Professor Gregory Cooney

Professorial Research Fellow
Physiology: School Medical Sciences

Member of the Charles Perkins Centre

Telephone +61 2 8627 4756

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Biographical details

Greg Cooney completed his PhD at the Department of Biochemistry, University of Sydney in 1979 and from 1980 to 1984 worked as a Departmental Demonstrator in the Department of Biochemistry at the University of Oxford, UK. There he developed an interest in the role of thermogenic brown adipose tissue in energy balance and the development of obesity. Greg returned to Sydney in 1985 to work in the Department of Endocrinology, Royal Prince Alfred Hospital on the biochemical mechanisms involved in the development of obesity and insulin resistance.

He joined the Diabetes Group at the Garvan Institute in 1997 to continue examination of the links between obesity, insulin resistance and type 2 diabetes. In 2015 Greg moved to the Charles Perkins Centre at the University of Sydney as a professorial Research fellow in the Sydney Medical School to continue his research on mechanisms of obesity-induced insulin resistance. Greg served for 12 years as a Senior Editor for the Journal of Endocrinology, and 6 years as an Associate Editor for the journal Diabetologia. He is currently a member of the Editorial Board of Diabetes and the American Journal of Physiology – Endocrinology and Metabolism.

Greg has served on the Council of the Australia New Zealand Obesity Society acting as Honorary Treasurer of the Society. He has also been as a Councilor, Treasurer and Vice President of the Australian Diabetes Society.

Research interests

Obesity, insulin resistance, type 2 diabetes, glucose metabolism, fat metabolism, energy balance

Selected grants

2017

  • Can enhancing futile cycles combat obesity related insulin resistance?; Brandon A, Cooney G; Diabetes Australia/Research Grant.
  • Investigating Mechanisims of Obesity-Related Insulin Resistance; Cooney G; DVC Research/Bridging Support Grant.

2015

  • Finding ways to reduce obesity, improve insulin action and reduce type 2 diabetes; Cooney G; National Health and Medical Research Council (NHMRC)/Research Fellowships.
  • Metabolic wiring in adipocytes - unique role in maintaining long-term health; James D, Cooney G, Cooney G; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Turner, N., Lim, X., Toop, H., Osborne, B., Brandon, A., Taylor, E., Fiveash, C., Govindaraju, H., Teo, J., McEwen, H., Couttas, T., Cooney, G., Don, A., et al (2018). A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, 9(1). [More Information]
  • Holt, L., Brandon, A., Small, L., Suryana, E., Preston, E., Wilks, D., Mokbel, N., Coles, C., White, J., Turner, N., Cooney, G., et al (2018). Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice. Endocrinology, 159(3), 1339-1351. [More Information]
  • Small, L., Brandon, A., Quek, L., Krycer, J., James, D., Turner, N., Cooney, G. (2018). Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake. American Journal of Physiology: Endocrinology and Metabolism, 315(2), E258-E266. [More Information]
  • Bakshi, I., Suryana, E., Small, L., Quek, L., Brandon, A., Turner, N., Cooney, G. (2018). Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle. Journal of Endocrinology, 237(2), 101-111. [More Information]
  • Burchfield, J., Kebede, M., Meoli, C., Stoeckli, J., Whitworth, P., Wright, A., Hoffman, N., Minard, A., Ma, X., Krycer, J., Healy, M., Yau, B., Thomas, K., Cooney, G., James, D., Fazakerley, D., et al (2018). High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice. Journal of Biological Chemistry, 293(15), 5731-5745. [More Information]
  • Small, L., Brandon, A., Turner, N., Cooney, G. (2018). Modeling insulin resistance in rodents by alterations in diet: what have high-fat and high-calorie diets revealed? American Journal of Physiology: Endocrinology and Metabolism, 314(3), E251-E265. [More Information]
  • Small, L., Brandon, A., Turner, N., Cooney, G. (2018). Modeling insulin resistance in rodents by alterations in diet: What have high-fat and high-calorie diets revealed? American Journal of Physiology: Endocrinology and Metabolism, 314(3), E251-E265. [More Information]
  • Bentley, N., Fiveash, C., Osborne, B., Quek, L., Ogura, M., Inagaki, N., Cooney, G., Polly, P., Montgomery, M., Turner, N. (2018). Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice. Biochemical and Biophysical Research Communications, 503(3), 1349-1355. [More Information]
  • Gokarn, R., Solon-Biet, S., Youngson, N., Wahl, D., Cogger, V., McMahon, A., Cooney, G., Ballard, J., Raubenheimer, D., Morris, M., Simpson, S., Le Couteur, D. (2018). The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(4), 446-449. [More Information]
  • Montgomery, M., Brown, S., Mitchell, T., Coster, A., Cooney, G., Turner, N. (2017). Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains. Scientific Reports, 7, 1-9. [More Information]
  • Loh, K., Zhang, L., Brandon, A., Wang, K., Begg, D., Qi, Y., Fu, M., Kulkarni, R., Teo, J., Baldock, P., Cooney, G., Neely, G., et al (2017). Corrigendum to Insulin controls food intake and energy balance via NPY neurons" [Mol Metabol 6 (2017) 574-584]". Molecular Metabolism, 6(11), 1562. [More Information]
  • Simpson, S., Le Couteur, D., Raubenheimer, D., Solon-Biet, S., Cooney, G., Cogger, V., Fontana, L. (2017). Dietary protein, aging and nutritional geometry. Ageing Research Reviews, 39, 78-86. [More Information]
  • Krycer, J., Yugi, K., Hirayama, A., Fazakerley, D., Quek, L., Scalzo, R., Ohno, S., Hodson, M., Ikeda, S., Shoji, F., Domanova, W., Parker, B., Healy, M., Humphrey, S., Cooney, G., James, D., et al (2017). Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism. Cell Reports, 21(12), 3536-3547. [More Information]
  • Wang, D., Opperhuizen, A., Reznick, J., Turner, N., Su, Y., Cooney, G., Kalsbeek, A. (2017). Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus. Brain Research, 1671, 93-101. [More Information]
  • Houwelling, P., Berman, Y., Turner, N., Quinlan, K., Seto, J., Yang, N., Lek, M., MacArthur, D., Cooney, G., North, K. (2017). Exploring the relationship between (alpha)-actinin-3 deficiency and obesity in mice and humans. International Journal of Obesity, 41(7), 1154-1157. [More Information]
  • Nelson, M., Lahiri, S., Chow, J., Byrne, F., Hargett, S., Breen, D., Olzomer, E., Wu, L., Cooney, G., Turner, N., James, D., et al (2017). Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. Nature Communications, 8, 1-11. [More Information]
  • Nagarajan, S., Brandon, A., McKenna, J., Shtein, H., Nguyen, T., Suryana, E., Poronnik, P., Cooney, G., Saunders, D., Hoy, A. (2017). Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver. PloS One, 12(3), 1-14. [More Information]
  • Loh, K., Zhang, L., Brandon, A., Wang, K., Begg, D., Qi, Y., Fu, M., Kulkarni, R., Cooney, G., Teo, J., Neely, G., et al (2017). Insulin controls food intake and energy balance via NPY neurons. Molecular Metabolism, 6(6), 574-584. [More Information]
  • Stoeckli, J., Fisher-Wellman, K., Chaudhuri, R., Zeng, X., Fazakerley, D., Meoli, C., Thomas, K., Hoffman, N., Mangiafico, S., Xirouchaki, C., Cooney, G., James, D., et al (2017). Metabolomic analysis of insulin resistance across different mouse strains and diets. Journal of Biological Chemistry, 292(47), 19135-19145. [More Information]
  • Minard, A., Wong, M., Chaudhuri, R., Tan, S., Humphrey, S., Parker, B., Yang, J., Laybutt, D., Cooney, G., Coster, A., Stoeckli, J., James, D. (2016). Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes. Journal of Biological Chemistry, 291(49), 25629-25640. [More Information]
  • Brandon, A., Stuart, E., Leslie, S., Hoehn, K., James, D., Kraegen, E., Turner, N., Cooney, G. (2016). Minimal impact of age and housing temperature on the metabolic phenotype of Acc2K/K mice. Journal of Endocrinology, 228(3), 127-134. [More Information]
  • Montgomery, M., Brown, S., Lim, X., Fiveash, C., Osborne, B., Bentley, N., Braude, J., Mitchell, T., Coster, A., Don, A., et al (2016). Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species. Biochimica et Biophysica Acta, 1861 (11), 1828-1839. [More Information]
  • Kee, A., Yang, L., Lucas, C., Greenberg, M., Martel, N., Leong, G., Hughes, W., Cooney, G., James, D., Ostap, M., et al (2015). An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake. Traffic, 16(7), 691-711. [More Information]
  • Coughlan, K., Balon, T., Valentine, R., Petrocelli, R., Schultz, V., Brandon, A., Cooney, G., Kraegen, E., Ruderman, N., Saha, A. (2015). Nutrient excess and AMPK downregulation in incubated skeletal muscle and muscle of glucose infused rats. PloS One, 10(5), 1-17. [More Information]
  • Brandon, A., Tid-Ang, J., Wright, L., Stuart, E., Suryana, E., Bentley, N., Turner, N., Cooney, G., Ruderman, N., Kraegen, E. (2015). Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. PloS One, 10(3), 1-12. [More Information]
  • Hocking, S., Stewart, R., Brandon, A., Suryana, E., Stuart, E., Baldwin, E., Kolumam, G., Modrusan, Z., Junutula, J., Gunton, J., James, D., et al (2015). Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice. Diabetologia, 58(7), 1587-1600. [More Information]
  • Stoeckli, J., Meoli, C., Hoffman, N., Fazakerley, D., Pant, H., Cleasby, M., Ma, X., Kleinert, M., Brandon, A., Lopez, J., James, D., et al (2015). The RabGAP TBC1D1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle. Diabetes, 64(6), 1914-1922. [More Information]
  • Turner, N., Cooney, G., Kraegen, E., Bruce, C. (2014). Fatty acid metabolism, energy expenditure and insulin resistance in muscle. The Journal of Endocrinology, 220(2), T61-T79. [More Information]
  • Mokbel, N., Hoffman, N., Girgis, C., Small, L., Turner, N., Daly, R., Cooney, G., Holt, L. (2014). Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation. Journal of Cellular Physiology, 229(11), 1753-1764. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Liu, M., Montgomery, M., Fiveash, C., Osborne, B., Cooney, G., Bell-Anderson, K., Turner, N. (2014). PPARa-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis. Scientific Reports, 4, 1-9. [More Information]
  • Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]
  • Iseli, T., Turner, N., Zeng, X., Cooney, G., Kraegen, E., Yao, S., Ye, Y., James, D., Ye, J. (2013). Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKbeta. PloS One, 8(4), 1-9. [More Information]
  • Seto, J., Quinlan (nee Edwards), K., Lek, M., Zheng, X., Garton, F., MacArthur, D., Hogarth, M., Houweling, P., Gregorevic, P., Turner, N., Yang, N., North, K., et al (2013). ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling. Journal of Clinical Investigation, 123(10), 4255-4263. [More Information]
  • Montgomery, M., Osborne, B., Brown, S., Small, L., Mitchell, T., Cooney, G., Turner, N. (2013). Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle. Journal of Lipid Research, 54(12), 3322-3333. [More Information]
  • Turner, N., Kowalski, G., Leslie, S., Risis, S., Yang, C., Lee-Young, R., Babb, J., Meikle, P., Lancaster, G., Henstridge, D., et al (2013). Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia, 56(7), 1638-1648. [More Information]
  • Li, C., Young, P., Maloney, C., Eaton, S., Cowley, M., Buckland, M., Preiss, T., Henstridge, D., Cooney, G., Febbraio, M., et al (2013). Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice. Epigenetics, 8(6), 602-611. [More Information]
  • Montgomery, M., Hallahan, N., Brown, S., Liu, M., Mitchell, T., Cooney, G., Turner, N. (2013). Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia, 56(5), 1129-1139. [More Information]
  • Tsoli, M., Moore, M., Burg, D., Painter, A., Taylor, R., Lockie, S., Turner, N., Warren, A., Cooney, G., Oldfield, B., Clarke, S., et al (2012). Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice. Cancer Research, 72(17), 4372-4382. [More Information]
  • Ren, L., Chan, S., Zeng, X., Laybutt, D., Iseli, T., Sun, R., Kraegen, E., Cooney, G., Turner, N., Ye, J. (2012). Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance. PloS One, 7(2), 1-11. [More Information]
  • Gunton, J., Sisavanh, M., Stokes, R., Satin, J., Satin, L., Zhang, M., Liu, S., Cai, W., Cheng, K., Cooney, G., et al (2012). Mice Deficient in GEM GTPase Show Abnormal Glucose Homeostasis Due to Defects in Beta-Cell Calcium Handling. PloS One, 7(6), 1-9. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
  • Boden, M., Brandon, A., Tid-Ang, J., Preston, E., Wilks, D., Stuart, E., Cleasby, M., Turner, N., Cooney, G., Kraegen, E. (2012). Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle. American Journal of Physiology: Endocrinology and Metabolism, 303(6), E798-E805. [More Information]
  • Hoehn, K., Turner, N., Cooney, G., James, D. (2012). Phenotypic Discrepancies in Acetyl-CoA Carboxylase 2-deficient Mice. Journal of Biological Chemistry, 287(19), 1-1. [More Information]
  • Wright, L., Brandon, A., Hoy, A., Forsberg, G., Lelliott, C., Reznick, J., Löfgren, L., Oscarsson, J., Strömstedt, M., Cooney, G., et al (2011). Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1(beta) involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia, 54(6), 1417-1426. [More Information]
  • Preston, E., Cooney, G., Wilks, D., Baran, K., Zhang, L., Kraegen, E., Salis (nee Sainsbury), A. (2011). Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways. Neuropeptides, 45(6), 407-415. [More Information]
  • Seto, J., Chan, S., Turner, N., MacArthur, D., Raftery, J., Berman, Y., Quinlan (nee Edwards), K., Cooney, G., Head, S., Yang, N., North, K. (2011). The effect of α-actinin-3 deficiency on muscle aging. Experimental Gerontology, 46(4), 292-302. [More Information]
  • Brandon, A., Hoy, A., Wright, L., Turner, N., Hegarty, B., Iseli, T., Xu, J., Cooney, G., Saha, A., Ruderman, N., et al (2011). The evolution of insulin resistance in muscle of the glucose infused rat. Archives of Biochemistry and Biophysics, 509(2), 133-141. [More Information]
  • Hoehn, K., Turner, N., Swarbrick, M., Wilks, D., Preston, E., Phua, Y., Hoy, A., James, D., Cooney, G., et al (2010). Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism, 11(1), 70-76. [More Information]
  • Quinlan (nee Edwards), K., Seto, J., Turner, N., Vandebrouck, A., Floetenmeyer, M., Macarthur, D., Raftery, J., Lek, M., Yang, N., Parton, R., North, K., et al (2010). Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle. Human Molecular Genetics, 19(7), 1335-1346. [More Information]
  • Kanzleiter, T., Preston, E., Wilks, D., Ho, B., Benrick, A., Reznick, J., Heilbronn, L., Turner, N., Cooney, G. (2010). Overexpression of the orphan receptor Nur77 alters glucose metabolism in rat muscle cells and rat muscle in vivo. Diabetologia, 53(6), 1174-1183. [More Information]
  • Hoehn, K., Salmon, A., Hohnen-Behrens, C., Turner, N., Hoy, A., Maghzal, G., Stocker, R., Van Remmen, H., Kraegen, E., Cooney, G., et al (2009). Insulin resistance is a cellular antioxidant defense mechanism. Proceedings of the National Academy of Sciences of the United States of America, 106(42), 17787-17792. [More Information]
  • Hoy, A., Brandon, A., Turner, N., Watt, M., Bruce, C., Cooney, G., Kraegen, E. (2009). Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism, 297(1), E67-E75. [More Information]
  • Bruce, C., Hoy, A., Turner, N., Watt, M., Allen, T., Carpenter, K., Cooney, G., Febbraio, M., Kraegen, E. (2009). Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes, 58(3), 550-558. [More Information]
  • MacArthur, D., Seto, J., Chan, S., Quinlan (nee Edwards), K., Raftery, J., Turner, N., Nicholson, M., Kee, A., Hardeman, E., Gunning, P., North, K., et al (2008). An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance. Human Molecular Genetics, 17(8), 1076-1086. [More Information]
  • Turner, N., Li, J., Gosby, A., To, S., Cheng, Z., Miyoshi, H., Taketo, M., Cooney, G., Kraegen, E., James, D., et al (2008). Berberine and its more Biologically Availible Derivative Dihyroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMPK and Improve Insulin Action. Diabetes, 57(5), 1414-1418. [More Information]
  • Hoy, A., Bruce, C., Cederberg, A., Turner, N., James, D., Cooney, G., Kraegen, E. (2007). Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism, 293(5), e1358-e1364. [More Information]
  • Kraegen, E., Saha, A., Preston, E., Wilks, D., Hoy, A., Cooney, G., Ruderman, N. (2006). Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology: Endocrinology and Metabolism, 290, e471-e479. [More Information]

Conferences

  • Seto, J., Macarthur, D., Quinlan, K., Raferty, J., Chan, S., Turner, N., Nicholson, M., Kee, A., Cooney, G., Gunningberg, P., et al (2013). Metabolic and physiological changes in Actn3 deficient mice: defining the association between alpha-actinin-3 and human athletic performance. Westmead Association Research Symposium, Sydney.
  • Seto, J., Frank, D., Quinlan, K., Turner, N., Lek, M., Houweling, P., MacArthur, D., Raferty, J., Yang, N., Cooney, G., et al (2010). Enhanced exercise training response with alpha -actinin-3 deficiency is associated with calcineurin/NF AT activation. Gage Conferences - Muscle, Canberra: Canberra Boys Grammar School.
  • Seto, J., MacArthur, D., Chan, S., Quinlan (nee Edwards), K., Cooney, G., Head, S., Yang, N., North, K. (2008). Metabolic and physiological changes in Actn3 deficient mice: defining the association between alpha -actinin-3 and human athletic performance. New Directions in Biology and Disease of Skeletal Muscle, The Westin at Canal Place: The Westin at Canal Place.

Patents

  • Ke, C., James, D., Kraegen, E., Cooney, G., Ye, Y., Tan, M., Chen, T., Li, X., Ye, J. (2009). Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity. Patent No. 2009212026.

2018

  • Turner, N., Lim, X., Toop, H., Osborne, B., Brandon, A., Taylor, E., Fiveash, C., Govindaraju, H., Teo, J., McEwen, H., Couttas, T., Cooney, G., Don, A., et al (2018). A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, 9(1). [More Information]
  • Holt, L., Brandon, A., Small, L., Suryana, E., Preston, E., Wilks, D., Mokbel, N., Coles, C., White, J., Turner, N., Cooney, G., et al (2018). Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice. Endocrinology, 159(3), 1339-1351. [More Information]
  • Small, L., Brandon, A., Quek, L., Krycer, J., James, D., Turner, N., Cooney, G. (2018). Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake. American Journal of Physiology: Endocrinology and Metabolism, 315(2), E258-E266. [More Information]
  • Bakshi, I., Suryana, E., Small, L., Quek, L., Brandon, A., Turner, N., Cooney, G. (2018). Fructose bisphosphatase 2 overexpression increases glucose uptake in skeletal muscle. Journal of Endocrinology, 237(2), 101-111. [More Information]
  • Burchfield, J., Kebede, M., Meoli, C., Stoeckli, J., Whitworth, P., Wright, A., Hoffman, N., Minard, A., Ma, X., Krycer, J., Healy, M., Yau, B., Thomas, K., Cooney, G., James, D., Fazakerley, D., et al (2018). High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice. Journal of Biological Chemistry, 293(15), 5731-5745. [More Information]
  • Small, L., Brandon, A., Turner, N., Cooney, G. (2018). Modeling insulin resistance in rodents by alterations in diet: what have high-fat and high-calorie diets revealed? American Journal of Physiology: Endocrinology and Metabolism, 314(3), E251-E265. [More Information]
  • Small, L., Brandon, A., Turner, N., Cooney, G. (2018). Modeling insulin resistance in rodents by alterations in diet: What have high-fat and high-calorie diets revealed? American Journal of Physiology: Endocrinology and Metabolism, 314(3), E251-E265. [More Information]
  • Bentley, N., Fiveash, C., Osborne, B., Quek, L., Ogura, M., Inagaki, N., Cooney, G., Polly, P., Montgomery, M., Turner, N. (2018). Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice. Biochemical and Biophysical Research Communications, 503(3), 1349-1355. [More Information]
  • Gokarn, R., Solon-Biet, S., Youngson, N., Wahl, D., Cogger, V., McMahon, A., Cooney, G., Ballard, J., Raubenheimer, D., Morris, M., Simpson, S., Le Couteur, D. (2018). The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(4), 446-449. [More Information]

2017

  • Montgomery, M., Brown, S., Mitchell, T., Coster, A., Cooney, G., Turner, N. (2017). Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains. Scientific Reports, 7, 1-9. [More Information]
  • Loh, K., Zhang, L., Brandon, A., Wang, K., Begg, D., Qi, Y., Fu, M., Kulkarni, R., Teo, J., Baldock, P., Cooney, G., Neely, G., et al (2017). Corrigendum to Insulin controls food intake and energy balance via NPY neurons" [Mol Metabol 6 (2017) 574-584]". Molecular Metabolism, 6(11), 1562. [More Information]
  • Simpson, S., Le Couteur, D., Raubenheimer, D., Solon-Biet, S., Cooney, G., Cogger, V., Fontana, L. (2017). Dietary protein, aging and nutritional geometry. Ageing Research Reviews, 39, 78-86. [More Information]
  • Krycer, J., Yugi, K., Hirayama, A., Fazakerley, D., Quek, L., Scalzo, R., Ohno, S., Hodson, M., Ikeda, S., Shoji, F., Domanova, W., Parker, B., Healy, M., Humphrey, S., Cooney, G., James, D., et al (2017). Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism. Cell Reports, 21(12), 3536-3547. [More Information]
  • Wang, D., Opperhuizen, A., Reznick, J., Turner, N., Su, Y., Cooney, G., Kalsbeek, A. (2017). Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus. Brain Research, 1671, 93-101. [More Information]
  • Houwelling, P., Berman, Y., Turner, N., Quinlan, K., Seto, J., Yang, N., Lek, M., MacArthur, D., Cooney, G., North, K. (2017). Exploring the relationship between (alpha)-actinin-3 deficiency and obesity in mice and humans. International Journal of Obesity, 41(7), 1154-1157. [More Information]
  • Nelson, M., Lahiri, S., Chow, J., Byrne, F., Hargett, S., Breen, D., Olzomer, E., Wu, L., Cooney, G., Turner, N., James, D., et al (2017). Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival. Nature Communications, 8, 1-11. [More Information]
  • Nagarajan, S., Brandon, A., McKenna, J., Shtein, H., Nguyen, T., Suryana, E., Poronnik, P., Cooney, G., Saunders, D., Hoy, A. (2017). Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver. PloS One, 12(3), 1-14. [More Information]
  • Loh, K., Zhang, L., Brandon, A., Wang, K., Begg, D., Qi, Y., Fu, M., Kulkarni, R., Cooney, G., Teo, J., Neely, G., et al (2017). Insulin controls food intake and energy balance via NPY neurons. Molecular Metabolism, 6(6), 574-584. [More Information]
  • Stoeckli, J., Fisher-Wellman, K., Chaudhuri, R., Zeng, X., Fazakerley, D., Meoli, C., Thomas, K., Hoffman, N., Mangiafico, S., Xirouchaki, C., Cooney, G., James, D., et al (2017). Metabolomic analysis of insulin resistance across different mouse strains and diets. Journal of Biological Chemistry, 292(47), 19135-19145. [More Information]

2016

  • Minard, A., Wong, M., Chaudhuri, R., Tan, S., Humphrey, S., Parker, B., Yang, J., Laybutt, D., Cooney, G., Coster, A., Stoeckli, J., James, D. (2016). Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes. Journal of Biological Chemistry, 291(49), 25629-25640. [More Information]
  • Brandon, A., Stuart, E., Leslie, S., Hoehn, K., James, D., Kraegen, E., Turner, N., Cooney, G. (2016). Minimal impact of age and housing temperature on the metabolic phenotype of Acc2K/K mice. Journal of Endocrinology, 228(3), 127-134. [More Information]
  • Montgomery, M., Brown, S., Lim, X., Fiveash, C., Osborne, B., Bentley, N., Braude, J., Mitchell, T., Coster, A., Don, A., et al (2016). Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species. Biochimica et Biophysica Acta, 1861 (11), 1828-1839. [More Information]

2015

  • Kee, A., Yang, L., Lucas, C., Greenberg, M., Martel, N., Leong, G., Hughes, W., Cooney, G., James, D., Ostap, M., et al (2015). An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake. Traffic, 16(7), 691-711. [More Information]
  • Coughlan, K., Balon, T., Valentine, R., Petrocelli, R., Schultz, V., Brandon, A., Cooney, G., Kraegen, E., Ruderman, N., Saha, A. (2015). Nutrient excess and AMPK downregulation in incubated skeletal muscle and muscle of glucose infused rats. PloS One, 10(5), 1-17. [More Information]
  • Brandon, A., Tid-Ang, J., Wright, L., Stuart, E., Suryana, E., Bentley, N., Turner, N., Cooney, G., Ruderman, N., Kraegen, E. (2015). Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance. PloS One, 10(3), 1-12. [More Information]
  • Hocking, S., Stewart, R., Brandon, A., Suryana, E., Stuart, E., Baldwin, E., Kolumam, G., Modrusan, Z., Junutula, J., Gunton, J., James, D., et al (2015). Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice. Diabetologia, 58(7), 1587-1600. [More Information]
  • Stoeckli, J., Meoli, C., Hoffman, N., Fazakerley, D., Pant, H., Cleasby, M., Ma, X., Kleinert, M., Brandon, A., Lopez, J., James, D., et al (2015). The RabGAP TBC1D1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle. Diabetes, 64(6), 1914-1922. [More Information]

2014

  • Turner, N., Cooney, G., Kraegen, E., Bruce, C. (2014). Fatty acid metabolism, energy expenditure and insulin resistance in muscle. The Journal of Endocrinology, 220(2), T61-T79. [More Information]
  • Mokbel, N., Hoffman, N., Girgis, C., Small, L., Turner, N., Daly, R., Cooney, G., Holt, L. (2014). Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation. Journal of Cellular Physiology, 229(11), 1753-1764. [More Information]
  • Sullivan, K., El-Hoss, J., Quinlan (nee Edwards), K., Deo, N., Garton, F., Seto, J., Gdalevitch, M., Turner, N., Cooney, G., Kolanczyk, M., North, K., Little, D., Schindeler, A. (2014). NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics, 23(5), 1250-1259. [More Information]
  • Liu, M., Montgomery, M., Fiveash, C., Osborne, B., Cooney, G., Bell-Anderson, K., Turner, N. (2014). PPARa-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis. Scientific Reports, 4, 1-9. [More Information]
  • Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
  • Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]

2013

  • Iseli, T., Turner, N., Zeng, X., Cooney, G., Kraegen, E., Yao, S., Ye, Y., James, D., Ye, J. (2013). Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKbeta. PloS One, 8(4), 1-9. [More Information]
  • Seto, J., Quinlan (nee Edwards), K., Lek, M., Zheng, X., Garton, F., MacArthur, D., Hogarth, M., Houweling, P., Gregorevic, P., Turner, N., Yang, N., North, K., et al (2013). ACTN3 genotype infuences muscle performance through the regulation of calcineurin signaling. Journal of Clinical Investigation, 123(10), 4255-4263. [More Information]
  • Montgomery, M., Osborne, B., Brown, S., Small, L., Mitchell, T., Cooney, G., Turner, N. (2013). Contrasting metabolic effects of medium-versus long-chain fatty acids in skeletal muscle. Journal of Lipid Research, 54(12), 3322-3333. [More Information]
  • Turner, N., Kowalski, G., Leslie, S., Risis, S., Yang, C., Lee-Young, R., Babb, J., Meikle, P., Lancaster, G., Henstridge, D., et al (2013). Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia, 56(7), 1638-1648. [More Information]
  • Li, C., Young, P., Maloney, C., Eaton, S., Cowley, M., Buckland, M., Preiss, T., Henstridge, D., Cooney, G., Febbraio, M., et al (2013). Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice. Epigenetics, 8(6), 602-611. [More Information]
  • Seto, J., Macarthur, D., Quinlan, K., Raferty, J., Chan, S., Turner, N., Nicholson, M., Kee, A., Cooney, G., Gunningberg, P., et al (2013). Metabolic and physiological changes in Actn3 deficient mice: defining the association between alpha-actinin-3 and human athletic performance. Westmead Association Research Symposium, Sydney.
  • Montgomery, M., Hallahan, N., Brown, S., Liu, M., Mitchell, T., Cooney, G., Turner, N. (2013). Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia, 56(5), 1129-1139. [More Information]

2012

  • Tsoli, M., Moore, M., Burg, D., Painter, A., Taylor, R., Lockie, S., Turner, N., Warren, A., Cooney, G., Oldfield, B., Clarke, S., et al (2012). Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice. Cancer Research, 72(17), 4372-4382. [More Information]
  • Ren, L., Chan, S., Zeng, X., Laybutt, D., Iseli, T., Sun, R., Kraegen, E., Cooney, G., Turner, N., Ye, J. (2012). Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance. PloS One, 7(2), 1-11. [More Information]
  • Gunton, J., Sisavanh, M., Stokes, R., Satin, J., Satin, L., Zhang, M., Liu, S., Cai, W., Cheng, K., Cooney, G., et al (2012). Mice Deficient in GEM GTPase Show Abnormal Glucose Homeostasis Due to Defects in Beta-Cell Calcium Handling. PloS One, 7(6), 1-9. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
  • Boden, M., Brandon, A., Tid-Ang, J., Preston, E., Wilks, D., Stuart, E., Cleasby, M., Turner, N., Cooney, G., Kraegen, E. (2012). Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle. American Journal of Physiology: Endocrinology and Metabolism, 303(6), E798-E805. [More Information]
  • Hoehn, K., Turner, N., Cooney, G., James, D. (2012). Phenotypic Discrepancies in Acetyl-CoA Carboxylase 2-deficient Mice. Journal of Biological Chemistry, 287(19), 1-1. [More Information]

2011

  • Wright, L., Brandon, A., Hoy, A., Forsberg, G., Lelliott, C., Reznick, J., Löfgren, L., Oscarsson, J., Strömstedt, M., Cooney, G., et al (2011). Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1(beta) involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia, 54(6), 1417-1426. [More Information]
  • Preston, E., Cooney, G., Wilks, D., Baran, K., Zhang, L., Kraegen, E., Salis (nee Sainsbury), A. (2011). Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways. Neuropeptides, 45(6), 407-415. [More Information]
  • Seto, J., Chan, S., Turner, N., MacArthur, D., Raftery, J., Berman, Y., Quinlan (nee Edwards), K., Cooney, G., Head, S., Yang, N., North, K. (2011). The effect of α-actinin-3 deficiency on muscle aging. Experimental Gerontology, 46(4), 292-302. [More Information]
  • Brandon, A., Hoy, A., Wright, L., Turner, N., Hegarty, B., Iseli, T., Xu, J., Cooney, G., Saha, A., Ruderman, N., et al (2011). The evolution of insulin resistance in muscle of the glucose infused rat. Archives of Biochemistry and Biophysics, 509(2), 133-141. [More Information]

2010

  • Hoehn, K., Turner, N., Swarbrick, M., Wilks, D., Preston, E., Phua, Y., Hoy, A., James, D., Cooney, G., et al (2010). Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism, 11(1), 70-76. [More Information]
  • Quinlan (nee Edwards), K., Seto, J., Turner, N., Vandebrouck, A., Floetenmeyer, M., Macarthur, D., Raftery, J., Lek, M., Yang, N., Parton, R., North, K., et al (2010). Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle. Human Molecular Genetics, 19(7), 1335-1346. [More Information]
  • Seto, J., Frank, D., Quinlan, K., Turner, N., Lek, M., Houweling, P., MacArthur, D., Raferty, J., Yang, N., Cooney, G., et al (2010). Enhanced exercise training response with alpha -actinin-3 deficiency is associated with calcineurin/NF AT activation. Gage Conferences - Muscle, Canberra: Canberra Boys Grammar School.
  • Kanzleiter, T., Preston, E., Wilks, D., Ho, B., Benrick, A., Reznick, J., Heilbronn, L., Turner, N., Cooney, G. (2010). Overexpression of the orphan receptor Nur77 alters glucose metabolism in rat muscle cells and rat muscle in vivo. Diabetologia, 53(6), 1174-1183. [More Information]

2009

  • Hoehn, K., Salmon, A., Hohnen-Behrens, C., Turner, N., Hoy, A., Maghzal, G., Stocker, R., Van Remmen, H., Kraegen, E., Cooney, G., et al (2009). Insulin resistance is a cellular antioxidant defense mechanism. Proceedings of the National Academy of Sciences of the United States of America, 106(42), 17787-17792. [More Information]
  • Hoy, A., Brandon, A., Turner, N., Watt, M., Bruce, C., Cooney, G., Kraegen, E. (2009). Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism, 297(1), E67-E75. [More Information]
  • Bruce, C., Hoy, A., Turner, N., Watt, M., Allen, T., Carpenter, K., Cooney, G., Febbraio, M., Kraegen, E. (2009). Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes, 58(3), 550-558. [More Information]
  • Ke, C., James, D., Kraegen, E., Cooney, G., Ye, Y., Tan, M., Chen, T., Li, X., Ye, J. (2009). Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity. Patent No. 2009212026.

2008

  • MacArthur, D., Seto, J., Chan, S., Quinlan (nee Edwards), K., Raftery, J., Turner, N., Nicholson, M., Kee, A., Hardeman, E., Gunning, P., North, K., et al (2008). An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance. Human Molecular Genetics, 17(8), 1076-1086. [More Information]
  • Turner, N., Li, J., Gosby, A., To, S., Cheng, Z., Miyoshi, H., Taketo, M., Cooney, G., Kraegen, E., James, D., et al (2008). Berberine and its more Biologically Availible Derivative Dihyroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMPK and Improve Insulin Action. Diabetes, 57(5), 1414-1418. [More Information]
  • Seto, J., MacArthur, D., Chan, S., Quinlan (nee Edwards), K., Cooney, G., Head, S., Yang, N., North, K. (2008). Metabolic and physiological changes in Actn3 deficient mice: defining the association between alpha -actinin-3 and human athletic performance. New Directions in Biology and Disease of Skeletal Muscle, The Westin at Canal Place: The Westin at Canal Place.

2007

  • Hoy, A., Bruce, C., Cederberg, A., Turner, N., James, D., Cooney, G., Kraegen, E. (2007). Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. American Journal of Physiology: Endocrinology and Metabolism, 293(5), e1358-e1364. [More Information]

2006

  • Kraegen, E., Saha, A., Preston, E., Wilks, D., Hoy, A., Cooney, G., Ruderman, N. (2006). Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology: Endocrinology and Metabolism, 290, e471-e479. [More Information]

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