Dr Garry Lynch

Honorary Senior Lecturer
Medicine, Central Clinical School

Telephone + 61 2 8627 0258

Map

Research interests

Garry is passionate about his studies of the structures and interactions of Proteins. And in particularly in the study proteins that act at the interface surfaces of cells and viruses and consequently central to cell infection and host immune interactions and protection.

HIV and Immunology Studies: He led a productive HIV-Protein Interactions Laboratory for a decade at Westmead Hospital and has supervised more than 30 laboratory personnel and students (eg 20 Honours and PhD students from the University of Sydney and the Universities of Wollongong, UTS and NSW). His HIV studies have led to several key discoveries in HIV cell-receptor (CD4) and coreceptor interactions that have changed paradigms in the understanding of CD4 structures in HIV infection and Immunology and have promoted new models of CD4 interactions with HIV. In studying Avian and Pandemic Influenzas and host antibody Immune protection new paradigms are being delivered to reveal how, by studying herd immunity to conserved protein sites of influenza's proteins, broad acting antibodies can be identified to potentially protect against all strains of influenza and therefore core for the design of universal influenza vaccines. This work is also being extended into studies of other viruses including Hendra/Nipah viruses and more recently Ebola virus, as well as the Bacterium,Neisseria Meningitidis. These studies are opening up the realisation of whole new areas of adaptive immunity. He is a reviewer of Grants and Fellowships, Journal manuscripts and examiner of PhD/Honours theses. The quality and impact of his studies is evident from the number of citations (>1,300) of his publications by others and a citation H index of 19.

Current research students

Project title Research student
Investigating the Major Histocompatibility Complex (MHC) in wild Suidae and Tayassuidae Carol LEE

Associations

Vice President & Treasurer of The Haemophilia Foundation of NSW (HFNSW) 2014 -2016

HFNSW Committee member 2013-

In the media

Invited Interviews / Media Responses:

Jan 2015 Radio (2UE) Invited Radio Interview and Expert Opinion Re situation of Ebola infected UK Nurse

24th August 2015 Australian Media Centre (AusMC) Invited Expert Reaction Response on recent universal Flu vaccine developments stemming from article by Yassine et al Nature Medicine 3927 Aug 2015. Subsequent quotations from that response were published in articles reported in the Scottish and Irish News daily papers, The San Diego Tribune etc ~ 25th August 2015

5th June 2015 Invited Presentation to Trinity Grammar Students on Infection and Immunity

Selected grants

1999

  • Studies of CXCR-4 associating proteins by mass spectrometry; Lynch G, Hochgrebe T, Cunningham A; Clive & Vera Ramaciotti Foundation/Research Grants.

Selected publications

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Journals

  • Rickard, J., Schmidt, R., Maddison, J., Bathgate, R., Lynch, G., Druart, X., de Graaf, S. (2016). Variation in seminal plasma alters the ability of ram spermatozoa to survive cryopreservation. Reproduction, Fertility and Development, 28(4), 516-523. [More Information]
  • Lynch, G., Portelli, S., Church, W. (2015). Composite Model of Full GP Structure of Ebola Virus Envelope Glycoprotein. Journal of Molecular and Genetic Medicine, 9, 1-4. [More Information]
  • Lynch, G., Portelli, S., Wong, S., Costa, M., Lemgruber, A., Williamson, P., Sullivan, J., Booy, R., Church, W. (2015). Imaging of High and Low Resolution Ebola Envelope GP Structures Composited with in silico Models of Difficult-to-Resolve Sections. Journal of Molecular and Genetic Medicine, 9(4), e1000186. [More Information]
  • Rickard, J., Leahy, T., Soleilhavoup, C., Tsikis, G., Labas, V., Harichaux, G., Lynch, G., Druart, X., de Graaf, S. (2015). The identification of proteomic markers of sperm freezing resilience in ram seminal plasma. Journal of Proteomics, 126, 303-311. [More Information]
  • Yuan, F., Velickovic, Z., Ashton, L., Dyer, W., Geczy, A., Dunckley, H., Lynch, G., Sullivan, J. (2014). Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus. Virologica Sinica, 29(2), 128-130. [More Information]
  • Rickard, J., Pini, T., Soleilhavoup, C., Cognie, J., Bathgate, R., Lynch, G., Evans, G., Maxwell, W., Druart, X., de Graaf, S. (2014). Seminal plasma aids the survival and cervical transit of epididymal ram spermatozoa. Reproduction, 148, 469-478. [More Information]
  • Muir, W., Lynch, G., Williamson, P., Cowieson, A. (2013). The oral administration of meat and bone meal-derived protein fractions improved the performance of young broiler chicks. Animal Production Science, 53(5), 369-377. [More Information]
  • Lynch, G., Selleck, P., Church, W., Sullivan, J. (2012). Seasoned adaptive antibody immunity for highly pathogenic pandemic influenza in humans. Immunology and Cell Biology, 90(2), 149-158. [More Information]
  • Lynch, G. (2011). Value of cell studies that reflect the natural situation and whether, histiocyte-derived U-937 cells are the cell-line of choice, for studies of HIV infection interactions of monocytes and macrophages. Virology, 8, 397. [More Information]
  • Bolitho (nee Donald), C., Xaymardan, M., Lynch, G., Zoellner, H. (2010). Vascularity during wound maturation correlates with fragmentation of serum albumin but not ceruloplasmin, transferrin, or haptoglobin. Wound Repair and Regeneration, 18, 211-222. [More Information]
  • Lynch, G., Selleck, P., Sullivan, J. (2009). Acquired heterosubtypic antibodies in human immunity for avian H5N1 influenza. Journal of Molecular and Genetic Medicine, 3(2), 205-209. [More Information]
  • Sullivan, J., Selleck, P., Downton, T., Boehm, I., Axell, A., Ayob, Y., Kapitza, N., Dyer, W., Fitzgerald, A., Walsh, B., Lynch, G. (2009). Heterosubtypic anti-avian H5N1 influenza antibodies in intravenous immunoglobulins from globally separate populations protect against H5N1 infection in cell culture. Journal of Molecular and Genetic Medicine, 3(2), 217-224. [More Information]
  • Stelzer-Braid, S., Wong, B., Robertson, P., Lynch, G., Laurie, K., Shaw, R., Barr, I., Selleck, P., Baleriola, C., Escott, R., et al (2008). A commercial ELISA detects high levels of human H5 antibody but cross-reacts with influenza A antibodies. Journal Of Clinical Virology, 43(2), 241-243. [More Information]
  • Greening, D., Glenister, K., Kapp, E., Moritz, R., Sparrow, R., Lynch, G., Simpson, R. (2008). Comparison of human platelet membrane-cytoskeletal proteins with the plasma proteome: Towards understanding the platelet-plasma nexus. Proteomics - Clinical Applications, 2(1), 63-77. [More Information]
  • Lynch, G., Selleck, P., Axell, A., Downton, T., Kaptiza, N., Boehm, I., Dyer, W., Wang, Y., Stelzer-Braid, S., Rawlinson, W., Sullivan, J. (2008). Cross-Reactive Anti-Avian H5N1 Influenza Neutralizing Antibodies in a Normal 'Exposure-Naive' Australian Blood Donor Population. The Open Immunology Journal, 1, 13-19.
  • Bolitho (nee Donald), C., Bayl, P., Hou, J., Lynch, G., Hassel, A., Wall, A., Zoellner, H. (2007). The anti-apoptotic activity of albumin for endothelium is mediated by a partially cryptic protein domain and reduced by inhibitors of G-coupled protein and PI-3 Kinase, but is independent of radical scavenging or bound lipid. Journal of Vascular Research, 44(4), 313-324. [More Information]
  • Lynch, G., Turville, S., Carter, B., Sloane, A., Chan, A., Muljadi, N., Li, S., Low, L., Armati, P., Raison, R., Zoellner, H., Williamson, P., Cunningham, A., Church, W. (2006). Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: Resolution of a novel CD4 isoform. Immunology and Cell Biology, 84(2), 154-165. [More Information]
  • Sloane, A., Raso, V., Dimitrov, D., Xiao, X., Deo, S., Muljadi, N., Restuccia, D., Turville, S., Kearney, C., Broder, C., Zoellner, H., Cunningham, A., Bendall, L., Lynch, G. (2005). Marked structural and functional heterogeneity in CXCR4: Separation of HIV-1 and SDF-1 alpha responses. Immunology and Cell Biology, 83(2), 129-143. [More Information]
  • Lynch, G., Slaytor, E., Elliott, F., Saurajen, A., Turville, S., Sloane, A., Cameron, P., Cunningham, A., Halliday, G. (2003). CD4 is expressed by epidermal Langerhans' cells predominantly as covalent dimers. Experimental Dermatology, 12(5), 700-711.
  • Wright, L., Djordjevic, J., Schibeci, S., Himmelreich, U., Muljadi, N., Williamson, P., Lynch, G. (2003). Detergent-resistant membrane factions contribute to the total 1h nmr-visible lipid signal in cells. The FEBS Journal, 270(9), 2091-2100.
  • Zoellner, H., Hou, J., Hochgrebe, T., Lynch, G., Poljak, A., Duncan, M., Golding,, J., Henderson, T. (2001). Fluorometric and mass spectrometric analysis on nonenzymatic glycosylated albumin. Biochemical and Biophysical Research Communications, 284, 83-89.
  • Turville, S., Lynch, G., Naif, H., Cunningham, A., Arthos,, J., MacDonald, K., Clark, G., Hart, D. (2001). HIV gp120 receptors on human dendritic cells. Blood, 98, 2482-2488.
  • Cunningham, A., Li, S., Juarez, J., Lynch, G., Alali, M., Naif, H. (2000). The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes. Journal of Leukocyte Biology, 68, 311-317.

Conferences

  • Rickard, J., Maddison, J., Pini, T., Bathgate, R., Evans, G., Maxwell, W., Lynch, G., Druart, X., de Graaf, S. (2013). Exposure to seminal plasma aids the migration of epididymal ram spermatozoa through the cervix. The Annual Conference of the Australian Society for Reproductive Biology, Australia: Australian Society for Reproductive Biology.
  • Rickard, J., Bathgate, R., Maddison, J., Schmidt, R., Lynch, G., Druart, X., de Graaf, S. (2013). The effect of seminal plasma from rams with varied freezing resilience on the cryosurvival of ram spermatozoa. European Society for Reproduction in Domestic Animals, Italy: Reproduction in Domestic Animals.
  • Rickard, J., Kohnke, P., Bathgate, R., Druart, X., Lynch, G., de Graaf, S. (2012). A preliminary assessment of the ram spermatozoa glycoproteome using 2DLC-MS/MS. International Congress on Animal Reproduction, Canada: Reproduction in Domestic Animals.
  • Muir, W., Lynch, G., Williamson, P. (2012). Improved Broiler Performance Following the early Administration of Protein Fractions Extracted from Meat and Bone Meal. 23rd Annual Australian Poultry Science Symposium, Sydney: Poultry Research Foundation, University of Sydney.
  • Bolitho (nee Donald), C., Bayl, P., Hou, J., Siddiqui, S., Rubin, T., Lynch, G., Zoellner, H. (2006). The anti-apoptotic activity of albumin for endothelium: investigation into mechanisms of action. Biological Mechanisms of Tooth Eruption, Resorption, and Movement (BMT 2005), Thailand: University of Southern California, School of Dentistry, 2006/ OS Printing House Co., Ltd, Bangkok.

2016

  • Rickard, J., Schmidt, R., Maddison, J., Bathgate, R., Lynch, G., Druart, X., de Graaf, S. (2016). Variation in seminal plasma alters the ability of ram spermatozoa to survive cryopreservation. Reproduction, Fertility and Development, 28(4), 516-523. [More Information]

2015

  • Lynch, G., Portelli, S., Church, W. (2015). Composite Model of Full GP Structure of Ebola Virus Envelope Glycoprotein. Journal of Molecular and Genetic Medicine, 9, 1-4. [More Information]
  • Lynch, G., Portelli, S., Wong, S., Costa, M., Lemgruber, A., Williamson, P., Sullivan, J., Booy, R., Church, W. (2015). Imaging of High and Low Resolution Ebola Envelope GP Structures Composited with in silico Models of Difficult-to-Resolve Sections. Journal of Molecular and Genetic Medicine, 9(4), e1000186. [More Information]
  • Rickard, J., Leahy, T., Soleilhavoup, C., Tsikis, G., Labas, V., Harichaux, G., Lynch, G., Druart, X., de Graaf, S. (2015). The identification of proteomic markers of sperm freezing resilience in ram seminal plasma. Journal of Proteomics, 126, 303-311. [More Information]

2014

  • Yuan, F., Velickovic, Z., Ashton, L., Dyer, W., Geczy, A., Dunckley, H., Lynch, G., Sullivan, J. (2014). Influence of HLA gene polymorphisms on susceptibility and outcome post infection with the SARS-CoV virus. Virologica Sinica, 29(2), 128-130. [More Information]
  • Rickard, J., Pini, T., Soleilhavoup, C., Cognie, J., Bathgate, R., Lynch, G., Evans, G., Maxwell, W., Druart, X., de Graaf, S. (2014). Seminal plasma aids the survival and cervical transit of epididymal ram spermatozoa. Reproduction, 148, 469-478. [More Information]

2013

  • Rickard, J., Maddison, J., Pini, T., Bathgate, R., Evans, G., Maxwell, W., Lynch, G., Druart, X., de Graaf, S. (2013). Exposure to seminal plasma aids the migration of epididymal ram spermatozoa through the cervix. The Annual Conference of the Australian Society for Reproductive Biology, Australia: Australian Society for Reproductive Biology.
  • Rickard, J., Bathgate, R., Maddison, J., Schmidt, R., Lynch, G., Druart, X., de Graaf, S. (2013). The effect of seminal plasma from rams with varied freezing resilience on the cryosurvival of ram spermatozoa. European Society for Reproduction in Domestic Animals, Italy: Reproduction in Domestic Animals.
  • Muir, W., Lynch, G., Williamson, P., Cowieson, A. (2013). The oral administration of meat and bone meal-derived protein fractions improved the performance of young broiler chicks. Animal Production Science, 53(5), 369-377. [More Information]

2012

  • Rickard, J., Kohnke, P., Bathgate, R., Druart, X., Lynch, G., de Graaf, S. (2012). A preliminary assessment of the ram spermatozoa glycoproteome using 2DLC-MS/MS. International Congress on Animal Reproduction, Canada: Reproduction in Domestic Animals.
  • Muir, W., Lynch, G., Williamson, P. (2012). Improved Broiler Performance Following the early Administration of Protein Fractions Extracted from Meat and Bone Meal. 23rd Annual Australian Poultry Science Symposium, Sydney: Poultry Research Foundation, University of Sydney.
  • Lynch, G., Selleck, P., Church, W., Sullivan, J. (2012). Seasoned adaptive antibody immunity for highly pathogenic pandemic influenza in humans. Immunology and Cell Biology, 90(2), 149-158. [More Information]

2011

  • Lynch, G. (2011). Value of cell studies that reflect the natural situation and whether, histiocyte-derived U-937 cells are the cell-line of choice, for studies of HIV infection interactions of monocytes and macrophages. Virology, 8, 397. [More Information]

2010

  • Bolitho (nee Donald), C., Xaymardan, M., Lynch, G., Zoellner, H. (2010). Vascularity during wound maturation correlates with fragmentation of serum albumin but not ceruloplasmin, transferrin, or haptoglobin. Wound Repair and Regeneration, 18, 211-222. [More Information]

2009

  • Lynch, G., Selleck, P., Sullivan, J. (2009). Acquired heterosubtypic antibodies in human immunity for avian H5N1 influenza. Journal of Molecular and Genetic Medicine, 3(2), 205-209. [More Information]
  • Sullivan, J., Selleck, P., Downton, T., Boehm, I., Axell, A., Ayob, Y., Kapitza, N., Dyer, W., Fitzgerald, A., Walsh, B., Lynch, G. (2009). Heterosubtypic anti-avian H5N1 influenza antibodies in intravenous immunoglobulins from globally separate populations protect against H5N1 infection in cell culture. Journal of Molecular and Genetic Medicine, 3(2), 217-224. [More Information]

2008

  • Stelzer-Braid, S., Wong, B., Robertson, P., Lynch, G., Laurie, K., Shaw, R., Barr, I., Selleck, P., Baleriola, C., Escott, R., et al (2008). A commercial ELISA detects high levels of human H5 antibody but cross-reacts with influenza A antibodies. Journal Of Clinical Virology, 43(2), 241-243. [More Information]
  • Greening, D., Glenister, K., Kapp, E., Moritz, R., Sparrow, R., Lynch, G., Simpson, R. (2008). Comparison of human platelet membrane-cytoskeletal proteins with the plasma proteome: Towards understanding the platelet-plasma nexus. Proteomics - Clinical Applications, 2(1), 63-77. [More Information]
  • Lynch, G., Selleck, P., Axell, A., Downton, T., Kaptiza, N., Boehm, I., Dyer, W., Wang, Y., Stelzer-Braid, S., Rawlinson, W., Sullivan, J. (2008). Cross-Reactive Anti-Avian H5N1 Influenza Neutralizing Antibodies in a Normal 'Exposure-Naive' Australian Blood Donor Population. The Open Immunology Journal, 1, 13-19.

2007

  • Bolitho (nee Donald), C., Bayl, P., Hou, J., Lynch, G., Hassel, A., Wall, A., Zoellner, H. (2007). The anti-apoptotic activity of albumin for endothelium is mediated by a partially cryptic protein domain and reduced by inhibitors of G-coupled protein and PI-3 Kinase, but is independent of radical scavenging or bound lipid. Journal of Vascular Research, 44(4), 313-324. [More Information]

2006

  • Lynch, G., Turville, S., Carter, B., Sloane, A., Chan, A., Muljadi, N., Li, S., Low, L., Armati, P., Raison, R., Zoellner, H., Williamson, P., Cunningham, A., Church, W. (2006). Marked differences in the structures and protein associations of lymphocyte and monocyte CD4: Resolution of a novel CD4 isoform. Immunology and Cell Biology, 84(2), 154-165. [More Information]
  • Bolitho (nee Donald), C., Bayl, P., Hou, J., Siddiqui, S., Rubin, T., Lynch, G., Zoellner, H. (2006). The anti-apoptotic activity of albumin for endothelium: investigation into mechanisms of action. Biological Mechanisms of Tooth Eruption, Resorption, and Movement (BMT 2005), Thailand: University of Southern California, School of Dentistry, 2006/ OS Printing House Co., Ltd, Bangkok.

2005

  • Sloane, A., Raso, V., Dimitrov, D., Xiao, X., Deo, S., Muljadi, N., Restuccia, D., Turville, S., Kearney, C., Broder, C., Zoellner, H., Cunningham, A., Bendall, L., Lynch, G. (2005). Marked structural and functional heterogeneity in CXCR4: Separation of HIV-1 and SDF-1 alpha responses. Immunology and Cell Biology, 83(2), 129-143. [More Information]

2003

  • Lynch, G., Slaytor, E., Elliott, F., Saurajen, A., Turville, S., Sloane, A., Cameron, P., Cunningham, A., Halliday, G. (2003). CD4 is expressed by epidermal Langerhans' cells predominantly as covalent dimers. Experimental Dermatology, 12(5), 700-711.
  • Wright, L., Djordjevic, J., Schibeci, S., Himmelreich, U., Muljadi, N., Williamson, P., Lynch, G. (2003). Detergent-resistant membrane factions contribute to the total 1h nmr-visible lipid signal in cells. The FEBS Journal, 270(9), 2091-2100.

2001

  • Zoellner, H., Hou, J., Hochgrebe, T., Lynch, G., Poljak, A., Duncan, M., Golding,, J., Henderson, T. (2001). Fluorometric and mass spectrometric analysis on nonenzymatic glycosylated albumin. Biochemical and Biophysical Research Communications, 284, 83-89.
  • Turville, S., Lynch, G., Naif, H., Cunningham, A., Arthos,, J., MacDonald, K., Clark, G., Hart, D. (2001). HIV gp120 receptors on human dendritic cells. Blood, 98, 2482-2488.

2000

  • Cunningham, A., Li, S., Juarez, J., Lynch, G., Alali, M., Naif, H. (2000). The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes. Journal of Leukocyte Biology, 68, 311-317.

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