Emeritus Professor Graham Johnston

AM
Professor of Pharmacology and Medicinal Chemistry
Pharmacology, School of Medical Sciences
Bosch Institute

Telephone +61 2 9351 6117
Fax +61 2 9351 2891

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Research interests

I study natural and synthetic chemicals that influence brain chemistry in relation to Alzheimer’s disease, anxiety, epilepsy, insomnia, memory disorders, myopia, schizophrenia and stress.

Selected grants

2013

  • Allosteric Targets on GABA-A Receptors; Hanrahan J, Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Bruker APEX II CCD Detector Fourth Generation APEX II ultra-low noise CCD X-ray detector with 16 megapixel chip; Hibbs D, Roufogalis B, Murray M, Hambley T, Hanrahan J, Church W, Collins M, Johnston G, Young P, Traini D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Novel blockers of the 5-HT3 receptor channel; Johnston G, Lummis S, Lummis S; University of Sydney/International Visiting Research Fellowship (IVRF).

2007

  • An investigation into the cellular mechanisms that cause asthma exacerbations during a common cold; Hinton T, Wark P, Wark P, McParland B, Johnston G, Oliver B, Reddel H; Asthma Foundation of NSW/Neil and Norma Hill Foundation Award.

2006

  • GABA modulators for the treatment of anxiety, epilepsy and insomnia; Johnston G, Hanrahan J, Collins M, Mewett K; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser; Lay P, Kable S, Downard K, Johnston G, Hanrahan J, Fisher K, Maschmeyer T, Karuso P, Gore D, McLeod M, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2005

  • Cage compounds as blockers of GABA and glycine receptor channels; Moorhouse A, Johnston G, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • The Roboocyte™: A Medium-throughput Secondary Functional Screening Facility.; Collins M, McLeod M, Jamie J, Johnston G; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2003

  • Constrained analogs of Gabapentin and Pregabalin; Collins M, O'Connor S, Hanrahan J, Johnston G; Pfizer Pty Ltd/Research Grants.
  • GABA receptor modulation by flavonoids; Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • The pharmacology and physiology of GABA-C receptors; Collins M, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Synthesis, testing and development of GABA-C antagonists, including cyclopentene phosphinates; Johnston G, Kaufman G, Serry L, Sharp S, Hanrahan J, Collins M; Polychip Pharmaceuticals Pty.Ltd./BLO Project.
  • Cage compounds, GABA and glycine receptors; Johnston G; DVC Research/Bridging Support Grant.
  • Cage compounds GABA and glycine receptors; Johnston G; University of Sydney/Medicine Bridging.

2001

  • Neurochemical pharmacology of synaptic transmission in the brain; Johnston G, Allan R; National Health and Medical Research Council (NHMRC)/Program, Unit, Centre, and Institute Grants.

2000

  • Flavonoids and GABA receptors; Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Modulation of glutamate transporters in the brain; Vandenberg R, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Novel GABA receptors in rat cerebellum, hippocampus, retina and spinal cord; Johnston G, Collins M, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Molecular biology and pharmacology of glutamate transporters in the brain; Vandenberg R, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Stress and GABA receptors - the role of steroids and phospholipids; Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.

1999

  • Molecular pharmacology of GABA-C receptor subtypes; Collins M, Johnston G, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Hanrahan, J., Johnston, G. (2009). Synthesis of -Aminobutyric Acid Analogs. In Hughes, A.B. (Eds.), Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids, (pp. 573-689). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]

Journals

  • Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Collins, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PLoS One, 9(1), 1-16. [More Information]
  • Hall, B., Karim, N., Chebib, M., Johnston, G., Hanrahan, J. (2014). Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone. Neurochemical Research, 39, 1068-1078. [More Information]
  • Johnston, G. (2013). Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology, 169(2), 328-336. [More Information]
  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Collins, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. A C S Medicinal Chemistry Letters, 4(4), 402-407. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Collins, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Collins, M., Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry, 56(13), 5626-5630. [More Information]
  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Collins, M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information]
  • Thompson, A., McGonigle, I., Duke, R., Johnston, G., Lummis, S. (2012). A single amino acid determines the toxicity of Ginkgo biloba extracts. The FASEB Journal, 26(5), 1884-1891. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Fernandez, S., Karim, N., Mewett, K., Collins, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Collins, M., Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the ginkgolides at recombinant human r1 GABAc receptors. Neuropharmacology, 63(6), 1127-1139. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]
  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Collins, M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983. [More Information]
  • Yamamoto, I., Deniau, G., Gavande, N., Collins, M., Johnston, G., O'Hagan, D. (2011). Agonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical Communications, 47(28), 7956-7958. [More Information]
  • Hanrahan, J., Collins, M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245. [More Information]
  • Thompson, A., Jarvis, G., Duke, R., Johnston, G., Lummis, S. (2011). Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology, 60, 488-495. [More Information]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Collins, M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Collins, M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. A C S Medicinal Chemistry Letters, 2(1), 11-16. [More Information]
  • Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136. [More Information]
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]
  • Skilbeck, K., Johnston, G., Hinton, T. (2010). Stress and GABA(A) Receptors. Journal of Neurochemistry, 112(5), 1115-1130. [More Information]
  • Locock, K., Johnston, G., Allan, R. (2009). GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid. Neurochemical Research, 34(10), 1698-1703. [More Information]
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Collins, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Collins, M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875. [More Information]
  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Collins, M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327. [More Information]
  • Hinton, T., Collins, M., Johnston, G. (2008). Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 18(1), 402-404. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Kumar, R., Collins, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840. [More Information]
  • Carland, J., Johnston, G., Collins, M. (2008). Relative impact of residues at the intracellular and extracellular ends of the human GABA(C) rho1 receptor M2 domain on picrotoxinin activity. European Journal of Pharmacology, 580(1), 27-35. [More Information]
  • Skilbeck, K., Hinton, T., Johnston, G. (2008). Sex-differences and stress: effects on regional high and low affinity [3H]GABA binding. Neurochemistry International, 52(6), 1212-1219. [More Information]
  • Hinton, T., Johnston, G. (2008). The role of GABA-A receptors in schizophrenia. Cell Science Reviews, 5, 180-194.
  • Collins, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2007). Antipsychotic drug administration differentially affects [(3)H]muscimol and [(3)H]flunitrazepam GABA(A) receptor binding sites. Progress in Neuro-Psychopharmacology and Biological Psychiatry, , 1-7. [More Information]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2007). The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined. Schizophrenia Research, 90(39508), 76-80. [More Information]
  • Fernandez, S., Wasowski, C., Loscalzo, L., Granger, R., Johnston, G., Paladini, A., Marder, M. (2006). Central nervous system depressant action of flavonoid glycosides. European Journal of Pharmacology, 539(3), 168-176. [More Information]
  • Hanrahan, J., Mewett, K., Collins, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Johnston, G., Jordan, M., Collins, M. (2006). Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2006). Mixed antagonistic effects of bilobalide at rho(1) GABA(C) receptor. Neuroscience, 137(2), 607-617. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.
  • Granger, R., Campbell, E., Johnston, G. (2005). (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. Biochemical Pharmacology, 69(7), 1101-1111. [More Information]
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104. [More Information]
  • Johnston, G. (2005). GABA(A) receptor channel pharmacology. Current Pharmaceutical Design, 11(15), 1867-1885. [More Information]
  • Schleimer, S., Johnston, G., Henderson, J. (2005). Novel oral drug administration in an animal model of neuroleptic therapy. Journal of Neuroscience Methods, 146(2), 159-164. [More Information]
  • Gibbs, M., Johnston, G. (2005). Opposing roles for GABAA and GABAC receptors in short-term memory formation in young chicks. Neuroscience, 131(3), 567-576. [More Information]
  • Carland, J., Moorhouse, A., Barry, P., Johnston, G., Collins, M. (2004). Charged Residues At The 2' Position Of Human GABAc ρ1 Receptors Invert Ion Selectivity And Influence Open State Probability. Journal of Biological Chemistry, 279(52), 54153-54160.
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8. [More Information]
  • Schleimer, S., Hinton, T., Dixon, G., Johnston, G. (2004). Gaba Transporters Gat-1 And Gat-3 In The Human Dorsolateral Prefrontal Cortex In Schizophrenia. Neuropsychobiology, 50(3), 226-230.
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Ginkgo Biloba, As Antagonists At Recombinant Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of Pharmacology, 494(2-3), 131-138. [More Information]
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Duke, R., Collins, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751.
  • Campbell, E., Collins, M., Johnston, G. (2004). The Dietary Flavonoids Apigenin And (-)-Epigallocatechin Gallate Enhance The Positive Modulation By Diazepam Of The Activation By GABA Of Recombinant GABA(A) Receptors. Biochemical Pharmacology, 68(8), 1631-1638. [More Information]
  • Granger, R., Campbell, E., Johnston, G. (2004). Valerian Monoterpenes Produce Unprecedented Enhancement Of GABA Action At GABA-A Receptors. Journal of Neurochemistry, 88(S1), 79-79.
  • Krehan, D., Frølund, B., Ebert, B., Nielsen, B., Krogsgaard-Larsen, P., Johnston, G., Collins, M. (2003). Aza-THIP and related analogues of THIP as GABAc antagonists. Bioorganic and Medicinal Chemistry, 11(23), 4891-4896. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA receptors. European Journal of Pharmacology, 464(1), 1-8.
  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Johnston, G. (2003). Dietary chemicals and brain function. Royal Society of New South Wales. Journal and Proceedings, 135, 57-71.
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Krehan, D., Frølund, B., Krogsgaard-Larsen, P., Kehler, J., Johnston, G., Collins, M. (2003). Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAc receptor antagonists. Neurochemistry International, 42(7), 561-565.
  • Hanrahan, J., Collins, M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 13(14), 2281-2284.
  • Duke, R., Collins, M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Johnston, G. (2002). Medicinal chemistry and molecular pharmacology of GABAc receptors. Current Topics in Medicinal Chemistry, 2(8), 903-913.
  • Topliss, J., Clark, A., Ernst, E., Hufford, C., Johnston, G., Rimoldi, J., Weimann, B. (2002). Natural and synthetic substances related to human health. Pure and Applied Chemistry, 74(10), 1957-1985.
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Collins, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889.
  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Hanrahan, J., Mewett, K., Collins, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.
  • Farrar, N., Chambers, N., Carlsson, A., Denyer, G., Johnston, G. (2001). Effect of a series of novel sulphonylthioureas on glucose tolerance in the obese fa/fa Zucker rat. Clinical and Experimental Pharmacology and Physiology, 28, 386-391.
  • Collins, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192.

Conferences

  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2006). Antipsychotic drug effects on GABA(A) receptors. Australasian Schizophrenia Conference 2006, United Kingdom: Taylor & Francis.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Bilobalide, from Ginkgo biloba, and enhancement of wild type alpha-1 beta-2gamma-2l GABAa receptors by diazepam, pentobarbitone and a steroid. 3rd College of Health Sciences Research Conference, Sydney: University of Sydney.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Effects of bilobalide and the sesquiterpene of Ginkgo bilobaon GABA-mediated currents modulated by GABAa modulators. 20th International Australasian Winter Conference on Brain Research.
  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha-1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. Australian Health and Meldical Research Conference.
  • Campbell, E., Duke, R., Johnston, G., Granger, R. (2002). Valerian and GABA receptors. Australian Health and Medical Research Congress.

Patents

  • Collins, M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Collins, M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Collins, M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.

2014

  • Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Collins, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PLoS One, 9(1), 1-16. [More Information]
  • Hall, B., Karim, N., Chebib, M., Johnston, G., Hanrahan, J. (2014). Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone. Neurochemical Research, 39, 1068-1078. [More Information]

2013

  • Johnston, G. (2013). Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology, 169(2), 328-336. [More Information]
  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Collins, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. A C S Medicinal Chemistry Letters, 4(4), 402-407. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Collins, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Collins, M., Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry, 56(13), 5626-5630. [More Information]

2012

  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Collins, M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information]
  • Thompson, A., McGonigle, I., Duke, R., Johnston, G., Lummis, S. (2012). A single amino acid determines the toxicity of Ginkgo biloba extracts. The FASEB Journal, 26(5), 1884-1891. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Fernandez, S., Karim, N., Mewett, K., Collins, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Collins, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Collins, M., Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the ginkgolides at recombinant human r1 GABAc receptors. Neuropharmacology, 63(6), 1127-1139. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Collins, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]

2011

  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Collins, M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983. [More Information]
  • Yamamoto, I., Deniau, G., Gavande, N., Collins, M., Johnston, G., O'Hagan, D. (2011). Agonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical Communications, 47(28), 7956-7958. [More Information]
  • Hanrahan, J., Collins, M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245. [More Information]
  • Thompson, A., Jarvis, G., Duke, R., Johnston, G., Lummis, S. (2011). Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology, 60, 488-495. [More Information]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Collins, M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Collins, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Collins, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Collins, M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. A C S Medicinal Chemistry Letters, 2(1), 11-16. [More Information]

2010

  • Gavande, N., Johnston, G., Hanrahan, J., Collins, M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136. [More Information]
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]
  • Skilbeck, K., Johnston, G., Hinton, T. (2010). Stress and GABA(A) Receptors. Journal of Neurochemistry, 112(5), 1115-1130. [More Information]

2009

  • Locock, K., Johnston, G., Allan, R. (2009). GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid. Neurochemical Research, 34(10), 1698-1703. [More Information]
  • Collins, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Collins, M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Collins, M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Collins, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Collins, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Hanrahan, J., Johnston, G. (2009). Synthesis of -Aminobutyric Acid Analogs. In Hughes, A.B. (Eds.), Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids, (pp. 573-689). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Collins, M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875. [More Information]

2008

  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Collins, M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327. [More Information]
  • Hinton, T., Collins, M., Johnston, G. (2008). Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 18(1), 402-404. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Collins, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Kumar, R., Collins, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840. [More Information]
  • Carland, J., Johnston, G., Collins, M. (2008). Relative impact of residues at the intracellular and extracellular ends of the human GABA(C) rho1 receptor M2 domain on picrotoxinin activity. European Journal of Pharmacology, 580(1), 27-35. [More Information]
  • Skilbeck, K., Hinton, T., Johnston, G. (2008). Sex-differences and stress: effects on regional high and low affinity [3H]GABA binding. Neurochemistry International, 52(6), 1212-1219. [More Information]
  • Hinton, T., Johnston, G. (2008). The role of GABA-A receptors in schizophrenia. Cell Science Reviews, 5, 180-194.

2007

  • Collins, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2007). Antipsychotic drug administration differentially affects [(3)H]muscimol and [(3)H]flunitrazepam GABA(A) receptor binding sites. Progress in Neuro-Psychopharmacology and Biological Psychiatry, , 1-7. [More Information]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2007). The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined. Schizophrenia Research, 90(39508), 76-80. [More Information]

2006

  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2006). Antipsychotic drug effects on GABA(A) receptors. Australasian Schizophrenia Conference 2006, United Kingdom: Taylor & Francis.
  • Fernandez, S., Wasowski, C., Loscalzo, L., Granger, R., Johnston, G., Paladini, A., Marder, M. (2006). Central nervous system depressant action of flavonoid glycosides. European Journal of Pharmacology, 539(3), 168-176. [More Information]
  • Hanrahan, J., Mewett, K., Collins, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Johnston, G., Jordan, M., Collins, M. (2006). Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2006). Mixed antagonistic effects of bilobalide at rho(1) GABA(C) receptor. Neuroscience, 137(2), 607-617. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press Elsevier. [More Information]
  • Johnston, G., Hanrahan, J., Collins, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316.

2005

  • Granger, R., Campbell, E., Johnston, G. (2005). (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. Biochemical Pharmacology, 69(7), 1101-1111. [More Information]
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104. [More Information]
  • Johnston, G. (2005). GABA(A) receptor channel pharmacology. Current Pharmaceutical Design, 11(15), 1867-1885. [More Information]
  • Collins, M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.
  • Schleimer, S., Johnston, G., Henderson, J. (2005). Novel oral drug administration in an animal model of neuroleptic therapy. Journal of Neuroscience Methods, 146(2), 159-164. [More Information]
  • Gibbs, M., Johnston, G. (2005). Opposing roles for GABAA and GABAC receptors in short-term memory formation in young chicks. Neuroscience, 131(3), 567-576. [More Information]

2004

  • Carland, J., Moorhouse, A., Barry, P., Johnston, G., Collins, M. (2004). Charged Residues At The 2' Position Of Human GABAc ρ1 Receptors Invert Ion Selectivity And Influence Open State Probability. Journal of Biological Chemistry, 279(52), 54153-54160.
  • Hall, B., Collins, M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8. [More Information]
  • Schleimer, S., Hinton, T., Dixon, G., Johnston, G. (2004). Gaba Transporters Gat-1 And Gat-3 In The Human Dorsolateral Prefrontal Cortex In Schizophrenia. Neuropsychobiology, 50(3), 226-230.
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Ginkgo Biloba, As Antagonists At Recombinant Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of Pharmacology, 494(2-3), 131-138. [More Information]
  • Collins, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23.
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Collins, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781.
  • Duke, R., Collins, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751.
  • Campbell, E., Collins, M., Johnston, G. (2004). The Dietary Flavonoids Apigenin And (-)-Epigallocatechin Gallate Enhance The Positive Modulation By Diazepam Of The Activation By GABA Of Recombinant GABA(A) Receptors. Biochemical Pharmacology, 68(8), 1631-1638. [More Information]
  • Granger, R., Campbell, E., Johnston, G. (2004). Valerian Monoterpenes Produce Unprecedented Enhancement Of GABA Action At GABA-A Receptors. Journal of Neurochemistry, 88(S1), 79-79.

2003

  • Krehan, D., Frølund, B., Ebert, B., Nielsen, B., Krogsgaard-Larsen, P., Johnston, G., Collins, M. (2003). Aza-THIP and related analogues of THIP as GABAc antagonists. Bioorganic and Medicinal Chemistry, 11(23), 4891-4896. [More Information]
  • Huang, S., Duke, R., Collins, M., Sasaki, K., Wada, K., Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA receptors. European Journal of Pharmacology, 464(1), 1-8.
  • Collins, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64.
  • Johnston, G. (2003). Dietary chemicals and brain function. Royal Society of New South Wales. Journal and Proceedings, 135, 57-71.
  • Johnston, G., Collins, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Krehan, D., Frølund, B., Krogsgaard-Larsen, P., Kehler, J., Johnston, G., Collins, M. (2003). Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAc receptor antagonists. Neurochemistry International, 42(7), 561-565.
  • Hanrahan, J., Collins, M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 13(14), 2281-2284.

2002

  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Bilobalide, from Ginkgo biloba, and enhancement of wild type alpha-1 beta-2gamma-2l GABAa receptors by diazepam, pentobarbitone and a steroid. 3rd College of Health Sciences Research Conference, Sydney: University of Sydney.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Effects of bilobalide and the sesquiterpene of Ginkgo bilobaon GABA-mediated currents modulated by GABAa modulators. 20th International Australasian Winter Conference on Brain Research.
  • Campbell, E., Collins, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Duke, R., Collins, M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Huang, S., Duke, R., Collins, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha-1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. Australian Health and Meldical Research Conference.
  • Johnston, G. (2002). Medicinal chemistry and molecular pharmacology of GABAc receptors. Current Topics in Medicinal Chemistry, 2(8), 903-913.
  • Topliss, J., Clark, A., Ernst, E., Hufford, C., Johnston, G., Rimoldi, J., Weimann, B. (2002). Natural and synthetic substances related to human health. Pure and Applied Chemistry, 74(10), 1957-1985.
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Collins, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889.
  • Campbell, E., Duke, R., Johnston, G., Granger, R. (2002). Valerian and GABA receptors. Australian Health and Medical Research Congress.

2001

  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Hanrahan, J., Mewett, K., Collins, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392.
  • Farrar, N., Chambers, N., Carlsson, A., Denyer, G., Johnston, G. (2001). Effect of a series of novel sulphonylthioureas on glucose tolerance in the obese fa/fa Zucker rat. Clinical and Experimental Pharmacology and Physiology, 28, 386-391.
  • Collins, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192.

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