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Emeritus Professor Graham Johnston

AM, FTSE, FRACI, FRSN, BSc, PhD, DPharm
Emeritus Professor of Pharmacology &
Medicinal Chemistry
Pharmacology, School of Medical Sciences
Room 474, Biomedical Sciences Building G08

Telephone +61419018107

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Curriculum vitae Curriculum vitae

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Biographical details

More than 440 research publications mainly on the neurochemistry and neuropharmacology of amino acid neurotrnsmitters in the brain. These publications have been cited more than 27,000 times in Google Scholar as at January 2019 with an h-index of 81, i.e. 81 of my publications have been cited at least 80 times. I am grateful to my many excellent students and co-workers that have enabled me to participate in such studies.

Graduated from The University of Sydney in 1959 BSc with 1st Class Honours & the University Medal in Organic Chemistry. PhD in organic chemistry at The University of Cambridge graduating in 1964. After a postdoc at The University of California, Berkeley took up a position in 1965 at the John Curtin School of Medical Research at The Australian National University. After 15 very productive years at ANU, moved to The University of Sydney to take up the Chair of Pharmacology in 1980. Formally retired in 2011 to become an Emeritus Professor of Pharmacology and Medicinal Chemistry continuing research studies.

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Research interests

I study natural and synthetic chemicals that influence brain chemistry in relation to Alzheimer’s disease, anxiety, epilepsy, insomnia, memory disorders, myopia, schizophrenia and stress with particular emphasis of the inhibitory neurotransmitter GABA.

My other interests include expert witnessing, science history and gender equity in pharmacology.

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Current projects

Reviewing recently “GABA, the major inhibitory neurotransmitter” for Elsevier’s Research Manual I came to realise that acting as a neurotransmitter may not be the major role of GABA in the brain and elsewhere! Currently interested in food products enriched with GABA, such as GABA-enriched tea. Developing an interest in GABA and type 2 diabetes.

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Associations

Life Member of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT), of the Royal Australian Chemical Institute (RACI) and of the International Society for Neurochemistry (ISN).

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Awards and honours

Member of the Order of Australia, for services to bio organic chemistry and pharmacology, to scientific organisations and to science policy development.

Fellow of the Australia Academy of Technological Sciences and Engineering, the Royal Society of NSW, the Royal Australian Chemical Institute, and the International Union of Pure and Applied Chemistry.

Awarded an honorary degree of Doctor Pharmaciae from the University of Copenhagen.

Other awards have included the H.G. Smith Memorial Medal,for contributions to chemical science in Australia during the previous 10 years and the Leighton Memorial Medal, in recognition of eminent services to chemistry in Australia, by the Royal Australian Chemical Institute, the Inaugural Michael Rand Medal, awarded by The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists for outstanding contributions to the discipline of clinical and experimental pharmacology and toxicology, and the ANZAAS Medal, Australian and New Zealand Association for the Advancement of Science for contributions to science particularly in the area of science policy.

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Served 22 years as a Specialist Member of the Administrative Appeals Tribunal of the Commonwealth of Australia

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Selected grants

2013

  • Allosteric Targets on GABA-A Receptors; Hanrahan J, Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Bruker APEX II CCD Detector Fourth Generation APEX II ultra-low noise CCD X-ray detector with 16 megapixel chip; Hibbs D, Roufogalis B, Murray M, Hambley T, Hanrahan J, Church W, Collins M, Johnston G, Young P, Traini D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Novel blockers of the 5-HT3 receptor channel; Johnston G, Lummis S, Lummis S; University of Sydney/International Visiting Research Fellowship (IVRF).

2007

  • An investigation into the cellular mechanisms that cause asthma exacerbations during a common cold; Hinton T, Wark P, Wark P, McParland B, Johnston G, Oliver B, Reddel H; Asthma Foundation of NSW/Neil and Norma Hill Foundation Award.

2006

  • GABA modulators for the treatment of anxiety, epilepsy and insomnia; Johnston G, Hanrahan J, Collins M, Mewett K; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser; Lay P, Kable S, Downard K, Johnston G, Hanrahan J, Fisher K, Maschmeyer T, Karuso P, Gore D, McLeod M, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2005

  • Cage compounds as blockers of GABA and glycine receptor channels; Moorhouse A, Johnston G, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • The Roboocyte™: A Medium-throughput Secondary Functional Screening Facility.; Collins M, McLeod M, Jamie J, Johnston G; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2003

  • GABA receptor modulation by flavonoids; Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Constrained analogs of Gabapentin and Pregabalin; Collins M, O'Connor S, Hanrahan J, Johnston G; Pfizer Pty Ltd/Research Grants.

2002

  • Cage compounds GABA and glycine receptors; Johnston G; University of Sydney/Medicine Bridging.
  • The pharmacology and physiology of GABA-C receptors; Collins M, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Synthesis, testing and development of GABA-C antagonists, including cyclopentene phosphinates; Johnston G, Kaufman G, Serry L, Sharp S, Hanrahan J, Collins M; Polychip Pharmaceuticals Pty.Ltd./BLO Project.
  • Cage compounds, GABA and glycine receptors; Johnston G; DVC Research/Bridging Support Grant.

2001

  • Neurochemical pharmacology of synaptic transmission in the brain; Johnston G, Allan R; National Health and Medical Research Council (NHMRC)/Program, Unit, Centre, and Institute Grants.

2000

  • Novel GABA receptors in rat cerebellum, hippocampus, retina and spinal cord; Johnston G, Collins M, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Stress and GABA receptors - the role of steroids and phospholipids; Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Molecular biology and pharmacology of glutamate transporters in the brain; Vandenberg R, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Modulation of glutamate transporters in the brain; Vandenberg R, Johnston G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Flavonoids and GABA receptors; Johnston G, Collins M; National Health and Medical Research Council (NHMRC)/Project Grants.

1999

  • Molecular pharmacology of GABA-C receptor subtypes; Collins M, Johnston G, Duke R; National Health and Medical Research Council (NHMRC)/Project Grants.
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Selected publications

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Book Chapters

  • Hinton, T., Johnston, G. (2018). Antagonists of Ionotropic Receptors for the Inhibitory Neurotransmitter GABA: Therapeutic Indications. In Janko Samardzic (Eds.), GABA And Glutamate - New Developments In Neurotransmission Research, (pp. 91-105). Serbia: IntechOpen. [More Information]
  • Hinton, T., Johnston, G. (2018). GABA, The Major Inhibitory Neurotransmitter in the Brain. Reference Module in Biomedical Sciences. United States: Elsevier. [More Information]
  • Hinton, T., Hanrahan, J., Johnston, G. (2017). Flavonoid Actions on Receptors for the Inhibitory Neurotransmitter GABA. In Goncalo C Justino (Eds.), Flavonoids: From Biosynthesis to Human Health, (pp. 335-350). Rijeka: InTech. [More Information]
  • Hanrahan, J., Johnston, G. (2009). Synthesis of -Aminobutyric Acid Analogs. In Hughes, A.B. (Eds.), Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids, (pp. 573-689). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. [More Information]
  • Johnston, G., Hanrahan, J., Chebib, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press. [More Information]

Journals

  • Hinton, T., Jelinek, H., Viengkhou, V., Johnston, G., Matthews, S. (2019). Effect of GABA-Fortified Oolong Tea on Reducing Stress in a University Student Cohort. Frontiers in Nutrition, 6, 1-8. [More Information]
  • Solomon, V., Tallapragada, V., Chebib, M., Johnston, G., Hanrahan, J. (2019). GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators. European Journal of Medicinal Chemistry, 171, 434-461. [More Information]
  • Devenish, S., Johnston, G., Chebib, M., Hanrahan, J. (2019). Optimising the transient expression of GABA(A) receptors in adherent HEK293 cells. Protein Expression and Purification, 154, 7-15. [More Information]
  • Skilbeck, K., Johnston, G., Hinton, T. (2018). Long-lasting effects of early-life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering. Pharmacological Research, 128, 179-189. [More Information]
  • Johnston, G. (2017). Drug analogues and substantial similarity, views of an expert witness. Australian Journal of Forensic Sciences, 49(6), 626-636. [More Information]
  • Ng, C., Duke, R., Hinton, T., Johnston, G. (2017). Effects of bilobalide, ginkgolide B and picrotoxinin on GABAA receptor modulation by structurally diverse positive modulators. European Journal of Pharmacology, 806, 83-90. [More Information]
  • Johnston, G. (2017). GABA Australis, some reflections on the history of GABA receptor research in Australia. Pharmacological Research, 116, 32-38. [More Information]
  • Naffa'a, M., Hung, S., Chebib, M., Johnston, G., Hanrahan, J. (2017). GABA-(rho) receptors: distinctive functions and molecular pharmacology. British Journal of Pharmacology, 174(13), 1881-1894. [More Information]
  • Johnston, G. (2017). Some personal thoughts on the Australasian Society of Clinical and Experimental Pharmacologists in the 1980s. Pharmacological Research, 116, 3-6. [More Information]
  • Ng, C., Duke, R., Hinton, T., Johnston, G. (2016). GABAA receptor cysteinyl mutants and the ginkgo terpenoid lactones bilobalide and ginkgolides. European Journal of Pharmacology, 777, 136-146. [More Information]
  • Johnston, G. (2016). Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids. Neurochemical Research, 41(3), 476-480. [More Information]
  • Abdelhalim, A., Karim, N., Chebib, M., Aburjai, T., Khan, I., Johnston, G., Hanrahan, J. (2015). Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. Journal of Pharmacy and Pharmaceutical Sciences, 18(4), 448-459. [More Information]
  • Johnston, G. (2015). Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA. Neurochemistry International, 89, 120-125. [More Information]
  • Hanrahan, J., Chebib, M., Johnston, G. (2015). Interactions of flavonoids with ionotropic GABA receptors. Advances in Pharmacology, 72, 189-200. [More Information]
  • Rae, C., Nasrallah, F., Balcar, V., Rowlands, B., Johnston, G., Hanrahan, J. (2015). Metabolomic Approaches to Defining the Role(s) of GABAI Receptors in the Brain. Journal of Neuroimmune Pharmacology, 10(3), 45-456. [More Information]
  • Abdelhalim, A., Chebib, M., Aburjai, T., Johnston, G., Hanrahan, J. (2014). GABAA Receptor Modulation by Compounds Isolated from Salvia triloba L. Advances in Biological Chemistry, 4(2), 148-159. [More Information]
  • Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Chebib, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PloS One, 9(1), 1-16. [More Information]
  • Hall, B., Karim, N., Chebib, M., Johnston, G., Hanrahan, J. (2014). Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone. Neurochemical Research, 39, 1068-1078. [More Information]
  • Johnston, G. (2014). Muscimol as an Ionotropic GABA Receptor Agonist. Neurochemical Research, 39(10), 1942-1947. [More Information]
  • Johnston, G. (2013). Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology, 169(2), 328-336. [More Information]
  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Chebib, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. ACS Medicinal Chemistry Letters, 4(4), 402-407. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Chebib, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Chebib, M., Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry, 56(13), 5626-5630. [More Information]
  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Chebib, M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information]
  • Thompson, A., McGonigle, I., Duke, R., Johnston, G., Lummis, S. (2012). A single amino acid determines the toxicity of Ginkgo biloba extracts. The FASEB Journal, 26(5), 1884-1891. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Chebib, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Fernandez, S., Karim, N., Mewett, K., Chebib, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Chebib, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Chebib, M., Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the ginkgolides at recombinant human r1 GABAc receptors. Neuropharmacology, 63(6), 1127-1139. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Chebib, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]
  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Chebib, M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983. [More Information]
  • Yamamoto, I., Deniau, G., Gavande, N., Chebib, M., Johnston, G., O'Hagan, D. (2011). Agonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical Communications, 47(28), 7956-7958. [More Information]
  • Hanrahan, J., Chebib, M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245. [More Information]
  • Thompson, A., Jarvis, G., Duke, R., Johnston, G., Lummis, S. (2011). Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology, 60, 488-495. [More Information]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Chebib, M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Chebib, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Chebib, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Chebib, M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. ACS Medicinal Chemistry Letters, 2(1), 11-16. [More Information]
  • Gavande, N., Johnston, G., Hanrahan, J., Chebib, M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136. [More Information]
  • Johnston, G., Chebib, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]
  • Skilbeck, K., Johnston, G., Hinton, T. (2010). Stress and GABA(A) Receptors. Journal of Neurochemistry, 112(5), 1115-1130. [More Information]
  • Locock, K., Johnston, G., Allan, R. (2009). GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid. Neurochemical Research, 34(10), 1698-1703. [More Information]
  • Chebib, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Chebib, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Chebib, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Chebib, M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875. [More Information]
  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Chebib, M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327. [More Information]
  • Hinton, T., Chebib, M., Johnston, G. (2008). Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry Letters, 18(1), 402-404. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Chebib, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Kumar, R., Chebib, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840. [More Information]
  • Carland, J., Johnston, G., Chebib, M. (2008). Relative impact of residues at the intracellular and extracellular ends of the human GABA(C) rho1 receptor M2 domain on picrotoxinin activity. European Journal of Pharmacology, 580(1), 27-35. [More Information]
  • Skilbeck, K., Hinton, T., Johnston, G. (2008). Sex-differences and stress: effects on regional high and low affinity [3H]GABA binding. Neurochemistry International, 52(6), 1212-1219. [More Information]
  • Hinton, T., Johnston, G. (2008). The role of GABA-A receptors in schizophrenia. Cell Science Reviews, 5, 180-194.
  • Chebib, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2007). Antipsychotic drug administration differentially affects [(3)H]muscimol and [(3)H]flunitrazepam GABA(A) receptor binding sites. Progress in Neuro-Psychopharmacology and Biological Psychiatry, , 1-7. [More Information]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2007). The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined. Schizophrenia Research, 90(39508), 76-80. [More Information]
  • Fernandez, S., Wasowski, C., Loscalzo, L., Granger, R., Johnston, G., Paladini, A., Marder, M. (2006). Central nervous system depressant action of flavonoid glycosides. European Journal of Pharmacology, 539(3), 168-176. [More Information]
  • Hanrahan, J., Mewett, K., Chebib, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Johnston, G., Jordan, M., Chebib, M. (2006). Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Information]
  • Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., Johnston, G. (2006). Mixed antagonistic effects of bilobalide at rho(1) GABA(C) receptor. Neuroscience, 137(2), 607-617. [More Information]
  • Johnston, G., Hanrahan, J., Chebib, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316. [More Information]
  • Granger, R., Campbell, E., Johnston, G. (2005). (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. Biochemical Pharmacology, 69(7), 1101-1111. [More Information]
  • Hall, B., Chebib, M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104. [More Information]
  • Johnston, G. (2005). GABA(A) receptor channel pharmacology. Current Pharmaceutical Design, 11(15), 1867-1885. [More Information]
  • Schleimer, S., Johnston, G., Henderson, J. (2005). Novel oral drug administration in an animal model of neuroleptic therapy. Journal of Neuroscience Methods, 146(2), 159-164. [More Information]
  • Gibbs, M., Johnston, G. (2005). Opposing roles for GABAA and GABAC receptors in short-term memory formation in young chicks. Neuroscience, 131(3), 567-576. [More Information]
  • Carland, J., Moorhouse, A., Barry, P., Johnston, G., Chebib, M. (2004). Charged Residues At The 2' Position Of Human GABAc �?1 Receptors Invert Ion Selectivity And Influence Open State Probability. Journal of Biological Chemistry, 279(52), 54153-54160. [More Information]
  • Hall, B., Chebib, M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8. [More Information]
  • Schleimer, S., Hinton, T., Dixon, G., Johnston, G. (2004). Gaba Transporters Gat-1 And Gat-3 In The Human Dorsolateral Prefrontal Cortex In Schizophrenia. Neuropsychobiology, 50(3), 226-230. [More Information]
  • Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Ginkgo Biloba, As Antagonists At Recombinant Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of Pharmacology, 494(2-3), 131-138. [More Information]
  • Chebib, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23. [More Information]
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Chebib, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781. [More Information]
  • Duke, R., Chebib, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751. [More Information]
  • Campbell, E., Chebib, M., Johnston, G. (2004). The Dietary Flavonoids Apigenin And (-)-Epigallocatechin Gallate Enhance The Positive Modulation By Diazepam Of The Activation By GABA Of Recombinant GABA(A) Receptors. Biochemical Pharmacology, 68(8), 1631-1638. [More Information]
  • Granger, R., Campbell, E., Johnston, G. (2004). Valerian Monoterpenes Produce Unprecedented Enhancement Of GABA Action At GABA-A Receptors. Journal of Neurochemistry, 88(S1), 79-79.
  • Krehan, D., Frølund, B., Ebert, B., Nielsen, B., Krogsgaard-Larsen, P., Johnston, G., Chebib, M. (2003). Aza-THIP and related analogues of THIP as GABAc antagonists. Bioorganic and Medicinal Chemistry, 11(23), 4891-4896. [More Information]
  • Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA receptors. European Journal of Pharmacology, 464(1), 1-8. [More Information]
  • Chebib, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64. [More Information]
  • Johnston, G. (2003). Dietary chemicals and brain function. Journal and Proceedings of the Royal Society of New South Wales, 135, 57-71.
  • Johnston, G., Chebib, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Krehan, D., Frølund, B., Krogsgaard-Larsen, P., Kehler, J., Johnston, G., Chebib, M. (2003). Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAc receptor antagonists. Neurochemistry International, 42(7), 561-565. [More Information]
  • Hanrahan, J., Chebib, M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters, 13(14), 2281-2284. [More Information]
  • Duke, R., Chebib, M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Johnston, G. (2002). Medicinal chemistry and molecular pharmacology of GABAc receptors. Current Topics in Medicinal Chemistry, 2(8), 903-913. [More Information]
  • Topliss, J., Clark, A., Ernst, E., Hufford, C., Johnston, G., Rimoldi, J., Weimann, B. (2002). Natural and synthetic substances related to human health. Pure and Applied Chemistry, 74(10), 1957-1985. [More Information]
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Chebib, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889. [More Information]
  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Hanrahan, J., Mewett, K., Chebib, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392. [More Information]
  • Farrar, N., Chambers, N., Carlsson, A., Denyer, G., Johnston, G. (2001). Effect of a series of novel sulphonylthioureas on glucose tolerance in the obese fa/fa Zucker rat. Clinical and Experimental Pharmacology and Physiology, 28, 386-391. [More Information]
  • Chebib, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192. [More Information]

Conferences

  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2006). Antipsychotic drug effects on GABA(A) receptors. Australasian Schizophrenia Conference 2006, United Kingdom: Taylor & Francis.
  • Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Wada, K. (2002). Bilobalide, from Ginkgo biloba, and enhancement of wild type alpha-1 beta-2gamma-2l GABAa receptors by diazepam, pentobarbitone and a steroid. 3rd College of Health Sciences Research Conference, Sydney: University of Sydney.
  • Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Wada, K. (2002). Effects of bilobalide and the sesquiterpene of Ginkgo bilobaon GABA-mediated currents modulated by GABAa modulators. 20th International Australasian Winter Conference on Brain Research.
  • Campbell, E., Chebib, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha-1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. Australian Health and Meldical Research Conference.
  • Campbell, E., Duke, R., Johnston, G., Granger, R. (2002). Valerian and GABA receptors. Australian Health and Medical Research Congress.

Patents

  • Chebib, M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Chebib, M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Chebib, M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.

2019

  • Hinton, T., Jelinek, H., Viengkhou, V., Johnston, G., Matthews, S. (2019). Effect of GABA-Fortified Oolong Tea on Reducing Stress in a University Student Cohort. Frontiers in Nutrition, 6, 1-8. [More Information]
  • Solomon, V., Tallapragada, V., Chebib, M., Johnston, G., Hanrahan, J. (2019). GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators. European Journal of Medicinal Chemistry, 171, 434-461. [More Information]
  • Devenish, S., Johnston, G., Chebib, M., Hanrahan, J. (2019). Optimising the transient expression of GABA(A) receptors in adherent HEK293 cells. Protein Expression and Purification, 154, 7-15. [More Information]

2018

  • Hinton, T., Johnston, G. (2018). Antagonists of Ionotropic Receptors for the Inhibitory Neurotransmitter GABA: Therapeutic Indications. In Janko Samardzic (Eds.), GABA And Glutamate - New Developments In Neurotransmission Research, (pp. 91-105). Serbia: IntechOpen. [More Information]
  • Hinton, T., Johnston, G. (2018). GABA, The Major Inhibitory Neurotransmitter in the Brain. Reference Module in Biomedical Sciences. United States: Elsevier. [More Information]
  • Skilbeck, K., Johnston, G., Hinton, T. (2018). Long-lasting effects of early-life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering. Pharmacological Research, 128, 179-189. [More Information]

2017

  • Johnston, G. (2017). Drug analogues and substantial similarity, views of an expert witness. Australian Journal of Forensic Sciences, 49(6), 626-636. [More Information]
  • Ng, C., Duke, R., Hinton, T., Johnston, G. (2017). Effects of bilobalide, ginkgolide B and picrotoxinin on GABAA receptor modulation by structurally diverse positive modulators. European Journal of Pharmacology, 806, 83-90. [More Information]
  • Hinton, T., Hanrahan, J., Johnston, G. (2017). Flavonoid Actions on Receptors for the Inhibitory Neurotransmitter GABA. In Goncalo C Justino (Eds.), Flavonoids: From Biosynthesis to Human Health, (pp. 335-350). Rijeka: InTech. [More Information]
  • Johnston, G. (2017). GABA Australis, some reflections on the history of GABA receptor research in Australia. Pharmacological Research, 116, 32-38. [More Information]
  • Naffa'a, M., Hung, S., Chebib, M., Johnston, G., Hanrahan, J. (2017). GABA-(rho) receptors: distinctive functions and molecular pharmacology. British Journal of Pharmacology, 174(13), 1881-1894. [More Information]
  • Johnston, G. (2017). Some personal thoughts on the Australasian Society of Clinical and Experimental Pharmacologists in the 1980s. Pharmacological Research, 116, 3-6. [More Information]

2016

  • Ng, C., Duke, R., Hinton, T., Johnston, G. (2016). GABAA receptor cysteinyl mutants and the ginkgo terpenoid lactones bilobalide and ginkgolides. European Journal of Pharmacology, 777, 136-146. [More Information]
  • Johnston, G. (2016). Unsaturated Analogues of the Neurotransmitter GABA: trans-4-Aminocrotonic, cis-4-Aminocrotonic and 4-Aminotetrolic Acids. Neurochemical Research, 41(3), 476-480. [More Information]

2015

  • Abdelhalim, A., Karim, N., Chebib, M., Aburjai, T., Khan, I., Johnston, G., Hanrahan, J. (2015). Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis. Journal of Pharmacy and Pharmaceutical Sciences, 18(4), 448-459. [More Information]
  • Johnston, G. (2015). Flavonoid nutraceuticals and ionotropic receptors for the inhibitory neurotransmitter GABA. Neurochemistry International, 89, 120-125. [More Information]
  • Hanrahan, J., Chebib, M., Johnston, G. (2015). Interactions of flavonoids with ionotropic GABA receptors. Advances in Pharmacology, 72, 189-200. [More Information]
  • Rae, C., Nasrallah, F., Balcar, V., Rowlands, B., Johnston, G., Hanrahan, J. (2015). Metabolomic Approaches to Defining the Role(s) of GABAI Receptors in the Brain. Journal of Neuroimmune Pharmacology, 10(3), 45-456. [More Information]

2014

  • Abdelhalim, A., Chebib, M., Aburjai, T., Johnston, G., Hanrahan, J. (2014). GABAA Receptor Modulation by Compounds Isolated from Salvia triloba L. Advances in Biological Chemistry, 4(2), 148-159. [More Information]
  • Blednov, Y., Benavidez, J., Black, M., Leiter, C., Osterndoff-Kahanek, E., Johnson, D., Borghese, C., Hanrahan, J., Johnston, G., Chebib, M., et al (2014). GABAA Receptors Containing p1 Subunits Contribute to In Vivo Effects of Ethanol in Mice. PloS One, 9(1), 1-16. [More Information]
  • Hall, B., Karim, N., Chebib, M., Johnston, G., Hanrahan, J. (2014). Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone. Neurochemical Research, 39, 1068-1078. [More Information]
  • Johnston, G. (2014). Muscimol as an Ionotropic GABA Receptor Agonist. Neurochemical Research, 39(10), 1942-1947. [More Information]

2013

  • Johnston, G. (2013). Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology, 169(2), 328-336. [More Information]
  • Gavande, N., Kim, H., Doddareddy, M., Johnston, G., Chebib, M., Hanrahan, J. (2013). Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of P1 GABA(c) receptors. ACS Medicinal Chemistry Letters, 4(4), 402-407. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Johnston, G., Hanrahan, J., Chebib, M. (2013). Potency of gaba at human recombinant gaba alpha receptors expressed in xenopus oocytes: a mini review. Amino Acids, 44(4), 1139-1149. [More Information]
  • Locock, K., Yamamoto, I., Tran, P., Hanrahan, J., Chebib, M., Johnston, G., Allan, R. (2013). γ-Aminobutyric Acid(C) (GABAC) Selective Antagonists Derived from the Bioisosteric Modification of 4-Aminocyclopent-1-enecarboxylic Acid: Amides and Hydroxamates. Journal of Medicinal Chemistry, 56(13), 5626-5630. [More Information]

2012

  • Karim, N., Curmi, J., Gavande, N., Johnston, G., Hanrahan, J., Tierney, L., Chebib, M. (2012). 2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors. British Journal of Pharmacology, 165(4), 880-896. [More Information]
  • Thompson, A., McGonigle, I., Duke, R., Johnston, G., Lummis, S. (2012). A single amino acid determines the toxicity of Ginkgo biloba extracts. The FASEB Journal, 26(5), 1884-1891. [More Information]
  • Yamamoto, I., Absalom, N., Carland, J., Doddareddy, M., Gavande, N., Johnston, G., Hanrahan, J., Chebib, M. (2012). Differentiating Enantioselective Actions of GABOB: A Possible Role for Threonine 244 in the Binding Site of GABAC rho1 Receptors. ACS Chemical Neuroscience, 3(9), 665-673. [More Information]
  • Fernandez, S., Karim, N., Mewett, K., Chebib, M., Johnston, G., Hanrahan, J. (2012). Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors. British Journal of Pharmacology, 165(4), 965-977. [More Information]
  • Karim, N., Wellendorph, P., Absalom, N., Bang, L., Jensen, M., Hansen, M., Lee, H., Johnston, G., Hanrahan, J., Chebib, M. (2012). Low nanomolar GABA effects at extrasynaptic a4b1/b3d GABAA receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology, 84(4), 549-557. [More Information]
  • Huang, S., Lewis, T., Lummis, S., Thompson, A., Chebib, M., Johnston, G., Duke, R. (2012). Mixed antagonistic effects of the ginkgolides at recombinant human r1 GABAc receptors. Neuropharmacology, 63(6), 1127-1139. [More Information]
  • Yamamoto, I., Carland, J., Locock, K., Gavande, N., Absalom, N., Hanrahan, J., Allan, R., Johnston, G., Chebib, M. (2012). Structurally Diverse GABA Antagonists Interact Differently with Open and Closed Conformational States of the p1 Receptor. ACS Chemical Neuroscience, 3(4), 293-301. [More Information]

2011

  • Karim, N., Gavande, N., Wellendorph, P., Johnston, G., Hanrahan, J., Chebib, M. (2011). 3-Hydroxy-2'-methoxy-6-methylflavone: A potent anxiolytic with a unique selectivity profile at GABBA receptor subtypes. Biochemical Pharmacology, 82(12), 1971-1983. [More Information]
  • Yamamoto, I., Deniau, G., Gavande, N., Chebib, M., Johnston, G., O'Hagan, D. (2011). Agonist responses of (R)- and (S)-3-fluoro-??-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABA(C) receptors. Chemical Communications, 47(28), 7956-7958. [More Information]
  • Hanrahan, J., Chebib, M., Johnston, G. (2011). Flavonoid modulation of GABA(A) receptors. British Journal of Pharmacology, 163(2), 234-245. [More Information]
  • Thompson, A., Jarvis, G., Duke, R., Johnston, G., Lummis, S. (2011). Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site. Neuropharmacology, 60, 488-495. [More Information]
  • Gavande, N., Karim, N., Johnston, G., Hanrahan, J., Chebib, M. (2011). Identification of Benzopyran-4-one Derivatives (Isoflavones) as Positive Modulators of GABAA Receptors. ChemMedChem: chemistry enabling drug discovery, 6(8), 1340-1346. [More Information]
  • Ng, C., Kim, H., Gavande, N., Yamamoto, I., Kumar, R., Mewett, K., Johnston, G., Hanrahan, J., Chebib, M. (2011). Medicinal Chemistry of p GABAc Receptors. Future Medicinal Chemistry, 3(2), 197-209. [More Information]
  • Yow, T., Pera, E., Absalom, N., Heblinski, M., Johnston, G., Hanrahan, J., Chebib, M. (2011). Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. British Journal of Pharmacology, 163(5), 1017-1033. [More Information]
  • Gavande, N., Yamamoto, I., Salam, N., Tu-Hoa, A., Burden, P., Johnston, G., Hanrahan, J., Chebib, M. (2011). Novel Cyclic Phosphinic Acids as GABAC F Receptor Antagonists: Design, Synthesis, and Pharmacology. ACS Medicinal Chemistry Letters, 2(1), 11-16. [More Information]

2010

  • Gavande, N., Johnston, G., Hanrahan, J., Chebib, M. (2010). Microwave-enhanced synthesis of 2,3,6-trisubstituted pyridazines: Application to four-step synthesis of gabazine (SR-95531). Organic and Biomolecular Chemistry, 8(18), 4131-4136. [More Information]
  • Johnston, G., Chebib, M., Hanrahan, J., Mewett, K. (2010). Neurochemicals for the Investigation of GABAc Receptors. Neurochemical Research, 35(12), 1970-1977. [More Information]
  • Skilbeck, K., Johnston, G., Hinton, T. (2010). Stress and GABA(A) Receptors. Journal of Neurochemistry, 112(5), 1115-1130. [More Information]

2009

  • Locock, K., Johnston, G., Allan, R. (2009). GABA Analogues Derived from 4-Aminocyclopent-1-enecarboxylic Acid. Neurochemical Research, 34(10), 1698-1703. [More Information]
  • Chebib, M., Gavande, N., Wong, K., Park, A., Premoli, I., Mewett, K., Allan, R., Duke, R., Johnston, G., Hanrahan, J. (2009). Guanidino Acids Act as p1 GABAc Receptor Antagonists. Neurochemical Research, 34(10), 1704-1711. [More Information]
  • Chebib, M., Hanrahan, J., Johnston, G. (2009). Neurologically-active Compounds (II). Patent No. 2002364767.
  • Hanrahan, J., Johnston, G., Kumar, R., Chebib, M. (2009). Neurologically-active Compounds (III). Patent No. 1773740.
  • Chebib, M., Hinton, T., Schmid, K., Brinkworth, D., Qian, H., Matos, S., Kim, H., Abdel-Halim, H., Kumar, R., Johnston, G., Hanrahan, J. (2009). Novel, potent and selective GABAC antagonists inhibit myopia development and facilitate learning and memory. Journal of Pharmacology and Experimental Therapeutics, 328(2), 448-457. [More Information]
  • Mewett, K., Fernandez, S., Pasricha, A., Pong, A., Devenish, S., Hibbs, D., Chebib, M., Johnston, G., Hanrahan, J. (2009). Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors. Bioorganic and Medicinal Chemistry, 17(20), 7156-7173. [More Information]
  • Hanrahan, J., Johnston, G. (2009). Synthesis of -Aminobutyric Acid Analogs. In Hughes, A.B. (Eds.), Amino Acids, Peptides and Proteins in Organic Chemistry Volume 1 Origins and Synthesis of Amino Acids, (pp. 573-689). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. [More Information]
  • Fernandez, S., Nguyen, M., Yow, T., Chu, C., Johnston, G., Hanrahan, J., Chebib, M. (2009). The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. Neurochemical Research, 34(10), 1867-1875. [More Information]

2008

  • Abdel-Halim, H., Hanrahan, J., Hibbs, D., Johnston, G., Chebib, M. (2008). A molecular basis for agonist and antagonist actions at GABA(C) receptors. Chemical Biology and Drug Design (Print), 71(4), 306-327. [More Information]
  • Hinton, T., Chebib, M., Johnston, G. (2008). Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry Letters, 18(1), 402-404. [More Information]
  • Fernandez, S., Mewett, K., Hanrahan, J., Chebib, M., Johnston, G. (2008). Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice. Neuropharmacology, 55(5), 900-907. [More Information]
  • Kumar, R., Chebib, M., Hibbs, D., Kim, H., Johnston, G., Salam, N., Hanrahan, J. (2008). Novel gamma-aminobutyric acid rho(1) receptor antagonists; Synthesis, pharmacological activity and structure-activity relationships. Journal of Medicinal Chemistry, 51(13), 3825-3840. [More Information]
  • Carland, J., Johnston, G., Chebib, M. (2008). Relative impact of residues at the intracellular and extracellular ends of the human GABA(C) rho1 receptor M2 domain on picrotoxinin activity. European Journal of Pharmacology, 580(1), 27-35. [More Information]
  • Skilbeck, K., Hinton, T., Johnston, G. (2008). Sex-differences and stress: effects on regional high and low affinity [3H]GABA binding. Neurochemistry International, 52(6), 1212-1219. [More Information]
  • Hinton, T., Johnston, G. (2008). The role of GABA-A receptors in schizophrenia. Cell Science Reviews, 5, 180-194.

2007

  • Chebib, M., Hanrahan, J., Kumar, R., Mewett, K., Morriss, G., Wooller, S., Johnston, G. (2007). (3-Aminocyclopentyl)methylphosphinic acids: Novel GABA(C) receptor antagonists. Neuropharmacology, 52(3), 779-787. [More Information]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2007). Antipsychotic drug administration differentially affects [(3)H]muscimol and [(3)H]flunitrazepam GABA(A) receptor binding sites. Progress in Neuro-Psychopharmacology and Biological Psychiatry, , 1-7. [More Information]
  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2007). The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined. Schizophrenia Research, 90(39508), 76-80. [More Information]

2006

  • Skilbeck, K., O'Reilly, J., Johnston, G., Hinton, T. (2006). Antipsychotic drug effects on GABA(A) receptors. Australasian Schizophrenia Conference 2006, United Kingdom: Taylor & Francis.
  • Fernandez, S., Wasowski, C., Loscalzo, L., Granger, R., Johnston, G., Paladini, A., Marder, M. (2006). Central nervous system depressant action of flavonoid glycosides. European Journal of Pharmacology, 539(3), 168-176. [More Information]
  • Hanrahan, J., Mewett, K., Chebib, M., Matos, S., Eliopoulos, C., Crean, C., Kumar, R., Burden, P., Johnston, G. (2006). Diastereoselective synthesis of (+/-)-(3-aminocyclopentane)alkylphosphinic acids, conformationally restricted analogues of GABA. Organic and Biomolecular Chemistry, 4(13), 2642-2649. [More Information]
  • Crittenden, D., Park, A., Qiu, J., Silverman, R., Duke, R., Johnston, G., Jordan, M., Chebib, M. (2006). Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors. Bioorganic and Medicinal Chemistry, 14(2), 447-455. [More Information]
  • Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., Johnston, G. (2006). Mixed antagonistic effects of bilobalide at rho(1) GABA(C) receptor. Neuroscience, 137(2), 607-617. [More Information]
  • Johnston, G., Hanrahan, J., Chebib, M., Duke, R., Mewett, K. (2006). Modulation of Ionotropic GABA Receptors by Natural Products of Plant Origin. In S.J. Enna (Eds.), GABA, (pp. 285-316). United States: Academic Press. [More Information]
  • Johnston, G., Hanrahan, J., Chebib, M., Duke, R., Mewett, K. (2006). Modulation of ionotropic GABA receptors by natural products of plant origin. Advances in Pharmacology, 54, 285-316. [More Information]

2005

  • Granger, R., Campbell, E., Johnston, G. (2005). (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinant alpha1beta2gamma2L GABA(A) receptors. Biochemical Pharmacology, 69(7), 1101-1111. [More Information]
  • Hall, B., Chebib, M., Hanrahan, J., Johnston, G. (2005). 6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytes. European Journal of Pharmacology, 512(2-3), 97-104. [More Information]
  • Johnston, G. (2005). GABA(A) receptor channel pharmacology. Current Pharmaceutical Design, 11(15), 1867-1885. [More Information]
  • Chebib, M., Hanrahan, J., Johnston, G., Kumar, R. (2005). Patent No. 6962907.
  • Schleimer, S., Johnston, G., Henderson, J. (2005). Novel oral drug administration in an animal model of neuroleptic therapy. Journal of Neuroscience Methods, 146(2), 159-164. [More Information]
  • Gibbs, M., Johnston, G. (2005). Opposing roles for GABAA and GABAC receptors in short-term memory formation in young chicks. Neuroscience, 131(3), 567-576. [More Information]

2004

  • Carland, J., Moorhouse, A., Barry, P., Johnston, G., Chebib, M. (2004). Charged Residues At The 2' Position Of Human GABAc �?1 Receptors Invert Ion Selectivity And Influence Open State Probability. Journal of Biological Chemistry, 279(52), 54153-54160. [More Information]
  • Hall, B., Chebib, M., Hanrahan, J., Johnston, G. (2004). Flumazenil-independent positive modulation of g-aminobutyric acid action by 6-methylflavone at human recombinant a1h2g2L and a1h2 GABAA receptors. European Journal of Pharmacology, 491(1), 1-8. [More Information]
  • Schleimer, S., Hinton, T., Dixon, G., Johnston, G. (2004). Gaba Transporters Gat-1 And Gat-3 In The Human Dorsolateral Prefrontal Cortex In Schizophrenia. Neuropsychobiology, 50(3), 226-230. [More Information]
  • Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., Johnston, G. (2004). Ginkgolides, Diterpene Trilactones Of Ginkgo Biloba, As Antagonists At Recombinant Alpha1Beta2Gamma2L Gabaa Receptors. European Journal of Pharmacology, 494(2-3), 131-138. [More Information]
  • Chebib, M., Hanrahan, J., Mewett, K., Duke, R., Johnston, G. (2004). Ionotropic Gaba Receptors As Therapeutic Targets For Memory And Sleep Disorders. Annual Reports in Medicinal Chemistry, 39(1), 13-23. [More Information]
  • Carland, J., Moore, A., Hanrahan, J., Mewett, K., Duke, R., Johnston, G., Chebib, M. (2004). Mutations Of The 2' Proline In The M2 Domain Of The Human Gabac Rho1 Subunit Alter Agonist Responses. Neuropharmacology, 46, 770-781. [More Information]
  • Duke, R., Chebib, M., Hibbs, D., Mewett, K., Johnston, G. (2004). Synthesis And Resolution Of 2-Methyl Analogues Of GABA. Tetrahedron-Asymmetry, 15(11), 1745-1751. [More Information]
  • Campbell, E., Chebib, M., Johnston, G. (2004). The Dietary Flavonoids Apigenin And (-)-Epigallocatechin Gallate Enhance The Positive Modulation By Diazepam Of The Activation By GABA Of Recombinant GABA(A) Receptors. Biochemical Pharmacology, 68(8), 1631-1638. [More Information]
  • Granger, R., Campbell, E., Johnston, G. (2004). Valerian Monoterpenes Produce Unprecedented Enhancement Of GABA Action At GABA-A Receptors. Journal of Neurochemistry, 88(S1), 79-79.

2003

  • Krehan, D., Frølund, B., Ebert, B., Nielsen, B., Krogsgaard-Larsen, P., Johnston, G., Chebib, M. (2003). Aza-THIP and related analogues of THIP as GABAc antagonists. Bioorganic and Medicinal Chemistry, 11(23), 4891-4896. [More Information]
  • Huang, S., Duke, R., Chebib, M., Sasaki, K., Wada, K., Johnston, G. (2003). Bilobalide, a sesquiterpene trilactone from ginkgo biloba, is an antagonist at recombinant a1b2y2l GABAA receptors. European Journal of Pharmacology, 464(1), 1-8. [More Information]
  • Chebib, M., Duke, R., Duke, C., Connor, M., Mewett, K., Johnston, G. (2003). Convulsant actions of Calycanthine. Toxicology and Applied Pharmacology, 190(1), 58-64. [More Information]
  • Johnston, G. (2003). Dietary chemicals and brain function. Journal and Proceedings of the Royal Society of New South Wales, 135, 57-71.
  • Johnston, G., Chebib, M., Hanrahan, J., Mewett, K. (2003). GABAc receptors as drug targets. CNS and Neurological Disorders, 2(4), 260-268.
  • Krehan, D., Frølund, B., Krogsgaard-Larsen, P., Kehler, J., Johnston, G., Chebib, M. (2003). Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAc receptor antagonists. Neurochemistry International, 42(7), 561-565. [More Information]
  • Hanrahan, J., Chebib, M., Davucheron, N., Hall, B., Johnston, G. (2003). Semisynthetic preparation of amentoflavone: a negative modulator at gabaa receptors. Bioorganic and Medicinal Chemistry Letters, 13(14), 2281-2284. [More Information]

2002

  • Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Wada, K. (2002). Bilobalide, from Ginkgo biloba, and enhancement of wild type alpha-1 beta-2gamma-2l GABAa receptors by diazepam, pentobarbitone and a steroid. 3rd College of Health Sciences Research Conference, Sydney: University of Sydney.
  • Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Wada, K. (2002). Effects of bilobalide and the sesquiterpene of Ginkgo bilobaon GABA-mediated currents modulated by GABAa modulators. 20th International Australasian Winter Conference on Brain Research.
  • Campbell, E., Chebib, M., Duke, R., Hall, B., Hanrahan, J., Johnston, G., Mewett, K. (2002). Epigallocatechin gallate, from green tea, and related agents as modulators of human brain GABA receptors. 5th Australia/Japan Symposium on Drug Design and Development.
  • Duke, R., Chebib, M., Duke, C., Johnston, G., Roufogalis, B. (2002). Ginkgo biloba - food for the brain. New Zealand Pharmacy, , 27-33.
  • Huang, S., Duke, R., Chebib, M., Johnston, G., Sasaki, K., Wada, K. (2002). Investigation of the effects of bilobalide from Ginkgo biloba on wild type alpha-5beta-2gamma-2l alpha-1beta-2gamma-2l and alpha-1beta-2 GABAa receptors. Australian Health and Meldical Research Conference.
  • Johnston, G. (2002). Medicinal chemistry and molecular pharmacology of GABAc receptors. Current Topics in Medicinal Chemistry, 2(8), 903-913. [More Information]
  • Topliss, J., Clark, A., Ernst, E., Hufford, C., Johnston, G., Rimoldi, J., Weimann, B. (2002). Natural and synthetic substances related to human health. Pure and Applied Chemistry, 74(10), 1957-1985. [More Information]
  • Vien, J., Duke, R., Mewett, K., Johnston, G., Shingai, R., Chebib, M. (2002). Trans-4-amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA (C) receptors. British Journal of Pharmacology, 135(4), 883-889. [More Information]
  • Campbell, E., Duke, R., Johnston, G., Granger, R. (2002). Valerian and GABA receptors. Australian Health and Medical Research Congress.

2001

  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Hanrahan, J., Mewett, K., Chebib, M., Burden, P., Johnston, G. (2001). An improved, versatile synthesis of the GABAc antagonists (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) and (piperidin-4-yl)methylphosphinic acid (P4MPA). Royal Chemical Society. Journal. Perkin Transactions 1, 1, 2389-2392. [More Information]
  • Farrar, N., Chambers, N., Carlsson, A., Denyer, G., Johnston, G. (2001). Effect of a series of novel sulphonylthioureas on glucose tolerance in the obese fa/fa Zucker rat. Clinical and Experimental Pharmacology and Physiology, 28, 386-391. [More Information]
  • Chebib, M., Duke, R., Allan, R., Johnston, G. (2001). The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABAc receptors. European Journal of Pharmacology, 430, 185-192. [More Information]
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