Dr Han Shen

Research Fellow
Westmead Institute for Medical Research


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Biographical details

Dr Shen is a Research Fellow at the Centre for Cancer Research at Westmead Institute for Medical Research (WIMR). He was previously a Postdoctoral Scientist at Children's Cancer Institute, UNSW Sydney, Australia. He received his Bachelor of Medicine from Hainan Medical University China in 2007. Followed on completion of his medical degree, he went on to complete a Master of Medical Science in Surgery at China Capital Medical University in 2010. This was followed by his PhD pursuit at the Cure Brain Cancer Foundation Neuro-Oncology Lab, UNSW Sydney, Australia, specialising in preclinical testing of novel therapeutics for treatment of high-grade gliomas. He is currently co-lead the Translational Radiation Biology and Oncology Group at WIMR. As an early career clinician-scientist, he has published 15 original peer-reviewed journal articles with 7 as first author in the field of brain tumours. He has attracted over half a million in research funding as lead investigator from the NHMRC, Cure Starts Now Foundation and DIPG collaborative.

Research interests

Dr Shen's current research is focused on the study of the mechanism of intrinsic and acquired radioresistance and radiosensitisation in adult and paediatric high-grade gliomas.

Current projects

  1. Radiosensitisation of high-grade gliomas by modulating the glucose metabolism
  2. Targeting tumour mitochondria and hypoxia to increase the radiosensitivity of diffuse intrinsic pontine gliomas
  3. Unravelling the mechanisms of radioresistance of adult and paediatric high-grade gliomas using a combinational approach of metabolomics and single cell transcriptomics

Selected grants

2017

  • Radiosensitisation of diffuse intrinsic pontine gliomas by modulating glucose metabolism; Shen H; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Bongers, A., Hau, E., Shen, H. (2018). Short Diffusion Time Diffusion-Weighted Imaging With Oscillating Gradient Preparation as an Early Magnetic Resonance Imaging Biomarker for Radiation Therapy Response Monitoring in Glioblastoma: A Preclinical Feasibility Study. International Journal of Radiation Oncology Biology Physics, 102(4), 1014-1023. [More Information]

2018

  • Bongers, A., Hau, E., Shen, H. (2018). Short Diffusion Time Diffusion-Weighted Imaging With Oscillating Gradient Preparation as an Early Magnetic Resonance Imaging Biomarker for Radiation Therapy Response Monitoring in Glioblastoma: A Preclinical Feasibility Study. International Journal of Radiation Oncology Biology Physics, 102(4), 1014-1023. [More Information]

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