Clinical Associate Professor James Guy Lyons

Clinical Associate Professor
Dermatology, Central Clinical School

D06 - Blackburn Building
The University of Sydney
NSW 2006 Australia

T:	+61 2 9036 6314
F:	9036 5130
E:
W:	Projects with this supervisor

Themes

Cancer; Infection and Immunological Conditions

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Research interests

Dr Lyons' research aims to determine the cellular and molecular mechanisms by which oncogenes and tumour suppressor genes contribute to the formation of squamous cell carcinomas of the skin and of the head and neck region, two of the most common sites for cancer. Of particular interest are genes involved in the progression from benign tumours, which are non-invasive and usually easily treated, to malignant tumours, which spread invasively from the site of origin and are difficult to treat successfully. This research encompasses a broad range of molecular and cell biological methods and analyses, including cell culture, plasmid and virus vector construction, gene expression analysis, small animal handling and microscopy. Both in vivo and in vitro models for squamous cell carcinogenesis are established in the laboratory.

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Current national competitive grants*

2012

Interactions between genes that cause cancer
Lyons J, Halliday G
NHMRC Project Grants ($536,010 over 3 years)

2011

Cell cooperation in cancer
Lyons J, Myerscough M
Human Frontier Science Program (France) Research Support ($300,000 over 3 years)

Susceptibility of the basal layer of human epidermis to UVA oxidative damage due to pheomelanin and suboptimal DNA repair
Halliday G, Lyons J
National Health and Medical Research Council Project Grant ($540,048 over 3 years)

2010

Brm and Brg-1 protect from ultraviolet radiation-induced skin and ocular damage
Halliday G, Lyons J, Di Girolamo N, Moloney F, Lee C
NHMRC Project Grant ($535,500 over 3 years)

* Grants administered through the University of Sydney

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