Professor Gustavo Duque

Professor
Medicine, Nepean Clinical School

Telephone +61 2 4734 4278
Fax +61 2 4734 1817

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Biographical details

Professor Duque, MD, PhD, FRACP is a geriatrician and bone biologist with a research interest in the mechanisms of age-related bone and muscle loss, osteoporosis, falls, fractures and frailty in older persons. His initial training included Internal Medicine at Javeriana University (Colombia) and Geriatric Medicine, which he completed at McGill University in Montreal (Canada). Subsequently, he obtained his PhD at McGill University in 2003 with a thesis entitled "Molecular Changes of the Aging Osteoblast" under the supervision of Dr. Richard Kremer. Between 2003 and November 2007, he joined the faculty at McGill University Medical School as a member of the Division of Geriatric Medicine and as Researcher at the Lady Davis Institute for Medical Research. In November 2007, he moved to Australia to join the Faculty as Associate Professor and Head of the Division of Geriatric Medicine at Sydney Medical School Nepean -University of Sydney. In 2012, he was promoted to Professor of Medicine at the University of Sydney.

Key Contributions to Research

  • New aspects of the interaction between bone and fat and the characterisation of the particular features of marrow fat in ageing bone. He has demonstrated that bone marrow fat is toxic against bone (J Cell Mol Med. 2010; Exp. Gerontology 2009), could be used as a diagnostic method to predict bone loss (Exp. Gerontology2011) and could become a source of new bone mass through its differentiation back into bone (J Bone Miner Res 2013; Biochimie 2012; Stem Cells 2012; J Bone Miner Res 2011; Osteoporos Int 2010; Biogerontology 2004; Exp. Gerontology 2004), thus bringing new evidence supporting a new anabolic approach for the treatment of osteoporosis.
  • His experiments with animal models of accelerating ageing and his in vitroand in vivomodels of nuclear lamina defects have provided new evidence to understand the ageing process in bone and the molecular mechanisms of senile osteoporosis(Bone 2011; PlosOne 2011; Mech Ageing Dev. 2011; J Gerontol A Biol Sci Med Sci. 2009; Biogerontology. 2009; J Bone Miner Res. 2009; Mech Ageing Dev. 2006).
  • He has a particular interest in the development of new anabolic therapies for osteoporosis and in the discovery and understanding of new anabolic effect of current compounds. He demonstrated a new anabolic effect of vitamin D on both osteoblasts and differentiating mesenchymal stem cells (Am J Physiol Endocrinol Metab. 2005; Bone 2004). He has also discovered a new role of protein prenylation in bone anabolism (Br J Pharmacol. 2011; J Bone Miner Res. 2007). More recently, he has made a breakthrough discovery by identifying a new role of interferon gamma in bone formation(Stem Cells. 2009; J Bone Miner Res. 2011) and by rescuing oophorectomised mice from osteoporosis by treating them with an inhibitor of PPARg(J Bone Miner Res, 2013), which may constitute new anabolic approaches to osteoporosis in the near future. In 2012, Prof. Duque obtained his first patent in Australia (patent PCT/AU2012/001095)after discovering that an end product of the kynurenine pathway has a strong anabolic effect on bone.
  • From his position as geriatrician at Nepean Hospital, he has also implemented a Clinical Research Unit in osteoporosis, frailty and falls. In 2008, Prof. Duque implemented a state-of-the-artFalls and Fractures Clinic, which was recognised in 2012 as a finalist in the Health NSW Awards in the category of innovative intervention to prevent hospitalisations.
  • After building a comprehensive database of more than 650 patients assessed at his Falls and Fractures Clinic, Prof. Duque has started a series of publications in clinical journals. Since 2011 he has published several important articles reporting clinical data on bone metabolism, falls, frailty, vitamin D and orthogeriatrics (J Nutr Health Ageing 2011, 2012; JAMDA 2011, 2012, Nut Res 2012, In J Pediatr Endocrinol, 2012).He has also participated as coauthor in two metanalysis in the field of Geriatric Medicine (Alzheimer?s and Dementia, 2012; J Am Coll Cardiol. 2008).He currently runs five investigator-initiated trials, which are still in the recruitment phase. His ongoing clinical trials include the ?Effect of Zoledronate on Endothelial Dysfunction (ZED)?study, the ?Fat Against Trabeculae (FAT)?study and the ?Effect of Vitamin D on Balance in Elderly Fallers (ViDaBe)? study. In addition, Prof. Duque is a Chief Investigator (CIE) in the NHMRC-funded study entitled ?The Australian Study of Costs and Utilities Related to Osteoporotic Fractures?. In 2012, his Clinical Research Unit started the Nepean Osteoporosis and Frailty (NOF) Study, a cohort study assessing the mechanisms and potential new diagnostic and therapeutic strategies for osteoporosis and frailty in older persons. His Clinical research Unit has also been invited to participate in four industry-sponsored international multi-centre placebo-controlled RCT testing novel therapeutic compounds to prevent falls and fractures in older persons.

National and International Reputation and Collaborations

  • 77 invitations as guest speaker in 25 different countries since 2004.
  • His Research Program has developed collaborations with 28 major academic institutions worldwide including access to the Framingham Osteoporosis Study database.

Industry and Educational Leadership

  • He has served as a member of several peer-review panels in major funding agencies in Canada (FRSQ and CIHR) and Australia (NHMRC) and reviews grants for more than 30 research Foundations worldwide.
  • Current member of the American Society for Bone and Mineral Research (ASBMR)-Membership Development Committee (2011-present) and the ANZBMS Program Committee (2010-present). Member of the ASBMR-Publications Committee (2007-2010).
  • Ad hocreviewer for more than 40 journals in the fields of bone, Internal Medicine, and Geriatric Medicine. He is also Associate Editor of the Journal of Aging Research.
  • His peers have recognized his research achievements with the Kaufman Award from the Canadian Geriatrics Society in 1998, the New Investigator Award from the AGS in 1999, the Young Investigator Award from the ASBMR in 2003, and the Nathan Shock New Investigator Award from the Biological Section of the Gerontological Society of America in 2005. In 2012, he was the inaugural recipient of the prestigious OA/ANZBMS Philip Sambrook Award as Outstanding Early Career Investigator. He has also received recent research awards from the AGS in 2009, 2011 and 2012 (Best Paper Award). One of his books was the winner of one of the 2009 British Medical Association?s Medical Book Competition Awards.

Funding and Publication Record

  • 72 publications in peer-reviewed journals (40 of them published after moving to Australia in 2007) (Scopus H-Index=16). He has also 18 book chapters in the field of ageing bone.
  • He has edited two books, ?Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach? (ISBN: 978-1-84628-515-8, Springer UK) co-edited with Dr. Douglas Kiel from Harvard Medical School, and ?Osteoporosis Research: Animal Models? (ISBN: 978-0857292926, Springer UK) co-edited with A/Prof. Ken Watanabe from the National Institute for Longevity Sciences of Japan. Together with Prof. Bruce Troen from the University of Miami, he is preparing his third book entitled ?Musculoskeletal Disease and Frailty in Older Persons? also under Springer?s sponsorship.

In terms of funding, Prof. Duque has received a research career award from the Quebec Funds for Health Research, five operating grants from the Canadian Institutes for Health Research (CIHR), three project grants from the NHMRC (2010-2012) and 15 grants from private foundations.

Research interests

Prof. Duque is the Head of the Division of Geriatric Medicine and Director of the Musculoskeletal Ageing Research Centre at Sydney Medical School Nepean. Prof. Duque's major research interests include the elucidation of the mechanisms of age-related bone and muscle loss, osteoporosis, sarcopenia, falls, fractures and frailty. He is also looking at the effect of vitamin D, exercise and proteins on bone and muscle mass. Finally, he implemented a Falls and Fractures clinic at Nepean Hospital where patients are assessed for falls and fractures risk in a comprehensive manner. For more information about the MUsculoskeletal Ageing Research Program at Nepean visit: http://www.boneresearch.edu.au For referrals to Prof. Duque's Falls and fractures Clinic: Referral Form-Falls and Fractures Clinic

In the media

Twitter: @boneresearch

International links

Belgium

(University of Leuven) Collaboration with Dr. Koen Milisen on mechanisms of falls in older persons

Canada

(McGill University) Collaboration with the Bone and Periodontal Research Centre

Canada

(University of Western Ontario) Collaboration with Dr. Manuel Montero-Odasso. "Effect of vitamin D on sarcopenia in the frail elderly"

United States

(Harvard Medical School) Collaboration with the Framingham Osteoporosis Study

United States

(Johns Hopkins University) Collaboration with Dr. Jeremy Walston in the project "Mechanisms of Osteopenia in Frail Mice"

United States

(Louisiana University System-Pennington Research Centre) International Collaboration

United States

(Maine Medical Center Research Institute) Collaboration with Dr. Clifford Rosen on the mechanisms of lipotoxicity in bone

United States

(University of Connecticut Health Centre) Research collaboration with Dr. George Kuchel (Geriatric Medicine) and Dr Hicham Drissi (Department of Orthopedics)

United States

(University of Miami) Collaboration with the GRECC both in basic sciences of aging bone (Dr. Bruce Troen) and Medical Education (Dr. Jorge Ruiz)

Uruguay

(British Hospital-Montevideo) Collaboration with Prof. Hamlet Suarez on methods for balance rehab in older persons

Selected grants

2013

  • The role of the Nuclear Envelope in Age-related Bone Loss; Vidal C, Duque G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2010

  • Tissue Processing System for Sydney Medical School-Nepean; Duque G, Li W; Nepean Medical Research Foundation/Project Grant.
  • The Role of Osteocalcin in Lipid and Glucose Metabolism; Herrmann M, Duque G; Nepean Medical Research Foundation/Project Grant.
  • Role of Lamin A/C in Osteoblastogenesis and Age-related Bone Loss; Duque G, Zhou H, Drissi H, Li W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Identification of the mechanisms of lipotoxicity within the bone marrow milieu; Duque G, Gimble J, Rosen C, Li W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Australian Study of Cost and Utilities Related to Osteoporotic Fractures; March L, Sanders K, Watts J, Nicholson G, Duque G, Winzenberg T; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Effect of Inhibition of Fatty Acid Synthase on Bone Mass of Aging C57BL6 Mice; Duque G; Nepean Medical Research Foundation/Project Grant.

2008

  • The effect of Risedronate on the adpocytuc proportion of bone marrow in osteoporotic patients; Duque G, Phipps R; Procter & Gamble Pharmaceuticals, Inc./Grant.
  • Identification of the toxic effect of adipose tissue within the bone marrow; Duque G; University of Sydney/Internal Scheme.

Selected publications

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Books

  • Duque, G., Watanabe, K. (2011). Osteoporosis Research: Animal Models. London: Springer.
  • Duque, G., Kiel, D. (2009). Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach. London, UK: Springer.

Book Chapters

  • Duque, G. (2013). Vitamin D and bone health. In Herrman, Wolfgang (Eds.), Hypo- and Hypervitaminosis of B and D Vitamins, (pp. 76-93). London: Uni-Med.
  • Li, W., Duque, G. (2011). Animal Models of Premature Aging. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 123-134). London: Springer.
  • Hermann, M., Duque, G. (2011). Vitamin D and Bone Health. In Wolfgang Herrmann, Rima Obeid (Eds.), Vitamins in the Prevention of Human Diseases, (pp. 429-455). Berlin: Walter de Gruyter.
  • Duque, G., Mallet, L. (2008). Treatment of Osteoporosis in Long-Term Care. In Gustavo Duque & Douglas P. Kiel (Eds.), Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach, (pp. 153-162). London, UK: Springer.

Journals

  • Ilich, J., Kelly, O., Inglis, J., Panton, L., Duque, G., Ormsbee, M. (2014). Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels. Ageing research reviews, 15(1), 51-60. [More Information]
  • Gunaratnam, K., Vidal, C., Gimble, J., Duque, G. (2014). Mechanisms of Palmitate-Induced Lipotoxicity in Human Osteoblasts. Endocrinology, 155(1), 108-116. [More Information]
  • Demontiero, O., Gunawardene, P., Duque, G. (2014). Postoperative Prevention of Falls in Older Adults with Fragility Fractures. Clinics in Geriatric Medicine, 30(2), 333-347. [More Information]
  • Sullivan, T., Duque, G., Keech, A., Herrmann, M. (2013). An Old Friend in a New Light: The Role of Osteocalcin in Energy Metabolism. Cardiovascular Therapeutics (Online), 31(2), 65-75. [More Information]
  • Vidal, C., Gunaratnam, K., Tong, J., Duque, G. (2013). Biochemical changes induced by strontium ranelate in differentiating adipocytes. Biochimie, 95(4), 793-798. [More Information]
  • Gomez, F., Curcio, C., Suriyaarachchi, P., Demontiero, O., Duque, G. (2013). Differing approaches to falls and fracture prevention between Australia and Colombia. Clinical Interventions in Aging, 8, 61-67. [More Information]
  • Duque, G., Boersma, D., Loza-Diaz, G., Hassan, S., Suarez, H., Geisinger, D., Suriyaarachchi, P., Sharma, A., Demontiero, O. (2013). Effects of balance training using a virtual-reality system in older fallers. Clinical Interventions in Aging, 8, 257-263. [More Information]
  • Duque, G., Demontiero, O., Whereat, S., Gunawardene, C., Leung, O., Webster, P., Sardinha, L., Boersma, D., Sharma, A. (2013). Evaluation of a blended learning model in geriatric medicine: A successful learning experience for medical students. Australasian Journal on Ageing, 32(2), 103-109. [More Information]
  • Silva, R., Eslick, G., Duque, G. (2013). Exercise for Falls and Fracture Prevention in Long Term Care Facilities: A Systematic Review and Meta-Analysis. Journal of the American Medical Directors Association, 14(9), 685-689. [More Information]
  • Barzigar, A., Mohtasham Amiri, Z., Rahimi-Kolamroudi, H., Hoseini, S., Rezvani, S., Dadashi, A., Jafari-Shakib, A., Fatemi, K., Jafari-Shakib, R., Duque, G. (2013). Gender Difference in Cardiovascular Risk Factors among Older Persons in Northern Iran. Ageing International: information bulletin of the International Federation on Ageing, 38(3), 233-244. [More Information]
  • Gunaratnam, K., Vidal, C., Boadle, R., Thekkedam, C., Duque, G. (2013). Mechanisms of palmitate-induced cell death in human osteoblasts. Biology Open, 2(12), 1382-1389. [More Information]
  • Annweiler, C., Montero-Odasso, M., Llewellyn, D., Richard-Devantoy, S., Duque, G., Beauchet, O. (2013). Meta-Analysis of Memory and Executive Dysfunctions in Relation to Vitamin D. Journal of Alzheimer's Disease, 37(1), 147-171. [More Information]
  • Duque, G. (2013). Osteoporosis in older persons: current pharmacotherapy and future directions. Expert Opinion on Pharmacotherapy, 14(14), 1949-1958. [More Information]
  • Duque, G., Li, W., Vidal, C., Bermeo, S., Rivas, D., Henderson, J. (2013). Pharmacological inhibition of PPARy increases osteoblastogenesis and bone mass in male C57BL/6 mice. Journal of Bone and Mineral Research, 28(3), 639-648. [More Information]
  • Rolland, Y., de Souto Barreto, P., Abbellan van kan, G., Annweiler, C., Beauchet, O., Bischoff-Ferrari, H., Berrut, G., Blain, H., Bonnefoy, M., Cesari, M., Duque, G., et al (2013). Vitamin D supplementation in older adults: searching for specific guidelines in nursing homes. The Journal of Nutrition, Health and Aging, 17(4), 402-412. [More Information]
  • Demontiero, O., Vidal, C., Duque, G. (2012). Aging and bone loss: new insights for the clinician. Therapeutic Advances in Musculoskeletal Disease, 4(2), 61-76. [More Information]
  • DeGuire, J., Makarem, N., Vanstone, C., Morin, S., Duque, G., Weiler, H. (2012). Conjugated linoleic acid is related to bone mineral density but does not affect parathyroid hormone in men. Nutrition Research, 32(12), 911-920. [More Information]
  • Vidal, C., Bermeo, S., Li, W., Huang, D., Kremer, R., Duque, G. (2012). Interferon Gamma Inhibits Adipogenesis In Vitro and Prevents Marrow Fat Infiltration in Oophorectomized Mice. Stem Cells, 30(5), 1042-1048. [More Information]
  • Vidal, C., Bermeo, S., Fatkin, D., Duque, G. (2012). Role of the nuclear envelope in the pathogenesis of age-related bone loss and osteoporosis. BoneKEy Reports, 1, 1-7. [More Information]
  • Martinez-Reig, M., Ahmad, L., Duque, G. (2012). The Orthogeriatrics Model of Care: Systematic Review of Predictors of Institutionalization and Mortality in Post-Hip Fracture Patients and Evidence for Interventions. Journal of the American Medical Directors Association, 13(9), 770-777. [More Information]
  • Boersma, D., Demontiero, O., Mohtasham Amiri, Z., Hassan, S., Suarez, H., Geisinger, D., Suriyaarachchi, P., Sharma, A., Duque, G. (2012). Vitamin D status in relation to postural stability in the elderly. The Journal of Nutrition, Health and Aging, 16(3), 270-275. [More Information]
  • Poulton, A., Briody, J., McCorquodale, T., Melzer, E., Herrmann, M., Baur, L., Duque, G. (2012). Weight loss on stimulant medication: how does it affect body composition and bone metabolism? -- A prospective longitudinal study. International Journal of Pediatric Endocrinology, 30(1), 1-9. [More Information]
  • Duque, G., Li, W., Yeo, L., Vidal, C., Fatkin, D. (2011). Attenuated anabolic response to exercise in lamin A/C haploinsufficient mice. Bone, 49(3), 412-418. [More Information]
  • Duque, G., Alonso, C. (2011). Comment to "Nocturia is not associated with falls among the elderly: a population study in the city of Sao Paulo". Actas Urologicas Españolas, 35(1), 9-9. [More Information]
  • Li, W., Yeo, L., Vidal, C., McCorquodale, T., Herrmann, M., Fatkin, D., Duque, G. (2011). Decreased Bone Formation and Osteopenia in Lamin A/C-Deficient Mice. PLoS One, 6(4), e19313-1-e19313-9. [More Information]
  • Gomez, F., Curcio, C., Duque, G. (2011). Dizziness as a Geriatric Condition among Rural Community-Dwelling Older Adults. The Journal of Nutrition, Health and Aging, 15(6), 490-497. [More Information]
  • Duque, G. (2011). In defence of calcium. Medical Journal of Australia, 194(8), 430-431. [More Information]
  • Duque, G., Huang, D., Dion, N., Macoritto, M., Rivas, D., Li, W., Yang, X., Li, J., Lian, J., Marino, F., et al (2011). Interferon-(gamma) Plays a Role in Bone Formation In Vivo and Rescues Osteoporosis in Ovariectomized Mice. Journal of Bone and Mineral Research, 26(7), 1472-1483. [More Information]
  • Tong, J., Li, W., Vidal, C., Sze Yeo, L., Fatkin, D., Duque, G. (2011). Lamin A/C deficiency is associated with fat infiltration of muscle and bone. Mechanisms of ageing and development, 132(11-12), 552-559. [More Information]
  • Duque, G., Vidal, C., Rivas, D. (2011). Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors. British Journal of Pharmacology, 162(5), 1109-1118. [More Information]
  • Alonso-Bouzon, C., Duque, G. (2011). Senile osteoporosis: an update. Revista Espanola de Geriatria y Gerontologia, 46(4), 223-229. [More Information]
  • Demontiero, O., Herrmann, M., Duque, G. (2011). Supplementation with vitamin D and calcium in long-term care residents. Journal of the American Medical Directors Association, 12(3), 190-194. [More Information]
  • Demontiero, O., Li, W., Thembani, E., Duque, G. (2011). Validation of noninvasive quantification of bone marrow fat volume with microCT in aging rats. Experimental Gerontology, 46(6), 435-440. [More Information]
  • Duque, G., Li, W., Adams, M., Xu, S., Phipps, R. (2010). Effects of risedronate on bone marrow adipocytes in postmenopausal women. Osteoporosis International, DOI 10.1007/s00198-010-1353-8, 1-7. [More Information]
  • Elbaz, A., Wu, X., Rivas, D., Gimble, J., Duque, G. (2010). Inhibition of Fatty Acid Biosynthesis Prevents Adipocyte Lipotoxicity on Human Osteoblasts In Vitro. Journal of Cellular and Molecular Medicine, 14(4), 982-991. [More Information]
  • Duque, G., Kuchel, G. (2010). Moving beyond static body composition paradigms to assessments of change, plasticity, and function. Journal of the American Geriatrics Society, 58(2), 377-379. [More Information]
  • Duque, G., Close, J., de Jager, J., Ebeling, P., Inderjeeth, C., Lord, S., McLachlan, A., Reid, I., Troen, B. (2010). Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention. Medical Journal of Australia, 193(3), 173-179. [More Information]
  • Rivas, D., Li, W., Akter, R., Henderson, J., Duque, G. (2009). Accelerated Features of Age-Related Bone Loss in Zmpste24 Metalloproteinase-Deficient Mice. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 64(10), 1015-1024. [More Information]
  • Duque, G., Rivas, D., Li, W., Li, A., Henderson, J., Ferland, G., Gaudreau, P. (2009). Age-related bone loss in the LOU/c rat model of healthy ageing. Experimental Gerontology, 44(3), 183-189. [More Information]
  • Kemeny-Suss, N., Kasneci, A., Rivas, D., Afilalo, J., Komarova, S., Chalifour, L., Duque, G. (2009). Alendronate affects calcium dynamics in cardiomyocytes in vitro. Vascular Pharmacology, 51(5-6), 350-358. [More Information]
  • Duque, G., Huang, D., Macoritto, M., Rivas, D., Yang, X., Ste-Marie, L., Kremer, R. (2009). Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis. Cell Stem Cell, 27(3), 550-558. [More Information]
  • Gasparrini, M., Rivas, D., Elbaz, A., Duque, G. (2009). Differential expression of cytokines in subcutaneous and marrow fat of aging C57BL/6J mice. Experimental Gerontology, 44(9), 613-618. [More Information]
  • Elbaz, A., Rivas, D., Duque, G. (2009). Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice. Biogerontology, 10(6), 747-755. [More Information]
  • Akter, R., Rivas, D., Geneau, G., Drissi, H., Duque, G. (2009). Effect of lamin A/C knockdown on osteoblast differentiation and function. Journal of Bone and Mineral Research, 24(2), 283-293. [More Information]
  • Gomez, F., Curcio, C., Duque, G. (2009). Health care for older persons in Colombia: a country profile. Journal of the American Geriatrics Society, 57(9), 1692-1696. [More Information]
  • Demontiero, O., Duque, G. (2009). Once-yearly zoledronic acid in hip fracture prevention. Clinical Interventions in Aging, 4(1), 153-164. [More Information]
  • Duque, G., Demontiero, O., Troen, B. (2009). Prevention and treatment of senile osteoporosis and hip fractures. Minerva medica, 100(1), 79-94. [More Information]
  • Duque, G. (2008). Bone and fat connection in aging bone. Current Opinion In Rheumatology, 20(4), 429-434. [More Information]
  • Duque, G. (2008). Intravenous zoledronic acid reduced new clinical fractures and deaths in patients who had recent surgery for hip fracture. ACP Journal Club, 148(2), 40-40. [More Information]
  • Duque, G., Fung, S., Mallet, L., Posel, N., Fleiszer, D. (2008). Learning while having fun: the use of video gaming to teach geriatric house calls to medical students. Journal of the American Geriatrics Society, 56(7), 1328-1332. [More Information]
  • Afilalo, J., Duque, G., Steele, R., Jukema, J., de Craen, A., Eisenberg, M. (2008). Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis. Journal of the American College of Cardiology, 51(1), 37-45. [More Information]
  • Duque, G., Troen, B. (2008). Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. Journal of the American Geriatrics Society, 56(5), 935-941. [More Information]
  • Afilalo, J., Sebag, I., Chalifour, L., Rivas, D., Akter, R., Sharma, K., Duque, G. (2007). Age-related changes in lamin A/C expression in cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 293(3), H1451-H1456. [More Information]
  • Duque, G., Rivas, D. (2007). Alendronate Has an Anabolic Effect on Bone Through the Differentiation of Mesenchymal Stem Cells. Journal of Bone and Mineral Research, 22(10), 1603-1611. [More Information]
  • Rivas, D., Akter, R., Duque, G. (2007). Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARgamma Expression and Activation in Differentiating Mesenchymal Stem Cells. PPAR Research, 2007, 81654-1-81654-7. [More Information]
  • Duque, G. (2007). To treat or not to treat, that is the question: proceedings of the Quebec symposium for the treatment of osteoporosis in long-term care institutions, Saint-Hyacinthe, Quebec, November 5, 2004. Journal of the American Medical Directors Association, 8(3 Supple 2), e67-e73. [More Information]
  • Duque, G., Rivas, D. (2006). Age-related changes in lamin A/C expression in the osteoarticular system: laminopathies as a potential new aging mechanism. Mechanisms of ageing and development, 127(4), 378-383. [More Information]
  • Duque, G. (2006). Dietetic assistants improved postoperative clinical outcomes in older women with hip fracture. ACP Journal Club, 145(2), 40-44. [More Information]
  • Duque, G., Roberts, A., Hui, J., Posel, N., Fleiszer, D., Chiu, W. (2006). From the facts to the screen: a blended model of teaching basic hospital skills to 2nd year medical students. Medical Teacher, 28(8), 729-733. [More Information]
  • Duque, G., Finkelstein, A., Roberts, A., Tabatabai, D., Gold, S., Winer, L. (2006). Learning while evaluating: the use of an electronic evaluation portfolio in a geriatric medicine clerkship. BMC Medical Education, 6(4), 1-7. [More Information]
  • Retornaz, F., Duque, G. (2006). Osteoporose chez Ie sujet age. Presse Medicale, La, 35(10(Pt 2)), 1547-1556.
  • Vecino-Vecino, C., Gratton, M., Kremer, R., Rodriguez-Mañas, L., Duque, G. (2006). Seasonal variance in serum levels of vitamin d determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec. Gerontology: international journal of experimental, clinical, behavioral, regenerative and technical gerontology, 52(1), 33-39. [More Information]
  • Duque, G., Mallet, L., Roberts, A., Gingrass, S., Kremer, R., Sainte-Marie, L., Kiel, D. (2006). To treat or not to treat, that is the question: proceedings of the Quebec Symposium for the Treatment of Osteoporosis in Long-term Care Institutions, Saint-Hyacinthe, Quebec, November 5, 2004. Journal of the American Medical Directors Association, 7(7), 435-441. [More Information]
  • Duque, G., Macoritto, M., Dion, N., Ste-Marie, L., Kremer, R. (2005). 1,25(OH)2D3 acts as a bone-forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6). American Journal of Physiology: Endocrinology and Metabolism, 288(4), E723-E730. [More Information]
  • Duque, G., Segal, R., Wise, F., Bianco, J. (2005). Chronic hypercalcemia as a reversible cause of cognitive impairment: improvement after a single administration of pamidronate. Journal of the American Geriatrics Society, 53(9), 1633-1634.
  • Montero-Odasso, M., Schapira, M., Duque, G., Soriano, E., Kaplan, R., Camera,, L. (2005). Gait disorders are associated with non-cardiovascular falls in elderly people: a preliminary study. BMC Geriatrics, 5(15), 1-6. [More Information]
  • Montero-Odasso, M., Schapira, M., Duque, G., Chercovsky, M., Fernández-Otero, L., Kaplan, R., Camera,, L. (2005). Is collectionism a diagnostic clue for Diogenes syndrome? International Journal of Geriatric Psychiatry, 20(8), 709-711. [More Information]
  • Joseph, C., Kenny, A., Taxele, P., Lorenzo, J., Duque, G., Kuchel, G. (2005). Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk. Molecular Aspects of Medicine, 26(3), 181-201. [More Information]
  • Duque, G. (2005). Taking musculoskeletal aging out of the bench: do we finally understand frailty? Molecular Aspects of Medicine, 26(3), 141-143. [More Information]
  • Duque, G., Montero-Odasso, M. (2005). Use of analgesics in elderly nursing home residents. Journal of the American Geriatrics Society, 53(5), 909-910.
  • Montero-Odasso, M., Duque, G. (2005). Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone. Molecular Aspects of Medicine, 26(3), 203-219. [More Information]
  • Duque, G., Macoritto, M., Kremer, R. (2004). 1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2). Experimental Gerontology, 39(3), 333-338. [More Information]
  • Duque, G., El Abdaimi, K., Henderson, J., Lomri, A., Kremer, R. (2004). Vitamin D inhibits Fas ligand-induced apoptosis in human osteoblasts by regulating components of both the mitochondrial and Fas-related pathways. Bone, 35(1), 57-64. [More Information]
  • Duque, G., Macoritto, M., Kremer, R. (2004). Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity. Biogerontology, 5(6), 421-429. [More Information]
  • Duque, G., Gold, S., Bergman, H. (2003). Early clinical exposure to geriatric medicine in second-year medical school students - the McGill experience. Journal of the American Geriatrics Society, 51(4), 544-548.
  • Duque, G. (2003). Web-based evaluation of medical clerkships: a new approach to immediacy and efficacy of feedback and assessment. Medical Teacher, 25(5), 510-514.
  • Duque, G., El Abdaimi, K., Macoritto, M., Miller, M., Kremer, R. (2002). Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation. Biochemical and Biophysical Research Communications, 299(3), 446-454.
  • Rodrigues, G., Tâmega, I., Duque, G., Neto, V. (2002). Severe bone changes in a case of Hutchinson-Gilford syndrome. European Journal of Medical Genetics; formerly Annales de Genetique (France) (0003-3995), 45(3), 151-155.
  • Duque, G. (2001). Anabolic agents to treat osteoporosis in older people: is there still place for fluoride? Fluoride for treating postmenopausal osteoporosis. Journal of the American Geriatrics Society, 49(10), 1387-1389.

Magazine / Newspaper Articles

  • Duque, G. (2003). Will reducing adopogenesis in bone increase bone mass?: PPARgamma2 as a key target in the treatment of age-related bone loss. Drug News & Perspectives: the international drug news magazine, July/ August 16(6).

2014

  • Ilich, J., Kelly, O., Inglis, J., Panton, L., Duque, G., Ormsbee, M. (2014). Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels. Ageing research reviews, 15(1), 51-60. [More Information]
  • Gunaratnam, K., Vidal, C., Gimble, J., Duque, G. (2014). Mechanisms of Palmitate-Induced Lipotoxicity in Human Osteoblasts. Endocrinology, 155(1), 108-116. [More Information]
  • Demontiero, O., Gunawardene, P., Duque, G. (2014). Postoperative Prevention of Falls in Older Adults with Fragility Fractures. Clinics in Geriatric Medicine, 30(2), 333-347. [More Information]

2013

  • Sullivan, T., Duque, G., Keech, A., Herrmann, M. (2013). An Old Friend in a New Light: The Role of Osteocalcin in Energy Metabolism. Cardiovascular Therapeutics (Online), 31(2), 65-75. [More Information]
  • Vidal, C., Gunaratnam, K., Tong, J., Duque, G. (2013). Biochemical changes induced by strontium ranelate in differentiating adipocytes. Biochimie, 95(4), 793-798. [More Information]
  • Gomez, F., Curcio, C., Suriyaarachchi, P., Demontiero, O., Duque, G. (2013). Differing approaches to falls and fracture prevention between Australia and Colombia. Clinical Interventions in Aging, 8, 61-67. [More Information]
  • Duque, G., Boersma, D., Loza-Diaz, G., Hassan, S., Suarez, H., Geisinger, D., Suriyaarachchi, P., Sharma, A., Demontiero, O. (2013). Effects of balance training using a virtual-reality system in older fallers. Clinical Interventions in Aging, 8, 257-263. [More Information]
  • Duque, G., Demontiero, O., Whereat, S., Gunawardene, C., Leung, O., Webster, P., Sardinha, L., Boersma, D., Sharma, A. (2013). Evaluation of a blended learning model in geriatric medicine: A successful learning experience for medical students. Australasian Journal on Ageing, 32(2), 103-109. [More Information]
  • Silva, R., Eslick, G., Duque, G. (2013). Exercise for Falls and Fracture Prevention in Long Term Care Facilities: A Systematic Review and Meta-Analysis. Journal of the American Medical Directors Association, 14(9), 685-689. [More Information]
  • Barzigar, A., Mohtasham Amiri, Z., Rahimi-Kolamroudi, H., Hoseini, S., Rezvani, S., Dadashi, A., Jafari-Shakib, A., Fatemi, K., Jafari-Shakib, R., Duque, G. (2013). Gender Difference in Cardiovascular Risk Factors among Older Persons in Northern Iran. Ageing International: information bulletin of the International Federation on Ageing, 38(3), 233-244. [More Information]
  • Gunaratnam, K., Vidal, C., Boadle, R., Thekkedam, C., Duque, G. (2013). Mechanisms of palmitate-induced cell death in human osteoblasts. Biology Open, 2(12), 1382-1389. [More Information]
  • Annweiler, C., Montero-Odasso, M., Llewellyn, D., Richard-Devantoy, S., Duque, G., Beauchet, O. (2013). Meta-Analysis of Memory and Executive Dysfunctions in Relation to Vitamin D. Journal of Alzheimer's Disease, 37(1), 147-171. [More Information]
  • Duque, G. (2013). Osteoporosis in older persons: current pharmacotherapy and future directions. Expert Opinion on Pharmacotherapy, 14(14), 1949-1958. [More Information]
  • Duque, G., Li, W., Vidal, C., Bermeo, S., Rivas, D., Henderson, J. (2013). Pharmacological inhibition of PPARy increases osteoblastogenesis and bone mass in male C57BL/6 mice. Journal of Bone and Mineral Research, 28(3), 639-648. [More Information]
  • Duque, G. (2013). Vitamin D and bone health. In Herrman, Wolfgang (Eds.), Hypo- and Hypervitaminosis of B and D Vitamins, (pp. 76-93). London: Uni-Med.
  • Rolland, Y., de Souto Barreto, P., Abbellan van kan, G., Annweiler, C., Beauchet, O., Bischoff-Ferrari, H., Berrut, G., Blain, H., Bonnefoy, M., Cesari, M., Duque, G., et al (2013). Vitamin D supplementation in older adults: searching for specific guidelines in nursing homes. The Journal of Nutrition, Health and Aging, 17(4), 402-412. [More Information]

2012

  • Demontiero, O., Vidal, C., Duque, G. (2012). Aging and bone loss: new insights for the clinician. Therapeutic Advances in Musculoskeletal Disease, 4(2), 61-76. [More Information]
  • DeGuire, J., Makarem, N., Vanstone, C., Morin, S., Duque, G., Weiler, H. (2012). Conjugated linoleic acid is related to bone mineral density but does not affect parathyroid hormone in men. Nutrition Research, 32(12), 911-920. [More Information]
  • Vidal, C., Bermeo, S., Li, W., Huang, D., Kremer, R., Duque, G. (2012). Interferon Gamma Inhibits Adipogenesis In Vitro and Prevents Marrow Fat Infiltration in Oophorectomized Mice. Stem Cells, 30(5), 1042-1048. [More Information]
  • Vidal, C., Bermeo, S., Fatkin, D., Duque, G. (2012). Role of the nuclear envelope in the pathogenesis of age-related bone loss and osteoporosis. BoneKEy Reports, 1, 1-7. [More Information]
  • Martinez-Reig, M., Ahmad, L., Duque, G. (2012). The Orthogeriatrics Model of Care: Systematic Review of Predictors of Institutionalization and Mortality in Post-Hip Fracture Patients and Evidence for Interventions. Journal of the American Medical Directors Association, 13(9), 770-777. [More Information]
  • Boersma, D., Demontiero, O., Mohtasham Amiri, Z., Hassan, S., Suarez, H., Geisinger, D., Suriyaarachchi, P., Sharma, A., Duque, G. (2012). Vitamin D status in relation to postural stability in the elderly. The Journal of Nutrition, Health and Aging, 16(3), 270-275. [More Information]
  • Poulton, A., Briody, J., McCorquodale, T., Melzer, E., Herrmann, M., Baur, L., Duque, G. (2012). Weight loss on stimulant medication: how does it affect body composition and bone metabolism? -- A prospective longitudinal study. International Journal of Pediatric Endocrinology, 30(1), 1-9. [More Information]

2011

  • Li, W., Duque, G. (2011). Animal Models of Premature Aging. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 123-134). London: Springer.
  • Duque, G., Li, W., Yeo, L., Vidal, C., Fatkin, D. (2011). Attenuated anabolic response to exercise in lamin A/C haploinsufficient mice. Bone, 49(3), 412-418. [More Information]
  • Duque, G., Alonso, C. (2011). Comment to "Nocturia is not associated with falls among the elderly: a population study in the city of Sao Paulo". Actas Urologicas Españolas, 35(1), 9-9. [More Information]
  • Li, W., Yeo, L., Vidal, C., McCorquodale, T., Herrmann, M., Fatkin, D., Duque, G. (2011). Decreased Bone Formation and Osteopenia in Lamin A/C-Deficient Mice. PLoS One, 6(4), e19313-1-e19313-9. [More Information]
  • Gomez, F., Curcio, C., Duque, G. (2011). Dizziness as a Geriatric Condition among Rural Community-Dwelling Older Adults. The Journal of Nutrition, Health and Aging, 15(6), 490-497. [More Information]
  • Duque, G. (2011). In defence of calcium. Medical Journal of Australia, 194(8), 430-431. [More Information]
  • Duque, G., Huang, D., Dion, N., Macoritto, M., Rivas, D., Li, W., Yang, X., Li, J., Lian, J., Marino, F., et al (2011). Interferon-(gamma) Plays a Role in Bone Formation In Vivo and Rescues Osteoporosis in Ovariectomized Mice. Journal of Bone and Mineral Research, 26(7), 1472-1483. [More Information]
  • Tong, J., Li, W., Vidal, C., Sze Yeo, L., Fatkin, D., Duque, G. (2011). Lamin A/C deficiency is associated with fat infiltration of muscle and bone. Mechanisms of ageing and development, 132(11-12), 552-559. [More Information]
  • Duque, G., Watanabe, K. (2011). Osteoporosis Research: Animal Models. London: Springer.
  • Duque, G., Vidal, C., Rivas, D. (2011). Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors. British Journal of Pharmacology, 162(5), 1109-1118. [More Information]
  • Alonso-Bouzon, C., Duque, G. (2011). Senile osteoporosis: an update. Revista Espanola de Geriatria y Gerontologia, 46(4), 223-229. [More Information]
  • Demontiero, O., Herrmann, M., Duque, G. (2011). Supplementation with vitamin D and calcium in long-term care residents. Journal of the American Medical Directors Association, 12(3), 190-194. [More Information]
  • Demontiero, O., Li, W., Thembani, E., Duque, G. (2011). Validation of noninvasive quantification of bone marrow fat volume with microCT in aging rats. Experimental Gerontology, 46(6), 435-440. [More Information]
  • Hermann, M., Duque, G. (2011). Vitamin D and Bone Health. In Wolfgang Herrmann, Rima Obeid (Eds.), Vitamins in the Prevention of Human Diseases, (pp. 429-455). Berlin: Walter de Gruyter.

2010

  • Duque, G., Li, W., Adams, M., Xu, S., Phipps, R. (2010). Effects of risedronate on bone marrow adipocytes in postmenopausal women. Osteoporosis International, DOI 10.1007/s00198-010-1353-8, 1-7. [More Information]
  • Elbaz, A., Wu, X., Rivas, D., Gimble, J., Duque, G. (2010). Inhibition of Fatty Acid Biosynthesis Prevents Adipocyte Lipotoxicity on Human Osteoblasts In Vitro. Journal of Cellular and Molecular Medicine, 14(4), 982-991. [More Information]
  • Duque, G., Kuchel, G. (2010). Moving beyond static body composition paradigms to assessments of change, plasticity, and function. Journal of the American Geriatrics Society, 58(2), 377-379. [More Information]
  • Duque, G., Close, J., de Jager, J., Ebeling, P., Inderjeeth, C., Lord, S., McLachlan, A., Reid, I., Troen, B. (2010). Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention. Medical Journal of Australia, 193(3), 173-179. [More Information]

2009

  • Rivas, D., Li, W., Akter, R., Henderson, J., Duque, G. (2009). Accelerated Features of Age-Related Bone Loss in Zmpste24 Metalloproteinase-Deficient Mice. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 64(10), 1015-1024. [More Information]
  • Duque, G., Rivas, D., Li, W., Li, A., Henderson, J., Ferland, G., Gaudreau, P. (2009). Age-related bone loss in the LOU/c rat model of healthy ageing. Experimental Gerontology, 44(3), 183-189. [More Information]
  • Kemeny-Suss, N., Kasneci, A., Rivas, D., Afilalo, J., Komarova, S., Chalifour, L., Duque, G. (2009). Alendronate affects calcium dynamics in cardiomyocytes in vitro. Vascular Pharmacology, 51(5-6), 350-358. [More Information]
  • Duque, G., Huang, D., Macoritto, M., Rivas, D., Yang, X., Ste-Marie, L., Kremer, R. (2009). Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis. Cell Stem Cell, 27(3), 550-558. [More Information]
  • Gasparrini, M., Rivas, D., Elbaz, A., Duque, G. (2009). Differential expression of cytokines in subcutaneous and marrow fat of aging C57BL/6J mice. Experimental Gerontology, 44(9), 613-618. [More Information]
  • Elbaz, A., Rivas, D., Duque, G. (2009). Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice. Biogerontology, 10(6), 747-755. [More Information]
  • Akter, R., Rivas, D., Geneau, G., Drissi, H., Duque, G. (2009). Effect of lamin A/C knockdown on osteoblast differentiation and function. Journal of Bone and Mineral Research, 24(2), 283-293. [More Information]
  • Gomez, F., Curcio, C., Duque, G. (2009). Health care for older persons in Colombia: a country profile. Journal of the American Geriatrics Society, 57(9), 1692-1696. [More Information]
  • Demontiero, O., Duque, G. (2009). Once-yearly zoledronic acid in hip fracture prevention. Clinical Interventions in Aging, 4(1), 153-164. [More Information]
  • Duque, G., Kiel, D. (2009). Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach. London, UK: Springer.
  • Duque, G., Demontiero, O., Troen, B. (2009). Prevention and treatment of senile osteoporosis and hip fractures. Minerva medica, 100(1), 79-94. [More Information]

2008

  • Duque, G. (2008). Bone and fat connection in aging bone. Current Opinion In Rheumatology, 20(4), 429-434. [More Information]
  • Duque, G. (2008). Intravenous zoledronic acid reduced new clinical fractures and deaths in patients who had recent surgery for hip fracture. ACP Journal Club, 148(2), 40-40. [More Information]
  • Duque, G., Fung, S., Mallet, L., Posel, N., Fleiszer, D. (2008). Learning while having fun: the use of video gaming to teach geriatric house calls to medical students. Journal of the American Geriatrics Society, 56(7), 1328-1332. [More Information]
  • Afilalo, J., Duque, G., Steele, R., Jukema, J., de Craen, A., Eisenberg, M. (2008). Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis. Journal of the American College of Cardiology, 51(1), 37-45. [More Information]
  • Duque, G., Mallet, L. (2008). Treatment of Osteoporosis in Long-Term Care. In Gustavo Duque & Douglas P. Kiel (Eds.), Osteoporosis in Older Persons: Pathophysiology and Therapeutic Approach, (pp. 153-162). London, UK: Springer.
  • Duque, G., Troen, B. (2008). Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. Journal of the American Geriatrics Society, 56(5), 935-941. [More Information]

2007

  • Afilalo, J., Sebag, I., Chalifour, L., Rivas, D., Akter, R., Sharma, K., Duque, G. (2007). Age-related changes in lamin A/C expression in cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 293(3), H1451-H1456. [More Information]
  • Duque, G., Rivas, D. (2007). Alendronate Has an Anabolic Effect on Bone Through the Differentiation of Mesenchymal Stem Cells. Journal of Bone and Mineral Research, 22(10), 1603-1611. [More Information]
  • Rivas, D., Akter, R., Duque, G. (2007). Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARgamma Expression and Activation in Differentiating Mesenchymal Stem Cells. PPAR Research, 2007, 81654-1-81654-7. [More Information]
  • Duque, G. (2007). To treat or not to treat, that is the question: proceedings of the Quebec symposium for the treatment of osteoporosis in long-term care institutions, Saint-Hyacinthe, Quebec, November 5, 2004. Journal of the American Medical Directors Association, 8(3 Supple 2), e67-e73. [More Information]

2006

  • Duque, G., Rivas, D. (2006). Age-related changes in lamin A/C expression in the osteoarticular system: laminopathies as a potential new aging mechanism. Mechanisms of ageing and development, 127(4), 378-383. [More Information]
  • Duque, G. (2006). Dietetic assistants improved postoperative clinical outcomes in older women with hip fracture. ACP Journal Club, 145(2), 40-44. [More Information]
  • Duque, G., Roberts, A., Hui, J., Posel, N., Fleiszer, D., Chiu, W. (2006). From the facts to the screen: a blended model of teaching basic hospital skills to 2nd year medical students. Medical Teacher, 28(8), 729-733. [More Information]
  • Duque, G., Finkelstein, A., Roberts, A., Tabatabai, D., Gold, S., Winer, L. (2006). Learning while evaluating: the use of an electronic evaluation portfolio in a geriatric medicine clerkship. BMC Medical Education, 6(4), 1-7. [More Information]
  • Retornaz, F., Duque, G. (2006). Osteoporose chez Ie sujet age. Presse Medicale, La, 35(10(Pt 2)), 1547-1556.
  • Vecino-Vecino, C., Gratton, M., Kremer, R., Rodriguez-Mañas, L., Duque, G. (2006). Seasonal variance in serum levels of vitamin d determines a compensatory response by parathyroid hormone: study in an ambulatory elderly population in Quebec. Gerontology: international journal of experimental, clinical, behavioral, regenerative and technical gerontology, 52(1), 33-39. [More Information]
  • Duque, G., Mallet, L., Roberts, A., Gingrass, S., Kremer, R., Sainte-Marie, L., Kiel, D. (2006). To treat or not to treat, that is the question: proceedings of the Quebec Symposium for the Treatment of Osteoporosis in Long-term Care Institutions, Saint-Hyacinthe, Quebec, November 5, 2004. Journal of the American Medical Directors Association, 7(7), 435-441. [More Information]

2005

  • Duque, G., Macoritto, M., Dion, N., Ste-Marie, L., Kremer, R. (2005). 1,25(OH)2D3 acts as a bone-forming agent in the hormone-independent senescence-accelerated mouse (SAM-P/6). American Journal of Physiology: Endocrinology and Metabolism, 288(4), E723-E730. [More Information]
  • Duque, G., Segal, R., Wise, F., Bianco, J. (2005). Chronic hypercalcemia as a reversible cause of cognitive impairment: improvement after a single administration of pamidronate. Journal of the American Geriatrics Society, 53(9), 1633-1634.
  • Montero-Odasso, M., Schapira, M., Duque, G., Soriano, E., Kaplan, R., Camera,, L. (2005). Gait disorders are associated with non-cardiovascular falls in elderly people: a preliminary study. BMC Geriatrics, 5(15), 1-6. [More Information]
  • Montero-Odasso, M., Schapira, M., Duque, G., Chercovsky, M., Fernández-Otero, L., Kaplan, R., Camera,, L. (2005). Is collectionism a diagnostic clue for Diogenes syndrome? International Journal of Geriatric Psychiatry, 20(8), 709-711. [More Information]
  • Joseph, C., Kenny, A., Taxele, P., Lorenzo, J., Duque, G., Kuchel, G. (2005). Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk. Molecular Aspects of Medicine, 26(3), 181-201. [More Information]
  • Duque, G. (2005). Taking musculoskeletal aging out of the bench: do we finally understand frailty? Molecular Aspects of Medicine, 26(3), 141-143. [More Information]
  • Duque, G., Montero-Odasso, M. (2005). Use of analgesics in elderly nursing home residents. Journal of the American Geriatrics Society, 53(5), 909-910.
  • Montero-Odasso, M., Duque, G. (2005). Vitamin D in the aging musculoskeletal system: an authentic strength preserving hormone. Molecular Aspects of Medicine, 26(3), 203-219. [More Information]

2004

  • Duque, G., Macoritto, M., Kremer, R. (2004). 1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2). Experimental Gerontology, 39(3), 333-338. [More Information]
  • Duque, G., El Abdaimi, K., Henderson, J., Lomri, A., Kremer, R. (2004). Vitamin D inhibits Fas ligand-induced apoptosis in human osteoblasts by regulating components of both the mitochondrial and Fas-related pathways. Bone, 35(1), 57-64. [More Information]
  • Duque, G., Macoritto, M., Kremer, R. (2004). Vitamin D treatment of senescence accelerated mice (SAM-P/6) induces several regulators of stromal cell plasticity. Biogerontology, 5(6), 421-429. [More Information]

2003

  • Duque, G., Gold, S., Bergman, H. (2003). Early clinical exposure to geriatric medicine in second-year medical school students - the McGill experience. Journal of the American Geriatrics Society, 51(4), 544-548.
  • Duque, G. (2003). Web-based evaluation of medical clerkships: a new approach to immediacy and efficacy of feedback and assessment. Medical Teacher, 25(5), 510-514.
  • Duque, G. (2003). Will reducing adopogenesis in bone increase bone mass?: PPARgamma2 as a key target in the treatment of age-related bone loss. Drug News & Perspectives: the international drug news magazine, July/ August 16(6).

2002

  • Duque, G., El Abdaimi, K., Macoritto, M., Miller, M., Kremer, R. (2002). Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation. Biochemical and Biophysical Research Communications, 299(3), 446-454.
  • Rodrigues, G., Tâmega, I., Duque, G., Neto, V. (2002). Severe bone changes in a case of Hutchinson-Gilford syndrome. European Journal of Medical Genetics; formerly Annales de Genetique (France) (0003-3995), 45(3), 151-155.

2001

  • Duque, G. (2001). Anabolic agents to treat osteoporosis in older people: is there still place for fluoride? Fluoride for treating postmenopausal osteoporosis. Journal of the American Geriatrics Society, 49(10), 1387-1389.

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