Dr Helen McGuire

Research Associate
Ramaciotti Facility for Human Systems Biology
Sydney Medical School: Pathology
Australasian Society for Immunology NSW Councillor
Australasian Cytometry Society Treasurer


Website LinkedIn Profile
Australasian Society for Immunology NSW Councillor
Australasian Cytometry Society

Map

Biographical details

I obtained my PhD from the Garvan Institute of Medical Research, Sydney in 2011. I subsequently received an NHMRC postdoctoral fellowship, allowing me to undertake training at Stanford University, California. At Stanford, I was under the mentorship of Professor Mark Davis in the Institute for Immunity Transplantation and Infection, a pioneering lab in the use of single cell proteomics technology know as Cytometry by Time-Of-Flight or CyTOF.

I have now returned from the States to joined Prof Barbara Fazekas’ team at the newly established Ramaciotti Facility for Human Systems Biology, University of Sydney, launching mass cytometry onto the Australian medical research scene.

Current research students

Project title Research student
Investigation of immune complexity in regulating clinical outcomes in cancer Diana SHINKO

Awards and honours

2013 Immunology Department, Stanford University Postdoctoral Fellow Mentor of the Year

2012 National Health and Medical Research Council (NHMRC)/Early Career Fellowship

Additional Publication

A. Vogelzang, H.M. McGuire,D. Yu, J. Sprent, C. Mackay, C. King. (2008) A fundamental role for Interleukin-21 in the generation of T follicular helper cells.Immunity. Jul 18;29(1):127-37

International links

United States

(Stanford University) Prof Mark Davis (Institute for Immunity, Transplantation and Infection)

Selected grants

2018

  • Cardiovascular Precision Medicine and Biomarker Development: Analysis of how underlying inflammatory status dictates susceptibility or resilience to coronary artery disease; McGuire H; Cardiovascular Initiative/Cardiovascular Precision Medicine.
  • Epigenetic targeting of T cell dysfunction ("exhaustion") in patients failing treatment with immune checkpoint inhibitors; Hersey P, McGuire H, Shklovskaya E, Gallagher S, Carlino M; Cancer Council New South Wales/Research Grant.
  • Regulatory T cell therapy for prevention of graft versus host disease; Fazekas de St Groth B, Hart D, Bolton H, McGuire H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Systems analysis for defining the biological effect of advanced cell therapies in haematooncology; McGuire H; Sydney Medical School/Kickstart Grant.

2017

  • SMS ECR Overseas Conference Support - McGuire; McGuire H; Sydney Medical School/Early Career Researcher Overseas Travel Grant.
  • Development of a novel test to predict clinical response to checkpoint therapy in lung cancer and mesothelioma.; McGuire H; University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding.
  • Setting up for health or disease: Understanding how the 'Immune-Rheostat' is tuned in early life; McGuire H; Lifespan Research Network/Lifespan Seed Grants Program.

2015

  • The Sydney 1000 Cancer Project – Stage 1 Gastrointestinal Cancers Immunophenotyping Study; Charles (nee Slaviero) K, Clarke S, Diakos C, Pavlakis N, Engel A, Samra J, Gill A, Kneebone A, Fazekas de St Groth B, Hart D, Smith A, Byrne S, McGuire H, Vafaee F, King M; DVC Research/SPARC Implementation - Cancer.

2014

  • Contained reactivity in the immune system; McGuire H; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • King, C., McGuire, H. (2014). The Immunobiology of Interleukin-21. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 496-506). New York: Springer Science+Business Media.

Journals

  • Hsu, J., Bryant, C., Papadimitrious, M., Kong, B., Gasiorowski, R., Orellana, D., McGuire, H., Fazekas de St Groth, B., Joshua, D., Ho, P., Iland, H., Gibson, J., Clark, G., Fromm, P., Hart, D., et al (2018). A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission. OncoImmunology, 7(4), e1419114-1-e1419114-11. [More Information]
  • McGuire, H., Shklovskaya, E., Edwards, J., Trevillian, P., McCaughan, G., Bertolino, P., McKenzie, C., Gourlay, R., Gallagher, S., Fazekas de St Groth, B., Hersey, P. (2018). Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report. Cancer Immunology, Immunotherapy, 67(4), 563-573. [More Information]
  • Kaur, S., Sehgal, R., Shastry, S., McCaughan, G., McGuire, H., Fazekas de St Groth, B., Sarin, S., Trehanpati, N., Seth, D. (2018). Circulating endothelial progenitor cells present an inflammatory phenotype and function in patients with alcoholic liver cirrhosis. Frontiers in Physiology, 9, 1-10. [More Information]
  • Stern, L., McGuire, H., Avdic, S., Rizzetto, S., Fazekas de St Groth, B., Luciani, F., Slobedman, B., Blyth, E. (2018). Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 9, 1-18. [More Information]
  • Lomax, A., McGuire, H., McNeil, C., Choi, C., Hersey, P., Karikios, D., Shannon, K., Van Hal, S., Carr, U., Crotty, A., Hollingsworth, J., Kim, H., Fazekas de St Groth, B., McGill, N., et al (2017). Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic analysis. International Journal of Rheumatic Diseases, 20(9), 1277-1285. [More Information]
  • Guy, T., Terry, A., Bolton, H., Hancock, D., Zhu, E., Brink, R., McGuire, H., Shklovskaya, E., Fazekas de St Groth, B. (2016). Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity. Oncotarget, 7(21), 30211-30229. [More Information]
  • Havenar-Daughton, C., Lindqvist, M., Heit, A., Wu, J., Reiss, S., Kendric, K., Belanger, S., Kasturi, S., Landais, E., Akondy, R., et al (2016). CXCL13 is a plasma biomarker of germinal center activity. Proceedings of the National Academy of Sciences of the United States of America, 113(10), 2702-2707. [More Information]
  • Rubelt, F., Bolen, C., McGuire, H., Vander Heiden, J., Gadala-Maria, D., Levin, M., Euskirchen, G., Mamedov, M., Swan, G., Dekker, C., et al (2016). Individual heritable differences result in unique cell lymphocyte receptor repertoires of naive and antigen-experienced cells. Nature Communications, 7, 1-12. [More Information]
  • Withani, N., Ma, X., McGuire, H., Verdoes, M., van der Linden, W., Ofori, L., Zhang, R., Li, H., Sanman, L., Wei, K., et al (2016). Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes. Scientific Reports, 6, 1-10. [More Information]
  • McGuire, H., Vogelzang, A., Warren, J., Loetsch, C., Natividad, K., Chan, T., Brink, R., Batten, M., King, C. (2015). IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses. Journal of Immunology, 195(11), 5123-5135. [More Information]
  • Andres-Terre, M., McGuire, H., Pouliot, Y., Bongen, E., Sweeney, T., Tato, C., Khatri, P. (2015). Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses. Immunity, 43(6), 1199-1211. [More Information]
  • Vogelzang, A., McGuire, H., Liu, S., Gloss, B., Mercado, K., Earls, P., Dinger, M., Batten, M., Sprent, J., King, C. (2014). IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells. Journal of Immunology, 192(4), 1404-1414. [More Information]
  • Su, L., Han, A., McGuire, H., Furman, D., Newell, E., Davis, M. (2013). The Promised Land of Human Immunology. Cold Spring Harbor Laboratory Symposia on Quantitative Biology, 78(1), 203-213. [More Information]
  • McGuire, H., Vogelzang, A., Ma, C., Hughes, W., Silveira, P., Tangye, S., Christ, D., Fulcher, D., Falcone, M., King, C. (2011). A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity. Immunity, 34(4), 602-615. [More Information]
  • McGuire, H., Walters, S., Vogelzang, A., Lee, C., Webster, K., Sprent, J., Christ, D., Grey, S., King, C. (2011). Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models. Diabetes, 60(3), 867-875. [More Information]
  • Lee, C., McGuire, H., Basten, A., King, C., Christ, D. (2010). Expression, purification and characterization of recombinant interleukin-21. Journal of Immunological Methods, 362(1-2), 185-189. [More Information]
  • McGuire, H., Vogelzang, A., Hill, N., Flodstrom-Tulllberg, M., Sprent, J., King, C. (2009). Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proceedings of the National Academy of Sciences of the United States of America, 106(46), 19438-19443. [More Information]
  • Akerfeldt, M., Howes, J., Chan, J., Stevens, V., Boubenna, N., McGuire, H., King, C., Biden, T., Laybutt, D. (2008). Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes, 57(11), 3034-3044. [More Information]
  • Akerfeldt, M., Howes, J., Chan, J., Stevens, V., McGuire, H., Boubenna, N., King, C., Biden, T., Laybutt, D. (2008). Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes, 57(11), 3034-3044. [More Information]

2018

  • Hsu, J., Bryant, C., Papadimitrious, M., Kong, B., Gasiorowski, R., Orellana, D., McGuire, H., Fazekas de St Groth, B., Joshua, D., Ho, P., Iland, H., Gibson, J., Clark, G., Fromm, P., Hart, D., et al (2018). A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission. OncoImmunology, 7(4), e1419114-1-e1419114-11. [More Information]
  • McGuire, H., Shklovskaya, E., Edwards, J., Trevillian, P., McCaughan, G., Bertolino, P., McKenzie, C., Gourlay, R., Gallagher, S., Fazekas de St Groth, B., Hersey, P. (2018). Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report. Cancer Immunology, Immunotherapy, 67(4), 563-573. [More Information]
  • Kaur, S., Sehgal, R., Shastry, S., McCaughan, G., McGuire, H., Fazekas de St Groth, B., Sarin, S., Trehanpati, N., Seth, D. (2018). Circulating endothelial progenitor cells present an inflammatory phenotype and function in patients with alcoholic liver cirrhosis. Frontiers in Physiology, 9, 1-10. [More Information]
  • Stern, L., McGuire, H., Avdic, S., Rizzetto, S., Fazekas de St Groth, B., Luciani, F., Slobedman, B., Blyth, E. (2018). Mass Cytometry for the Assessment of Immune Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology, 9, 1-18. [More Information]

2017

  • Lomax, A., McGuire, H., McNeil, C., Choi, C., Hersey, P., Karikios, D., Shannon, K., Van Hal, S., Carr, U., Crotty, A., Hollingsworth, J., Kim, H., Fazekas de St Groth, B., McGill, N., et al (2017). Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic analysis. International Journal of Rheumatic Diseases, 20(9), 1277-1285. [More Information]

2016

  • Guy, T., Terry, A., Bolton, H., Hancock, D., Zhu, E., Brink, R., McGuire, H., Shklovskaya, E., Fazekas de St Groth, B. (2016). Collaboration between tumor-specific CD4+ T cells and B cells in anti-cancer immunity. Oncotarget, 7(21), 30211-30229. [More Information]
  • Havenar-Daughton, C., Lindqvist, M., Heit, A., Wu, J., Reiss, S., Kendric, K., Belanger, S., Kasturi, S., Landais, E., Akondy, R., et al (2016). CXCL13 is a plasma biomarker of germinal center activity. Proceedings of the National Academy of Sciences of the United States of America, 113(10), 2702-2707. [More Information]
  • Rubelt, F., Bolen, C., McGuire, H., Vander Heiden, J., Gadala-Maria, D., Levin, M., Euskirchen, G., Mamedov, M., Swan, G., Dekker, C., et al (2016). Individual heritable differences result in unique cell lymphocyte receptor repertoires of naive and antigen-experienced cells. Nature Communications, 7, 1-12. [More Information]
  • Withani, N., Ma, X., McGuire, H., Verdoes, M., van der Linden, W., Ofori, L., Zhang, R., Li, H., Sanman, L., Wei, K., et al (2016). Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes. Scientific Reports, 6, 1-10. [More Information]

2015

  • McGuire, H., Vogelzang, A., Warren, J., Loetsch, C., Natividad, K., Chan, T., Brink, R., Batten, M., King, C. (2015). IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses. Journal of Immunology, 195(11), 5123-5135. [More Information]
  • Andres-Terre, M., McGuire, H., Pouliot, Y., Bongen, E., Sweeney, T., Tato, C., Khatri, P. (2015). Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses. Immunity, 43(6), 1199-1211. [More Information]

2014

  • Vogelzang, A., McGuire, H., Liu, S., Gloss, B., Mercado, K., Earls, P., Dinger, M., Batten, M., Sprent, J., King, C. (2014). IL-21 contributes to fatal inflammatory disease in the absence of Foxp3+ T regulatory cells. Journal of Immunology, 192(4), 1404-1414. [More Information]
  • King, C., McGuire, H. (2014). The Immunobiology of Interleukin-21. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 496-506). New York: Springer Science+Business Media.

2013

  • Su, L., Han, A., McGuire, H., Furman, D., Newell, E., Davis, M. (2013). The Promised Land of Human Immunology. Cold Spring Harbor Laboratory Symposia on Quantitative Biology, 78(1), 203-213. [More Information]

2011

  • McGuire, H., Vogelzang, A., Ma, C., Hughes, W., Silveira, P., Tangye, S., Christ, D., Fulcher, D., Falcone, M., King, C. (2011). A Subset of Interleukin-21(+) Chemokine Receptor CCR9(+) T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity. Immunity, 34(4), 602-615. [More Information]
  • McGuire, H., Walters, S., Vogelzang, A., Lee, C., Webster, K., Sprent, J., Christ, D., Grey, S., King, C. (2011). Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models. Diabetes, 60(3), 867-875. [More Information]

2010

  • Lee, C., McGuire, H., Basten, A., King, C., Christ, D. (2010). Expression, purification and characterization of recombinant interleukin-21. Journal of Immunological Methods, 362(1-2), 185-189. [More Information]

2009

  • McGuire, H., Vogelzang, A., Hill, N., Flodstrom-Tulllberg, M., Sprent, J., King, C. (2009). Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proceedings of the National Academy of Sciences of the United States of America, 106(46), 19438-19443. [More Information]

2008

  • Akerfeldt, M., Howes, J., Chan, J., Stevens, V., Boubenna, N., McGuire, H., King, C., Biden, T., Laybutt, D. (2008). Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes, 57(11), 3034-3044. [More Information]
  • Akerfeldt, M., Howes, J., Chan, J., Stevens, V., McGuire, H., Boubenna, N., King, C., Biden, T., Laybutt, D. (2008). Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes, 57(11), 3034-3044. [More Information]

To update your profile click here. For support on your academic profile contact .