Professor Georges Emile Raymond Grau
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Professor of Vascular Immunology
K25 - Medical Foundation Building |
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Themes | Biographical details | Research interests | Grants | PhD & Masters' project opportunities | Honours project opportunities | Keywords
Biographical details
2006 - present: Professor, Chair of Vascular Immunology, Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of Sydney [More...]
Research interests
Immunopathology of microvascular lesions, particularly of cerebral and pulmonary complications of infectious and auto-immune diseases, especially in cerebral malaria, septic shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms of the interactions between microvascular endothelial cells and cells of the immune system. Experience in various in vivo and in vitro experimental systems as well as in clinical studies. More recently, focus on the neurovascular lesion of murine and human cerebral malaria, using co-culture model systems involving brain endothelium, P. falciparum infected erythrocytes, as well as circulating cells, particularly platelets and monocytes.
Additional keywords: endothelium; cytokines; platelets; microparticles; brain diseases; cerebral malaria; sepsis; septic shock
Current national competitive grants*
2012
Microparticles are pathogenic elements in the pathophysiology of cerebral malaria
Combes V, Grau G, Wheway J
NHMRC Project Grants ($584,700 over 3 years)
The astrocyte: a crossroads in cerebral malaria pathogenesis
Hunt N, Ball H, Grau G
NHMRC Project Grants ($577,350 over 3 years)
The link between the angiogenesis of live birth and cancer: a lizard model
Thompson M, Murphy C, Grau G
ARC Discovery Projects ($550,000 over 3 years)
2011
The involvement of the kynurenine pathway in blood brain barrier disruption and its relevance for neuroinflammatory diseases
Guillemin G, Combes V, Grau G, Brew B
University of New South Wales Shared Research Support ($60,557 over 3 years)
Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers
Bebawy M, Grau G, Combes V
National Health and Medical Research Council Project Grants ($60,000 over 3 years)
Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers
Bebawy M, Grau G, Combes V
NHMRC Project Grant ($396,273 over 3 years)
* Grants administered through the University of Sydney
Honours project opportunities
The role of microparticles in the immune response to WNV
Assessing microparticles as effectors in the microvascular lesion of cerebral malaria
Investigating mechanisms of microparticle production by microvascular endothelial cells and defining clinically useful inhibitors.
Defining the antigen presentation capacity of endothelial cells