomization and allocation concealment: a practical guide for researchers. Journal of Critical Care, 20(2), 187-91; discussion 191-3. [More Information]

Conferences

  • Doig, G., Simpson, F. (2006). The relative effectiveness of practice change interventions in overcoming common barriers to change: A survey of 14 hospitals with experience implementing evidence-based guidelines. 35th Critical Care Congress of the Society of Critical Care Medicine, United States: Lippincott Williams & Wilkins.

2015

  • Doig, G., Simpson, F. (2015). CALORIES trial offers confirmatory evidence that parenteral nutrition does not cause infectious complications in critically ill patients. Evidence-Based Medicine, 20(2), 60-60. [More Information]
  • Doig, G., Simpson, F., Bellomo, R., Heighes, P., Sweetman, E., Chesher, D., Pollock, C., Davies, A., Botha, J., Harrigan, P., et al (2015). Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial. Intensive Care Medicine, 41(7), 1197-1208. [More Information]
  • Doig, G., Simpson, F., Heighes, P. (2015). Mortality in Intensive Care and the Role of Enteral Nutrition in Trauma Patients. In Rajkumar Rajendram, Victor R. Preedy, Vinood B. Patel (Eds.), Diet and Nutrition in Critical Care, (pp. 1333-1338). New York: Springer Science+Business Media. [More Information]
  • Simpson, F., Doig, G. (2015). Physical Assessment and Anthropometric Measures for Use in Clinical Research Conducted in Critically Ill Patient Populations: An Analytic Observational Study. Journal of Parenteral and Enteral Nutrition, 39(3), 313-321. [More Information]
  • Doig, G., Simpson, F., Heighes, P., Bellomo, R., Chesher, D., Caterson, I., Reade, M., Harrigan, P. (2015). Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: A randomised, parallel-group, multicentre, single-blind controlled trial. The Lancet Respiratory Medicine, 3(12), 943-952. [More Information]

2014

  • Doig, G., Simpson, F. (2014). Hydroxyethyl starch 130/0.42 for bolus resuscitation in severe sepsis: long-term follow-up, confidence intervals and clinically important differences in outcomes. Intensive Care Medicine, 40(7), 1036-1038. [More Information]
  • Doig, G., Simpson, F. (2014). Understanding clinical trials: emerging methodological issues. Intensive Care Medicine, 40(11), 1755-1757. [More Information]

2013

  • Doig, G., Chevrou-Severac, H., Simpson, F. (2013). Early enteral nutrition in critical illness: a full economic analysis using US costs. ClinicoEconomics and Outcome Research, 5, 429-436. [More Information]
  • Doig, G., Simpson, F. (2013). Early parenteral nutrition in critical illness--reply. JAMA, 310(11), 1184-1184. [More Information]
  • Doig, G., Simpson, F. (2013). Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a full economic analysis of a multicenter randomized controlled trial based on US costs. ClinicoEconomics and Outcome Research, 5, 369-379. [More Information]
  • Doig, G., Simpson, F., Sweetman, E., Finfer, S., Cooper, J., Heighes, P., Davies, A., O'Leary, M., Solano, T., Peake, S. (2013). Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA, 309(20), 2130-2138. [More Information]

2011

  • Doig, G., Heighes, P., Simpson, F., Sweetman, E. (2011). Early enteral nutrition reduces mortality in trauma patients requiring intensive care: A meta-analysis of randomised controlled trials. Injury, 42(1), 50-56. [More Information]

2010

  • Simpson, F., Sweetman, E., Doig, G. (2010). A systematic review of techniques and interventions for improving adherence to inclusion and exclusion criteria during enrolment into randomised controlled trials. Trials, 11(17), 17-1-17-7. [More Information]
  • Heighes, P., Doig, G., Sweetman, E., Simpson, F. (2010). An overview of evidence from systematic reviews evaluating early enteral nutrition in critically ill patients: more convincing evidence is needed. Anaesthesia and Intensive Care, 38(1), 167-174. [More Information]
  • Doig, G., Simpson, F. (2010). Early enteral nutrition in critically ill patients: authors' response. Intensive Care Medicine, 36, 1089-1090. [More Information]

2009

  • Doig, G., Heighes, P., Simpson, F., Sweetman, E., Davies, A. (2009). Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta-analysis of randomised controlled trials. Intensive Care Medicine, 35(12), 2018-2027. [More Information]
  • Doig, G., Simpson, F., Sweetman, E. (2009). Evidence-based nutrition support in the intensive care unit: an update on reported trial quality. Current Opinion In Clinical Nutrition And Metabolic Care, 12(2), 201-206. [More Information]
  • Doig, G., Simpson, F. (2009). Parenteral Nutrition. In C Ronco, R Bellomo, J Kellum (Eds.), Critical Care Nephrology (2nd Ed.), (pp. 751-756). United Kingdom: W B Saunders.

2008

  • Doig, G., Simpson, F., Finfer, S., Delaney, A., Davies, A., Miotchell, I., Dobb, G. (2008). Effect of Evidence-Based Feeding Guidelines on Mortality of Critically Ill Adults. JAMA: The Journal of the American Medical Association, 300(23), 2731-2741. [More Information]

2007

  • Simpson, F., Doig, G. (2007). The relative effectiveness of practice change interventions in overcoming common barriers to change: a survey of 14 hospitals with experience implementing evidence-based guidelines. Journal of Evaluation in Clinical Practice, 13(5), 709-715. [More Information]

2006

  • Doig, G., Simpson, F. (2006). Early enteral nutrition in the critically ill: do we need more evidence or better evidence? Current Opinion in Critical Care. [More Information]
  • Doig, G., Simpson, F. (2006). The relative effectiveness of practice change interventions in overcoming common barriers to change: A survey of 14 hospitals with experience implementing evidence-based guidelines. 35th Critical Care Congress of the Society of Critical Care Medicine, United States: Lippincott Williams & Wilkins.
  • Doig, G., Simpson, F. (2006). With caveats, varying the block size can adequately conceal the allocation sequence: authors' response. Journal of Critical Care, 21(2), 229-30. [More Information]

2005

  • Doig, G., Simpson, F., Delaney, A. (2005). A review of the true methodological quality of nutritional support trials conducted in the critically ill: time for improvement. Anesthesia and Analgesia, 100(2), 527-33. [More Information]
  • Simpson, F., Doig, G. (2005). Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intensive Care Medicine, 31(1), 12-23. [More Information]
  • Doig, G., Simpson, F. (2005). Randomization and allocation concealment: a practical guide for researchers. Journal of Critical Care, 20(2), 187-91; discussion 191-3. [More Information]

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