Dr Frank Iorfino
Brain and Mind Centre
Faculty of Medicine and Health
Dr Frank Iorfino is an NHMRC Emerging Leadership Fellow at the University of Sydney's Brain and Mind Centre. His research interests and expertise are in youth mental health and early intervention with a specific focus on how digital health can change the way we assess and manage emerging anxiety, mood and psychotic disorders. His work has contributed to our understanding of illness trajectories with a specific focus on illness progression, suicidality and functioning among youth mental health service populations. He currently leads a digital mental health program that has established multidisciplinary partnerships with health service organisations, data scientists and industry to drive real-world impact that improves the quality of youth mental health care and leads to better outcomes for young people.
Project title | Research student |
---|---|
Understanding the Trajectories of Mental Illness in Young People to Inform Personalised Care | William CAPON |
Publications
Book Chapters
- Scott, E., Carpenter, J., Iorfino, F., Cross, S., Hermens, D., White, D., Lee, R., Naismith, S., Guastella, A., Glozier, N., Leweke, F., Koethe, D., Lagopoulos, J., Scott, J., Hamilton, B., Crouse, J., Tickell (nee Kennedy), A., Nichles, A., Zmicerevska, N., Gehue, L., Kaur, M., Chitty, K., Hickie, I. (2020). Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health care. In Bernhard T. Baune (Eds.), Personalized Psychiatry, (pp. 39-62). London: Elsevier. [More Information]
Journals
- Tai, A., Krausz, R., Kim, J., Schmeckenbecher, J., Kitchin, V., Wang, J., Kazemi, A., Masoudi, R., Fadakar, H., Iorfino, F. (2024). Clinical decision support systems in addiction and concurrent disorders: A systematic review and meta-analysis. Journal of Evaluation in Clinical Practice. [More Information]
- Dimitropoulos, G., Bassi, E., Bright, K., Gondziola, J., Bradley, J., Fersovitch, M., Stamp, L., LaMonica, H., Iorfino, F., Gaskell, T., et al (2024). Implementation of an Electronic Mental Health Platform for Youth and Young Adults in a School Context Across Alberta, Canada: Thematic Analysis of the Perspectives of Stakeholders. JMIR Mental Health, 11(1). [More Information]
- Crosland, P., Marshall, D., Hosseini, H., Ho, N., Vacher, C., Skinner, A., Nguyen, K., Iorfino, F., Rosenberg, S., Song, C., Tran, K., Occhipinti, J., Hickie, I., et al (2024). Incorporating Complexity and System Dynamics into Economic Modelling for Mental Health Policy and Planning. PharmacoEconomics. [More Information]
2024
- Tai, A., Krausz, R., Kim, J., Schmeckenbecher, J., Kitchin, V., Wang, J., Kazemi, A., Masoudi, R., Fadakar, H., Iorfino, F. (2024). Clinical decision support systems in addiction and concurrent disorders: A systematic review and meta-analysis. Journal of Evaluation in Clinical Practice. [More Information]
- Dimitropoulos, G., Bassi, E., Bright, K., Gondziola, J., Bradley, J., Fersovitch, M., Stamp, L., LaMonica, H., Iorfino, F., Gaskell, T., et al (2024). Implementation of an Electronic Mental Health Platform for Youth and Young Adults in a School Context Across Alberta, Canada: Thematic Analysis of the Perspectives of Stakeholders. JMIR Mental Health, 11(1). [More Information]
- Crosland, P., Marshall, D., Hosseini, H., Ho, N., Vacher, C., Skinner, A., Nguyen, K., Iorfino, F., Rosenberg, S., Song, C., Tran, K., Occhipinti, J., Hickie, I., et al (2024). Incorporating Complexity and System Dynamics into Economic Modelling for Mental Health Policy and Planning. PharmacoEconomics. [More Information]
2023
- Capon, W., Hickie, I., Fetanat, M., Varidel, M., LaMonica, H., Prodan, A., Piper, S., Davenport, T., Mughal, S., Shah, J., Scott, E., Iorfino, F. (2023). A multidimensional approach for differentiating the clinical needs of young people presenting for primary mental health care. Comprehensive Psychiatry, 126. [More Information]
- Capon, W., Hickie, I., Mckenna, S., Varidel, M., Richards, M., LaMonica, H., Rock, D., Scott, E., Iorfino, F. (2023). Characterising variability in youth mental health service populations: A detailed and scalable approach using digital technology. Australasian Psychiatry. [More Information]
- Hickie, I., Merikangas, K., Carpenter, J., Iorfino, F., Scott, E., Scott, J., Crouse, J. (2023). Does circadian dysrhythmia drive the switch into high- or low-activation states in bipolar I disorder? Bipolar Disorders. [More Information]
2022
- Capon, W., Hickie, I., Varidel, M., Prodan, A., Crouse, J., Carpenter, J., Cross, S., Nichles, A., Zmicerevska, N., Guastella, A., Scott, E., Iorfino, F., et al (2022). Clinical staging and the differential risks for clinical and functional outcomes in young people presenting for youth mental health care. BMC Medicine, 20(1). [More Information]
- Campos, A., Byrne, E., Iorfino, F., Fabbri, C., Hickie, I., Lewis, C., Wray, N., Medland, S., Rentería, M., Martin, N. (2022). Clinical, demographic, and genetic risk factors of treatment-attributed suicidality in >10,000 Australian adults taking antidepressants. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 189(6), 196-206. [More Information]
- Burton, A., Hamilton, B., Iorfino, F., LaMonica, H., Scott, E., Hickie, I. (2022). Examining the prevalence of disordered eating in a cohort of young Australians presenting for mental health care at a headspace centre: results from a cross-sectional clinical survey study. BMJ Open, 12(8). [More Information]
2021
- Scott, J., Crouse, J., Ho, N., Iorfino, F., Martin, N., Parker, R., McGrath, J., Gillespie, N., Medland, S., Hickie, I. (2021). Early expressions of psychopathology and risk associated with trans-diagnostic transition to mood and psychotic disorders in adolescents and young adults. PloS One, 16(6-Jun), e0252550. [More Information]
- Iorfino, F., Marangoni, C., Cui, L., Hermens, D., Hickie, I., Merikangas, K. (2021). Familial aggregation of anxiety disorder subtypes and anxious temperament in the NIMH Family Study of Affective Spectrum Disorders. Journal of Affective Disorders, 281, 751-758. [More Information]
- Piper, S., Davenport, T., LaMonica, H., Ottavio, A., Iorfino, F., Cheng, W., Cross, S., Lee, G., Scott, E., Hickie, I. (2021). Implementing a digital health model of care in Australian youth mental health services: protocol for impact evaluation. BMC Health Services Research, 21(1), 452. [More Information]
2020
- Carpenter, J., Iorfino, F., Cross, S., Nichles, A., Zmicerevska, N., Crouse, J., Palmer, J., Whitton, A., White, D., Naismith, S., Guastella, A., Hermens, D., Scott, J., Scott, E., Hickie, I. (2020). Cohort profile: The Brain and Mind Centre Optymise cohort: Tracking multidimensional outcomes in young people presenting for mental healthcare. BMJ Open, 10(3), e030985. [More Information]
- Scott, E., Carpenter, J., Iorfino, F., Cross, S., Hermens, D., White, D., Lee, R., Naismith, S., Guastella, A., Glozier, N., Leweke, F., Koethe, D., Lagopoulos, J., Scott, J., Hamilton, B., Crouse, J., Tickell (nee Kennedy), A., Nichles, A., Zmicerevska, N., Gehue, L., Kaur, M., Chitty, K., Hickie, I. (2020). Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health care. In Bernhard T. Baune (Eds.), Personalized Psychiatry, (pp. 39-62). London: Elsevier. [More Information]
- Davenport, T., Cheng, W., Iorfino, F., Hamilton, B., Castaldi, E., Burton, A., Scott, E., Hickie, I. (2020). Flip the clinic: A digital health approach to youth mental health service delivery during the COVID-19 pandemic and beyond. JMIR Mental Health, 7(12), e24578. [More Information]
2019
- Iorfino, F., Cross, S., Davenport, T., Carpenter, J., Scott, E., Shiran, S., Hickie, I. (2019). A Digital Platform Designed for Youth Mental Health Services to Deliver Personalized and Measurement-Based Care. Frontiers in Psychiatry, 10, 1-9. [More Information]
- Iorfino, F., Scott, E., Carpenter, J., Cross, S., Hermens, D., Killedar, M., Nichles, A., Zmicerevska, N., White, D., Guastella, A., Hickie, I., et al (2019). Clinical Stage Transitions in Persons Aged 12 to 25 Years Presenting to Early Intervention Mental Health Services with Anxiety, Mood, and Psychotic Disorders. JAMA Psychiatry, 76(11), 1167-1175. [More Information]
- Tickell (nee Kennedy), A., Scott, E., Davenport, T., Iorfino, F., Ospina Pinillos, L., White, D., Harel, K., Parker, L., Hickie, I., Hermens, D. (2019). Developing neurocognitive standard clinical care: A study of young adult inpatients. Psychiatry Research, 276, 232-238. [More Information]
2018
- Iorfino, F., Hermens, D., Cross, S., Zmicerevska, N., Nichles, A., Badcock, C., Groot, J., Scott, E., Hickie, I. (2018). Delineating the trajectories of social and occupational functioning of young people attending early intervention mental health services in Australia: a longitudinal study. BMJ Open, 8(3), e020678. [More Information]
- Iorfino, F., Hermens, D., Cross, S., Zmicerevska, N., Nichles, A., Groot, J., Guastella, A., Scott, E., Hickie, I. (2018). Prior suicide attempts predict worse clinical and functional outcomes in young people attending a mental health service. Journal of Affective Disorders, 238, 563-569. [More Information]
- Ospina Pinillos, L., Davenport, T., Iorfino, F., Tickell (nee Kennedy), A., Cross, S., Scott, E., Hickie, I. (2018). Using new and innovative technologies to assess clinical stage in early intervention youth mental health services: Evaluation study. Journal of Medical Internet Research, 20(9), 1-13. [More Information]
2017
- Iorfino, F., Davenport, T., Ospina Pinillos, L., Hermens, D., Cross, S., Burns, J., Hickie, I. (2017). Correction of: Using new and emerging technologies to identify and respond to suicidality among help-seeking young people: a cross-sectional study. Journal of Medical Internet Research, 19(10:e310). [More Information]
- Iorfino, F., Davenport, T., Ospina Pinillos, L., Hermens, D., Cross, S., Burns, J., Hickie, I. (2017). Using new and emerging technologies to identify and respond to suicidality among help-seeking young people: A cross-sectional study. Journal of Medical Internet Research, 19(7), 1-14. [More Information]
2016
- Iorfino, F., Alvares, G., Guastella, A., Quintana, D. (2016). Cold face test-induced increases in heart rate variability are abolished by engagement in a social cognition task. Journal of Psychophysiology, 30(1), 38-46. [More Information]
- Iorfino, F., Hickie, I., Lee, R., Lagopoulos, J., Hermens, D. (2016). The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: A systematic review. BMC Psychiatry, 16(1), 1-38. [More Information]
Selected Grants
2025
- From complexity to clarity: individual-level models for personalised youth mental health care, Iorfino F, Department of Health and Aged Care (Federal - administered by NHMRC)/MRFF - 2024 Mental Health Research
2024
- Testing a causal model of sleep and circadian rhythm disturbance and youth-onset mood disorders. RESTORE/MELODY, Hickie I, Hockey S, Iorfino F, Naismith S, Crouse J, Wellcome Trust (UK)/Mental Health Award: looking backwards, moving forward understanding how interventions for anxiety
- BMC compact with UofT - Child Youth Mental Health, early child development and related use of digital technologies, Hickie I, Szatmari P, Gallagher L, Guastella A, Ameis S, LaMonica H, Iorfino F, Boulton K, Office of Global Engagement/Compact Agreement Global Research Partnerships