Dr Heather Medbury

Senior Research Fellow
Surgery, Westmead Clinical School

Telephone +61 2 9845 7677
Fax +61 2 9893 7440

Map

Research interests

Our research is focused on understanding wound healing in particular the vascular wounds such as atherosclerosis and intimal hyperplasia.

In atherosclerosis our aim is to 'stabilise' the disease to reduce the incidence of heart attack and stroke. Our approach is to redefine the role of monocytes in plaque stabily. For while monocytes have traditionally been known to play a detrimental role in atherosclerosis(and indeed there is a wealth of literature in this area), we are the first group to provide evidence that it may play an opposing beneficial role (by transforming into a muscular type cell) that stabilizes the disease. Understanding monocyte transformation will help us to identify targets for therapeutic manipulation that could stabilize the disease. This will potentially result in a reduction in events such as heart attack and stroke that will not only decrease the morbidity and mortality associated with the disease but also limit the associated, health, social and economic burdens it poses.

Associations

Director of the Australian Atherosclerosis Society 2011 -

Selected grants

2008

  • Redefining the Role of Monocytes in Atherosclerosis; Fletcher J, Medbury H; Heart Foundation of Australia/Grants-in-Aid.
  • Factors affecting monocyte differentiation: implications for plaque stability; Vicaretti M, Medbury H; Pfizer Australia Pty Ltd/Cardio Vascular Lipid Research Grants (CVL).

2006

  • The affect on statins on monocyte differentiation; Vicaretti M, Medbury H; Pfizer Aust/Cardio Vascular Lipid Research Grant.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Medbury, H. (2007). Fibrocytes in atherogenesis. In Richard Bucala (Eds.), Fibrocytes: New Insights into Tissue Repair and Systemic Fibroses. Singapore: World Scientific Publishing.

Journals

  • Zhou, J., Wang, Y., Harris, D., Medbury, H., Williams, H., Durkan, A., Alexander, S., Lee, V., Tan, T., Hu, M., et al (2013). Adenine-induced Chronic Kidney Disease Is Associated with Arterial Macrophage Infiltration and Medial Vascular Calcification. Nephrology, 18(Supp 1), 52-52.
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Medbury, H., James, V., Ngo, J., Hitos, K., Wang, Y., Harris, D., Fletcher, J. (2013). Differing association of macrophage subsets with atherosclerotic plaque stability. International Angiology, 32(1), 74-84. [More Information]
  • Zoellner, H., Siddiqui, S., Kelly, E., Medbury, H. (2009). The anti-apoptotic activity of albumin for endothelium is inhibited by advanced glycation end products restricting intramolecular movement. Cellular and Molecular Biology Letters, 14(DOI: 10.2478/s11658-009-0021-5), 575-586. [More Information]
  • Holland, A., Tarran, S., Medbury, H., Guiffre, A. (2008). Are Fibrocytes Present in Pediatric Burn Wounds? Journal of Burn Care and Research, 29(4), 619-626. [More Information]
  • Medbury, H., Tarran, S., Guiffre, A., Williams, M., Lam, T., Vicaretti, M., Fletcher, J. (2008). Monocytes contribute to the atherosclerotic cap by transformation into fibrocytes. International Angiology, 27(2), 114-123. [More Information]
  • Russo, R., Medbury, H., Guiffre, A., Englert, H., Manolios, N. (2006). Lack of increased expression of cell surface markers for circulating fibrocyte progenitors in limited scleroderma. Clinical Rheumatology, 26(7), 1136-1141. [More Information]
  • Medbury, H., Guiffre, A., Williams, M., Vicaretti, M., Fletcher, J. (2006). The opposing roles of monocytes in atherosclerosis. Atherosclerosis, 7 (Special Issues)(3S), 34-34.
  • Varcoe, R., Mikhail, M., Guiffre, A., Pennings, G., Vicaretti, M., Hawthorne, W., Fletcher, J., Medbury, H. (2006). The role of the fibrocyte in intimal hyperplasia. Journal of Thrombosis and Haemostasis, 4(5), 1125-1133. [More Information]
  • Fletcher, J., Guiffre, A., Medbury, H. (2005). Fibrocytes in atherosclerosis. ANZ Journal of Surgery, 75(Suppl.1), A119 (point VS022)-A119.
  • McEwen, A., Emmanuel, C., Medbury, H., Leick, A., Walker, D., Zoellner, H. (2003). Induction of contact-dependent endothelial apoptosis by osteosarcoma cells suggests a role for endothelial cell apoptosis in blood-borne metastasis. Journal of Pathology, 201(3), 395-403. [More Information]
  • Huang, P., Hawthorne, W., Ao, P., Angeli, G., Medbury, H., Fletcher, J. (2002). Perigraft adventitia and intima remodeling after synthetic patch implantation in sheep carotid artery: Role of apoptosis and proliferation. Journal Of Vascular Surgery, 36(2), 371-378.

Conferences

  • Varcoe, R., Medbury, H., Vicaretti, M., Guiffre, A., Fletcher, J. (2006). The fibrocyte in intimal hyperplasia. XIV International Symposium on Atherosclerosis, Ireland: Elsevier Ireland Ltd.
  • Fletcher, J., Vasista, A., Judge, C., Guiffre, A., Mamo, P., Medbury, H. (2004). Fibrocytes in atherosclerosis. 21st World Congress of the International Union of Angiology, Rome.
  • Fletcher, J., Vasista, A., Guiffre, A., Medbury, H. (2004). Fibrocytes in atherosclerosis. American Heart Association Scientific Sessions, Not published: Not Published.

Other

  • Fletcher, J., Vasista, A., Guiffre, A., Medbury, H. (2004), Fibrocytes in atherosclerosis.

2013

  • Zhou, J., Wang, Y., Harris, D., Medbury, H., Williams, H., Durkan, A., Alexander, S., Lee, V., Tan, T., Hu, M., et al (2013). Adenine-induced Chronic Kidney Disease Is Associated with Arterial Macrophage Infiltration and Medial Vascular Calcification. Nephrology, 18(Supp 1), 52-52.
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Medbury, H., James, V., Ngo, J., Hitos, K., Wang, Y., Harris, D., Fletcher, J. (2013). Differing association of macrophage subsets with atherosclerotic plaque stability. International Angiology, 32(1), 74-84. [More Information]

2009

  • Zoellner, H., Siddiqui, S., Kelly, E., Medbury, H. (2009). The anti-apoptotic activity of albumin for endothelium is inhibited by advanced glycation end products restricting intramolecular movement. Cellular and Molecular Biology Letters, 14(DOI: 10.2478/s11658-009-0021-5), 575-586. [More Information]

2008

  • Holland, A., Tarran, S., Medbury, H., Guiffre, A. (2008). Are Fibrocytes Present in Pediatric Burn Wounds? Journal of Burn Care and Research, 29(4), 619-626. [More Information]
  • Medbury, H., Tarran, S., Guiffre, A., Williams, M., Lam, T., Vicaretti, M., Fletcher, J. (2008). Monocytes contribute to the atherosclerotic cap by transformation into fibrocytes. International Angiology, 27(2), 114-123. [More Information]

2007

  • Medbury, H. (2007). Fibrocytes in atherogenesis. In Richard Bucala (Eds.), Fibrocytes: New Insights into Tissue Repair and Systemic Fibroses. Singapore: World Scientific Publishing.

2006

  • Russo, R., Medbury, H., Guiffre, A., Englert, H., Manolios, N. (2006). Lack of increased expression of cell surface markers for circulating fibrocyte progenitors in limited scleroderma. Clinical Rheumatology, 26(7), 1136-1141. [More Information]
  • Varcoe, R., Medbury, H., Vicaretti, M., Guiffre, A., Fletcher, J. (2006). The fibrocyte in intimal hyperplasia. XIV International Symposium on Atherosclerosis, Ireland: Elsevier Ireland Ltd.
  • Medbury, H., Guiffre, A., Williams, M., Vicaretti, M., Fletcher, J. (2006). The opposing roles of monocytes in atherosclerosis. Atherosclerosis, 7 (Special Issues)(3S), 34-34.
  • Varcoe, R., Mikhail, M., Guiffre, A., Pennings, G., Vicaretti, M., Hawthorne, W., Fletcher, J., Medbury, H. (2006). The role of the fibrocyte in intimal hyperplasia. Journal of Thrombosis and Haemostasis, 4(5), 1125-1133. [More Information]

2005

  • Fletcher, J., Guiffre, A., Medbury, H. (2005). Fibrocytes in atherosclerosis. ANZ Journal of Surgery, 75(Suppl.1), A119 (point VS022)-A119.

2004

  • Fletcher, J., Vasista, A., Guiffre, A., Medbury, H. (2004), Fibrocytes in atherosclerosis.
  • Fletcher, J., Vasista, A., Judge, C., Guiffre, A., Mamo, P., Medbury, H. (2004). Fibrocytes in atherosclerosis. 21st World Congress of the International Union of Angiology, Rome.
  • Fletcher, J., Vasista, A., Guiffre, A., Medbury, H. (2004). Fibrocytes in atherosclerosis. American Heart Association Scientific Sessions, Not published: Not Published.

2003

  • McEwen, A., Emmanuel, C., Medbury, H., Leick, A., Walker, D., Zoellner, H. (2003). Induction of contact-dependent endothelial apoptosis by osteosarcoma cells suggests a role for endothelial cell apoptosis in blood-borne metastasis. Journal of Pathology, 201(3), 395-403. [More Information]

2002

  • Huang, P., Hawthorne, W., Ao, P., Angeli, G., Medbury, H., Fletcher, J. (2002). Perigraft adventitia and intima remodeling after synthetic patch implantation in sheep carotid artery: Role of apoptosis and proliferation. Journal Of Vascular Surgery, 36(2), 371-378.

To update your profile click here. For support on your academic profile contact .