Professor Gemma Figtree

Professor
Medicine, Northern Clinical School
Kolling Institute of Medical Research

Telephone +61 2 9926 7111

Map

International links

Denmark

(Department of Physiology and Biophysics, Aarhus University, Denmark) Collaboration with Professor Flemming Cornelius, investigating the effect of oxidative signals on Na+-K+ ATPase kinetics.

Switzerland

(Department of Pharmacology and Toxicology, University of Lausanne, Switzerland) Working with Professor Kaethi Geering and Dr Stephanie Bibert to identify the candidate cysteine residue on the beta 1 subunit of Na+-K+ pump subunit that mediates its oxidative regulation.

United Kingdom

(Cardiac Medicine, National Heart and Lung Institute, Imperial College, London) Longstanding collaboration with Professor Peter Collins, with a focus on estrogen and related sex-steroids actions on the vasculature.

United Kingdom

(Cardiovascular Medicine, University of Oxford.) Investigating the influence of novel genetic variants in the estrogen receptor alpha gene on endothelial function, cholesterol levels and cardiovascular events, in collaboration with Professors Hugh Watkins and Keith Channon

Selected grants

2014

  • Salary Support - Laboratory Manager/Senior Scientist support for Oxidative Signaling Laboratory; Figtree G; Heart Research Australia/Research Support.
  • Pregnancy as a stress test determining mother's cardiovascular risk; Figtree G, Roberts C, Morris J, Ford J; Heart Foundation of Australia/Vanguard Grant.
  • Clinical CDF Level 2 - Oxidative stress and myocardial infarction; Figtree G; National Health and Medical Research Council (NHMRC)/Career Development Fellowship.
  • Level 1 - Improving risk stratification and targeted treatment of patients with heart attack (project funding for NHMRC CDF APP1062262); Figtree G; Heart Foundation of Australia/Future Leader Fellowship.
  • ROS-inhibition of the Na+ pump and vascular function in vivo; Figtree G; Heart Research Australia/Research Support.

2013

  • New approach to protecting the heart from oxidative stress in heart attack; Figtree G; DVC Research/Bridging Support Grant.
  • Effect of beta 3 adrenergic receptor signaling on redox-mediated platelet hyperactivity and hypercoagulable state in diabetes; Figtree G, Karimi Galougahi K; North Shore Heart Research Foundation/Research Support.

2011

  • PHOSPHOLEMMAN: A CARDIAC MEMBRANE PROTEIN WITH CAPACITY TO REDUCE MYOCARDIAL ISCHAEMIA REPERFUSION INJURY; Figtree G; Sylvia and Charles Viertel Charitable Foundation/Viertel Clinical Investigator Awards.
  • FXYDI and effects on ischaemia reperfusion injury; Figtree G; DVC Research/Bridging Support Grant.
  • Diffusion Tensor Imaging in the assessment of myocardial microarchitecture:implications for health and disease; Grieve S, Figtree G; The Royal Australian and New Zealand College of Radiologists/Research Grant.
  • PLM: a rescue protein in heart attack; Figtree G; North Shore Heart Research Foundation/Research Support.

2010

  • Therapeutic Silencing of Egr-1 by Novel Catalytic Oligodeoxynucleotides for The Treatment of Acute Myocardial Infarction; Bhindi R, McCrohon J, Figtree G, Grieve S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Molecular mechanism of insulin induced Na+-K+ pump stimulation in cardiac myocytes; Liu C, Rasmussen H, Figtree G; North Shore Heart Research Foundation/Research Support.
  • Reversing oxidative inhibition of the Na-K pump by beta3 adrenergic agonists: implications for heart failure therapy; Rasmussen H, Figtree G, McLachlan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Rapid and reversible ocidative modification: a key mechanism of hormonal regulation of the cardiac Na+-K+; Rasmussen H, Figtree G, Liu C; North Shore Heart Research Foundation/Research Support.
  • Effects of irreversible oxidative modification of reactive cysteine on the B1 subunit of the Na-k pump on its regulation in the cardiac myocytes; Figtree G; Royal Australasian College of Physicians/Foundation for High Blood Pressure Research Fellowship.

2008

  • Establishment of a High Field (3T) Cardiac Magnetic Resonance Imaging Research Unit at Royal North Shore Hospital, University of Sydney; Figtree G; Faculty of Medicine/Medical Foundation.
  • Estrogen receptor alpha: a candidate gene for altered vascular reactivity and Tako-tsubo phenomenon; Ward M, Figtree G; North Shore Heart Research Foundation/Research Support.

2007

  • Mechanisms of oxidative regulation of the cardiac sodium pump: possible role of s-glutathionylation; Figtree G; Royal Australasian College of Physicians/Scholarship.

Selected publications

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Books

  • Figtree, G. (2009). Genetic Variants in Estrogen Signaling Pathways. Germany: VDM Verlag.

Journals

  • Kozor, R., Grieve, S., Buchholz, S., Kaye, S., Darke, S., Bhindi, R., Figtree, G. (2014). Regular cocaine use is associated with increased systolic blood pressure, aortic stiffness and left ventricular mass in young otherwise healthy individuals. PLoS One, 9(4), e89710. [More Information]
  • Ho, E., Karimi Galougahi, K., Liu, C., Bhindi, R., Figtree, G. (2013). Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biology, 1(1), 483-491. [More Information]
  • Grieve, S., Lonborg, J., Mazhar, J., Tan, T., Ho, E., Liu, C., Lay, W., Gill, A., Kuchel, P., Bhindi, R., Figtree, G. (2013). Cardiac magnetic resonance imaging of rapid VCAM-1 up-regulation in myocardial ischemia–reperfusion injury. European Biophysics Journal, 42(1), 61-70. [More Information]
  • McMahon, R., Siow, W., Bhindi, R., Hoo, S., Figtree, G., Hansen, P., Nelson, G., Rasmussen, H., Ward, M. (2013). Left bundle branch block without concordant ST changes is rarely associated with acute coronary occlusion. International Journal of Cardiology, 167(4), 1339-1342. [More Information]
  • Figtree, G., Bagnall, R., Abdulla, I., Buchholz, S., Karimi Galougahi, K., Yan, W., Tan, T., Neil, C., Horowitz, J., Semsarian, C., Ward, M. (2013). No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. European Journal of Heart Failure, 15(7), 730-733. [More Information]
  • Mazhar, J., Murphy, J., Figtree, G., Hansen, P., Nelson, G., Bhindi, R. (2013). Optical coherence tomography (OCT) as an adjunct to percutaneous coronary intervention; a single centre experience. International Journal of Cardiology, 163(3), e49-e52. [More Information]
  • Kanagaratnam, L., Lee, A., Whalley, D., Figtree, G. (2013). Overcoming Artifacts and Fears: Electrophysiology Study and Radiofrequency Ablation in a Parkinsonian Patient with Supraventricular Tachycardia and a Brain Neurostimulator. PACE - Pacing and Clinical Electrophysiology, 36(1), 1-3. [More Information]
  • Liu, C., Karimi Galougahi, K., Weisbrod, R., Hansen, T., Ravaie, R., Nunez, A., Liu, Y., Fry, N., Garcia, A., Hamilton, E., Figtree, G., et al (2013). Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction. Free Radical Biology and Medicine, 65(2013), 563-572. [More Information]
  • Figtree, G., Rasmussen, H., Liu, C. (2013). Oxidative regulation of the na+-k+ pump in cardiac physiology and pathology: clarifying the published evidence. Circulation Research, 112(1), e1-e1. [More Information]
  • Karimi Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Karimi Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Grieve, S., Figtree, G., Kuchel, P. (2013). Stoichiometric relationship between Na+ ions transported and glucose consumed in human erythrocytes: Bayesian analysis of 23Na and 13C NMR time course data. Biophysical Journal, 104(8), 1676-1684. [More Information]
  • Figtree, G., Bhindi, R., Cockburn, J., Wilkes, N., Ward, M., Hansen, P. (2013). Use of optical coherence tomography to guide treatment of an undeployed stent trapped in the right coronary artery to cover a proximal stent outflow dissection. International Journal of Cardiology, 167, e163-e166. [More Information]
  • Lonborg, J., Ward, M., Gill, A., Grieve, S., Figtree, G. (2013). Utility of cardiac magnetic resonance in assessing right-sided heart failure in sarcoidosis. BMC Medical Imaging, 13(1), 1-5. [More Information]
  • Mazhar, J., Lawley, C., Gill, A., Grieve, S., Figtree, G. (2013). Visualizing pericardial inflammation as the cause of acute chest pain in a patient with a congenital pericardial cyst: the incremental diagnostic value of cardiac magnetic resonance. European Heart Journal, 34(19), 1413-1413. [More Information]
  • Lawley, C., Mazhar, J., Grieve, S., Figtree, G. (2013). Visualizing pericardial inflammation in Dressler's syndrome with cardiac magnetic resonance imaging. International Journal of Cardiology, 168(1), e32-e33. [More Information]
  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Huang, A., Mathur, M., Figtree, G. (2012). Cardiac magnetic resonance characterization of an iatrogenic left ventricular apical pseudo- aneurysm. European journal of Echocardiography, 13(12), 1000-1000. [More Information]
  • Buchholz, S., Shakil, A., Figtree, G., Hansen, P., Bhindi, R. (2012). Diagnosis and management of patent foramen ovale. Postgraduate Medical Journal, 88(1038), 217-225. [More Information]
  • Kozor, R., Nelson, G., Figtree, G. (2012). Extensive mid-wall myocardial oedema after aborted sudden death in hypertrophic cardiomyopathy. International Journal of Cardiology, 154(1), e14-e15. [More Information]
  • Ward, M., Figtree, G. (2012). Letter by Ward and Figtree article, "mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease". Circulation, 126(6), e82-e82. [More Information]
  • Yan, W., Nelson, G., Figtree, G., Bhindi, R. (2012). Overcoming Limited Depth Penetration of Optical Coherence Tomography With Wire Bias. J A C C: Cardiovascular Interventions, 5(1), e1-e2. [More Information]
  • Figtree, G., Karimi Galougahi, K., Liu, C., Rasmussen, H. (2012). Oxidative regulation of the Na+ -K+ pump in the cardiovascular system. Free Radical Biology and Medicine, 53(12), 2263-2268. [More Information]
  • Murphy, J., Kozor, R., Figtree, G., Ward, M., Bhindi, R. (2012). Percutaneous coronary intervention via the radial artery: comparison of procedural success in emergency versus non-emergency cases. Cardiovascular Revascularization Medicine, 13(5), 277-280. [More Information]
  • Murphy, J., Kozor, R., Figtree, G., Hansen, P., Rasmussen, H., Ward, M., Nelson, G., Bhindi, R. (2012). Procedural and in-patient outcomes in patients aged 80 years or older undergoing contemporary primary percutaneous coronary intervention. EuroIntervention, 8(8), 912-919. [More Information]
  • Rowell, A., Figtree, M., Dimmick, S., Kotsiou, G., Grieve, S., Figtree, G. (2012). Recurrent right ventricular echinococcosis characterized by cardiac magnetic resonance. International Journal of Cardiology, 158(2), 293-294. [More Information]
  • Fong, L., Mathur, M., Bhindi, R., Figtree, G. (2012). Right atrial Merkel cell tumour metastasis characterization using a multimodality approach. European Heart Journal, 33(17), 2205-2205. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]
  • Figtree, G., Lonborg, J., Grieve, S., Ward, M., Bhindi, R. (2011). Cardiac Magnetic Resonance Imaging for the Interventional Cardiologist. J A C C: Cardiovascular Interventions, 4(2), 137-148. [More Information]
  • Hamilton, E., Figtree, G., Rasmussen, H. (2011). Consideration of natriuretic peptide receptor C. Circulation Research, 108(4), e4-e5. [More Information]
  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]
  • Ho, E., Bhindi, R., Ashley, E., Figtree, G. (2011). Genetic analysis in cardiovascular disease: a clinical perspective. Cardiology in Review, 19(2), 81-89. [More Information]
  • Karimi Galougahi, K., Harden, M., Maher, R., Gill, A., Bhindi, R., Grieve, S., Brady, P., Figtree, G. (2011). Incremental Diagnostic Value of Magnetic Resonance Imaging in the Characterization of a Cardiac Mass. Journal of the American College of Cardiology, 58(10), e19-e19. [More Information]
  • Bhindi, R., Grieve, S., Figtree, G. (2011). Micromyocardial infarction in apical hypertrophic cardiomyopathy with obliterative coronary artery bridging. International Journal of Cardiology, 151(1), e24-e25. [More Information]
  • Yu, C., Grieve, S., Brazier, D., Bhindi, R., Figtree, G. (2011). Post-infarct ventricular thrombus: a critical diagnosis made by cardiac magnetic resonance imaging. Heart, Lung and Circulation, 20(6), 373-373. [More Information]
  • Montfort, J., Maher, R., Grieve, S., Figtree, G. (2011). Syringomyelia: A rare extracardiac contributor to syncope detected incidentally by CMR. International Journal of Cardiology, 150(2), e62-e64. [More Information]
  • Yu, C., Brazier, D., Bhindi, R., Figtree, G., Ward, M. (2011). Use of computer tomography coronary angiography in assessment of aorto-ostial coronary disease. International Journal of Cardiology, 147(1), 153-154. [More Information]
  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Robaei, D., Grieve, S., Nelson, G., Figtree, G. (2010). Cocaine-induced epicardial coronary artery thrombosis resulting in extensive myocardial injury assessed by cardiac magnetic resonance imaging. European heart journal, 31(20), 2446. [More Information]
  • Buchholz, S., Grieve, S., Maher, R., Figtree, G. (2010). Cocaine-induced myocardial injury seen as multiple mid-wall foci of late enhancement by contrast-enhanced cardiac magnetic resonance imaging. European heart journal, 31(11), 1422. [More Information]
  • Lonborg, J., Mathur, M., Grieve, S., Bhindi, R., Ward, M., Lowe, H., McCrohon, J., Figtree, G. (2010). Constrictive Pericarditis Diagnosed by Cardiac Magnetic Resonance. Journal of the American College of Cardiology, 56(20), e39-e39. [More Information]
  • Testa, L., Biondi Zoccai, G., Valgimigli, M., Latini, R., Pizzocri, S., Lanotte, S., Laudisa, M., Brambilla, N., Ward, M., Figtree, G., et al (2010). Current concepts on antiplatelet therapy: focus on the novel thienopyridine and non-thienopyridine agents. Advances in Hematology, 2010, 595934. [More Information]
  • Figtree, G., Guzik, T., Robinson, B., Channon, K., Watkins, H. (2010). Functional estrogen receptor alpha promoter polymorphism is associated with improved endothelial-dependent vasolidation. International Journal of Cardiology, 143(2), 207-208. [More Information]
  • Grieve, S., Bhindi, R., Seow, J., Doyle, A., Turner, A., Tomka, J., Lay, W., Gill, A., Hunyor, S., Figtree, G. (2010). Microvascular obstruction by intracoronary delivery of mesenchymal stem cells and quantification of resulting myocardial infarction by cardiac magnetic resonance. Circulation. Heart Failure, 3(3), e5-e6. [More Information]
  • Rasmussen, H., Liu, C., Figtree, G. (2010). Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology. Trends In Cardiovascular Medicine, 20(3), 85-90. [More Information]
  • Figtree, G., Thiruvallapan, N., Brereton, J., Whalley, D., Tofler, G. (2010). The effect of elevated right atrial pressure due to pulmonary emboli on detection of patent foramen ovale and potential paradoxical embolus. Journal of Cardiovascular Medicine (Hagerstown), 11(1), 61-63. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]
  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Noonan, J., Bhindi, R., Collins, P. (2009). Estrogen Receptor Polymorphisms: Significance to Human Physiology, Disease and Therapy. Recent Patents on DNA and Gene Sequences. [More Information]
  • Bhindi, R., Figtree, G. (2009). Percutaneous coronary intervention versus coronary-artery bypass grafting. The New England Journal of Medicine, 360(25), 2672; author reply 2674-5. [More Information]
  • Figtree, G., Robinson, B., Channon, K., Watkins, H. (2009). Polymorphism upstream of estrogen receptor alpha reverses negative regulation of transcription. International Journal of Cardiology, 144(1), 86-8. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]
  • Rasmussen, H., Figtree, G., Krum, H., Bundgaard, H. (2009). The use of beta3-adrenergic receptor agonists in the treatment of heart failure. Current Opinion in Investigational Drugs (Print), 10(9), 955-962. [More Information]
  • Figtree, G., Grieve, S., Speller, B., Geiger, M., Robinson, B., Channon, K., Ragoussis, J., Collins, P., Watkins, H. (2008). A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL. Atherosclerosis, 199(2), 354-361. [More Information]
  • William, M., Hamilton, E., Bundgaard, H., Garcia, A., Chia, K., Figtree, G., Rasmussen, H. (2008). Natriuretic peptides stimulate the cardiac sodium pump via NPR-C coupled NOS activation. American Journal of Physiology: Cell Physiology, 294(4), C1067-C1073. [More Information]
  • White, C., Hamilton, E., Garcia, A., Wang, D., Chia, K., Figtree, G., Rasmussen, H. (2008). Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. American Journal of Physiology: Cell Physiology, 294, C572-C578. [More Information]
  • Rasmussen, H., Figtree, G. (2007). "Don't flog the heart!" - development of specific drug therapies for heart failure. Critical Care and Resuscitation, 9(4), 364-369. [More Information]
  • Goodstadt, L., Powell, T., Figtree, G. (2006). 17β-Estradiol Potentiates the Cardiac Cystic Fibrosis Transmembrane Conductance Regulator Chloride Current in Guinea-pig Ventricular Myocytes. The Journal of Physiological Sciences, 56(1), 29-37. [More Information]
  • Figtree, G., Kindmark, A., Lind, L., Grundberg, E., Speller, B., Robinson, B., Channon, K., Watkins, H. (2006). Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension. Journal of Steroid Biochemistry and Molecular Biology, 103(2), 110-118. [More Information]
  • Figtree, G., Robinson, B. (2004). Estrogen receptor polymorphisms in common disease: recent developments. Current Opinion in Endocrinology, Diabetes and Obesity, 11(3), 141-146.
  • Figtree, G., Robinson, B. (2004). Estrogen Receptor Polymorphisms In Common Disease:Recent Developments. Current Opinion in Endocrinology, Diabetes and Obesity, 11(3), 141-146.
  • Figtree, G., McDonald, D., Watkins, H., Channon, K. (2003). Truncated Estrogen Receptor α 46-kDa Isoform in Human Endothelial Cells: Relationship to Acute Activation of Nitric Oxide Synthase. Circulation, 107(1), 120-126.
  • Cooper, L., Clifton-Bligh, P., Nery, M., Figtree, G., Twigg, S., Hibbert, E., Robinson, B. (2003). Vitamin D supplementation and bone mineral density in early postmenopausal women. American Journal of Clinical Nutrition, 77(5), 1324-1329.

Conferences

  • Figtree, G., Watkins, H., Robinson, B., Channon, K. (2006). Novel polymorphism in estrogen receptor alpha reverses negative transcriptional regulation and is associated with improved endothelial-dependent vasodilation. American Heart Association Annual Scientific Sessions 2005, United States: American Heart Association.

2014

  • Kozor, R., Grieve, S., Buchholz, S., Kaye, S., Darke, S., Bhindi, R., Figtree, G. (2014). Regular cocaine use is associated with increased systolic blood pressure, aortic stiffness and left ventricular mass in young otherwise healthy individuals. PLoS One, 9(4), e89710. [More Information]

2013

  • Ho, E., Karimi Galougahi, K., Liu, C., Bhindi, R., Figtree, G. (2013). Biological markers of oxidative stress: Applications to cardiovascular research and practice. Redox Biology, 1(1), 483-491. [More Information]
  • Grieve, S., Lonborg, J., Mazhar, J., Tan, T., Ho, E., Liu, C., Lay, W., Gill, A., Kuchel, P., Bhindi, R., Figtree, G. (2013). Cardiac magnetic resonance imaging of rapid VCAM-1 up-regulation in myocardial ischemia–reperfusion injury. European Biophysics Journal, 42(1), 61-70. [More Information]
  • McMahon, R., Siow, W., Bhindi, R., Hoo, S., Figtree, G., Hansen, P., Nelson, G., Rasmussen, H., Ward, M. (2013). Left bundle branch block without concordant ST changes is rarely associated with acute coronary occlusion. International Journal of Cardiology, 167(4), 1339-1342. [More Information]
  • Figtree, G., Bagnall, R., Abdulla, I., Buchholz, S., Karimi Galougahi, K., Yan, W., Tan, T., Neil, C., Horowitz, J., Semsarian, C., Ward, M. (2013). No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort. European Journal of Heart Failure, 15(7), 730-733. [More Information]
  • Mazhar, J., Murphy, J., Figtree, G., Hansen, P., Nelson, G., Bhindi, R. (2013). Optical coherence tomography (OCT) as an adjunct to percutaneous coronary intervention; a single centre experience. International Journal of Cardiology, 163(3), e49-e52. [More Information]
  • Kanagaratnam, L., Lee, A., Whalley, D., Figtree, G. (2013). Overcoming Artifacts and Fears: Electrophysiology Study and Radiofrequency Ablation in a Parkinsonian Patient with Supraventricular Tachycardia and a Brain Neurostimulator. PACE - Pacing and Clinical Electrophysiology, 36(1), 1-3. [More Information]
  • Liu, C., Karimi Galougahi, K., Weisbrod, R., Hansen, T., Ravaie, R., Nunez, A., Liu, Y., Fry, N., Garcia, A., Hamilton, E., Figtree, G., et al (2013). Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction. Free Radical Biology and Medicine, 65(2013), 563-572. [More Information]
  • Figtree, G., Rasmussen, H., Liu, C. (2013). Oxidative regulation of the na+-k+ pump in cardiac physiology and pathology: clarifying the published evidence. Circulation Research, 112(1), e1-e1. [More Information]
  • Karimi Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Karimi Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]
  • Rayner, B., Figtree, G., Sabaretnam, T., Shang, P., Mazhar, J., Weaver, J., Lay, W., Witting, P., Hunyor, S., Grieve, S., Bhindi, R., et al (2013). Selective Inhibition of the Master Regulator Transcription Factor Egr-1 With Catalytic Oligonucleotides Reduces Myocardial Injury and Improves Left Ventricular Systolic Function in a Preclinical Model of Myocardial Infarction. Journal of the American Heart Association, 2(4), 1-9. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Grieve, S., Figtree, G., Kuchel, P. (2013). Stoichiometric relationship between Na+ ions transported and glucose consumed in human erythrocytes: Bayesian analysis of 23Na and 13C NMR time course data. Biophysical Journal, 104(8), 1676-1684. [More Information]
  • Figtree, G., Bhindi, R., Cockburn, J., Wilkes, N., Ward, M., Hansen, P. (2013). Use of optical coherence tomography to guide treatment of an undeployed stent trapped in the right coronary artery to cover a proximal stent outflow dissection. International Journal of Cardiology, 167, e163-e166. [More Information]
  • Lonborg, J., Ward, M., Gill, A., Grieve, S., Figtree, G. (2013). Utility of cardiac magnetic resonance in assessing right-sided heart failure in sarcoidosis. BMC Medical Imaging, 13(1), 1-5. [More Information]
  • Mazhar, J., Lawley, C., Gill, A., Grieve, S., Figtree, G. (2013). Visualizing pericardial inflammation as the cause of acute chest pain in a patient with a congenital pericardial cyst: the incremental diagnostic value of cardiac magnetic resonance. European Heart Journal, 34(19), 1413-1413. [More Information]
  • Lawley, C., Mazhar, J., Grieve, S., Figtree, G. (2013). Visualizing pericardial inflammation in Dressler's syndrome with cardiac magnetic resonance imaging. International Journal of Cardiology, 168(1), e32-e33. [More Information]

2012

  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Huang, A., Mathur, M., Figtree, G. (2012). Cardiac magnetic resonance characterization of an iatrogenic left ventricular apical pseudo- aneurysm. European journal of Echocardiography, 13(12), 1000-1000. [More Information]
  • Buchholz, S., Shakil, A., Figtree, G., Hansen, P., Bhindi, R. (2012). Diagnosis and management of patent foramen ovale. Postgraduate Medical Journal, 88(1038), 217-225. [More Information]
  • Kozor, R., Nelson, G., Figtree, G. (2012). Extensive mid-wall myocardial oedema after aborted sudden death in hypertrophic cardiomyopathy. International Journal of Cardiology, 154(1), e14-e15. [More Information]
  • Ward, M., Figtree, G. (2012). Letter by Ward and Figtree article, "mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease". Circulation, 126(6), e82-e82. [More Information]
  • Yan, W., Nelson, G., Figtree, G., Bhindi, R. (2012). Overcoming Limited Depth Penetration of Optical Coherence Tomography With Wire Bias. J A C C: Cardiovascular Interventions, 5(1), e1-e2. [More Information]
  • Figtree, G., Karimi Galougahi, K., Liu, C., Rasmussen, H. (2012). Oxidative regulation of the Na+ -K+ pump in the cardiovascular system. Free Radical Biology and Medicine, 53(12), 2263-2268. [More Information]
  • Murphy, J., Kozor, R., Figtree, G., Ward, M., Bhindi, R. (2012). Percutaneous coronary intervention via the radial artery: comparison of procedural success in emergency versus non-emergency cases. Cardiovascular Revascularization Medicine, 13(5), 277-280. [More Information]
  • Murphy, J., Kozor, R., Figtree, G., Hansen, P., Rasmussen, H., Ward, M., Nelson, G., Bhindi, R. (2012). Procedural and in-patient outcomes in patients aged 80 years or older undergoing contemporary primary percutaneous coronary intervention. EuroIntervention, 8(8), 912-919. [More Information]
  • Rowell, A., Figtree, M., Dimmick, S., Kotsiou, G., Grieve, S., Figtree, G. (2012). Recurrent right ventricular echinococcosis characterized by cardiac magnetic resonance. International Journal of Cardiology, 158(2), 293-294. [More Information]
  • Fong, L., Mathur, M., Bhindi, R., Figtree, G. (2012). Right atrial Merkel cell tumour metastasis characterization using a multimodality approach. European Heart Journal, 33(17), 2205-2205. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]

2011

  • Figtree, G., Lonborg, J., Grieve, S., Ward, M., Bhindi, R. (2011). Cardiac Magnetic Resonance Imaging for the Interventional Cardiologist. J A C C: Cardiovascular Interventions, 4(2), 137-148. [More Information]
  • Hamilton, E., Figtree, G., Rasmussen, H. (2011). Consideration of natriuretic peptide receptor C. Circulation Research, 108(4), e4-e5. [More Information]
  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]
  • Ho, E., Bhindi, R., Ashley, E., Figtree, G. (2011). Genetic analysis in cardiovascular disease: a clinical perspective. Cardiology in Review, 19(2), 81-89. [More Information]
  • Karimi Galougahi, K., Harden, M., Maher, R., Gill, A., Bhindi, R., Grieve, S., Brady, P., Figtree, G. (2011). Incremental Diagnostic Value of Magnetic Resonance Imaging in the Characterization of a Cardiac Mass. Journal of the American College of Cardiology, 58(10), e19-e19. [More Information]
  • Bhindi, R., Grieve, S., Figtree, G. (2011). Micromyocardial infarction in apical hypertrophic cardiomyopathy with obliterative coronary artery bridging. International Journal of Cardiology, 151(1), e24-e25. [More Information]
  • Yu, C., Grieve, S., Brazier, D., Bhindi, R., Figtree, G. (2011). Post-infarct ventricular thrombus: a critical diagnosis made by cardiac magnetic resonance imaging. Heart, Lung and Circulation, 20(6), 373-373. [More Information]
  • Montfort, J., Maher, R., Grieve, S., Figtree, G. (2011). Syringomyelia: A rare extracardiac contributor to syncope detected incidentally by CMR. International Journal of Cardiology, 150(2), e62-e64. [More Information]
  • Yu, C., Brazier, D., Bhindi, R., Figtree, G., Ward, M. (2011). Use of computer tomography coronary angiography in assessment of aorto-ostial coronary disease. International Journal of Cardiology, 147(1), 153-154. [More Information]

2010

  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Robaei, D., Grieve, S., Nelson, G., Figtree, G. (2010). Cocaine-induced epicardial coronary artery thrombosis resulting in extensive myocardial injury assessed by cardiac magnetic resonance imaging. European heart journal, 31(20), 2446. [More Information]
  • Buchholz, S., Grieve, S., Maher, R., Figtree, G. (2010). Cocaine-induced myocardial injury seen as multiple mid-wall foci of late enhancement by contrast-enhanced cardiac magnetic resonance imaging. European heart journal, 31(11), 1422. [More Information]
  • Lonborg, J., Mathur, M., Grieve, S., Bhindi, R., Ward, M., Lowe, H., McCrohon, J., Figtree, G. (2010). Constrictive Pericarditis Diagnosed by Cardiac Magnetic Resonance. Journal of the American College of Cardiology, 56(20), e39-e39. [More Information]
  • Testa, L., Biondi Zoccai, G., Valgimigli, M., Latini, R., Pizzocri, S., Lanotte, S., Laudisa, M., Brambilla, N., Ward, M., Figtree, G., et al (2010). Current concepts on antiplatelet therapy: focus on the novel thienopyridine and non-thienopyridine agents. Advances in Hematology, 2010, 595934. [More Information]
  • Figtree, G., Guzik, T., Robinson, B., Channon, K., Watkins, H. (2010). Functional estrogen receptor alpha promoter polymorphism is associated with improved endothelial-dependent vasolidation. International Journal of Cardiology, 143(2), 207-208. [More Information]
  • Grieve, S., Bhindi, R., Seow, J., Doyle, A., Turner, A., Tomka, J., Lay, W., Gill, A., Hunyor, S., Figtree, G. (2010). Microvascular obstruction by intracoronary delivery of mesenchymal stem cells and quantification of resulting myocardial infarction by cardiac magnetic resonance. Circulation. Heart Failure, 3(3), e5-e6. [More Information]
  • Rasmussen, H., Liu, C., Figtree, G. (2010). Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology. Trends In Cardiovascular Medicine, 20(3), 85-90. [More Information]
  • Figtree, G., Thiruvallapan, N., Brereton, J., Whalley, D., Tofler, G. (2010). The effect of elevated right atrial pressure due to pulmonary emboli on detection of patent foramen ovale and potential paradoxical embolus. Journal of Cardiovascular Medicine (Hagerstown), 11(1), 61-63. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]

2009

  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Noonan, J., Bhindi, R., Collins, P. (2009). Estrogen Receptor Polymorphisms: Significance to Human Physiology, Disease and Therapy. Recent Patents on DNA and Gene Sequences. [More Information]
  • Figtree, G. (2009). Genetic Variants in Estrogen Signaling Pathways. Germany: VDM Verlag.
  • Bhindi, R., Figtree, G. (2009). Percutaneous coronary intervention versus coronary-artery bypass grafting. The New England Journal of Medicine, 360(25), 2672; author reply 2674-5. [More Information]
  • Figtree, G., Robinson, B., Channon, K., Watkins, H. (2009). Polymorphism upstream of estrogen receptor alpha reverses negative regulation of transcription. International Journal of Cardiology, 144(1), 86-8. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]
  • Rasmussen, H., Figtree, G., Krum, H., Bundgaard, H. (2009). The use of beta3-adrenergic receptor agonists in the treatment of heart failure. Current Opinion in Investigational Drugs (Print), 10(9), 955-962. [More Information]

2008

  • Figtree, G., Grieve, S., Speller, B., Geiger, M., Robinson, B., Channon, K., Ragoussis, J., Collins, P., Watkins, H. (2008). A commonly occurring polymorphism upstream of the estrogen receptor alpha alters transcription and is associated with increased HDL. Atherosclerosis, 199(2), 354-361. [More Information]
  • William, M., Hamilton, E., Bundgaard, H., Garcia, A., Chia, K., Figtree, G., Rasmussen, H. (2008). Natriuretic peptides stimulate the cardiac sodium pump via NPR-C coupled NOS activation. American Journal of Physiology: Cell Physiology, 294(4), C1067-C1073. [More Information]
  • White, C., Hamilton, E., Garcia, A., Wang, D., Chia, K., Figtree, G., Rasmussen, H. (2008). Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. American Journal of Physiology: Cell Physiology, 294, C572-C578. [More Information]

2007

  • Rasmussen, H., Figtree, G. (2007). "Don't flog the heart!" - development of specific drug therapies for heart failure. Critical Care and Resuscitation, 9(4), 364-369. [More Information]

2006

  • Goodstadt, L., Powell, T., Figtree, G. (2006). 17β-Estradiol Potentiates the Cardiac Cystic Fibrosis Transmembrane Conductance Regulator Chloride Current in Guinea-pig Ventricular Myocytes. The Journal of Physiological Sciences, 56(1), 29-37. [More Information]
  • Figtree, G., Kindmark, A., Lind, L., Grundberg, E., Speller, B., Robinson, B., Channon, K., Watkins, H. (2006). Novel estrogen receptor alpha promoter polymorphism increases ventricular hypertrophic response to hypertension. Journal of Steroid Biochemistry and Molecular Biology, 103(2), 110-118. [More Information]
  • Figtree, G., Watkins, H., Robinson, B., Channon, K. (2006). Novel polymorphism in estrogen receptor alpha reverses negative transcriptional regulation and is associated with improved endothelial-dependent vasodilation. American Heart Association Annual Scientific Sessions 2005, United States: American Heart Association.

2004

  • Figtree, G., Robinson, B. (2004). Estrogen receptor polymorphisms in common disease: recent developments. Current Opinion in Endocrinology, Diabetes and Obesity, 11(3), 141-146.
  • Figtree, G., Robinson, B. (2004). Estrogen Receptor Polymorphisms In Common Disease:Recent Developments. Current Opinion in Endocrinology, Diabetes and Obesity, 11(3), 141-146.

2003

  • Figtree, G., McDonald, D., Watkins, H., Channon, K. (2003). Truncated Estrogen Receptor α 46-kDa Isoform in Human Endothelial Cells: Relationship to Acute Activation of Nitric Oxide Synthase. Circulation, 107(1), 120-126.
  • Cooper, L., Clifton-Bligh, P., Nery, M., Figtree, G., Twigg, S., Hibbert, E., Robinson, B. (2003). Vitamin D supplementation and bone mineral density in early postmenopausal women. American Journal of Clinical Nutrition, 77(5), 1324-1329.

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