Dr Grant Hill-Cawthorne

MA MB BChir PhD MRCP(UK)
Lecturer in Communicable Disease Epidemiology
Sydney School of Public Health
Marie Bashir Institute


Website Marie Bashir Institute
Clinical Virology Network
Twitter

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Biographical details

I studied medicine in Cambridge and during my junior doctor years was very interested in both neurology and infectious diseases. Clinically I specialised in medical microbiology, keeping a particular interest in neurological infections. For the past 3 years I have been in Saudi Arabia developing a pathogen genomics laboratory where I have gained first-hand experience of second generation sequencing and bioinformatics.

Research interests

Infectious diseases and medical microbiology are undergoing the most significant shift since PCR was introduced. By the end of this decade, sequencing will have become the main option when investigating any outbreak or infection. I study the interface between genomics as a pure science and its translation into clinical and public health benefits.

At present I am examining the worldwide genomics of tuberculosis, the use of sequencing to characterise MRSA strains and the genomic variations in BCG vaccine strains used around the globe.

To get copies of my publications please see sydney.academia.edu

Follow me on Twitter: @drbrainbugz

And go to clinicalvirology.org for my weekly and monthly News and Journal Watch

Teaching and supervision

Master of International Public Health

MIPH5112 Global Communicable Disease Control

Master of Public Health

PUBH5117 Communicable Disease Control

New Master of Health Security

Launches in 2016. Read more here

Current projects

  1. Genomics of Mycobacterium tuberculosis in NSW and Mongolia
  2. Evolution of Mycobacterium tuberculosis drug resistance
  3. Investigation of an outbreak of tuberculosis in an indigenous population
  4. Investigation of a listeria outbreak in NSW hospitals
  5. Investigation of an EV71 outbreak in NSW
  6. Impact of masks during the Hajj in Saudi Arabia
  7. Combining Community Health Advocates with Village Cocoa Specialists in Bougainville
  8. Salmonella strains in livestock and wildlife in Australia
  9. Civil-Military Relations during the West Africa Ebola crisis
  10. Causes of undiagnosed encephalitis syndromes

Associations

  • Founding Member of the Faculty of Medical Leadership and Management, Academy of Medical Royal Colleges
  • Associate Fellow of the Royal College of Pathologists
  • Member of the Royal College of Physicians of London
  • Member of the Institute of Safety in Technology and Research
  • Member of the British Infection Association
  • Member of the UK Clinical Virology Network
  • Member with a License to Practise from the General Medical Council

In the media

Keywords

Microbiology; Virus diseases; Bioinformatics; Genomics; Nervous system diseases

Clinical Specialty

Infection and Immunity

International links

Saudi Arabia

(King Abdullah University of Science and Technology) University at which I did my PhD. Many ongoing collaborative projects on pathogen genomics.

United Kingdom

(London School of Hygiene and Tropical Medicine) Ongoing study on global diversity of tuberculosis

United Kingdom

(National Clinical Guideline Centre) National guideline on chronic hepatitis B (National Institute for Health and Clinical Excellence)

United Kingdom

(University of Cambridge) Research on alemtuzumab for multiple sclerosis and neuroimmunology

Selected grants

2015

  • Bridging the gap from the Cradle to the Mosh Pit: A pilot study to develop links between childhood and youth brain disorder prospective cohorts and develop new research opportunities to elucidate causes, predictors and outcomes of abnormal brain developme; Jones C, Scott E, Dale R, Banati R, Booy R, Lagopoulos J, Barnett M, Hill-Cawthorne G, Hermens D, Khandaker G; DVC Research/HMR+ Implementation Fund - University.

Selected publications

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Journals

  • Outhred, A., Jelfs, P., Suliman, B., Hill-Cawthorne, G., Crawford, A., Marais, B., Sintchenko, V. (2015). Added value of whole-genome sequencing for management of highly drug-resistant TB. Journal of Antimicrobial Chemotherapy, 70(4), 1198-1202. [More Information]
  • Hill-Cawthorne, G., Tuohy, O., Costelloe, L., Bjornson, I., Harding, K., Robertson, N., May, K., Button, T., Azzopardi, L., Kousin-Ezewu, O., et al (2015). Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy. Journal of Neurology, Neurosurgery, and Psychiatry, 86(2), 208-215. [More Information]
  • Kanji, A., Hasan, Z., Ali, A., McNerney, R., Mallard, K., Coll, F., Hill-Cawthorne, G., Nair, M., Clark, T., Zaver, A., et al (2015). Characterization of genomic variations in SNPs of PE_PGRS genes reveals deletions and insertions in extensively drug resistant (XDR) M. tuberculosis strains from Pakistan. International Journal of Mycobacteriology, 4, 73-79. [More Information]
  • Coll, F., McNerney, R., Preston, M., Guerra-Assuncao, J., Warry, A., Hill-Cawthorne, G., Mallard, K., Nair, M., Miranda, A., Alves, A., et al (2015). Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences. Genome Medicine, 7(1), 51. [More Information]
  • Ali, A., Hasan, Z., McNerney, R., Mallard, K., Hill-Cawthorne, G., Coll, F., Nair, M., Pain, A., Clark, T., Hasan, R. (2015). Whole genome sequencing based characterization of extensively drug-resistant mycobacterium tuberculosis isolates from pakistan. PloS One, 10(2), 1-17. [More Information]
  • Azeem, M., Tashani, M., Barasheed, O., Heron, L., Hill-Cawthorne, G., Haworth, E., Dwyer, D., Rashid, H., Booy, R. (2014). Knowledge, attitude and practice (KAP) survey concerning antimicrobial use among Australian Hajj pilgrims. Infectious Disorders - Drug Targets, 14, 125-132.
  • Coll, F., Preston, M., Guerra-Assuncao, J., Hill-Cawthorne, G., Harris, D., Perdigao, J., Viveiros, M., Portugal, I., Drobniewski, F., Gagneux, S., et al (2014). PolyTB: A genomic variation map for Mycobacterium tuberculosis. Tuberculosis, 94(3), 346-354. [More Information]
  • Hill-Cawthorne, G., Hudson, L., Ghany, M., Piepenburg, O., Nair, M., Dodgson, A., Forrest, M., Clark, T., Pain, A. (2014). Recombinations in Staphylococcal Cassette Chromosome mec Elements Compromise the Molecular Detection of Methicillin Resistance in Staphylococcus aureus. PloS One, 9(6), 1-10. [More Information]
  • Ghany, M., Chander, J., Mutreja, A., Rashid, M., Hill-Cawthorne, G., Ali, S., Naeem, R., Thomson, N., Dougan, G., Pain, A. (2014). The Population Structure of Vibrio cholerae from the Chandigarh Region of Northern India. PLoS Neglected Tropical Diseases, 8(7), 1-9. [More Information]
  • Perdigao, J., Silva, H., Machado, D., Macedo, R., Maltez, F., Silva, C., Jordao, L., Couto, I., Mallard, K., Coll, F., Hill-Cawthorne, G., et al (2014). Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting. BMC Genomics, 15(1), 1-20. [More Information]
  • Banerjee, A., Mor, S., Kok, J., Sorrell, T., Hill-Cawthorne, G. (2014). Vulnerability, hysteria and fear - conquering Ebola virus. Medical Journal of Australia, 201(6), 320-321. [More Information]
  • Sarri, G., Westby, M., Kelsey, A., Ritchie, G., Hill-Cawthorne, G., Thomas, H. (2013). Chronic hepatitis B in children, young people and adults: summary of the new NICE guideline. Viral Hepatitis in Practice, 5(2), 4-7.
  • Sarri, G., Westby, M., Bermingham, S., Hill-Cawthorne, G., Thomas, T. (2013). Diagnosis and management of chronic hepatitis B in children, young people, and adults: summary of NICE guidance. BMJ, 346, 1-5. [More Information]
  • Jones, J., Thompson, S., Loh, P., Davies, J., Tuohy, O., Curry, A., Azzopardi, L., Hill-Cawthorne, G., Fahey, M., Compston, A., et al (2013). Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 110(50), 20200-20205. [More Information]
  • Sarri, G., Ritchie, G., Hill-Cawthorne, G. (2013). Identification, testing, and support are key in chronic hepatitis B. Guidelines in Practice, 16(11), 11-24.
  • Reid, A., Vermont, S., Cotton, J., Harris, D., Hill-Cawthorne, G., Konen-Waisman, S., Latham, S., Mourier, T., Norton, R., Quail, M., et al (2012). Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy. PLoS Pathogens, 8(3), 1-15. [More Information]
  • Hill-Cawthorne, G., Button, T., Tuohy, O., Jones, J., May, K., Somerfield, J., Green, A., Giovannoni, G., Compston, A., Fahey, M., et al (2012). Long term lymphocyte reconstitution after alemtuzumab treatment of multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 83(3), 298-304. [More Information]
  • Somer�?eld, J., Hill-Cawthorne, G., Lin, A., Zandi, M., McCarthy, C., Jones, J., Willcox, M., Shaw, D., Thompson, S., Compston, A., et al (2010). A Novel Strategy To Reduce the Immunogenicity of Biological Therapies. The Journal of Immunology, 185(1), 763-768. [More Information]
  • Chakrabarti, B., Dudbridge, F., Kent, L., Wheelwright, S., Hill-Cawthorne, G., Allison, C., Banerjee-Basu, S., Baron-Cohen, S. (2009). Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Research, 2(3), 157-177. [More Information]

Conferences

  • Hill-Cawthorne, G. (2011). Long-term lymphocyte reconstitution after alemtuzumab treatment of multiple scierosis. King Abdullah University of Science and Technology Graduate Research Symposium.

2015

  • Outhred, A., Jelfs, P., Suliman, B., Hill-Cawthorne, G., Crawford, A., Marais, B., Sintchenko, V. (2015). Added value of whole-genome sequencing for management of highly drug-resistant TB. Journal of Antimicrobial Chemotherapy, 70(4), 1198-1202. [More Information]
  • Hill-Cawthorne, G., Tuohy, O., Costelloe, L., Bjornson, I., Harding, K., Robertson, N., May, K., Button, T., Azzopardi, L., Kousin-Ezewu, O., et al (2015). Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy. Journal of Neurology, Neurosurgery, and Psychiatry, 86(2), 208-215. [More Information]
  • Kanji, A., Hasan, Z., Ali, A., McNerney, R., Mallard, K., Coll, F., Hill-Cawthorne, G., Nair, M., Clark, T., Zaver, A., et al (2015). Characterization of genomic variations in SNPs of PE_PGRS genes reveals deletions and insertions in extensively drug resistant (XDR) M. tuberculosis strains from Pakistan. International Journal of Mycobacteriology, 4, 73-79. [More Information]
  • Coll, F., McNerney, R., Preston, M., Guerra-Assuncao, J., Warry, A., Hill-Cawthorne, G., Mallard, K., Nair, M., Miranda, A., Alves, A., et al (2015). Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences. Genome Medicine, 7(1), 51. [More Information]
  • Ali, A., Hasan, Z., McNerney, R., Mallard, K., Hill-Cawthorne, G., Coll, F., Nair, M., Pain, A., Clark, T., Hasan, R. (2015). Whole genome sequencing based characterization of extensively drug-resistant mycobacterium tuberculosis isolates from pakistan. PloS One, 10(2), 1-17. [More Information]

2014

  • Azeem, M., Tashani, M., Barasheed, O., Heron, L., Hill-Cawthorne, G., Haworth, E., Dwyer, D., Rashid, H., Booy, R. (2014). Knowledge, attitude and practice (KAP) survey concerning antimicrobial use among Australian Hajj pilgrims. Infectious Disorders - Drug Targets, 14, 125-132.
  • Coll, F., Preston, M., Guerra-Assuncao, J., Hill-Cawthorne, G., Harris, D., Perdigao, J., Viveiros, M., Portugal, I., Drobniewski, F., Gagneux, S., et al (2014). PolyTB: A genomic variation map for Mycobacterium tuberculosis. Tuberculosis, 94(3), 346-354. [More Information]
  • Hill-Cawthorne, G., Hudson, L., Ghany, M., Piepenburg, O., Nair, M., Dodgson, A., Forrest, M., Clark, T., Pain, A. (2014). Recombinations in Staphylococcal Cassette Chromosome mec Elements Compromise the Molecular Detection of Methicillin Resistance in Staphylococcus aureus. PloS One, 9(6), 1-10. [More Information]
  • Ghany, M., Chander, J., Mutreja, A., Rashid, M., Hill-Cawthorne, G., Ali, S., Naeem, R., Thomson, N., Dougan, G., Pain, A. (2014). The Population Structure of Vibrio cholerae from the Chandigarh Region of Northern India. PLoS Neglected Tropical Diseases, 8(7), 1-9. [More Information]
  • Perdigao, J., Silva, H., Machado, D., Macedo, R., Maltez, F., Silva, C., Jordao, L., Couto, I., Mallard, K., Coll, F., Hill-Cawthorne, G., et al (2014). Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting. BMC Genomics, 15(1), 1-20. [More Information]
  • Banerjee, A., Mor, S., Kok, J., Sorrell, T., Hill-Cawthorne, G. (2014). Vulnerability, hysteria and fear - conquering Ebola virus. Medical Journal of Australia, 201(6), 320-321. [More Information]

2013

  • Sarri, G., Westby, M., Kelsey, A., Ritchie, G., Hill-Cawthorne, G., Thomas, H. (2013). Chronic hepatitis B in children, young people and adults: summary of the new NICE guideline. Viral Hepatitis in Practice, 5(2), 4-7.
  • Sarri, G., Westby, M., Bermingham, S., Hill-Cawthorne, G., Thomas, T. (2013). Diagnosis and management of chronic hepatitis B in children, young people, and adults: summary of NICE guidance. BMJ, 346, 1-5. [More Information]
  • Jones, J., Thompson, S., Loh, P., Davies, J., Tuohy, O., Curry, A., Azzopardi, L., Hill-Cawthorne, G., Fahey, M., Compston, A., et al (2013). Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 110(50), 20200-20205. [More Information]
  • Sarri, G., Ritchie, G., Hill-Cawthorne, G. (2013). Identification, testing, and support are key in chronic hepatitis B. Guidelines in Practice, 16(11), 11-24.

2012

  • Reid, A., Vermont, S., Cotton, J., Harris, D., Hill-Cawthorne, G., Konen-Waisman, S., Latham, S., Mourier, T., Norton, R., Quail, M., et al (2012). Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy. PLoS Pathogens, 8(3), 1-15. [More Information]
  • Hill-Cawthorne, G., Button, T., Tuohy, O., Jones, J., May, K., Somerfield, J., Green, A., Giovannoni, G., Compston, A., Fahey, M., et al (2012). Long term lymphocyte reconstitution after alemtuzumab treatment of multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 83(3), 298-304. [More Information]

2011

  • Hill-Cawthorne, G. (2011). Long-term lymphocyte reconstitution after alemtuzumab treatment of multiple scierosis. King Abdullah University of Science and Technology Graduate Research Symposium.

2010

  • Somer�?eld, J., Hill-Cawthorne, G., Lin, A., Zandi, M., McCarthy, C., Jones, J., Willcox, M., Shaw, D., Thompson, S., Compston, A., et al (2010). A Novel Strategy To Reduce the Immunogenicity of Biological Therapies. The Journal of Immunology, 185(1), 763-768. [More Information]

2009

  • Chakrabarti, B., Dudbridge, F., Kent, L., Wheelwright, S., Hill-Cawthorne, G., Allison, C., Banerjee-Basu, S., Baron-Cohen, S. (2009). Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Research, 2(3), 157-177. [More Information]

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