Dr Guoping Zheng

NHMRC Senior Research Fellow
Medicine, Westmead Clinical School

Telephone +61 2 9845 0000

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Selected grants

2013

  • Differentiation of pro-fibrotic from anti-inflammatory effects of TGF-B in kidney fibrosis by targeting B-catenin; Harris D, Zheng G; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Targeting Beta-catenin in Kidney Fibrosis; Harris D, Zheng G; DVC Research/Bridging Support Grant.

2010

  • Preventing Kidney Fibrosis By Targeting Matrix Metalloproteinase-9 in Chronic Kidney Disease; Harris D, Zheng G; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • NHMRC - Peter Doherty Fellowship; Zheng G; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Book Chapters

  • Tian, X., Dong, Y., Zhang, J., Wang, H., Xie, J., Niu, B., Harris, D., Zheng, G. (2013). Beta-Catenin and Kidney Fibrosis. In Abel Braunfeld, Gabriel R. Mirsky (Eds.), Beta-Catenin: Structure, Function and Clinical Significance, (pp. 63-88). New York: Nova Science Publishers.
  • Zheng, G., Zhang, J., Tan, T., Hsu, T., Tian, X., Niu, B., Harris, D. (2012). Matrix Metalloproteinases (MMPs) in Renal Fibrosis. In Namae Oshiro and Eiko Miyagi (Eds.), Matrix Metalloproteinases: Biology, Functions and Clinical Implications, (pp. 169-186). New York: Nova Science Publishers, Inc.

Journals

  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Tan, T., Lee, S., Zhang, J., Zhang, G., Hu, M., Wang, C., Cao, Q., Zhao, Y., Harris, D., et al (2014). Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis. International Journal of Clinical and Experimental Pathology, 7(1), 38-47.
  • Tian, X., Zhang, J., Tan, T., Lyons, G., Zhao, H., Niu, B., Lee, S., Tsatralis, T., Zhao, Y., Wang, Y., Cao, Q., Wang, C., Wang, Y., Lee, V., Zheng, G., Harris, D., et al (2013). Association of beta catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF- beta1. Journal of Cell Science, 126(1), 67-76. [More Information]
  • Wang, C., Yu, X., Cao, Q., Wang, Y., Zheng, G., Tan, T., Zhao, H., Zhao, Y., Wang, Y., Harris, D. (2013). Characterization of murine macrophages from bone marrow, spleen and peritoneum. BMC Immunology, 14(1), 1-10. [More Information]
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6(3), 326-333. [More Information]
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Harris, D., et al (2013). DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International, 83(2), 223-232. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Harris, D., et al (2013). Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation, 93(4), 434-449. [More Information]
  • Zhao, H., Dong, Y., Tian, X., Tan, T., Liu, Z., Zhao, Y., Zhang, Y., Harris, D., Zheng, G. (2013). Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases. World Journal of Nephrology, 2(3), 84-89. [More Information]
  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]
  • Tian, X., Liu, Z., Niu, B., Zhang, J., Tan, T., Lee, S., Zhao, Y., Harris, D., Zheng, G. (2011). E-cadherin/β-catenin complex and the epithelial barrier. Journal of Biomedicine and Biotechnology, 2011, 567305-1-567305-6. [More Information]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011). Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. [More Information]
  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Wang, Y., Lee, V., Tian, X., Wang, Y., Cao, Q., Wang, Y., Harris, D. (2010). Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells. The American Journal of Pathology: cellular and molecular biology of disease, 176(3), 1256-1270. [More Information]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010). The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, Dialysis, Transplantation, 25(3), 717-730. [More Information]
  • Watson, D., Zheng, G., Wu, H., Wang, Y., Wang, Y., Harris, D., Alexander, S. (2009). CCL2 DNA vaccine to treat renal disease. The International Journal of Biochemistry and Cell Biology, 41(4), 729-732. [More Information]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Wang, Y., Wang, Y., Cai, Q., Zheng, G., Lee, V., Zheng, D., Li, X., Tan, T., Harris, D. (2008). By Homing to the Kidney, Activated Macrophages Potently Exacerbate Renal Injury. The American Journal of Pathology: cellular and molecular biology of disease, 172(6), 1491-1499. [More Information]
  • Wang, Y., Wang, Y., Zheng, G., Lee, V., Ouyang, L., Chang, D., Mahajan, D., Coombs, J., Wang, Y., Alexander, S., Harris, D. (2007). Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney International, 72(3), 290-299. [More Information]
  • Qin, X., Lee, V., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006). A protective role for programmed death 1 in progression of murine adriamycin nephropathy. Kidney International, 70, 1244-1250. [More Information]
  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, Dialysis, Transplantation. [More Information]
  • Zheng, G., Wang, Y., XIANG, S., Tay, Y., Wu, H., Watson, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury. Journal of the American Society of Nephrology, 17(2), 465-474. [More Information]
  • Zheng, G., Zheng, L., Wang, Y., Wu, H., Kairaitis, L., Zhang, C., Tay, Y., Wang, Y., Alexander, S., Harris, D. (2006). NK cells do not mediate renal injury in murine adriamycin nephropathy. Kidney International, 69(7), 1159-1165. [More Information]
  • Wu, H., Wang, Y., Tay, Y., Zheng, G., Zhang, C., Alexander, S., Harris, D. (2005). DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Kidney International, 67(6), 2178-2186. [More Information]
  • Zheng, G., Wang, Y., Mahajan, D., Qin, X., Wang, Y., Wang, Y., Alexander, S., Harris, D. (2005). The role of tubulointerstitial inflammation. Kidney International, 67(S94), S96-S100. [More Information]
  • Zheng, G., Harris, D. (2004). Plasmin in renal interstitial fibrosis: Innocent or guilty? Kidney International, 66(1), 455-456.
  • Zheng, G., Lyons, G. (2002). Cyclosporin A improves the selection of cells transfected with the puromycin acetyltransferase gene. BioTechniques: the journal of laboratory technology for bioresearch, 33(1), 32-36.

2014

  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Tan, T., Lee, S., Zhang, J., Zhang, G., Hu, M., Wang, C., Cao, Q., Zhao, Y., Harris, D., et al (2014). Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis. International Journal of Clinical and Experimental Pathology, 7(1), 38-47.

2013

  • Tian, X., Zhang, J., Tan, T., Lyons, G., Zhao, H., Niu, B., Lee, S., Tsatralis, T., Zhao, Y., Wang, Y., Cao, Q., Wang, C., Wang, Y., Lee, V., Zheng, G., Harris, D., et al (2013). Association of beta catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF- beta1. Journal of Cell Science, 126(1), 67-76. [More Information]
  • Tian, X., Dong, Y., Zhang, J., Wang, H., Xie, J., Niu, B., Harris, D., Zheng, G. (2013). Beta-Catenin and Kidney Fibrosis. In Abel Braunfeld, Gabriel R. Mirsky (Eds.), Beta-Catenin: Structure, Function and Clinical Significance, (pp. 63-88). New York: Nova Science Publishers.
  • Wang, C., Yu, X., Cao, Q., Wang, Y., Zheng, G., Tan, T., Zhao, H., Zhao, Y., Wang, Y., Harris, D. (2013). Characterization of murine macrophages from bone marrow, spleen and peritoneum. BMC Immunology, 14(1), 1-10. [More Information]
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6(3), 326-333. [More Information]
  • Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Harris, D., et al (2013). DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International, 83(2), 223-232. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Lee, S., Zhang, J., Zhao, Y., Tian, X., Wang, Y., Wang, Y., Cao, Q., Wang, Y., Lee, V., Wang, C., Zheng, D., Alexander, S., Harris, D., et al (2013). Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage. Laboratory Investigation, 93(4), 434-449. [More Information]
  • Zhao, H., Dong, Y., Tian, X., Tan, T., Liu, Z., Zhao, Y., Zhang, Y., Harris, D., Zheng, G. (2013). Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases. World Journal of Nephrology, 2(3), 84-89. [More Information]

2012

  • Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International. [More Information]
  • Zheng, G., Zhang, J., Tan, T., Hsu, T., Tian, X., Niu, B., Harris, D. (2012). Matrix Metalloproteinases (MMPs) in Renal Fibrosis. In Namae Oshiro and Eiko Miyagi (Eds.), Matrix Metalloproteinases: Biology, Functions and Clinical Implications, (pp. 169-186). New York: Nova Science Publishers, Inc.
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]

2011

  • Tian, X., Liu, Z., Niu, B., Zhang, J., Tan, T., Lee, S., Zhao, Y., Harris, D., Zheng, G. (2011). E-cadherin/β-catenin complex and the epithelial barrier. Journal of Biomedicine and Biotechnology, 2011, 567305-1-567305-6. [More Information]
  • Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
  • Zheng, D., Wang, Y., Cao, Q., Lee, V., Zheng, G., Sun, Y., Tan, T., Wang, Y., Alexander, S., Harris, D. (2011). Transfused Macrophages Ameliorate Pancreatic and Renal Injury in Murine Diabetes Mellitus. Nephron Experimental Nephrology, 118(4), e87-e99. [More Information]

2010

  • Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
  • Tan, T., Zheng, G., Hsu, T., Wang, Y., Lee, V., Tian, X., Wang, Y., Cao, Q., Wang, Y., Harris, D. (2010). Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells. The American Journal of Pathology: cellular and molecular biology of disease, 176(3), 1256-1270. [More Information]
  • Lee, V., Qin, X., Wang, Y., Zheng, G., Wang, Y., Wang, Y., Ince, J., Tan, T., Kairaitis, L., Alexander, S., Harris, D. (2010). The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. Nephrology, Dialysis, Transplantation, 25(3), 717-730. [More Information]

2009

  • Watson, D., Zheng, G., Wu, H., Wang, Y., Wang, Y., Harris, D., Alexander, S. (2009). CCL2 DNA vaccine to treat renal disease. The International Journal of Biochemistry and Cell Biology, 41(4), 729-732. [More Information]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]

2008

  • Wang, Y., Wang, Y., Cai, Q., Zheng, G., Lee, V., Zheng, D., Li, X., Tan, T., Harris, D. (2008). By Homing to the Kidney, Activated Macrophages Potently Exacerbate Renal Injury. The American Journal of Pathology: cellular and molecular biology of disease, 172(6), 1491-1499. [More Information]

2007

  • Wang, Y., Wang, Y., Zheng, G., Lee, V., Ouyang, L., Chang, D., Mahajan, D., Coombs, J., Wang, Y., Alexander, S., Harris, D. (2007). Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney International, 72(3), 290-299. [More Information]

2006

  • Qin, X., Lee, V., Wang, Y., Zheng, G., Wang, Y., Alexander, S., Harris, D. (2006). A protective role for programmed death 1 in progression of murine adriamycin nephropathy. Kidney International, 70, 1244-1250. [More Information]
  • Lee, V., Wang, Y., Qin, X., Wang, Y., Zheng, G., Mahajan, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). Adriamycin nephropathy in severe combined immunodeficient (SCID) mice. Nephrology, Dialysis, Transplantation. [More Information]
  • Zheng, G., Wang, Y., XIANG, S., Tay, Y., Wu, H., Watson, D., Coombes, J., Rangan, G., Alexander, S., Harris, D. (2006). DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury. Journal of the American Society of Nephrology, 17(2), 465-474. [More Information]
  • Zheng, G., Zheng, L., Wang, Y., Wu, H., Kairaitis, L., Zhang, C., Tay, Y., Wang, Y., Alexander, S., Harris, D. (2006). NK cells do not mediate renal injury in murine adriamycin nephropathy. Kidney International, 69(7), 1159-1165. [More Information]

2005

  • Wu, H., Wang, Y., Tay, Y., Zheng, G., Zhang, C., Alexander, S., Harris, D. (2005). DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Kidney International, 67(6), 2178-2186. [More Information]
  • Zheng, G., Wang, Y., Mahajan, D., Qin, X., Wang, Y., Wang, Y., Alexander, S., Harris, D. (2005). The role of tubulointerstitial inflammation. Kidney International, 67(S94), S96-S100. [More Information]

2004

  • Zheng, G., Harris, D. (2004). Plasmin in renal interstitial fibrosis: Innocent or guilty? Kidney International, 66(1), 455-456.

2002

  • Zheng, G., Lyons, G. (2002). Cyclosporin A improves the selection of cells transfected with the puromycin acetyltransferase gene. BioTechniques: the journal of laboratory technology for bioresearch, 33(1), 32-36.

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