Associate Professor Gopala Rangan

Associate Professor (Conjoint)
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 6962
Fax +61 2 9633 9351

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Research interests

Polycystic Kidney Disease, Glomerulonephritis, Chronic Kidney Disease

Selected grants

2014

  • Randomised controlled trial to prevent Kidney Disease due to ADPKD; Rangan G, Harris D; DVC Research/Bridging Support Grant.

2013

  • CKD-FIX: a randomised, controlled trial of allopurinol in the slowing of kidney disease progression; Johnson D, Harris D, Faull R, Palmer S, Boudville N, Badve S, Rangan G, Kanellis J, Walker R, Brown F; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Vitamin D3 receptor signalling to prevent kidney failure due to polycystic kidney disease; Rangan G, Harris D; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Loss of E-cadherin in distal tubule cells as a common pathway for cyst formation in polycystic kidney disease; Rangan G, Harris D; National Health and Medical Research Council (NHMRC)/Project Grants.

2003

  • Regulators of cell cycle as therapeutic drug-targets for cortical tubular hyperplasia in proteinuric renal disease; Rangan G; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Books

  • Harris, D., Elder, G., Kairaitis, L., Rangan, G. (2012). Pocket Guide to Clinical Dialysis. Sydney, Australia: McGraw-Hill Education.

Edited Books

  • Harris, D., Elder, G., Kairaitis, L., Rangan, G. (2005). Basic Clinical Dialysis. Sydney: McGraw-Hill, Medical Pub. Division.

Book Chapters

  • Sud, K., Rangan, G. (2012). Peritonitis and exit-site infections. In David Harris (Eds.), Pocket Guide to Clinical Dialysis, (pp. 245-255). Sydney, Australia: McGraw-Hill Education.
  • Succar, L., Harris, D., Rangan, G. (2011). Role of the Mammalian Target of Rapamycin (mTOR) Signalling Pathway in Podocytes in Glomerular Disease. In Sharma S. Prabhakar (Eds.), An Update on Glomerulopathies – Etiology and Pathogenesis, (pp. 183-202). Rijeka, Croatia: InTech Publishers.
  • Rangan, G. (2008). Haematuria. In David Harris (Eds.), Clinical Cases in Kidney Disease, (pp. 63-75). Australia: McGraw Hill.
  • Rangan, G., Succar, L. (2008). Rapidly Progressive Glomerulonephritis. In David Harris (Eds.), Clinical Cases in Kidney Disease, (pp. 192-204). Australia: McGraw Hill.
  • Rangan, G. (2008). Renal Mass. In David Harris (Eds.), Clinical Cases in Kidney Disease, (pp. 49-62). Australia: McGraw Hill.

Journals

  • Bose, B., Badve, S., Hiremath, S., Boudville, N., Brown, F., Cass, A., de Zoysa, J., Fassett, R., Faull, R., Harris, D., Perkovic, V., Rangan, G., et al (2014). Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis. Nephrology, Dialysis, Transplantation, 29(2), 406-413. [More Information]
  • Myint, T., Rangan, G., Webster, A. (2014). Treatments to slow progression of autosomal dominant polycystic kidney disease: systematic review and meta -analysis of randomized trials. Nephrology, 19(4), 217-226. [More Information]
  • Chapman, J., Rangan, G. (2013). Are Nonesterified Fatty Acids Protective in Chronic Allograft Nephropathy? Transplantation, 95(11), 1313-1314. [More Information]
  • Rangan, G., Schwensen, K., Foster, S., Korgaonkar, M., Peduto, A., Harris, D. (2013). Chronic effects of dietary Vitamin D deficiency without increased calcium supplementation on the progression of experimental polycystic kidney disease. American Journal of Physiology: Renal Physiology (Print), 305(4), F574-F582. [More Information]
  • Ta, M., Rao, P., Korgaonkar, M., Foster, S., Peduto, A., Harris, D., Rangan, G. (2013). Pyrrolidine Dithiocarbamate Attenuates Kidney Enlargement in Experimental Polycystic Kidney Disease. Nephrology, 18(Supp. 1), 37-37.
  • Rangan, G., Harris, D. (2013). Rationale and Design of an Observational Study to Determine the Effects of Cholecalciferol on Hypertension, Proteinuria and Urinary MCP-1 in ADPKD. Current Hypertension Reviews, 9(2), 115-120. [More Information]
  • Ta, M., Harris, D., Rangan, G. (2013). Role of interstitial inflammation in the pathogenesis of polycystic kidney disease. Nephrology, 18(5), 317-330. [More Information]
  • Badve, S., Brown, F., Hawley, C., Johnson, D., Kanellis, J., Rangan, G., Perkovic, V. (2011). Challenges of conducting a trial of uric-acid-lowering therapy in CKD. Nature Reviews Nephrology, 7(5), 295-300. [More Information]
  • Schwensen, K., Burgess, J., Graf, N., Alexander, S., Harris, D., Phillips, J., Rangan, G. (2011). Early Cyst Growth Is Associated with the Increased Nuclear Expression of Cyclin D1/Rb Protein in an Autosomal-Recessive Polycystic Kidney Disease Rat Model. Nephron Experimental Nephrology, 117(4), e93-e103. [More Information]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Rangan, G., Wang, Y., Harris, D. (2009). NF-kappaB signalling in chronic kidney disease. Frontiers in Bioscience, 14, 3496-3522. [More Information]
  • Rangan, G., Nguyen, T., Mainra, R., Succar, L., Schwensen, K., Burgess, J., Ho, K. (2009). Therapeutic role of sirolimus in non-transplant kidney disease. Pharmacology and Therapeutics, 123(2), 187-206. [More Information]
  • Rangan, G., Tesch, G. (2007). Quantification of renal pathology by image analysis (Methods in Renal Research). Nephrology, 12(6), 553-558. [More Information]
  • Rangan, G., Coombes, J. (2007). Renoprotective effects of sirolimus in non-immune initiated focal segmental glomerulosclerosis. Nephrology, Dialysis, Transplantation, 22(8), 2175-2182. [More Information]
  • Phillips, J., Hopwood, D., Loxley, R., Ghatora, K., Coombes, J., Tan, Y., Harrison, J., McKitrick, D., Holobotvskyy, V., Arnolda, L., Rangan, G. (2007). Temporal relationship between renal cyst development, hypertension and cardiac hypertrophy in a new rat model of autosomal recessive polycystic kidney disease. Kidney and Blood Pressure Research, 30(3), 129-144.
  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, Dialysis, Transplantation. [More Information]
  • Rangan, G., Kan, G., Steer, J., Dogra, G., Croft, K., Rhodes, H., Woodroffe, A., Joyce, D. (2006). Altered expression of nuclear factor-kappa B in peripheral blood mononuclear cells in chronic haemodialysis patients. Nephrology, Dialysis, Transplantation, 21(4), 1137-1139.
  • Zheng, G., Wang, Y., XIANG, S., Tay, Y., Wu, H., Watson, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury. Journal of the American Society of Nephrology, 17(2), 465-474. [More Information]
  • Zhu, G., Wang, Y., Wang, J., Tay, Y., Yung, T., Rangan, G., Harris, D. (2006). Significance of CD25 positive cells and macrophages in noncrescentic IgA nephropathy. Renal Failure, 28(3), 229-235. [More Information]
  • Rangan, G. (2006). Sirolimus-associated proteinuria and renal dysfunction. Drug Safety, 29(12), 1153-1161. [More Information]
  • Geevasinga, N., Kairaitis, L., Rangan, G., Coleman, P. (2005). Acute interstitial nephritis secondary to esomeprazole. Medical Journal of Australia, 182(5). [More Information]
  • Rangan, G., Kan, G., Steer, J., Dogra, G., Croft, K., Rhodes, H., Woodroffe, A., Joyce, D. (2005). Altered expression of nuclear factor-{kappa}B in peripheral blood mononuclear cells in chronic haemodialysis patients. Nephrology, Dialysis, Transplantation, 21, 1137-9. [More Information]
  • Rangan, G., Pippin, J., Coombes, J., Couser, W. (2005). C5b-9 does not mediate chronic tubulointerstitial disease in the absence of proteinuria. Kidney International, 67(2), 492-503. [More Information]
  • Tay, Y., Wang, Y., Kairaitis, L., Rangan, G., Zhang, C., Harris, D. (2005). Can murine diabetic nephropathy be separated from superimposed acute renal failure? Kidney International, 68(1), 391-398. [More Information]
  • Rangan, G., Wang, Y., Tay, Y., Harris, D. (2005). Differential effects of albumin on cytokine gene expression in proximal tubular epithelial cells. Nephrology, Dialysis, Transplantation, 20(5), 1013-1014.
  • Rangan, G., Tay, Y., Harris, D. (2005). Differential effects of albumin on cytokine gene expression in proximal tubular epithelial cells. Nephrology, Dialysis, Transplantation, 20(5), 1013-4. [More Information]
  • Rangan, G., Wang, Y., Harris, D., Tay, Y., Coombes, J. (2005). Effect of nephrotoxins on tubulointerstitial injury and NF-kappaB activation in Adriamycin nephropathy. Renal Failure, 27(5), 609-14. [More Information]
  • Wang, Y., Mahajan, D., Tay, Y., Bao, B., Spicer, T., Kairaitis, L., Rangan, G., Harris, D. (2005). Partial depletion of macrophages by ED7 reduces renal injury in Adriamycin nephropathy. Nephrology, 10(5), 470-7. [More Information]
  • Liddle, C., Rangan, G., Coombes, J., Mreich, E. (2005). Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy. Kidney International. [More Information]
  • Harris, D., Rangan, G. (2005). Retardation of kidney failure -- applying principles to practice. Annals of the Academy of Medicine, Singapore (AAMS), 34(1), 16-23. [More Information]
  • Rangan, G., Pippin, J., Couser, W. (2004). C5B-9 Regulates Peritubular Myofibroblast Accumulation In Experimental Focal Segmental Glomerulosclerosis. Kidney International, 66(5), 1838-1848.
  • Rangan, G., Harris, D. (2003). A blast from the mast? Kidney International, 64(3), 1134-1135.

2014

  • Bose, B., Badve, S., Hiremath, S., Boudville, N., Brown, F., Cass, A., de Zoysa, J., Fassett, R., Faull, R., Harris, D., Perkovic, V., Rangan, G., et al (2014). Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis. Nephrology, Dialysis, Transplantation, 29(2), 406-413. [More Information]
  • Myint, T., Rangan, G., Webster, A. (2014). Treatments to slow progression of autosomal dominant polycystic kidney disease: systematic review and meta -analysis of randomized trials. Nephrology, 19(4), 217-226. [More Information]

2013

  • Chapman, J., Rangan, G. (2013). Are Nonesterified Fatty Acids Protective in Chronic Allograft Nephropathy? Transplantation, 95(11), 1313-1314. [More Information]
  • Rangan, G., Schwensen, K., Foster, S., Korgaonkar, M., Peduto, A., Harris, D. (2013). Chronic effects of dietary Vitamin D deficiency without increased calcium supplementation on the progression of experimental polycystic kidney disease. American Journal of Physiology: Renal Physiology (Print), 305(4), F574-F582. [More Information]
  • Ta, M., Rao, P., Korgaonkar, M., Foster, S., Peduto, A., Harris, D., Rangan, G. (2013). Pyrrolidine Dithiocarbamate Attenuates Kidney Enlargement in Experimental Polycystic Kidney Disease. Nephrology, 18(Supp. 1), 37-37.
  • Rangan, G., Harris, D. (2013). Rationale and Design of an Observational Study to Determine the Effects of Cholecalciferol on Hypertension, Proteinuria and Urinary MCP-1 in ADPKD. Current Hypertension Reviews, 9(2), 115-120. [More Information]
  • Ta, M., Harris, D., Rangan, G. (2013). Role of interstitial inflammation in the pathogenesis of polycystic kidney disease. Nephrology, 18(5), 317-330. [More Information]

2012

  • Sud, K., Rangan, G. (2012). Peritonitis and exit-site infections. In David Harris (Eds.), Pocket Guide to Clinical Dialysis, (pp. 245-255). Sydney, Australia: McGraw-Hill Education.
  • Harris, D., Elder, G., Kairaitis, L., Rangan, G. (2012). Pocket Guide to Clinical Dialysis. Sydney, Australia: McGraw-Hill Education.

2011

  • Badve, S., Brown, F., Hawley, C., Johnson, D., Kanellis, J., Rangan, G., Perkovic, V. (2011). Challenges of conducting a trial of uric-acid-lowering therapy in CKD. Nature Reviews Nephrology, 7(5), 295-300. [More Information]
  • Schwensen, K., Burgess, J., Graf, N., Alexander, S., Harris, D., Phillips, J., Rangan, G. (2011). Early Cyst Growth Is Associated with the Increased Nuclear Expression of Cyclin D1/Rb Protein in an Autosomal-Recessive Polycystic Kidney Disease Rat Model. Nephron Experimental Nephrology, 117(4), e93-e103. [More Information]
  • Succar, L., Harris, D., Rangan, G. (2011). Role of the Mammalian Target of Rapamycin (mTOR) Signalling Pathway in Podocytes in Glomerular Disease. In Sharma S. Prabhakar (Eds.), An Update on Glomerulopathies – Etiology and Pathogenesis, (pp. 183-202). Rijeka, Croatia: InTech Publishers.

2009

  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Rangan, G., Wang, Y., Harris, D. (2009). NF-kappaB signalling in chronic kidney disease. Frontiers in Bioscience, 14, 3496-3522. [More Information]
  • Rangan, G., Nguyen, T., Mainra, R., Succar, L., Schwensen, K., Burgess, J., Ho, K. (2009). Therapeutic role of sirolimus in non-transplant kidney disease. Pharmacology and Therapeutics, 123(2), 187-206. [More Information]

2008

  • Rangan, G. (2008). Haematuria. In David Harris (Eds.), Clinical Cases in Kidney Disease, (pp. 63-75). Australia: McGraw Hill.
  • Rangan, G., Succar, L. (2008). Rapidly Progressive Glomerulonephritis. In David Harris (Eds.), Clinical Cases in Kidney Disease, (pp. 192-204). Australia: McGraw Hill.
  • Rangan, G. (2008). Renal Mass. In David Harris (Eds.), Clinical Cases in Kidney Disease, (pp. 49-62). Australia: McGraw Hill.

2007

  • Rangan, G., Tesch, G. (2007). Quantification of renal pathology by image analysis (Methods in Renal Research). Nephrology, 12(6), 553-558. [More Information]
  • Rangan, G., Coombes, J. (2007). Renoprotective effects of sirolimus in non-immune initiated focal segmental glomerulosclerosis. Nephrology, Dialysis, Transplantation, 22(8), 2175-2182. [More Information]
  • Phillips, J., Hopwood, D., Loxley, R., Ghatora, K., Coombes, J., Tan, Y., Harrison, J., McKitrick, D., Holobotvskyy, V., Arnolda, L., Rangan, G. (2007). Temporal relationship between renal cyst development, hypertension and cardiac hypertrophy in a new rat model of autosomal recessive polycystic kidney disease. Kidney and Blood Pressure Research, 30(3), 129-144.

2006

  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, Dialysis, Transplantation. [More Information]
  • Rangan, G., Kan, G., Steer, J., Dogra, G., Croft, K., Rhodes, H., Woodroffe, A., Joyce, D. (2006). Altered expression of nuclear factor-kappa B in peripheral blood mononuclear cells in chronic haemodialysis patients. Nephrology, Dialysis, Transplantation, 21(4), 1137-1139.
  • Zheng, G., Wang, Y., XIANG, S., Tay, Y., Wu, H., Watson, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury. Journal of the American Society of Nephrology, 17(2), 465-474. [More Information]
  • Zhu, G., Wang, Y., Wang, J., Tay, Y., Yung, T., Rangan, G., Harris, D. (2006). Significance of CD25 positive cells and macrophages in noncrescentic IgA nephropathy. Renal Failure, 28(3), 229-235. [More Information]
  • Rangan, G. (2006). Sirolimus-associated proteinuria and renal dysfunction. Drug Safety, 29(12), 1153-1161. [More Information]

2005

  • Geevasinga, N., Kairaitis, L., Rangan, G., Coleman, P. (2005). Acute interstitial nephritis secondary to esomeprazole. Medical Journal of Australia, 182(5). [More Information]
  • Rangan, G., Kan, G., Steer, J., Dogra, G., Croft, K., Rhodes, H., Woodroffe, A., Joyce, D. (2005). Altered expression of nuclear factor-{kappa}B in peripheral blood mononuclear cells in chronic haemodialysis patients. Nephrology, Dialysis, Transplantation, 21, 1137-9. [More Information]
  • Harris, D., Elder, G., Kairaitis, L., Rangan, G. (2005). Basic Clinical Dialysis. Sydney: McGraw-Hill, Medical Pub. Division.
  • Rangan, G., Pippin, J., Coombes, J., Couser, W. (2005). C5b-9 does not mediate chronic tubulointerstitial disease in the absence of proteinuria. Kidney International, 67(2), 492-503. [More Information]
  • Tay, Y., Wang, Y., Kairaitis, L., Rangan, G., Zhang, C., Harris, D. (2005). Can murine diabetic nephropathy be separated from superimposed acute renal failure? Kidney International, 68(1), 391-398. [More Information]
  • Rangan, G., Wang, Y., Tay, Y., Harris, D. (2005). Differential effects of albumin on cytokine gene expression in proximal tubular epithelial cells. Nephrology, Dialysis, Transplantation, 20(5), 1013-1014.
  • Rangan, G., Tay, Y., Harris, D. (2005). Differential effects of albumin on cytokine gene expression in proximal tubular epithelial cells. Nephrology, Dialysis, Transplantation, 20(5), 1013-4. [More Information]
  • Rangan, G., Wang, Y., Harris, D., Tay, Y., Coombes, J. (2005). Effect of nephrotoxins on tubulointerstitial injury and NF-kappaB activation in Adriamycin nephropathy. Renal Failure, 27(5), 609-14. [More Information]
  • Wang, Y., Mahajan, D., Tay, Y., Bao, B., Spicer, T., Kairaitis, L., Rangan, G., Harris, D. (2005). Partial depletion of macrophages by ED7 reduces renal injury in Adriamycin nephropathy. Nephrology, 10(5), 470-7. [More Information]
  • Liddle, C., Rangan, G., Coombes, J., Mreich, E. (2005). Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy. Kidney International. [More Information]
  • Harris, D., Rangan, G. (2005). Retardation of kidney failure -- applying principles to practice. Annals of the Academy of Medicine, Singapore (AAMS), 34(1), 16-23. [More Information]

2004

  • Rangan, G., Pippin, J., Couser, W. (2004). C5B-9 Regulates Peritubular Myofibroblast Accumulation In Experimental Focal Segmental Glomerulosclerosis. Kidney International, 66(5), 1838-1848.

2003

  • Rangan, G., Harris, D. (2003). A blast from the mast? Kidney International, 64(3), 1134-1135.

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