Dr Grant Logan

Senior Lecturer
Children's Medical Research Institute
Sydney Medical School


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Biographical details

Grant Logan is a Senior Scientist at the Children’s Medical Research Institute and Senior Lecturer at the University of Sydney. He is specialised in the design, synthesis and application of viral vector systemsfor therapeutic gene delivery and in vivo genome editing. With over twenty years experience in academic research and the biotech industry, Grant has developed a strong interest in the clinical translation of gene therapy and immunotherapy for disease treatment. Prior to joining the CMRI, he worked in clinical pathology and public health microbiology.

Research interests

Gene Therapy, Immunotherapy, Clinical Translation of Gene & Cell Therapies

Selected publications

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Book Chapters

  • Earl, J., Nath, C., Hanlon, M., Leach, C., Dale, R., Logan, G., Alexander, I., Bishop, G. (2015). The tryptophan damage signal and indoleamine 2, 3-dioxygenase. In Angel Catala (Eds.), Indoleamines: Sources, role in biological processes and health effects, (pp. 107-121). New York: Nova Science Publishers, Inc.

Journals

  • Tu, L., Wang, J., Barathi, V., Prea, S., He, Z., Lee, J., Bender, J., King, A., Logan, G., Alexander, I., et al (2018). AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization. Angiogenesis, 21(1), 95-109. [More Information]
  • Paul-Heng, M., Leong, M., Cunningham, E., Bunker, D., Bremner, K., Wang, Z., Wang, C., Tay, S., McGuffog, C., Logan, G., Alexander, I., Hu, M., Alexander, S., Bertolino, P., Bowen, D., Bishop, A., Sharland, A., et al (2018). Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction. JCI Insight, 3(15), 1-19. [More Information]
  • Logan, G., Dane, A., Hallwirth, C., Smyth, C., Wilkie, E., Amaya, A., Zhu, E., Khandekar, N., Ginn, S., Liao, S., Cunningham, S., Sasaki, N., Cabanes-Creus, M., Tam, P., Lisowski, L., Alexander, I., et al (2017). Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome. Nature Genetics, 49(8), 1267-1273. [More Information]
  • Gray, P., Logan, G., Alexander, I., Poulton, S., Roscioli, T., Ziegler, J. (2015). A novel intronic splice site deletion of the IL-2 receptor common gamma chain results in expression of a dysfunctional protein and T-cell-positive X-linked Severe combined immunodeficiency. International Journal of Immunogenetics, 42(1), 11-14. [More Information]
  • Dane, A., Cunningham, S., Kok, C., Logan, G., Alexander, I. (2015). Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus. Gene Therapy, 22(11), 917-922. [More Information]
  • Logan, G., de Alencastro, G., Alexander, I., Yeoh, G. (2014). Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease. The International Journal of Biochemistry and Cell Biology, 56, 141-152. [More Information]
  • Kojima, Y., Kaufman-Francis, K., Studdert, J., Steiner, K., Power, M., Loebel, D., Jones, V., Hor, A., de Alencastro, G., Logan, G., Alexander, I., Pickett, H., Tam, P., et al (2014). The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak. Cell Stem Cell, 14(1), 107-120. [More Information]
  • Kok, C., Cunningham, S., Carpenter, K., Dane, A., Siew, S., Logan, G., Kuchel, P., Alexander, I. (2013). Adeno-associated Virus-mediated Rescue of Neonatal Lethality in Argininosuccinate Synthetase-deficient Mice. Molecular Therapy, 21(10), 1823-1831. [More Information]
  • Logan, G., Alexander, I. (2012). Adeno-associated virus vectors: immunobiology and potential use for immune modulation. Current Gene Therapy, 12(4), 333-343. [More Information]
  • Chung, H., Lin, R., Logan, G., Alexander, I., Sachdev, P., Sidhu, K. (2012). Human Induced Pluripotent Stem Cells Derived Under Feeder-Free Conditions Display Unique Cell Cycle and DNA Replication Gene Profiles. Stem Cells and Development, 21(2), 206-216. [More Information]
  • Logan, G., Wang, L., Zheng, M., Coppel, R., Alexander, I. (2010). Antigen fusion with C3d(3) augments or inhibits humoral immunity to AAV genetic vaccines in a transgene-dependent manner. Immunology and Cell Biology, 88(2), 228-232. [More Information]
  • Sharland, A., Logan, G., Bishop, A., Alexander, I. (2010). Liver-directed gene expression using recombinant AAV 2/8 vectors -- a tolerogenic strategy for gene delivery? Discovery Medicine, 9(49), 519-527. [More Information]
  • Logan, G., Wang, L., Zheng, M., Ginn, S., Coppel, R., Alexander, I. (2009). Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene Therapy (Basingstoke), 16(2), 200-210. [More Information]
  • Laurence, J., McCaughan, G., Logan, G., Alexander, I., Bishop, A., Sharland, A. (2009). Gene therapy in transplantation. Transplantation Reviews, 23(3), 159-170. [More Information]
  • Alexander, I., Cunningham, S., Logan, G., Christodoulou, J. (2008). Potential of AAV vectors in the treatment of metabolic disease. Gene Therapy, 15(11), 831-839. [More Information]
  • Smyth, C., Ginn, S., Deakin, C., Logan, G., Alexander, I. (2007). Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood, 110(1), 91-98. [More Information]
  • Ganesan, P., Alexander, S., Watson, D., Logan, G., Zhang, G., Alexander, I. (2007). Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer Immunology, Immunotherapy: other biological response modifications, 56(12), 1955-1965. [More Information]
  • Logan, G., Wang, L., Zheng, M., Cunningham, S., Coppel, R., Alexander, I. (2006). AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection. Vaccine, 25(6), 1014-1022. [More Information]
  • Alexander, I., Logan, G., Logan, G., Boadle, R., Rowe, P., Smythe, J. (2005). Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy. International Immunology, 17(2), 123-132. [More Information]
  • Smyth, C., Logan, G., Boadle, R., Rowe, P., Smythe, J., Alexander, I. (2005). Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy. International Immunology, 17(2), 123-132. [More Information]
  • Logan, G., Spinoulas, A., Alexander, S., Smythe, J., Alexander, I. (2004). CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection. Immunology and Cell Biology, 82(2), 132-135. [More Information]
  • Logan, G., Smyth, C., Earl, J., Rowe, P., Zaikina, I., Smythe, J., Alexander, I. (2002). HeLa cells cocultured with periopheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity. Immunology, 105(4), 478-487. [More Information]

2018

  • Tu, L., Wang, J., Barathi, V., Prea, S., He, Z., Lee, J., Bender, J., King, A., Logan, G., Alexander, I., et al (2018). AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization. Angiogenesis, 21(1), 95-109. [More Information]
  • Paul-Heng, M., Leong, M., Cunningham, E., Bunker, D., Bremner, K., Wang, Z., Wang, C., Tay, S., McGuffog, C., Logan, G., Alexander, I., Hu, M., Alexander, S., Bertolino, P., Bowen, D., Bishop, A., Sharland, A., et al (2018). Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction. JCI Insight, 3(15), 1-19. [More Information]

2017

  • Logan, G., Dane, A., Hallwirth, C., Smyth, C., Wilkie, E., Amaya, A., Zhu, E., Khandekar, N., Ginn, S., Liao, S., Cunningham, S., Sasaki, N., Cabanes-Creus, M., Tam, P., Lisowski, L., Alexander, I., et al (2017). Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome. Nature Genetics, 49(8), 1267-1273. [More Information]

2015

  • Gray, P., Logan, G., Alexander, I., Poulton, S., Roscioli, T., Ziegler, J. (2015). A novel intronic splice site deletion of the IL-2 receptor common gamma chain results in expression of a dysfunctional protein and T-cell-positive X-linked Severe combined immunodeficiency. International Journal of Immunogenetics, 42(1), 11-14. [More Information]
  • Earl, J., Nath, C., Hanlon, M., Leach, C., Dale, R., Logan, G., Alexander, I., Bishop, G. (2015). The tryptophan damage signal and indoleamine 2, 3-dioxygenase. In Angel Catala (Eds.), Indoleamines: Sources, role in biological processes and health effects, (pp. 107-121). New York: Nova Science Publishers, Inc.
  • Dane, A., Cunningham, S., Kok, C., Logan, G., Alexander, I. (2015). Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus. Gene Therapy, 22(11), 917-922. [More Information]

2014

  • Logan, G., de Alencastro, G., Alexander, I., Yeoh, G. (2014). Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease. The International Journal of Biochemistry and Cell Biology, 56, 141-152. [More Information]
  • Kojima, Y., Kaufman-Francis, K., Studdert, J., Steiner, K., Power, M., Loebel, D., Jones, V., Hor, A., de Alencastro, G., Logan, G., Alexander, I., Pickett, H., Tam, P., et al (2014). The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak. Cell Stem Cell, 14(1), 107-120. [More Information]

2013

  • Kok, C., Cunningham, S., Carpenter, K., Dane, A., Siew, S., Logan, G., Kuchel, P., Alexander, I. (2013). Adeno-associated Virus-mediated Rescue of Neonatal Lethality in Argininosuccinate Synthetase-deficient Mice. Molecular Therapy, 21(10), 1823-1831. [More Information]

2012

  • Logan, G., Alexander, I. (2012). Adeno-associated virus vectors: immunobiology and potential use for immune modulation. Current Gene Therapy, 12(4), 333-343. [More Information]
  • Chung, H., Lin, R., Logan, G., Alexander, I., Sachdev, P., Sidhu, K. (2012). Human Induced Pluripotent Stem Cells Derived Under Feeder-Free Conditions Display Unique Cell Cycle and DNA Replication Gene Profiles. Stem Cells and Development, 21(2), 206-216. [More Information]

2010

  • Logan, G., Wang, L., Zheng, M., Coppel, R., Alexander, I. (2010). Antigen fusion with C3d(3) augments or inhibits humoral immunity to AAV genetic vaccines in a transgene-dependent manner. Immunology and Cell Biology, 88(2), 228-232. [More Information]
  • Sharland, A., Logan, G., Bishop, A., Alexander, I. (2010). Liver-directed gene expression using recombinant AAV 2/8 vectors -- a tolerogenic strategy for gene delivery? Discovery Medicine, 9(49), 519-527. [More Information]

2009

  • Logan, G., Wang, L., Zheng, M., Ginn, S., Coppel, R., Alexander, I. (2009). Antigen-specific humoral tolerance or immune augmentation induced by intramuscular delivery of adeno-associated viruses encoding CTLA4-Ig-antigen fusion molecules. Gene Therapy (Basingstoke), 16(2), 200-210. [More Information]
  • Laurence, J., McCaughan, G., Logan, G., Alexander, I., Bishop, A., Sharland, A. (2009). Gene therapy in transplantation. Transplantation Reviews, 23(3), 159-170. [More Information]

2008

  • Alexander, I., Cunningham, S., Logan, G., Christodoulou, J. (2008). Potential of AAV vectors in the treatment of metabolic disease. Gene Therapy, 15(11), 831-839. [More Information]

2007

  • Smyth, C., Ginn, S., Deakin, C., Logan, G., Alexander, I. (2007). Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood, 110(1), 91-98. [More Information]
  • Ganesan, P., Alexander, S., Watson, D., Logan, G., Zhang, G., Alexander, I. (2007). Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer Immunology, Immunotherapy: other biological response modifications, 56(12), 1955-1965. [More Information]

2006

  • Logan, G., Wang, L., Zheng, M., Cunningham, S., Coppel, R., Alexander, I. (2006). AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection. Vaccine, 25(6), 1014-1022. [More Information]

2005

  • Alexander, I., Logan, G., Logan, G., Boadle, R., Rowe, P., Smythe, J. (2005). Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy. International Immunology, 17(2), 123-132. [More Information]
  • Smyth, C., Logan, G., Boadle, R., Rowe, P., Smythe, J., Alexander, I. (2005). Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy. International Immunology, 17(2), 123-132. [More Information]

2004

  • Logan, G., Spinoulas, A., Alexander, S., Smythe, J., Alexander, I. (2004). CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection. Immunology and Cell Biology, 82(2), 132-135. [More Information]

2002

  • Logan, G., Smyth, C., Earl, J., Rowe, P., Zaikina, I., Smythe, J., Alexander, I. (2002). HeLa cells cocultured with periopheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity. Immunology, 105(4), 478-487. [More Information]

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