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Dr Helen Williams

Research Fellow
Surgery, Westmead Clinical School

Telephone 8890 5775

Website Honours in Medical Sciences at Westmead

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Biographical details

I am a postdoctoral scientist working at Westmead Hospital to improve the diagnosis and treatment of patients with cardiovascular disease.

In my research I investigate the underlying mechanisms of cardiovascular disease, specifically the role of monocytes, a type of white blood cell, in the development of fatty plaques in the blood vessel walls. The rupture of these plaques can cause heart attack and stroke.

I completed my PhD (University of Sydney) in 2011 examining the metabolic profile of genetically modified mouse models. This work showed that mice lacking a gene called Klf3 remain lean even when fed a high-fat diet.

In 2011, I began postdoctoral work at the Department of Surgery, Westmead Hospital. I currently investigate how monocytes change in people with cardiovascular disease.

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Associations

Australian Atherosclerosis Society Member, director from 2015-2017

International Atherosclerosis Society (member)

Asian Pacific Society for Atherosclerosis and Vascular Diseases (member)

Franklin Women (member)

Australian cardiovascular alliance (member)

NSW cardiovascular Research Network (member)

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Awards and honours

2018: ISA Travel Grant

2016: AAS trust Travel Grant

2016: Award for best oral in session IUA 2016 conference

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Selected publications

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Journals

  • Alahakoon, T., Medbury, H., Williams, H., Fewings, N., Wang, X., Lee, V. (2019). Characterization of fetal monocytes in preeclampsia and fetal growth restriction. Journal of Perinatal Medicine: official journal of the World Association of Perinatal Medicine, 47(4), 434. [More Information]
  • Marimuthu, R., Francis, H., Dervish, S., Li, S., Medbury, H., Williams, H. (2018). Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis. Journal of Visualized Experiments, 140, 1-10. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Tan, T., Harris, D., Alexander, S., Durkan, A. (2018). DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice. PloS One, 13(4), e0195657. [More Information]
  • Alahakoon, T., Medbury, H., Williams, H., Fewings, N., Wang, X., Lee, V. (2018). Distribution of monocyte subsets and polarization in preeclampsia and intrauterine fetal growth restriction. The Journal of Obstetrics and Gynaecology Research, 44(12), 2135-2148. [More Information]
  • Ridiandries, A., Tan, J., Ravindran, D., Williams, H., Medbury, H., Lindsay, L., Hawkins, C., Prosser, H., Bursill, C. (2017). CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis. The FASEB Journal, 31(3), 1179-1192. [More Information]
  • Williams, H., Cassorla, G., Pertsoulis, N., Patel, V., Vicaretti, M., Marmash, N., Hitos, K., Fletcher, J., Medbury, H. (2017). Human classical monocytes display unbalanced M1/M2 phenotype with increased atherosclerotic risk and presence of disease. International Angiology, 36(2), 145-155. [More Information]
  • Patel, V., Williams, H., Li, S., Fletcher, J., Medbury, H. (2017). Monocyte inflammatory profile is specific for individuals and associated with altered blood lipid levels. Atherosclerosis, 263, 15-23. [More Information]
  • Suda, S., Williams, H., Medbury, H., Holland, A. (2016). A Review of Monocytes and Monocyte-Derived Cells in Hypertrophic Scarring Post Burn. Journal of Burn Care and Research, 37(5), 265-272. [More Information]
  • Medbury, H., Williams, H., Li, S., Fletcher, J. (2015). The Bidirectional Relationship between Cholesterol and Macrophage Polarization. Journal of Clinical & Cellular Immunology, 6, 1-7. [More Information]
  • Medbury, H., Williams, H., Fletcher, J. (2014). Clinical significance of macrophage phenotypes in cardiovascular disease. Clinical and Translational Medicine, 3, 1-9. [More Information]
  • Zhou, J., Wang, Y., Harris, D., Medbury, H., Williams, H., Durkan, A., Alexander, S., Lee, V., Tan, T., Hu, M., et al (2013). Adenine-induced Chronic Kidney Disease Is Associated with Arterial Macrophage Infiltration and Medial Vascular Calcification. Nephrology, 18(Supp 1), 52-52.
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Bell-Anderson, K., Aouad, L., Williams, H., Sanz, F., Phuyal, J., Larter, C., Farrell, G., Caterson, I. (2011). Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice. International Journal of Obesity, 35(12), 1539-1548. [More Information]

2019

  • Alahakoon, T., Medbury, H., Williams, H., Fewings, N., Wang, X., Lee, V. (2019). Characterization of fetal monocytes in preeclampsia and fetal growth restriction. Journal of Perinatal Medicine: official journal of the World Association of Perinatal Medicine, 47(4), 434. [More Information]

2018

  • Marimuthu, R., Francis, H., Dervish, S., Li, S., Medbury, H., Williams, H. (2018). Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis. Journal of Visualized Experiments, 140, 1-10. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Tan, T., Harris, D., Alexander, S., Durkan, A. (2018). DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice. PloS One, 13(4), e0195657. [More Information]
  • Alahakoon, T., Medbury, H., Williams, H., Fewings, N., Wang, X., Lee, V. (2018). Distribution of monocyte subsets and polarization in preeclampsia and intrauterine fetal growth restriction. The Journal of Obstetrics and Gynaecology Research, 44(12), 2135-2148. [More Information]

2017

  • Ridiandries, A., Tan, J., Ravindran, D., Williams, H., Medbury, H., Lindsay, L., Hawkins, C., Prosser, H., Bursill, C. (2017). CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis. The FASEB Journal, 31(3), 1179-1192. [More Information]
  • Williams, H., Cassorla, G., Pertsoulis, N., Patel, V., Vicaretti, M., Marmash, N., Hitos, K., Fletcher, J., Medbury, H. (2017). Human classical monocytes display unbalanced M1/M2 phenotype with increased atherosclerotic risk and presence of disease. International Angiology, 36(2), 145-155. [More Information]
  • Patel, V., Williams, H., Li, S., Fletcher, J., Medbury, H. (2017). Monocyte inflammatory profile is specific for individuals and associated with altered blood lipid levels. Atherosclerosis, 263, 15-23. [More Information]

2016

  • Suda, S., Williams, H., Medbury, H., Holland, A. (2016). A Review of Monocytes and Monocyte-Derived Cells in Hypertrophic Scarring Post Burn. Journal of Burn Care and Research, 37(5), 265-272. [More Information]

2015

  • Medbury, H., Williams, H., Li, S., Fletcher, J. (2015). The Bidirectional Relationship between Cholesterol and Macrophage Polarization. Journal of Clinical & Cellular Immunology, 6, 1-7. [More Information]

2014

  • Medbury, H., Williams, H., Fletcher, J. (2014). Clinical significance of macrophage phenotypes in cardiovascular disease. Clinical and Translational Medicine, 3, 1-9. [More Information]

2013

  • Zhou, J., Wang, Y., Harris, D., Medbury, H., Williams, H., Durkan, A., Alexander, S., Lee, V., Tan, T., Hu, M., et al (2013). Adenine-induced Chronic Kidney Disease Is Associated with Arterial Macrophage Infiltration and Medial Vascular Calcification. Nephrology, 18(Supp 1), 52-52.
  • Zhou, J., Wang, Y., Lee, V., Zhang, G., Medbury, H., Williams, H., Wang, Y., Harris, D., Alexander, S., Durkan, A. (2013). Cx3cr1-dec205 dc-targeted dna Vaccine Induces Specific Antibodies and Limits Atherosclerosis and Macrophage Infiltration in the apo-e Knockout Mouse Model of Atherosclerosis. Nephrology, 18(Supp. 1), 16-16.
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]

2011

  • Bell-Anderson, K., Aouad, L., Williams, H., Sanz, F., Phuyal, J., Larter, C., Farrell, G., Caterson, I. (2011). Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice. International Journal of Obesity, 35(12), 1539-1548. [More Information]
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