Dr Grant Parnell

PhD, BSc (Hons Class I)
Postdoctoral Research Fellow
Centre for Immunology and Allergy Research
Westmead Institute for Medical Research
Honorary Research Fellow
Sydney Medical School - Westmead

Telephone +61286273604

Website https://www.westmeadinstitute.org.au/people/researcher-profiles-search/dr-grant-parnell

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Biographical details

I am a postdoctoral research fellow with a strong focus on the translation of transcriptomic technologies into clinical practice. I am a lab member at the Centre for Immunology and Allergy Research at the Westmead Institute for Medical Research. I was awarded my PhD from the University of Sydney in 2014 for my work on transcriptome profiling of the immune response in patients admitted to intensive care due to systemic infection. My research identified distinct differences in the immune response in patients with pneumonia caused by bacterial as opposed to influenza infection. As part of this work, a single gene biomarker, IFI27, was identified that is capable of stratification of severity of infection in influenza infected individuals. I am a co-inventor on an international patent application for this biomarker. The aim of my current fellowship is to investigate the role of vitamin D in myeloid cell differentiation and immunological tolerance, using next generation transcriptomic and genomic techniques. I am also currently involved in projects investigating the transcriptome of the immune response in multiple sclerosis patients, where we have identified transcription factors which define molecular subtypes of disease and may be useful in assessing suitability of patients for certain treatments, and also response to treatment. Further, I am involved in a project investigating the role of the Epstein Barr virus in the pathogenesis of multiple sclerosis.

In the media

Selected grants

2017

  • Is the MS risk critical period mediated by the effects of Vitamin D on DNA methylation?; Ong L, Parnell G, Booth D; Multiple Sclerosis Research Australia/Incubator Grant.
  • How Does Vitamin D protect From Autoimmunity?; Parnell G; Multiple Sclerosis Research Australia/Postdoctoral Fellowships.

2015

  • MS Research Australia - JDRF Australia Macquarie Group Foundation Joint Fellowship; Parnell G; Multiple Sclerosis Research Australia/JDRF Australia Macquarie Group Foundation Joint Fellowship.
  • The Effects of Exogenous Lactate on LPS Stimulated Human Monocytes and Lymphocytes - Comprehensive Functional and Genomic Approach; Nalos M, Parnell G; Nepean Medical Research Foundation/Project Grant.

Selected publications

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Book Chapters

  • Parnell, G., Booth, D. (2014). Whole Blood Transcriptomic Analysis to Identify Clinical Biomarkers of Drug Response. In Qing Yan (Eds.), Pharmacogenomics in Drug Discovery and Development, (pp. 35-43). New York: Springer Science+Business Media. [More Information]

Journals

  • Wirasinha, R., Vijayan, D., Smith, N., Parnell, G., Swarbrick, A., Brink, R., King, C., Stewart, G., Booth, D., Batten, M. (2018). GPR65 inhibits experimental autoimmune encephalomyelitis through CD4+ T cell independent mechanisms that include effects on iNKT cells. Immunology and Cell Biology, 96(2), 128-136. [More Information]
  • Read, S., Parnell, G., Booth, D., Douglas, M., George, J., Ahlenstiel, G. (2018). The antiviral role of zinc and metallothioneins in hepatitis C infection. Journal of Viral Hepatitis, 25(5), 491-501. [More Information]
  • Fewings, N., Gatt, P., McKay, F., Parnell, G., Schibeci, S., Edwards, J., Basuki, M., Goldinger, A., Fabis-Pedrini, M., Kermode, A., Burke, T., Vucic, S., Stewart, G., Booth, D., et al (2017). Data characterizing the ZMIZ1 molecular phenotype of multiple sclerosis. Data in Brief, 11, 364-370. [More Information]
  • Fewings, N., Gatt, P., McKay, F., Parnell, G., Schibeci, S., Edwards, J., Basuki, M., Goldinger, A., Fabis-Pedrini, M., Kermode, A., Burke, T., Vucic, S., Stewart, G., Booth, D., et al (2017). The autoimmune risk gene ZMIZ1 is a vitamin D responsive marker of a molecular phenotype of multiple sclerosis. Journal of Autoimmunity, 78, 57-69. [More Information]
  • Parnell, G., Booth, D. (2017). The Multiple Sclerosis (MS) genetic risk factors indicate both acquired and innate immune cell subsets contribute to MS pathogenesis and identify novel therapeutic opportunities. Frontiers in Immunology, 8(ARP), 1-6. [More Information]
  • Booth, D., Ding, N., Parnell, G., Shahijanian, F., Coulter, S., Schibeci, S., Atkins, A., Stewart, G., Evans, R., Downes, M., Liddle, C. (2016). Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases. Genes and Immunity, 17(4), 213-219. [More Information]
  • Booth, D., Fewings, N., Parnell, G., McKay, F., Stewart, G. (2016). Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, 1-4. [More Information]
  • McKay, F., Gatt, P., Fewings, N., Parnell, G., Schibeci, S., Basuki, M., Powell, J., Goldinger, A., Fabis-Pedrini, M., Kermode, A., Burke, T., Vucic, S., Stewart, G., Booth, D. (2016). The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies. Clinical Immunology, 163, 96-107. [More Information]
  • Nalos, M., Parnell, G., Robergs, R., Booth, D., McLean, A., Tang, B. (2016). Transcriptional reprogramming of metabolic pathways in critically ill patients. Intensive Care Medicine Experimental, 4, 1-15. [More Information]
  • Field, J., Shahijanian, F., Schibeci, S., Johnson, L., Gresle, M., Laverick, L., Parnell, G., Stewart, G., McKay, F., Kilpatrick, T., Booth, D., et al (2015). The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function. PloS One, 10(6), 1-4. [More Information]
  • O'Connor, K., Parnell, G., Patrick, E., Ahlenstiel, G., Suppiah, V., van der Poorten, D., Read, S., Leung, R., Douglas, M., Yang, J., Stewart, G., Liddle, C., George, J., Booth, D. (2014). Hepatic metallothionein expression in chronic hepatitis C virus infection is IFNL3 genotype-dependent. Genes and Immunity, 15(2), 88-94. [More Information]
  • Parnell, G., Gatt, P., McKay, F., Schibeci, S., Krupa, M., Powell, J., Visscher, P., Montgomery, G., Lechner-Scott, J., Broadley, S., Liddle, C., Vucic, S., Stewart, G., Booth, D., et al (2014). Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season. Multiple Sclerosis Journal, 20(6), 675-685. [More Information]
  • Parnell, G., Gatt, P., Krupa, M., Dorothee, N., McKay, F., Schibeci, S., Batten, M., Baranzini, S., Henderson, A., Barnett, M., Vucic, S., Stewart, G., Booth, D., et al (2014). The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clinical Immunology, 151(1), 16-24. [More Information]
  • Shahijanian, F., Parnell, G., McKay, F., Gatt, P., Shojaei, M., O'Connor, K., Schibeci, S., Brilot-Turville, F., Liddle, C., Batten, M., Stewart, G., Booth, D. (2014). The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells. Human Molecular Genetics, 23(6), 1425-1434. [More Information]
  • Nanan, B., Straubinger, K., Hsu, P., Parnell, G., Tang, B., Xu, B., Makris, A., Hennessy, A., Peek, M., Busch, D., Nanan, R., et al (2013). Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy. Journal of Immunology, 191(1), 145-153. [More Information]
  • Parnell, G., Tang, B., Nalos, M., Armstrong, N., Huang, S., Booth, D., McLean, A. (2013). Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions. Shock, 40(3), 166-174. [More Information]
  • McKay, F., Hoe, E., Parnell, G., Gatt, P., Schibeci, S., Stewart, G., Booth, D. (2013). IL7Ralpha Expression and Upregulation by IFNbeta in Dendritic Cell Subsets Is Haplotype-Dependent. PloS One, 8(10), 1-10. [More Information]
  • Parnell, G., McLean, A., Booth, D., Armstrong, N., Nalos, M., Huang, S., Manak, J., Tang, W., Tam, O., Chan, S., Tang, B. (2012). A distinct influenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia. Critical Care, 16(4), 1-12. [More Information]
  • Nalos, M., Nanan, B., Parnell, G., Tang, B., McLean, A., Nanan, R. (2012). Immune effects of interferon gamma in persistent staphylococcal sepsis. American Journal of Respiratory and Critical Care Medicine, 185(1), 110-112. [More Information]
  • Parnell, G., McLean, A., Booth, D., Huang, S., Nalos, M., Tang, B. (2011). Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection - A Meta-Analysis of Genomic Signatures in Circulating Leukocytes. PloS One, 6(3), e17186-1-e17186-10. [More Information]

2018

  • Wirasinha, R., Vijayan, D., Smith, N., Parnell, G., Swarbrick, A., Brink, R., King, C., Stewart, G., Booth, D., Batten, M. (2018). GPR65 inhibits experimental autoimmune encephalomyelitis through CD4+ T cell independent mechanisms that include effects on iNKT cells. Immunology and Cell Biology, 96(2), 128-136. [More Information]
  • Read, S., Parnell, G., Booth, D., Douglas, M., George, J., Ahlenstiel, G. (2018). The antiviral role of zinc and metallothioneins in hepatitis C infection. Journal of Viral Hepatitis, 25(5), 491-501. [More Information]

2017

  • Fewings, N., Gatt, P., McKay, F., Parnell, G., Schibeci, S., Edwards, J., Basuki, M., Goldinger, A., Fabis-Pedrini, M., Kermode, A., Burke, T., Vucic, S., Stewart, G., Booth, D., et al (2017). Data characterizing the ZMIZ1 molecular phenotype of multiple sclerosis. Data in Brief, 11, 364-370. [More Information]
  • Fewings, N., Gatt, P., McKay, F., Parnell, G., Schibeci, S., Edwards, J., Basuki, M., Goldinger, A., Fabis-Pedrini, M., Kermode, A., Burke, T., Vucic, S., Stewart, G., Booth, D., et al (2017). The autoimmune risk gene ZMIZ1 is a vitamin D responsive marker of a molecular phenotype of multiple sclerosis. Journal of Autoimmunity, 78, 57-69. [More Information]
  • Parnell, G., Booth, D. (2017). The Multiple Sclerosis (MS) genetic risk factors indicate both acquired and innate immune cell subsets contribute to MS pathogenesis and identify novel therapeutic opportunities. Frontiers in Immunology, 8(ARP), 1-6. [More Information]

2016

  • Booth, D., Ding, N., Parnell, G., Shahijanian, F., Coulter, S., Schibeci, S., Atkins, A., Stewart, G., Evans, R., Downes, M., Liddle, C. (2016). Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases. Genes and Immunity, 17(4), 213-219. [More Information]
  • Booth, D., Fewings, N., Parnell, G., McKay, F., Stewart, G. (2016). Differences in common heritable blood immune cell populations may underlie MS susceptibility and progression. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, 1-4. [More Information]
  • McKay, F., Gatt, P., Fewings, N., Parnell, G., Schibeci, S., Basuki, M., Powell, J., Goldinger, A., Fabis-Pedrini, M., Kermode, A., Burke, T., Vucic, S., Stewart, G., Booth, D. (2016). The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies. Clinical Immunology, 163, 96-107. [More Information]
  • Nalos, M., Parnell, G., Robergs, R., Booth, D., McLean, A., Tang, B. (2016). Transcriptional reprogramming of metabolic pathways in critically ill patients. Intensive Care Medicine Experimental, 4, 1-15. [More Information]

2015

  • Field, J., Shahijanian, F., Schibeci, S., Johnson, L., Gresle, M., Laverick, L., Parnell, G., Stewart, G., McKay, F., Kilpatrick, T., Booth, D., et al (2015). The MS Risk Allele of CD40 Is Associated with Reduced Cell-Membrane Bound Expression in Antigen Presenting Cells: Implications for Gene Function. PloS One, 10(6), 1-4. [More Information]

2014

  • O'Connor, K., Parnell, G., Patrick, E., Ahlenstiel, G., Suppiah, V., van der Poorten, D., Read, S., Leung, R., Douglas, M., Yang, J., Stewart, G., Liddle, C., George, J., Booth, D. (2014). Hepatic metallothionein expression in chronic hepatitis C virus infection is IFNL3 genotype-dependent. Genes and Immunity, 15(2), 88-94. [More Information]
  • Parnell, G., Gatt, P., McKay, F., Schibeci, S., Krupa, M., Powell, J., Visscher, P., Montgomery, G., Lechner-Scott, J., Broadley, S., Liddle, C., Vucic, S., Stewart, G., Booth, D., et al (2014). Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season. Multiple Sclerosis Journal, 20(6), 675-685. [More Information]
  • Parnell, G., Gatt, P., Krupa, M., Dorothee, N., McKay, F., Schibeci, S., Batten, M., Baranzini, S., Henderson, A., Barnett, M., Vucic, S., Stewart, G., Booth, D., et al (2014). The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple sclerosis and define a molecular subtype of disease. Clinical Immunology, 151(1), 16-24. [More Information]
  • Shahijanian, F., Parnell, G., McKay, F., Gatt, P., Shojaei, M., O'Connor, K., Schibeci, S., Brilot-Turville, F., Liddle, C., Batten, M., Stewart, G., Booth, D. (2014). The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells. Human Molecular Genetics, 23(6), 1425-1434. [More Information]
  • Parnell, G., Booth, D. (2014). Whole Blood Transcriptomic Analysis to Identify Clinical Biomarkers of Drug Response. In Qing Yan (Eds.), Pharmacogenomics in Drug Discovery and Development, (pp. 35-43). New York: Springer Science+Business Media. [More Information]

2013

  • Nanan, B., Straubinger, K., Hsu, P., Parnell, G., Tang, B., Xu, B., Makris, A., Hennessy, A., Peek, M., Busch, D., Nanan, R., et al (2013). Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy. Journal of Immunology, 191(1), 145-153. [More Information]
  • Parnell, G., Tang, B., Nalos, M., Armstrong, N., Huang, S., Booth, D., McLean, A. (2013). Identifying key regulatory genes in the whole blood of septic patients to monitor underlying immune dysfunctions. Shock, 40(3), 166-174. [More Information]
  • McKay, F., Hoe, E., Parnell, G., Gatt, P., Schibeci, S., Stewart, G., Booth, D. (2013). IL7Ralpha Expression and Upregulation by IFNbeta in Dendritic Cell Subsets Is Haplotype-Dependent. PloS One, 8(10), 1-10. [More Information]

2012

  • Parnell, G., McLean, A., Booth, D., Armstrong, N., Nalos, M., Huang, S., Manak, J., Tang, W., Tam, O., Chan, S., Tang, B. (2012). A distinct influenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia. Critical Care, 16(4), 1-12. [More Information]
  • Nalos, M., Nanan, B., Parnell, G., Tang, B., McLean, A., Nanan, R. (2012). Immune effects of interferon gamma in persistent staphylococcal sepsis. American Journal of Respiratory and Critical Care Medicine, 185(1), 110-112. [More Information]

2011

  • Parnell, G., McLean, A., Booth, D., Huang, S., Nalos, M., Tang, B. (2011). Aberrant Cell Cycle and Apoptotic Changes Characterise Severe Influenza A Infection - A Meta-Analysis of Genomic Signatures in Circulating Leukocytes. PloS One, 6(3), e17186-1-e17186-10. [More Information]

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