Dr Helen Williams

Research Fellow
Surgery, Westmead Clinical School

Telephone 9845 5775

Website Honours in Medical Sciences at Westmead

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Biographical details

I am a postdoctoral scientist working at Westmead Hospital to improve the diagnosis and treatment of patients with cardiovascular disease.

In my research I investigate the underlying mechanisms of cardiovascular disease, specifically the role of monocytes, a type of white blood cell, in the development of fatty plaques in the blood vessel walls. The rupture of these plaques can cause heart attack and stroke.

I completed my PhD (University of Sydney) in 2011 examining the metabolic profile of genetically modified mouse models. This work showed that mice lacking a gene called Klf3 remain lean even when fed a high-fat diet.

In 2011, I began postdoctoral work at the Department of Surgery, Westmead Hospital. I currently investigate how monocytes change in people with cardiovascular disease.

Current research students

Project title Research student
Functional effects of monocyte subset M1 polarisation in atherosclerosis Vyoma PATEL

Selected publications

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Journals

  • Medbury, H., Williams, H., Li, S., Fletcher, J. (2015). The Bidirectional Relationship between Cholesterol and Macrophage Polarization. Journal of Clinical & Cellular Immunology, 6, 1-7. [More Information]
  • Medbury, H., Williams, H., Fletcher, J. (2014). Clinical significance of macrophage phenotypes in cardiovascular disease. Clinical and Translational Medicine, 3, 1-9. [More Information]
  • Zhou, J., Wang, Y., Harris, D., Medbury, H., Williams, H., Durkan, A., Alexander, S., Lee, V., Tan, T., Hu, M., et al (2013). Adenine-induced Chronic Kidney Disease Is Associated with Arterial Macrophage Infiltration and Medial Vascular Calcification. Nephrology, 18(Supp 1), 52-52.
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Bell-Anderson, K., Aouad, L., Williams, H., Sanz, F., Phuyal, J., Larter, C., Farrell, G., Caterson, I. (2011). Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice. International Journal of Obesity, 35(12), 1539-1548. [More Information]

2015

  • Medbury, H., Williams, H., Li, S., Fletcher, J. (2015). The Bidirectional Relationship between Cholesterol and Macrophage Polarization. Journal of Clinical & Cellular Immunology, 6, 1-7. [More Information]

2014

  • Medbury, H., Williams, H., Fletcher, J. (2014). Clinical significance of macrophage phenotypes in cardiovascular disease. Clinical and Translational Medicine, 3, 1-9. [More Information]

2013

  • Zhou, J., Wang, Y., Harris, D., Medbury, H., Williams, H., Durkan, A., Alexander, S., Lee, V., Tan, T., Hu, M., et al (2013). Adenine-induced Chronic Kidney Disease Is Associated with Arterial Macrophage Infiltration and Medial Vascular Calcification. Nephrology, 18(Supp 1), 52-52.
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]

2011

  • Bell-Anderson, K., Aouad, L., Williams, H., Sanz, F., Phuyal, J., Larter, C., Farrell, G., Caterson, I. (2011). Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice. International Journal of Obesity, 35(12), 1539-1548. [More Information]

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