Dr Helen Ball

Postdoctoral Research Fellow
Pathology, School of Medical Sciences

Telephone +61 2 9036 3238
Fax +61 2 9036 3286

Map

Selected grants

2012

  • The astrocyte: a crossroads in cerebral malaria pathogenesis; Hunt N, Ball H, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Mechanisms of disease in Bacterial meningitis; Hunt N, Ball H, Jones C, McGregor I; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Indoleamine 2,3-dioxygenase-2: a newly discovered enzyme with a key role in kidney function.; Ball H, Hunt N; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • Dysregulation of cytokine networks: a key determinant of the pathogenesis of cerebral malaria; Hunt N, Ball H, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Pathophysiology of malaria-associated lung disease; Hunt N, Ball H, Grau G, Anstey N; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Gene expression in the pathogenesis of cerebral malaria; Ball H; Clive & Vera Ramaciotti Foundation/Research Grant.

Selected publications

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Journals

  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis. Brain, Behavior, and Immunity, 35, 107-124. [More Information]
  • Too, L., Mitchell, A., Yau, B., Ball, H., McGregor, I., Hunt, N. (2014). Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis. Behavioural Brain Research, 263, 176-189. [More Information]
  • Aitken, J., Austin, C., Hunt, N., Ball, H., Lay, P. (2014). The Fe-heme structure of met-indoleamine 2,3-dioxygenase-2 determined by X-ray absorption fine structure. Biochemical and Biophysical Research Communications, 450(1), 25-29. [More Information]
  • Khaw, L., Ball, H., Golenser, J., Combes, V., Grau, G., Wheway, J., Mitchell, A., Hunt, N. (2013). Endothelial Cells Potentiate Interferon-γ Production in a Novel Tripartite Culture Model of Human Cerebral Malaria. PLoS One, 8(7), 1-13. [More Information]
  • Jusof, F., Khaw, L., Ball, H., Hunt, N. (2013). Improved spectrophotometric human interferon-gamma bioassay. Journal of Immunological Methods, 394(1), 115-120. [More Information]
  • Fatokun, A., Hunt, N., Ball, H. (2013). Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids, 45(6), 1319-1329. [More Information]
  • Yuasa, H., Ball, H. (2013). Indoleamine 2,3-dioxygenases with very low catalytic activity are well conserved across kingdoms: IDOs of Basidiomycota. Fungal Genetics and Biology, 56, 98-106. [More Information]
  • Bakmiwewa, S., Fatokun, A., Tran, A., Payne, R., Hunt, N., Ball, H. (2012). Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorganic & Medicinal Chemistry Letters, 22(24), 7641-7646. [More Information]
  • Mitchell, A., Yau, B., McQuillan, J., Ball, H., Too, L., Abtin, A., Hertzog, P., Leib, S., Jones, C., Gerega, S., Weninger, W., Hunt, N. (2012). Inflammasome-Dependent IFN-y Drives Pathogenesis in Streptococcus pneumoniae Meningitis. Journal of Immunology, 189(10), 4970-4980. [More Information]
  • Yuasa, H., Ball, H. (2012). The evolution of three types of indoleamine 2,3 dioxygenases in fungi with distinct molecular and biochemical characteristics. Gene, 504(1), 64-74. [More Information]
  • McQuillan, J., Mitchell, A., Ho, Y., Combes, V., Ball, H., Golenser, J., Grau, G., Hunt, N. (2011). Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. International Journal for Parasitology, 41(2), 155-163. [More Information]
  • El Assaad, F., Hempel, C., Combes, V., Mitchell, A., Ball, H., Kurtzhals, J., Hunt, N., Mathys, J., Grau, G. (2011). Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. Infection and Immunity, 79(6), 2379-2384. [More Information]
  • Yuasa, H., Ball, H. (2011). Molecular Evolution and Characterization of Fungal Indoleamine 2,3-Dioxygenases. Journal of Molecular Evolution, 72(2), 160-168. [More Information]
  • Yuasa, H., Ushigoe, A., Ball, H. (2011). Molecular evolution of bacterial indoleamine 2,3-dioxygenase. Gene, 485(1), 22-31. [More Information]
  • Hee, L., Dinudom, A., Mitchell, A., Grau, G., Cook, D., Hunt, N., Ball, H. (2011). Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. International Journal for Parasitology, 41(1), 81-88. [More Information]
  • Jackman, K., Brait, V., Wang, Y., Maghzal, G., Ball, H., McKenzie, G., De Silva, T., Stocker, R., Sobey, C. (2011). Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, 383(5), 471-481. [More Information]
  • Yuasa, H., Ball, H., Austin, C., Hunt, N. (2010). 1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan. Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, 157(1), 10-15. [More Information]
  • Austin, C., Mailu, B., Maghzal, G., Sanchez-Perez, A., Rahlfs, S., Zocher, K., Yuasa, H., Arthur, J., Becker, K., Stocker, R., Hunt, N., Ball, H. (2010). Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2. Amino Acids, 39(2), 565-578. [More Information]
  • Wang, Y., Liu, H., McKenzie, G., Witting, P., Stasch, J., Hahn, M., Changsirivathanathamrong, D., Wu, B., Ball, H., Thomas, S., Celermajer, D., Hunt, N., Stocker, R., et al (2010). Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature Medicine, 16(3), 279-285. [More Information]
  • Yuasa, H., Ball, H., Ho, Y., Austin, C., Whittington, C., Belov, K., Maghzal, G., Jermiin, L., Hunt, N. (2009). Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases (IDOs) from monotremes and marsupials. Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, 153(2), 137-144. [More Information]
  • Miu, J., Ball, H., Mellor, A., Hunt, N. (2009). Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. International Journal for Parasitology, 39(3), 363-370. [More Information]
  • Togbe, D., de Sousa, P., Fauconnier, M., Boissay, V., Fick, L., Scheu, S., Pfeffer, K., Menard, R., Grau, G., Doan, B., Hansen, A., Ball, H., Hunt, N., et al (2008). Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One, 3(7), e2608-1-e2608-12. [More Information]
  • Miu, J., Mitchell, A., Muller, M., Carter, S., Manders, P., McQuillan, J., Saunders, B., Ball, H., Lu, B., Campbell, I., Hunt, N. (2008). Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. Journal of Immunology, 180(2), 1217-1230. [More Information]
  • Hunt, N., Mitchell, A., Hee, L., Xu, Y., Ho, Y., McQuillan, J., Sanchez-Perez, A., Miu, J., Weiser, S., Austin, C., Grau, G., Combes, V., Jambou, R., Ball, H. (2008). Early interactions between malaria-infected erythrocytes and the innate immune system determine the course of immune and immunopathological outcomes. International Journal for Parasitology, 38(Suppl 1), S23-S24. [More Information]
  • Ball, H., Yuasa, H., Austin, C., Weiser, S., Hunt, N. (2008). Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. The International Journal of Biochemistry and Cell Biology, 41(3), 467-471. [More Information]
  • Austin, C., Astelbauer, F., Kosim-Satyaputra, P., Ball, H., Willows, R., Jamie, J., Hunt, N. (2008). Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties. Amino Acids, 36(1), 99-106. [More Information]
  • Miu, J., Hunt, N., Ball, H. (2008). Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis. Infection and Immunity, 76(5), 1812-1824. [More Information]
  • Ball, H., Sanchez-Perez, A., Weiser, S., Austin, C., Astelbauer, F., Miu, J., McQuillan, J., Stocker, R., Jermiin, L., Hunt, N. (2007). Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene, 396(1), 203-213. [More Information]
  • Weiser, S., Miu, J., Ball, H., Hunt, N. (2007). Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine, 37(1), 84-91. [More Information]
  • Potter, S., Chan-Ling, T., Rosinova, E., Ball, H., Mitchell, A., Hunt, N. (2006). A critical role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. Journal of Neuroimmunology, 173(1-2), 96-107. [More Information]
  • Miu, J., Mitchell, A., Ball, H., Hunt, N. (2006). Chemokines and malarial infection. Current Immunology Reviews, 2, 331-344.
  • Hunt, N., Golenser, J., Chan-Ling, T., Parekh, S., Rae, C., Potter, S., Medana, I., Miu, J., Ball, H. (2006). Immunopathogenesis of cerebral malaria. International Journal for Parasitology, 36(5), 569-582. [More Information]
  • Potter, S., Chan-Ling, T., Ball, H., Mansour, H., Mitchell, A., Maluish, L., Hunt, N. (2006). Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. International Journal for Parasitology, 36(4), 485-496. [More Information]
  • Mitchell, A., Hansen, A., Hee, L., Ball, H., Potter, S., Walker, J., Hunt, N. (2005). Early cytokine production is associated with protection from murine cerebral malaria. Infection and Immunity. [More Information]
  • Rae, C., McQuillan, J., Parekh, S., Bubb, W., Weiser, S., Balcar, V., Hansen, A., Ball, H., Hunt, N. (2004). Brain Gene Expression, Metabolism, And Bioenergetics: Interrelationships In Murine Models Of Cerebral And Noncerebral Malaria. The F A S E B Journal, 18(3), 499-510.
  • Ball, H., MacDougall, H., McGregor, I., Hunt, N. (2004). Cyclooxygenase-2 In The Pathogenesis Of Murine Cerebral Malaria. The Journal of Infectious Diseases, 189(4), 751-758.
  • Hansen, A., Ball, H., Mitchell, A., Miu, J., Takikawa, O., Hunt, N. (2004). Increased Expression Of Indoleamine 2,3-Dioxygenase In Murine Malaria Infection Is Predominantly Localised To The Vascular Endothelium. International Journal for Parasitology, 34(12), 1309-1319.
  • Ball, H., Hunt, N. (2004). Needle In A Haystack: Microdissecting The Proteome Of A Tissue. Amino Acids, 27(1), 1-7. [More Information]
  • Ball, H., McParland, B., Driussi, C., Hunt, N. (2002). Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain Research Protocols, 9(3), 206-213.
  • Borgland, S., Connor, M., Ryan, R., Ball, H., Christie, M. (2002). Prostaglandin E2 inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. The Journal of Physiology, 539(2), 433-444.

2014

  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis. Brain, Behavior, and Immunity, 35, 107-124. [More Information]
  • Too, L., Mitchell, A., Yau, B., Ball, H., McGregor, I., Hunt, N. (2014). Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis. Behavioural Brain Research, 263, 176-189. [More Information]
  • Aitken, J., Austin, C., Hunt, N., Ball, H., Lay, P. (2014). The Fe-heme structure of met-indoleamine 2,3-dioxygenase-2 determined by X-ray absorption fine structure. Biochemical and Biophysical Research Communications, 450(1), 25-29. [More Information]

2013

  • Khaw, L., Ball, H., Golenser, J., Combes, V., Grau, G., Wheway, J., Mitchell, A., Hunt, N. (2013). Endothelial Cells Potentiate Interferon-γ Production in a Novel Tripartite Culture Model of Human Cerebral Malaria. PLoS One, 8(7), 1-13. [More Information]
  • Jusof, F., Khaw, L., Ball, H., Hunt, N. (2013). Improved spectrophotometric human interferon-gamma bioassay. Journal of Immunological Methods, 394(1), 115-120. [More Information]
  • Fatokun, A., Hunt, N., Ball, H. (2013). Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids, 45(6), 1319-1329. [More Information]
  • Yuasa, H., Ball, H. (2013). Indoleamine 2,3-dioxygenases with very low catalytic activity are well conserved across kingdoms: IDOs of Basidiomycota. Fungal Genetics and Biology, 56, 98-106. [More Information]

2012

  • Bakmiwewa, S., Fatokun, A., Tran, A., Payne, R., Hunt, N., Ball, H. (2012). Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorganic & Medicinal Chemistry Letters, 22(24), 7641-7646. [More Information]
  • Mitchell, A., Yau, B., McQuillan, J., Ball, H., Too, L., Abtin, A., Hertzog, P., Leib, S., Jones, C., Gerega, S., Weninger, W., Hunt, N. (2012). Inflammasome-Dependent IFN-y Drives Pathogenesis in Streptococcus pneumoniae Meningitis. Journal of Immunology, 189(10), 4970-4980. [More Information]
  • Yuasa, H., Ball, H. (2012). The evolution of three types of indoleamine 2,3 dioxygenases in fungi with distinct molecular and biochemical characteristics. Gene, 504(1), 64-74. [More Information]

2011

  • McQuillan, J., Mitchell, A., Ho, Y., Combes, V., Ball, H., Golenser, J., Grau, G., Hunt, N. (2011). Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. International Journal for Parasitology, 41(2), 155-163. [More Information]
  • El Assaad, F., Hempel, C., Combes, V., Mitchell, A., Ball, H., Kurtzhals, J., Hunt, N., Mathys, J., Grau, G. (2011). Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. Infection and Immunity, 79(6), 2379-2384. [More Information]
  • Yuasa, H., Ball, H. (2011). Molecular Evolution and Characterization of Fungal Indoleamine 2,3-Dioxygenases. Journal of Molecular Evolution, 72(2), 160-168. [More Information]
  • Yuasa, H., Ushigoe, A., Ball, H. (2011). Molecular evolution of bacterial indoleamine 2,3-dioxygenase. Gene, 485(1), 22-31. [More Information]
  • Hee, L., Dinudom, A., Mitchell, A., Grau, G., Cook, D., Hunt, N., Ball, H. (2011). Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. International Journal for Parasitology, 41(1), 81-88. [More Information]
  • Jackman, K., Brait, V., Wang, Y., Maghzal, G., Ball, H., McKenzie, G., De Silva, T., Stocker, R., Sobey, C. (2011). Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, 383(5), 471-481. [More Information]

2010

  • Yuasa, H., Ball, H., Austin, C., Hunt, N. (2010). 1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan. Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, 157(1), 10-15. [More Information]
  • Austin, C., Mailu, B., Maghzal, G., Sanchez-Perez, A., Rahlfs, S., Zocher, K., Yuasa, H., Arthur, J., Becker, K., Stocker, R., Hunt, N., Ball, H. (2010). Biochemical characteristics and inhibitor selectivity of mouse indoleamine 2,3-dioxygenase-2. Amino Acids, 39(2), 565-578. [More Information]
  • Wang, Y., Liu, H., McKenzie, G., Witting, P., Stasch, J., Hahn, M., Changsirivathanathamrong, D., Wu, B., Ball, H., Thomas, S., Celermajer, D., Hunt, N., Stocker, R., et al (2010). Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature Medicine, 16(3), 279-285. [More Information]

2009

  • Yuasa, H., Ball, H., Ho, Y., Austin, C., Whittington, C., Belov, K., Maghzal, G., Jermiin, L., Hunt, N. (2009). Characterization and evolution of vertebrate indoleamine 2, 3-dioxygenases (IDOs) from monotremes and marsupials. Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, 153(2), 137-144. [More Information]
  • Miu, J., Ball, H., Mellor, A., Hunt, N. (2009). Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria. International Journal for Parasitology, 39(3), 363-370. [More Information]

2008

  • Togbe, D., de Sousa, P., Fauconnier, M., Boissay, V., Fick, L., Scheu, S., Pfeffer, K., Menard, R., Grau, G., Doan, B., Hansen, A., Ball, H., Hunt, N., et al (2008). Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PLoS One, 3(7), e2608-1-e2608-12. [More Information]
  • Miu, J., Mitchell, A., Muller, M., Carter, S., Manders, P., McQuillan, J., Saunders, B., Ball, H., Lu, B., Campbell, I., Hunt, N. (2008). Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. Journal of Immunology, 180(2), 1217-1230. [More Information]
  • Hunt, N., Mitchell, A., Hee, L., Xu, Y., Ho, Y., McQuillan, J., Sanchez-Perez, A., Miu, J., Weiser, S., Austin, C., Grau, G., Combes, V., Jambou, R., Ball, H. (2008). Early interactions between malaria-infected erythrocytes and the innate immune system determine the course of immune and immunopathological outcomes. International Journal for Parasitology, 38(Suppl 1), S23-S24. [More Information]
  • Ball, H., Yuasa, H., Austin, C., Weiser, S., Hunt, N. (2008). Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. The International Journal of Biochemistry and Cell Biology, 41(3), 467-471. [More Information]
  • Austin, C., Astelbauer, F., Kosim-Satyaputra, P., Ball, H., Willows, R., Jamie, J., Hunt, N. (2008). Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties. Amino Acids, 36(1), 99-106. [More Information]
  • Miu, J., Hunt, N., Ball, H. (2008). Predominance of interferon-related responses in the brain during murine malaria, as identified by microarray analysis. Infection and Immunity, 76(5), 1812-1824. [More Information]

2007

  • Ball, H., Sanchez-Perez, A., Weiser, S., Austin, C., Astelbauer, F., Miu, J., McQuillan, J., Stocker, R., Jermiin, L., Hunt, N. (2007). Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene, 396(1), 203-213. [More Information]
  • Weiser, S., Miu, J., Ball, H., Hunt, N. (2007). Interferon-gamma synergises with tumour necrosis factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells. Cytokine, 37(1), 84-91. [More Information]

2006

  • Potter, S., Chan-Ling, T., Rosinova, E., Ball, H., Mitchell, A., Hunt, N. (2006). A critical role for Fas-Fas ligand interactions during the late-stage neuropathological processes of experimental cerebral malaria. Journal of Neuroimmunology, 173(1-2), 96-107. [More Information]
  • Miu, J., Mitchell, A., Ball, H., Hunt, N. (2006). Chemokines and malarial infection. Current Immunology Reviews, 2, 331-344.
  • Hunt, N., Golenser, J., Chan-Ling, T., Parekh, S., Rae, C., Potter, S., Medana, I., Miu, J., Ball, H. (2006). Immunopathogenesis of cerebral malaria. International Journal for Parasitology, 36(5), 569-582. [More Information]
  • Potter, S., Chan-Ling, T., Ball, H., Mansour, H., Mitchell, A., Maluish, L., Hunt, N. (2006). Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria. International Journal for Parasitology, 36(4), 485-496. [More Information]

2005

  • Mitchell, A., Hansen, A., Hee, L., Ball, H., Potter, S., Walker, J., Hunt, N. (2005). Early cytokine production is associated with protection from murine cerebral malaria. Infection and Immunity. [More Information]

2004

  • Rae, C., McQuillan, J., Parekh, S., Bubb, W., Weiser, S., Balcar, V., Hansen, A., Ball, H., Hunt, N. (2004). Brain Gene Expression, Metabolism, And Bioenergetics: Interrelationships In Murine Models Of Cerebral And Noncerebral Malaria. The F A S E B Journal, 18(3), 499-510.
  • Ball, H., MacDougall, H., McGregor, I., Hunt, N. (2004). Cyclooxygenase-2 In The Pathogenesis Of Murine Cerebral Malaria. The Journal of Infectious Diseases, 189(4), 751-758.
  • Hansen, A., Ball, H., Mitchell, A., Miu, J., Takikawa, O., Hunt, N. (2004). Increased Expression Of Indoleamine 2,3-Dioxygenase In Murine Malaria Infection Is Predominantly Localised To The Vascular Endothelium. International Journal for Parasitology, 34(12), 1309-1319.
  • Ball, H., Hunt, N. (2004). Needle In A Haystack: Microdissecting The Proteome Of A Tissue. Amino Acids, 27(1), 1-7. [More Information]

2002

  • Ball, H., McParland, B., Driussi, C., Hunt, N. (2002). Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain Research Protocols, 9(3), 206-213.
  • Borgland, S., Connor, M., Ryan, R., Ball, H., Christie, M. (2002). Prostaglandin E2 inhibits calcium current in two sub-populations of acutely isolated mouse trigeminal sensory neurons. The Journal of Physiology, 539(2), 433-444.

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