Professor Frank Lovicu

Professor
Anatomy & Histology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 5170
Fax +61 2 9351 2813

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Research interests

Our research is directed at identifying the molecules and mechanisms that govern the behaviour of lens cells of the eye, in health, ageing & disease. Our studies have identified a number of molecules, namely growth factors, that play key roles in both normal and pathological lens development and growth. Currently we are working to gain a better understanding of how these molecules function and how they are regulated in the eye. This is fundamental to identifying new therapeutics for retarding or preventing cataract, one of the most common & costly diseases of ageing.

Selected grants

2014

  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Zeiss Confocal Microscope, LSM700; McAvoy J, Martin P, Gillies M, Grunert U, Watson S, Lovicu F; DVC Research/Equipment Grant.

2012

  • Preventing Blindness: Blocking TGF-induced EMT and Cataract Development; Lovicu F, McAvoy J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Role of primary cilia and PCP proteins in lens development: implication for lens regeneration after cataract surgery; McAvoy J, Lovicu F; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ciliogenesis is a key feature of FGF -induced lens fibre differentiation that is required for coordinating fibre cell alignment and orientation.; McAvoy J, Lovicu F; Ophthalmic Research Institute of Australia (ORIA)/Research Grant.
  • Blocking cataract development by promoting the maintenance of the lens epithelium.; Lovicu F, McAvoy J; DVC Research/Bridging Support Grant.
  • Bio-Rad CFX384 Real-Time PCR Detection System; McAvoy J, Truscott R, Gillies M, Lovicu F, Martin P, Grunert U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Growth factor regulation of lens development: implications for understanding cataract; McAvoy J, Lovicu F; Sydney Foundation for Medical Research/Research Support.

2009

  • Zeiss Axio Imager.M1 microscope.; Lovicu F, McAvoy J; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Roles for MAPK/ERK1/2, B-catenin/TCF and Smad3 mediated signalling pathways in TGFB-induced cataract; McAvoy J, Lovicu F; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Tecan Infinite M200 monochromator microplate reader and detector plus software; McAvoy J, Lovicu F; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Promoting maintenance of the lens epithelium: implications for controlling cataract development; Lovicu F; Ophthalmic Research Institute of Australia (ORIA)/Research Grant.
  • Receptor Tyrosine Kinase Antagonists, Sef and Sprouty, Regulate Eye Lens Cell Behaviour; Lovicu F, McAvoy J; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Fluorchem Sp Digital Imaging System For Multi-User Molecular Biology Facility; Lovicu F; Clive & Vera Ramaciotti Foundation/General Grants.

2005

  • FACS Aria for the University of Sydney Flow Cytometry Facility; King N, Pollard J, Rasko J, Lovicu F, Bishop A, Bertolino P, Briscoe H, Gillies M, Madigan M, McAvoy J, Murphy C, Balcar V, Armour C, Hughes M, Reeve V, Christopherson R, Halliday G, Christie M, Pollock C, McCaughan G, Gorrell M, Dong Q, Abendroth A, Menzies S, Barnetson R, Byrne S, Hunt N, Hambly B, Cook D, Mason R, Day M, Black J; University of Sydney/Equipment Grant.

2004

  • Inverted flourescence microscope workstation, including:; McAvoy J, Lovicu F, Truscott R, Madigan M, Provis J, Gillies M, McClellan K; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Growth factor-induced signalling pathways involved in regulation of lens cell behaviour; Lovicu F, Rasko J; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Ultrasec 3100 pro: UV-vis spectrophotmeter; Mason R, Byrne M, Dos Remedios C, Keay K, Lovicu F; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inductive interactions between lens and optic cup specify cell fates; McAvoy J, Lovicu F; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • The role of growth factors in lens biology and pathology; Lovicu F; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).
  • HM355S rotary motorised microtome; HM340E manual rotary microtome; McAvoy J, Provis J, Gillies M, Madigan M, Lovicu F; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2000

  • Lens differentiation and cataract: role of TGFB; De Iongh R, Hales A, Lovicu F, McAvoy J; National Institutes of Health/National Eye Institute Project Support.
  • Roles of FGF and TGF-beta in lens development; McAvoy J, Lovicu F; Australian Research Council (ARC)/Small Grants.
  • Analysis of FGF receptor signalling involved in lens cell proliferation and differentiation; Lovicu F, McAvoy J; National Health and Medical Research Council (NHMRC)/Project Grants.

1998

  • Lens differentiation and cataract: role of FGF and WNT; McAvoy J, Lovicu F, De Iongh R, Hales A; National Institutes of Health (USA)/Research Grant.

1996

  • The role of FGF in controlling lens cell behaviour; Lovicu F; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Edited Books

  • Lovicu, F. (2004). Development of the Ocular Lens. Canada: Cambridge University Press.

Book Chapters

  • Lovicu, F., McAvoy, J. (2008). Epithelial explants and their application to study developmental processes in the lens. In P A Tsonis (Eds.), Animal Models in Eye Research, (pp. 134-147). United States: Academic Press Elsevier.
  • Robinson, M., Lovicu, F. (2004). The Lens: Historical And Comparative Perspectives. In Frank Lovicu, Michael Robinson (Eds.), Development of the Ocular Lens, (pp. 3-26). Canada: Cambridge University Press.

Journals

  • Dawes, L., Sugiyama, Y., Lovicu, F., Harris, C., Shelley, E., McAvoy, J. (2014). Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism. Developmental Biology, 385(2), 291-303. [More Information]
  • Wang, C., Dawes, L., Liu, Y., Wen, L., Lovicu, F., McAvoy, J. (2013). Dexamethasone influences fgf-induced responses in lens epithelial explants and promotes the posterior capsule coverage that is a feature of glucocorticoid-induced cataract. Experimental Eye Research, 111, 79-87. [More Information]
  • Sugiyama, Y., Shelley, E., Wen, L., Stump, R., Shimono, A., Lovicu, F., McAvoy, J. (2013). Sfrp1 and Sfrp2 are not involved in Wnt/β-catenin signal silencing during lens induction but are required for maintenance of Wnt/β-catenin signaling in lens epithelial cells. Developmental Biology, 384(2), 181-193. [More Information]
  • Dawes, L., Sugiyama, Y., Tanedo, A., Lovicu, F., McAvoy, J. (2013). Wnt-Frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Investigative Ophthalmology and Visual Science, 54(3), 1582-1590. [More Information]
  • Cheung, F., Lovicu, F., Reichardt, J. (2012). Current progress in using vitamin D and its analogs for cancer prevention and treatment. Expert Review of Anticancer Therapy: an essential contribution to decision making in cancer care, 12(6), 811-837. [More Information]
  • Madakashira, B., Kobrinski, D., Hancher, A., Arneman, E., Wagner, B., Wang, F., Shin, H., Lovicu, F., Reneker, L., Robinson, M. (2012). Frs2(alpha) enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development (Cambridge), 139(24), 4601-4612. [More Information]
  • Shin, E., Basson, M., Robinson, M., McAvoy, J., Lovicu, F. (2012). Sprouty Is a Negative Regulator of Transforming Growth Factor B-induced Epithelial-to-Mesenchymal Transition and Cataract. Molecular Medicine, 18, 861-873. [More Information]
  • Sugiyama, Y., Lovicu, F., McAvoy, J. (2011). Planar cell polarity in the mammalian eye lens. Organogenesis, 7(3), 191-201. [More Information]
  • Kallifatidis, G., Boros, J., Shin, E., McAvoy, J., Lovicu, F. (2011). The fate of dividing cells during lens morphogenesis, differentiation and growth. Experimental Eye Research, 92(6), 502-511. [More Information]
  • Lovicu, F., McAvoy, J., de Iongh, R. (2011). Understanding the role of growth factors in embryonic development: insights from the lens. Philosophical Transactions of the Royal Society B. Biological Sciences, 366(1568), 1204-1218. [More Information]
  • West-Mays, J., Pino, G., Lovicu, F. (2010). Development and Use of the Lens Epithelial Explant System to Study Lens Differentiation and Cataractogenesis. Progress in Retinal and Eye Research, 29(2), 135-143. [More Information]
  • Wang, Q., McAvoy, J., Lovicu, F. (2010). Growth Factor Signaling in Vitreous Humor–Induced Lens Fiber Differentiation. Investigative Ophthalmology and Visual Science, 51(7), 3599-3610. [More Information]
  • Alibardi, L., Lovicu, F. (2010). Immunolocalization of FGF1 and FGF2 in the regenerating tail of the lizard Lampropholis guichenoti: Implications for FGFs as trophic factors in lizard tail regeneration. Acta histochemica, 112(5), 459-473. [More Information]
  • Sugiyama, Y., Stump, R., Nguyen, A., Wen, L., Chen, Y., Murdoch, J., Lovicu, F., McAvoy, J. (2010). Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia. Developmental Biology, 338(2), 193-201. [More Information]
  • Newitt, P., Boros, J., Madakashira, B., Robinson, M., Reneker, L., McAvoy, J., Lovicu, F. (2010). Sef is a negative regulator of fiber cell differentiation in the ocular lens. Differentiation: ontogeny, neoplasia and differentiation therapy, 80(1), 53-67. [More Information]
  • Iyengar, L., Patkunanathan, B., McAvoy, J., Lovicu, F. (2009). Growth factors involved in aqueous humour-induced lens cell proliferation. Growth Factors, 27(1), 50-62. [More Information]
  • Wang, Q., Stump, R., McAvoy, J., Lovicu, F. (2009). MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation. Experimental Eye Research, 88(2), 293-306. [More Information]
  • Chong, C., Stump, R., Lovicu, F., McAvoy, J. (2009). TGF{beta} promotes Wnt expression during cataract development. Experimental Eye Research, 88(2), 307-313. [More Information]
  • O'Connor, M., Wederell, E., de Iongh, R., Lovicu, F., McAvoy, J. (2008). Generation of transparency and cellular organization in lens explants. Experimental Eye Research, 86(5), 734-745. [More Information]
  • Chen, Y., Stump, R., Lovicu, F., Shimono, A., McAvoy, J. (2008). Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Developmental Biology, 324(1), 161-176. [More Information]
  • Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al (2007). Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More Information]
  • Pennisi, D., Wilkinson, L., Kolle, G., Sohaskey, M., Gillinder, K., Piper, M., McAvoy, J., Lovicu, F., Little, M. (2007). Crim1(KST264/KST264) mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Developmental Dynamics, 236(2), 502-511. [More Information]
  • Iyengar, L., Wang, Q., Rasko, J., McAvoy, J., Lovicu, F. (2007). Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate. Differentiation: ontogeny, neoplasia and differentiation therapy, 75(7), 662-668. [More Information]
  • Thompson, J., Lovicu, F., Ziman, M. (2007). Pax7 and superior collicular polarity: insights from Pax6 (Sey) mutant mice. Experimental Brain Research, 178(3), 316-325. [More Information]
  • Markus, A., Goy, C., Adams, D., Lovicu, F., Morris, B. (2007). Renin Enhancer Is Crucial for Full Response in Renin Expression to an In Vivo Stimulus. Hypertension, 50, 933-938. [More Information]
  • Chen, Y., Stump, R., Lovicu, F., McAvoy, J. (2006). A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation? Seminars in Cell and Developmental Biology, 17(6), 712-725. [More Information]
  • Iyengar, L., Patkunanathan, B., Lynch, O., McAvoy, J., Rasko, J., Lovicu, F. (2006). Aqueous humour- and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Experimental Eye Research, 83(3), 667-678. [More Information]
  • Lovicu, F. (2006). Cell Signaling in Lens Development. Seminars in Cell and Developmental Biology, 17(6), 675-675. [More Information]
  • Symonds, J., Lovicu, F., Chamberlain, C. (2006). Differing effects of dexamethasone and diclofenac on posterior capsule opacification-like changes in a rat lens explant model. Experimental Eye Research, 83(4), 771-782. [More Information]
  • Stump, R., Lovicu, F., Ang, S., Pandey, S., McAvoy, J. (2006). Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. Journal of Pathology, 210(2), 249-257. [More Information]
  • Symonds, J., Lovicu, F., Chamberlain, C. (2006). Posterior capsule opacification-like changes in rat lens explants cultured with TGFbeta and FGF: effects of cell coverage and regional differences. Experimental Eye Research, 82(4), 693-699. [More Information]
  • Adams, D., Head, G., Markus, A., Lovicu, F., Van Der Weyden, L., Köntgen, F., Arends, M., Thiru, S., Mayorov, D., Morris, B. (2006). Renin enhancer is critical for control of renin gene expression and cardiovascular function. Journal of Biological Chemistry, 281(42), 31753-31761. [More Information]
  • Boros, J., Newitt, P., Wang, Q., McAvoy, J., Lovicu, F. (2006). Sef and Sprouty expression in the developing ocular lens: Implications for regulating lens cell proliferation and differentiation. Seminars in Cell and Developmental Biology, 17(6), 741-752. [More Information]
  • Lovicu, F., McAvoy, J. (2005). Growth factor regulation of lens development. Developmental Biology, 280(1), 1-14. [More Information]
  • de Iongh, R., Wederell, E., Lovicu, F., McAvoy, J. (2005). Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs, 179(1-2), 43-55. [More Information]
  • Lovicu, F., Steven, P., Saika, S., McAvoy, J. (2004). Aberrant Lens Fiber Differentiation In Anterior Subcapsular Cataract Formation: A Process Dependent On Reduced Levels Of Pax6. Investigative Ophthalmology and Visual Science, 45(6), 1946-1953.
  • Lovicu, F., Ang, S., Chorazyczewska, M., McAvoy, J. (2004). Deregulation Of Lens Epithelial Cell Proliferation And Differentiation During The Development Of Tgf?-Induced Anterior Subcapsular Cataract. Developmental Neuroscience, 26(5-6), 446-455.
  • Chen, Y., Stump, R., Lovicu, F., McAvoy, J. (2004). Expression Of Frizzleds And Secreted Frizzled-Related Proteins (Sfrps) During Mammalian Lens Development. International Journal of Developmental Biology, 48(8-9), 867-877.
  • Ang, S., Stump, R., Lovicu, F., McAvoy, J. (2004). Spatial And Temporal Expression Of Wnt And Dickkopf Genes During Murine Lens Development. Gene Expression Patterns, 4(3), 289-295.
  • Thompson, J., Lovicu, F., Ziman, M. (2004). The Role Of Pax7 In Determining The Cytoarchitecture Of The Superior Colliculus. Development, Growth and Differentiation, 46(3), 213-218.
  • Stump, R., Ang, S., Chen, Y., von Bahr, T., Lovicu, F., Pinson, K., De Iongh, R., Yamaguchi, T., Sassoon, D., McAvoy, J. (2003). A role for Wnt/Beta-catenin signaling in lens epithelial differentiation. Developmental Biology, 259(1), 48-61.
  • Yager, M., Hughes, J., Lovicu, F., Gunning, P., Weinberger, R., O'Neill, G. (2003). Functional analysis of the actin-binding protein, tripomyosin 1, in neuroblastoma. British Journal of Cancer, 89(5), 860-863.
  • Maruno, K., Lovicu, F., Chamberlain, C., McAvoy, J. (2002). Apoptosis is a feature of TGFb-induced cataract. Clinical and Experimental Optometry, 85(2), 76-82.
  • Kok, A., Lovicu, F., Chamberlain, C., McAvoy, J. (2002). Influence of platelet-derived growth factor on lens epithelial cell proliferation and differentiation. Growth Factors, , 27-34.
  • Bradbury, R., Cropley, J., Kifor, O., Lovicu, F., De Iongh, R., Kable, E., Brown, E., Seely, E., Peat, B., Conigrave, A. (2002). Localization of the extracellular Ca2+ -sensing receptor in the human placenta. Placenta, 23(2-3), 192-200.
  • Lovicu, F., Schulz, M., Hales, A., Vincent, L., Overbeek, P., Chamberlain, C., McAvoy, J. (2002). TGFB induces morphological and molecular changes similar to human anterior subcapsular cataract. The British Journal of Ophthalmology, 86(2), 220-226.
  • Lovicu, F., McAvoy, J. (2001). FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/1) signalling. Development (Cambridge), 128 (24), 5075-5084.
  • Lovicu, F., Zhao, S., Hung,, F., Colvin,, J., White, A., Dai,, W., Ornitz, D., Overbeek, P. (2001). Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development (Cambridge), 128 (24), 5051-5060.
  • De Iongh, R., Lovicu, F., Hardeman, E., McAvoy, J., Overbeek, P., Schneider, M., Joya, J. (2001). Requirement for TGFb receptor signalling during terminal lens fiber differentiation. Development (Cambridge), 128, 3995-4010.

2014

  • Dawes, L., Sugiyama, Y., Lovicu, F., Harris, C., Shelley, E., McAvoy, J. (2014). Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism. Developmental Biology, 385(2), 291-303. [More Information]

2013

  • Wang, C., Dawes, L., Liu, Y., Wen, L., Lovicu, F., McAvoy, J. (2013). Dexamethasone influences fgf-induced responses in lens epithelial explants and promotes the posterior capsule coverage that is a feature of glucocorticoid-induced cataract. Experimental Eye Research, 111, 79-87. [More Information]
  • Sugiyama, Y., Shelley, E., Wen, L., Stump, R., Shimono, A., Lovicu, F., McAvoy, J. (2013). Sfrp1 and Sfrp2 are not involved in Wnt/β-catenin signal silencing during lens induction but are required for maintenance of Wnt/β-catenin signaling in lens epithelial cells. Developmental Biology, 384(2), 181-193. [More Information]
  • Dawes, L., Sugiyama, Y., Tanedo, A., Lovicu, F., McAvoy, J. (2013). Wnt-Frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Investigative Ophthalmology and Visual Science, 54(3), 1582-1590. [More Information]

2012

  • Cheung, F., Lovicu, F., Reichardt, J. (2012). Current progress in using vitamin D and its analogs for cancer prevention and treatment. Expert Review of Anticancer Therapy: an essential contribution to decision making in cancer care, 12(6), 811-837. [More Information]
  • Madakashira, B., Kobrinski, D., Hancher, A., Arneman, E., Wagner, B., Wang, F., Shin, H., Lovicu, F., Reneker, L., Robinson, M. (2012). Frs2(alpha) enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development (Cambridge), 139(24), 4601-4612. [More Information]
  • Shin, E., Basson, M., Robinson, M., McAvoy, J., Lovicu, F. (2012). Sprouty Is a Negative Regulator of Transforming Growth Factor B-induced Epithelial-to-Mesenchymal Transition and Cataract. Molecular Medicine, 18, 861-873. [More Information]

2011

  • Sugiyama, Y., Lovicu, F., McAvoy, J. (2011). Planar cell polarity in the mammalian eye lens. Organogenesis, 7(3), 191-201. [More Information]
  • Kallifatidis, G., Boros, J., Shin, E., McAvoy, J., Lovicu, F. (2011). The fate of dividing cells during lens morphogenesis, differentiation and growth. Experimental Eye Research, 92(6), 502-511. [More Information]
  • Lovicu, F., McAvoy, J., de Iongh, R. (2011). Understanding the role of growth factors in embryonic development: insights from the lens. Philosophical Transactions of the Royal Society B. Biological Sciences, 366(1568), 1204-1218. [More Information]

2010

  • West-Mays, J., Pino, G., Lovicu, F. (2010). Development and Use of the Lens Epithelial Explant System to Study Lens Differentiation and Cataractogenesis. Progress in Retinal and Eye Research, 29(2), 135-143. [More Information]
  • Wang, Q., McAvoy, J., Lovicu, F. (2010). Growth Factor Signaling in Vitreous Humor–Induced Lens Fiber Differentiation. Investigative Ophthalmology and Visual Science, 51(7), 3599-3610. [More Information]
  • Alibardi, L., Lovicu, F. (2010). Immunolocalization of FGF1 and FGF2 in the regenerating tail of the lizard Lampropholis guichenoti: Implications for FGFs as trophic factors in lizard tail regeneration. Acta histochemica, 112(5), 459-473. [More Information]
  • Sugiyama, Y., Stump, R., Nguyen, A., Wen, L., Chen, Y., Murdoch, J., Lovicu, F., McAvoy, J. (2010). Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia. Developmental Biology, 338(2), 193-201. [More Information]
  • Newitt, P., Boros, J., Madakashira, B., Robinson, M., Reneker, L., McAvoy, J., Lovicu, F. (2010). Sef is a negative regulator of fiber cell differentiation in the ocular lens. Differentiation: ontogeny, neoplasia and differentiation therapy, 80(1), 53-67. [More Information]

2009

  • Iyengar, L., Patkunanathan, B., McAvoy, J., Lovicu, F. (2009). Growth factors involved in aqueous humour-induced lens cell proliferation. Growth Factors, 27(1), 50-62. [More Information]
  • Wang, Q., Stump, R., McAvoy, J., Lovicu, F. (2009). MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation. Experimental Eye Research, 88(2), 293-306. [More Information]
  • Chong, C., Stump, R., Lovicu, F., McAvoy, J. (2009). TGF{beta} promotes Wnt expression during cataract development. Experimental Eye Research, 88(2), 307-313. [More Information]

2008

  • Lovicu, F., McAvoy, J. (2008). Epithelial explants and their application to study developmental processes in the lens. In P A Tsonis (Eds.), Animal Models in Eye Research, (pp. 134-147). United States: Academic Press Elsevier.
  • O'Connor, M., Wederell, E., de Iongh, R., Lovicu, F., McAvoy, J. (2008). Generation of transparency and cellular organization in lens explants. Experimental Eye Research, 86(5), 734-745. [More Information]
  • Chen, Y., Stump, R., Lovicu, F., Shimono, A., McAvoy, J. (2008). Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Developmental Biology, 324(1), 161-176. [More Information]

2007

  • Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al (2007). Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More Information]
  • Pennisi, D., Wilkinson, L., Kolle, G., Sohaskey, M., Gillinder, K., Piper, M., McAvoy, J., Lovicu, F., Little, M. (2007). Crim1(KST264/KST264) mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Developmental Dynamics, 236(2), 502-511. [More Information]
  • Iyengar, L., Wang, Q., Rasko, J., McAvoy, J., Lovicu, F. (2007). Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate. Differentiation: ontogeny, neoplasia and differentiation therapy, 75(7), 662-668. [More Information]
  • Thompson, J., Lovicu, F., Ziman, M. (2007). Pax7 and superior collicular polarity: insights from Pax6 (Sey) mutant mice. Experimental Brain Research, 178(3), 316-325. [More Information]
  • Markus, A., Goy, C., Adams, D., Lovicu, F., Morris, B. (2007). Renin Enhancer Is Crucial for Full Response in Renin Expression to an In Vivo Stimulus. Hypertension, 50, 933-938. [More Information]

2006

  • Chen, Y., Stump, R., Lovicu, F., McAvoy, J. (2006). A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation? Seminars in Cell and Developmental Biology, 17(6), 712-725. [More Information]
  • Iyengar, L., Patkunanathan, B., Lynch, O., McAvoy, J., Rasko, J., Lovicu, F. (2006). Aqueous humour- and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Experimental Eye Research, 83(3), 667-678. [More Information]
  • Lovicu, F. (2006). Cell Signaling in Lens Development. Seminars in Cell and Developmental Biology, 17(6), 675-675. [More Information]
  • Symonds, J., Lovicu, F., Chamberlain, C. (2006). Differing effects of dexamethasone and diclofenac on posterior capsule opacification-like changes in a rat lens explant model. Experimental Eye Research, 83(4), 771-782. [More Information]
  • Stump, R., Lovicu, F., Ang, S., Pandey, S., McAvoy, J. (2006). Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. Journal of Pathology, 210(2), 249-257. [More Information]
  • Symonds, J., Lovicu, F., Chamberlain, C. (2006). Posterior capsule opacification-like changes in rat lens explants cultured with TGFbeta and FGF: effects of cell coverage and regional differences. Experimental Eye Research, 82(4), 693-699. [More Information]
  • Adams, D., Head, G., Markus, A., Lovicu, F., Van Der Weyden, L., Köntgen, F., Arends, M., Thiru, S., Mayorov, D., Morris, B. (2006). Renin enhancer is critical for control of renin gene expression and cardiovascular function. Journal of Biological Chemistry, 281(42), 31753-31761. [More Information]
  • Boros, J., Newitt, P., Wang, Q., McAvoy, J., Lovicu, F. (2006). Sef and Sprouty expression in the developing ocular lens: Implications for regulating lens cell proliferation and differentiation. Seminars in Cell and Developmental Biology, 17(6), 741-752. [More Information]

2005

  • Lovicu, F., McAvoy, J. (2005). Growth factor regulation of lens development. Developmental Biology, 280(1), 1-14. [More Information]
  • de Iongh, R., Wederell, E., Lovicu, F., McAvoy, J. (2005). Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs, 179(1-2), 43-55. [More Information]

2004

  • Lovicu, F., Steven, P., Saika, S., McAvoy, J. (2004). Aberrant Lens Fiber Differentiation In Anterior Subcapsular Cataract Formation: A Process Dependent On Reduced Levels Of Pax6. Investigative Ophthalmology and Visual Science, 45(6), 1946-1953.
  • Lovicu, F., Ang, S., Chorazyczewska, M., McAvoy, J. (2004). Deregulation Of Lens Epithelial Cell Proliferation And Differentiation During The Development Of Tgf?-Induced Anterior Subcapsular Cataract. Developmental Neuroscience, 26(5-6), 446-455.
  • Lovicu, F. (2004). Development of the Ocular Lens. Canada: Cambridge University Press.
  • Chen, Y., Stump, R., Lovicu, F., McAvoy, J. (2004). Expression Of Frizzleds And Secreted Frizzled-Related Proteins (Sfrps) During Mammalian Lens Development. International Journal of Developmental Biology, 48(8-9), 867-877.
  • Ang, S., Stump, R., Lovicu, F., McAvoy, J. (2004). Spatial And Temporal Expression Of Wnt And Dickkopf Genes During Murine Lens Development. Gene Expression Patterns, 4(3), 289-295.
  • Robinson, M., Lovicu, F. (2004). The Lens: Historical And Comparative Perspectives. In Frank Lovicu, Michael Robinson (Eds.), Development of the Ocular Lens, (pp. 3-26). Canada: Cambridge University Press.
  • Thompson, J., Lovicu, F., Ziman, M. (2004). The Role Of Pax7 In Determining The Cytoarchitecture Of The Superior Colliculus. Development, Growth and Differentiation, 46(3), 213-218.

2003

  • Stump, R., Ang, S., Chen, Y., von Bahr, T., Lovicu, F., Pinson, K., De Iongh, R., Yamaguchi, T., Sassoon, D., McAvoy, J. (2003). A role for Wnt/Beta-catenin signaling in lens epithelial differentiation. Developmental Biology, 259(1), 48-61.
  • Yager, M., Hughes, J., Lovicu, F., Gunning, P., Weinberger, R., O'Neill, G. (2003). Functional analysis of the actin-binding protein, tripomyosin 1, in neuroblastoma. British Journal of Cancer, 89(5), 860-863.

2002

  • Maruno, K., Lovicu, F., Chamberlain, C., McAvoy, J. (2002). Apoptosis is a feature of TGFb-induced cataract. Clinical and Experimental Optometry, 85(2), 76-82.
  • Kok, A., Lovicu, F., Chamberlain, C., McAvoy, J. (2002). Influence of platelet-derived growth factor on lens epithelial cell proliferation and differentiation. Growth Factors, , 27-34.
  • Bradbury, R., Cropley, J., Kifor, O., Lovicu, F., De Iongh, R., Kable, E., Brown, E., Seely, E., Peat, B., Conigrave, A. (2002). Localization of the extracellular Ca2+ -sensing receptor in the human placenta. Placenta, 23(2-3), 192-200.
  • Lovicu, F., Schulz, M., Hales, A., Vincent, L., Overbeek, P., Chamberlain, C., McAvoy, J. (2002). TGFB induces morphological and molecular changes similar to human anterior subcapsular cataract. The British Journal of Ophthalmology, 86(2), 220-226.

2001

  • Lovicu, F., McAvoy, J. (2001). FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/1) signalling. Development (Cambridge), 128 (24), 5075-5084.
  • Lovicu, F., Zhao, S., Hung,, F., Colvin,, J., White, A., Dai,, W., Ornitz, D., Overbeek, P. (2001). Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development (Cambridge), 128 (24), 5051-5060.
  • De Iongh, R., Lovicu, F., Hardeman, E., McAvoy, J., Overbeek, P., Schneider, M., Joya, J. (2001). Requirement for TGFb receptor signalling during terminal lens fiber differentiation. Development (Cambridge), 128, 3995-4010.

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