Dr Gautam Wali

Associate Lecturer
Northern Clinical School

Member of the Brain and Mind Centre


Map

Current research students

Project title Research student
Clinical Studies in Hereditary Spastic Paraplegia Sue-faye SIOW

Selected grants

2017

  • Patient-derived stem cell models to study disease mechanisms and screen drug candidates for SPG7 Hereditary Spastic Paraplegia; Sue C, Mackay-Sim A, Wali G, Park J; Spastic Paraplegia Foundation/Research Grant.

Selected publications

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Book Chapters

  • Stewart, R., Wali, G., Perry, C., Lavin, M., Feron, F., Mackay-Sim, A., Sutharsan, R. (2017). A Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia. In Sergei V. Kozlov (Eds.), ATM Kinase: Methods and Protocols, (pp. 391-400). New York: Springer. [More Information]

Journals

  • Kumar, K., Wali, G., Davis, R., Mallawaarachchi, A., Palmer, E., Gayevskiy, V., Minoche, A., Veivers, D., Dinger, M., Mackay-Sim, A., et al (2018). Expanding the spectrum of PEX16 mutations and novel insights into disease mechanisms. Molecular Genetics and Metabolism Reports, 16, 46-51. [More Information]
  • Wali, G., Sue, C., Mackay-Sim, A. (2018). Patient-Derived Stem Cell Models in SPAST HSP: Disease Modelling and Drug Discovery. Brain Sciences, 8(8), 1-14. [More Information]
  • Kumar, K., Wali, G., Kamate, M., Wali, G., Minoche, A., Puttick, C., Pinese, M., Gayevskiy, V., Dinger, M., Roscioli, T., Sue, C., et al (2016). Defining the genetic basis of early onset hereditary spastic paraplegia using whole genome sequencing. Neurogenetics, 17(4), 265-270. [More Information]
  • Wali, G., Sutharsan, R., Fan, Y., Stewart, R., Velasquez, J., Sue, C., Crane, D., Mackay-Sim, A. (2016). Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia. Scientific Reports, 6, 1-14. [More Information]
  • Fan, Y., Wali, G., Sutharsan, R., Bellette, B., Crane, D., Sue, C., Mackay-Sim, A. (2014). Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia. Biology Open, 3(6), 494-502. [More Information]
  • Stewart, R., Kozlov, S., Matigian, N., Wali, G., Gatei, M., Sutharsan, R., Bellette, B., Wraith-Kijas, A., Cochrane, J., et al (2013). A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Human Molecular Genetics, 22(12), 2495-2509. [More Information]
  • Abrahamsen, G., Fan, Y., Matigian, N., Wali, G., Bellette, B., Sutharsan, R., Raju, J., Wood, S., Veivers, D., Sue, C., et al (2013). A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations. Disease Models & Mechanisms, 6(2), 489-502. [More Information]

2018

  • Kumar, K., Wali, G., Davis, R., Mallawaarachchi, A., Palmer, E., Gayevskiy, V., Minoche, A., Veivers, D., Dinger, M., Mackay-Sim, A., et al (2018). Expanding the spectrum of PEX16 mutations and novel insights into disease mechanisms. Molecular Genetics and Metabolism Reports, 16, 46-51. [More Information]
  • Wali, G., Sue, C., Mackay-Sim, A. (2018). Patient-Derived Stem Cell Models in SPAST HSP: Disease Modelling and Drug Discovery. Brain Sciences, 8(8), 1-14. [More Information]

2017

  • Stewart, R., Wali, G., Perry, C., Lavin, M., Feron, F., Mackay-Sim, A., Sutharsan, R. (2017). A Patient-Specific Stem Cell Model to Investigate the Neurological Phenotype Observed in Ataxia-Telangiectasia. In Sergei V. Kozlov (Eds.), ATM Kinase: Methods and Protocols, (pp. 391-400). New York: Springer. [More Information]

2016

  • Kumar, K., Wali, G., Kamate, M., Wali, G., Minoche, A., Puttick, C., Pinese, M., Gayevskiy, V., Dinger, M., Roscioli, T., Sue, C., et al (2016). Defining the genetic basis of early onset hereditary spastic paraplegia using whole genome sequencing. Neurogenetics, 17(4), 265-270. [More Information]
  • Wali, G., Sutharsan, R., Fan, Y., Stewart, R., Velasquez, J., Sue, C., Crane, D., Mackay-Sim, A. (2016). Mechanism of impaired microtubule-dependent peroxisome trafficking and oxidative stress in SPAST-mutated cells from patients with Hereditary Spastic Paraplegia. Scientific Reports, 6, 1-14. [More Information]

2014

  • Fan, Y., Wali, G., Sutharsan, R., Bellette, B., Crane, D., Sue, C., Mackay-Sim, A. (2014). Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia. Biology Open, 3(6), 494-502. [More Information]

2013

  • Stewart, R., Kozlov, S., Matigian, N., Wali, G., Gatei, M., Sutharsan, R., Bellette, B., Wraith-Kijas, A., Cochrane, J., et al (2013). A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Human Molecular Genetics, 22(12), 2495-2509. [More Information]
  • Abrahamsen, G., Fan, Y., Matigian, N., Wali, G., Bellette, B., Sutharsan, R., Raju, J., Wood, S., Veivers, D., Sue, C., et al (2013). A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations. Disease Models & Mechanisms, 6(2), 489-502. [More Information]

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