Professor Helge Rasmussen

Professor
Medicine, Northern Clinical School

Telephone +61 2 9926 8680
Fax +61 2 9926 6521

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Biographical details

Clinical practice

I am a clinician who practices hospital-based general cardiology with a sub-specialty interest in emergency percutaneous coronary intervention (PCI, “angioplasty”) in acute myocardial infarction. I have made a major contribution to the development of a program that has delivered 24 hours/7 days/week PCI for patients presenting with myocardial infarction at Royal North Shore Hospital since 1997 (initially on a 1:2 and in more recent years on a 1: 4 roster). The program now includes all patients within the boundaries of Northern Sydney Area Health Service (NSAHS), and has a major ambulance-based field triage component. It also delivers emergency care for patients transferred from country hospitals after failed fibrinolysis. There is national recognition of the program for its excellence and a program based on it is being implemented across the entire Sydney region.

Basic Science / translational medicine

My basic research focuses is on regulation of the membrane Na+-K+ pump in cardiac myocytes, in particular regulation by hormones implicated in the pathogenesis of congestive heart failure. In functional studies on electrogenic Na+-K+ pump current in ventricular myocytes, work from my laboratory over the last ~15 years has shown that effective heart failure treatments are associated with blockade of neurohormone-induced Na+-K+ pump inhibition, i.e., effectively stimulation, while treatments that have turned out to be harmful are associated with pump inhibition. These findings are in good agreement with the widely accepted role of raised myocyte Na+ levels as important in the molecular mechanisms. My laboratory has described how activation of the β3 adrenergic receptor mediates Na+-K+ pump stimulation.
At the molecular level, I found the prevailing view that the Na+-K+ pump is regulated by phosphorylation of the pump molecule or associated FXYD membrane proteins untenable, and I was initially the sole promoter world-wide of an opposing view that regulation is mediated by glutathionylation, an oxidative modification. In collaborative work between my laboratory and highly regarded laboratories in Europe and the US, this paradigm-shifting concept has now been firmly established. Comprehensive articles describing this work have been published, and its wide acceptance is reflected by invitations to speak on oxidative Na+-K+ pump regulation to a broad range of audiences. It is also reflected by detailed discussions of it in recent review articles in by others across a range of disciplines.
My basic research on molecular mechanisms of Na+-K+ pump research has clinical implications, in particular in regards to treatment of heart failure. Since treatments of proven efficacy reverse the oxidative Na+-K+ pump inhibition, the pump has retained the status as a pharmacological target it had when cardiac glycosides were thought to be clinically useful. Its new role is well integrated with the accepted paradigms of neurohormonal abnormalities, raised myocardial oxidative stress and energy deficiency implicated in the pathophysiology of the failing heart, as discussed in recent review articles included in the list of publications.

Teaching and supervision

I teach cardiology to medical students. My other university-related duties include design of written examinations, marking of exams, and participation as an examiner in oral examinations. I supervise PhD students as the major component of my university work.

Selected grants

2014

  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Enzymatic Redox regulation of the Na+ pump; Rasmussen H, Liu C; Heart Research Australia/Research Support.
  • PDE5 inhibitor/beta 3 agonist combination therapy in heart failure; Rasmussen H, Hamilton E, Liu C; Heart Research Australia/Research Support.
  • A novel drug combination therapy for heart failure; Liu C, Rasmussen H; Heart Research Australia/Research Support.

2013

  • SF-61SX2/s stopped-flow fluorimeter and Service and upgrade of SX-17MV stopped-flow spectrometer; Clarke R, Davies M, Lay P, Witting P, Rasmussen H, Matthews J, Pattison D, Vandenberg J; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • ACE inhibitor, B-blocker and the Na-K Pump; Rasmussen H; North Shore Heart Research Foundation/Research Support.
  • Salary support grant-Laboratory manager; Rasmussen H; North Shore Heart Research Foundation/Research Contract.
  • Funding for Laboratory manager within the North Shore Heart Research Group at the Kolling Institute; Rasmussen H; North Shore Heart Research Foundation/Research Support.

2010

  • Molecular mechanism of insulin induced Na+-K+ pump stimulation in cardiac myocytes; Liu C, Rasmussen H, Figtree G; North Shore Heart Research Foundation/Research Support.
  • Reversing oxidative inhibition of the Na-K pump by beta3 adrenergic agonists: implications for heart failure therapy; Rasmussen H, Figtree G, McLachlan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Rapid and reversible ocidative modification: a key mechanism of hormonal regulation of the cardiac Na+-K+; Rasmussen H, Figtree G, Liu C; North Shore Heart Research Foundation/Research Support.

2006

  • Regulation of the sarcolemmal Na-K pump by FXYD proteins associated with it; Rasmussen H, Marassi F, Clarke R; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Regulation of the sarcolemmal Na+-K+ pump by nitric oxide synthase : Receptor and non-receptor pathways; Rasmussen H; North Shore Heart Research Foundation/Research Grant.

2003

  • Effects of atrial natriuretic peptide on the sarcolemmal Na-K pump in rabbit myocytes; Rasmussen H; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Ongoing variable research funding provided by the RNS Heart Research Foundation to support multiple research projects to nominated University of Sydney Grant Recipients working at the RNS hospital.; Rasmussen H; North Shore Heart Research Foundation/Research Grant.

2001

  • The sarcolemmal Na+ -K+ pump in Type 1 diabetes: role of PKC and effects of treatment.; Rasmussen H; Juvenile Diabetes Research Foundation International (JDRF)/Research Grant.

Selected publications

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Journals

  • Karimi Galougahi, K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N., Davies, M., Hawkins, C., Rasmussen, H., Figtree, G. (2014). Glutathionylation Mediates Angiotension II-Induced eNOS Uncoupling, Amplifying NADPH Oxidase-Dependent Endothelial Dysfunction. Journal of the American Heart Association, 3(2), 1-11. [More Information]
  • Mares, J., Garcia, A., Rasmussen, H., Cornelius, F., Mahmmoud, Y., Berlin, J., Lev, B., Allen, T., Clarke, R. (2014). Identification of Electric-Field-Dependent Steps in the Na+,K+ -Pump Cycle. Biophysical Journal, 107(6), 1352-1363. [More Information]
  • Garcia, A., Fry, N., Karimi, K., Liu, C., Apell, H., Rasmussen, H., Clarke, R. (2013). Extracellular allosteric Na+ binding to the Na+, K+-ATPase in cardiac myocytes. Biophysical Journal, 105(12), 2695-2705. [More Information]
  • McMahon, R., Siow, W., Bhindi, R., Hoo, S., Figtree, G., Hansen, P., Nelson, G., Rasmussen, H., Ward, M. (2013). Left bundle branch block without concordant ST changes is rarely associated with acute coronary occlusion. International Journal of Cardiology, 167(4), 1339-1342. [More Information]
  • Figtree, G., Rasmussen, H., Liu, C. (2013). Oxidative regulation of the na+-k+ pump in cardiac physiology and pathology: clarifying the published evidence. Circulation Research, 112(1), e1-e1. [More Information]
  • Karimi Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Clarke, R., Catauro, M., Rasmussen, H., Apell, H. (2013). Quantitative calculation of the role of the Na+ ,K+ -ATPase in thermogenesis. Biochimica et Biophysica Acta-Bioenergetics, 1827 (10), 1205-1212. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Karimi Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]
  • Karimi Galougahi, K., Liu, C., Bundgaard, H., Rasmussen, H. (2012). Beta-Adrenergic Regulation of the Cardiac Na+-K+ ATPase Mediated by Oxidative Signaling. Trends In Cardiovascular Medicine, 22(4), 83-87. [More Information]
  • Garcia, A., Rasmussen, H., Apell, H., Clarke, R. (2012). Kinetic comparisons of heart and kidney Na+, K+ -ATPases. Biophysical Journal, 103(4), 677-688. [More Information]
  • Figtree, G., Karimi Galougahi, K., Liu, C., Rasmussen, H. (2012). Oxidative regulation of the Na+ -K+ pump in the cardiovascular system. Free Radical Biology and Medicine, 53(12), 2263-2268. [More Information]
  • Murphy, J., Kozor, R., Figtree, G., Hansen, P., Rasmussen, H., Ward, M., Nelson, G., Bhindi, R. (2012). Procedural and in-patient outcomes in patients aged 80 years or older undergoing contemporary primary percutaneous coronary intervention. EuroIntervention, 8(8), 912-919. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]
  • Hamilton, E., Figtree, G., Rasmussen, H. (2011). Consideration of natriuretic peptide receptor C. Circulation Research, 108(4), e4-e5. [More Information]
  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]
  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Rasmussen, H., Liu, C., Figtree, G. (2010). Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology. Trends In Cardiovascular Medicine, 20(3), 85-90. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]
  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]
  • Rasmussen, H., Figtree, G., Krum, H., Bundgaard, H. (2009). The use of beta3-adrenergic receptor agonists in the treatment of heart failure. Current Opinion in Investigational Drugs (Print), 10(9), 955-962. [More Information]
  • William, M., Hamilton, E., Bundgaard, H., Garcia, A., Chia, K., Figtree, G., Rasmussen, H. (2008). Natriuretic peptides stimulate the cardiac sodium pump via NPR-C coupled NOS activation. American Journal of Physiology: Cell Physiology, 294(4), C1067-C1073. [More Information]
  • White, C., Hamilton, E., Garcia, A., Wang, D., Chia, K., Figtree, G., Rasmussen, H. (2008). Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. American Journal of Physiology: Cell Physiology, 294, C572-C578. [More Information]
  • Rasmussen, H., Figtree, G. (2007). "Don't flog the heart!" - development of specific drug therapies for heart failure. Critical Care and Resuscitation, 9(4), 364-369. [More Information]
  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2007). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292, C1070-C1077.
  • Carstensen, S., Nelson, G., Hansen, P., Macken, L., Irons, S., Flynn, M., Kovoor, P., Soo Hoo, S., Ward, M., Rasmussen, H. (2007). Field triage to primary angioplasty combined with emergency department bypass reduces treatment delays and is associated with improved outcome. European Heart Journal, 28(19), 2313-2319. [More Information]
  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2006). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292(3), C1070-C1077. [More Information]
  • Abdulla, I., Kay, S., Mussap, C., Nelson, G., Rasmussen, H., Hansen, P., Ward, M. (2006). Apical sparing in tako-tsubo cardiomyopathy. Internal Medicine Journal, 36(7), 414-418. [More Information]
  • William, M., Vien, J., Hamilton, E., Garcia, A., Bundgaard, H., Clarke, R., Rasmussen, H. (2005). The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes. The Journal of Physiology, 565.3(3), 815-825. [More Information]
  • Lozzi, L., Carstensen, S., Rasmussen, H., Nelson, G. (2005). Why do acute myocardial infarction patients not call an ambulance? An interview with patients presenting to hospital with acute myocardial infarction symptoms. Internal Medicine Journal, 35(11), 668-671. [More Information]
  • Buhagiar, K., Hansen, P., Kong, B., Clarke, R., Fernandes, C., Rasmussen, H. (2004). Dietary Cholesterol Alters Na+/K+ Selectivity At Intracellular Na+/K+ Pump Sites In Cardiac Myocytes. American Journal of Physiology: Cell Physiology, 286(2), C398-C405.
  • Pitt, A., Fernandes, C., Bewick, N., Hemsworth, P., Buhagiar, K., Hansen, P., Rasmussen, H., Delbridge, L., Whalley, D. (2003). Chronic amiodarone-induced inhibition of the Na+ -K+ pump in rabbit cardiac myocytes is thryoid-dependent: comparison with dronedarone. Cardiovascular Research, 57(1), 101-108.
  • Hansen, P., Buhagiar, K., Kong, B., Clarke, R., Gray, D., Rasmussen, H. (2002). Dependence of Na+-K+ pump current-voltage relationship on intracellular Na+, K+, and Cs+ in rabbit cardiac myocytes. American Journal of Physiology: Cell Physiology, 283(5), 1511-1521.
  • Hanratty, C., Koyama, Y., Rasmussen, H., Hansen, P., Nelson, G., Ward, M. (2002). Exaggeration of Nonculprit Stenosis Severity During Acute Myocardial Infarction: Implications for Immediate Multivessel Revascularization. Journal of the American College of Cardiology, 40(5), 911-916.
  • Koyama, Y., Hansen, P., Hanratty, C., Nelson, G., Rasmussen, H. (2002). Prevalance of Coronary Occlusion and Outcome of an Immediate Invasive Strategy in Suspected Acute Myocardial Infarction with and without ST-Segment Elevation. The American Journal of Cardiology, 90(6), 579-584.
  • Mardini, M., Rasmussen, H., Mihailidou, A., Wong, A. (2001). Cyclosporine and FK506 differentially regulate the sarcolemmal Na+-K+ pump. Journal of Pharmacology and Experimental Therapeutics, 297, 804-810.
  • Buhagiar, K., Hansen, P., Rasmussen, H., Bewick, N. (2001). Protein kinase C-omega contributes to regulation of the sarcolemmal Na+-K+ pump. American Journal of Physiology: Cell Physiology, 50.
  • Rasmussen, H., Hansen, P., Koyama, Y., Adelstein, B., O'Connell,, A., Nelson, G. (2001). Trial of a trial by media. Medical Journal of Australia, 175, 625-628.
  • Mihailidou, A., Bundgaard, H., Mardini, M., Hansen, P., Kjeldsen, H., Rasmussen, H. (2000). Hyperaldosteronemia in rabbits inhibits the cardiac sarcolemmal Na+-K+ pump. Circulation Research, 86, 37-42.

Conferences

  • White, C., Hamilton, E., Garcia, A., Rasmussen, H. (2006). PKA inhibits the Na+-K+ pump in cadiac myocytes via superoxide. 30th Annual Meeting of the Australiasian Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press.
  • Hamilton, E., Garcia, A., William, M., White, C., Franzin, C., Marassi, F., Rasmussen, H. (2005). Phospholemman enhances the sensitivity of the rabbit ventricular myocyte Na+-K+ pump to intracellular Na+. Biophysical Society 49th Annual Meeting, Bethesda, MD: Biophysical Society.

2014

  • Karimi Galougahi, K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N., Davies, M., Hawkins, C., Rasmussen, H., Figtree, G. (2014). Glutathionylation Mediates Angiotension II-Induced eNOS Uncoupling, Amplifying NADPH Oxidase-Dependent Endothelial Dysfunction. Journal of the American Heart Association, 3(2), 1-11. [More Information]
  • Mares, J., Garcia, A., Rasmussen, H., Cornelius, F., Mahmmoud, Y., Berlin, J., Lev, B., Allen, T., Clarke, R. (2014). Identification of Electric-Field-Dependent Steps in the Na+,K+ -Pump Cycle. Biophysical Journal, 107(6), 1352-1363. [More Information]

2013

  • Garcia, A., Fry, N., Karimi, K., Liu, C., Apell, H., Rasmussen, H., Clarke, R. (2013). Extracellular allosteric Na+ binding to the Na+, K+-ATPase in cardiac myocytes. Biophysical Journal, 105(12), 2695-2705. [More Information]
  • McMahon, R., Siow, W., Bhindi, R., Hoo, S., Figtree, G., Hansen, P., Nelson, G., Rasmussen, H., Ward, M. (2013). Left bundle branch block without concordant ST changes is rarely associated with acute coronary occlusion. International Journal of Cardiology, 167(4), 1339-1342. [More Information]
  • Figtree, G., Rasmussen, H., Liu, C. (2013). Oxidative regulation of the na+-k+ pump in cardiac physiology and pathology: clarifying the published evidence. Circulation Research, 112(1), e1-e1. [More Information]
  • Karimi Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Clarke, R., Catauro, M., Rasmussen, H., Apell, H. (2013). Quantitative calculation of the role of the Na+ ,K+ -ATPase in thermogenesis. Biochimica et Biophysica Acta-Bioenergetics, 1827 (10), 1205-1212. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Karimi Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]

2012

  • Karimi Galougahi, K., Liu, C., Bundgaard, H., Rasmussen, H. (2012). Beta-Adrenergic Regulation of the Cardiac Na+-K+ ATPase Mediated by Oxidative Signaling. Trends In Cardiovascular Medicine, 22(4), 83-87. [More Information]
  • Garcia, A., Rasmussen, H., Apell, H., Clarke, R. (2012). Kinetic comparisons of heart and kidney Na+, K+ -ATPases. Biophysical Journal, 103(4), 677-688. [More Information]
  • Figtree, G., Karimi Galougahi, K., Liu, C., Rasmussen, H. (2012). Oxidative regulation of the Na+ -K+ pump in the cardiovascular system. Free Radical Biology and Medicine, 53(12), 2263-2268. [More Information]
  • Murphy, J., Kozor, R., Figtree, G., Hansen, P., Rasmussen, H., Ward, M., Nelson, G., Bhindi, R. (2012). Procedural and in-patient outcomes in patients aged 80 years or older undergoing contemporary primary percutaneous coronary intervention. EuroIntervention, 8(8), 912-919. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]

2011

  • Hamilton, E., Figtree, G., Rasmussen, H. (2011). Consideration of natriuretic peptide receptor C. Circulation Research, 108(4), e4-e5. [More Information]
  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]

2010

  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Rasmussen, H., Liu, C., Figtree, G. (2010). Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology. Trends In Cardiovascular Medicine, 20(3), 85-90. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]

2009

  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]
  • Rasmussen, H., Figtree, G., Krum, H., Bundgaard, H. (2009). The use of beta3-adrenergic receptor agonists in the treatment of heart failure. Current Opinion in Investigational Drugs (Print), 10(9), 955-962. [More Information]

2008

  • William, M., Hamilton, E., Bundgaard, H., Garcia, A., Chia, K., Figtree, G., Rasmussen, H. (2008). Natriuretic peptides stimulate the cardiac sodium pump via NPR-C coupled NOS activation. American Journal of Physiology: Cell Physiology, 294(4), C1067-C1073. [More Information]
  • White, C., Hamilton, E., Garcia, A., Wang, D., Chia, K., Figtree, G., Rasmussen, H. (2008). Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. American Journal of Physiology: Cell Physiology, 294, C572-C578. [More Information]

2007

  • Rasmussen, H., Figtree, G. (2007). "Don't flog the heart!" - development of specific drug therapies for heart failure. Critical Care and Resuscitation, 9(4), 364-369. [More Information]
  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2007). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292, C1070-C1077.
  • Carstensen, S., Nelson, G., Hansen, P., Macken, L., Irons, S., Flynn, M., Kovoor, P., Soo Hoo, S., Ward, M., Rasmussen, H. (2007). Field triage to primary angioplasty combined with emergency department bypass reduces treatment delays and is associated with improved outcome. European Heart Journal, 28(19), 2313-2319. [More Information]

2006

  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2006). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292(3), C1070-C1077. [More Information]
  • Abdulla, I., Kay, S., Mussap, C., Nelson, G., Rasmussen, H., Hansen, P., Ward, M. (2006). Apical sparing in tako-tsubo cardiomyopathy. Internal Medicine Journal, 36(7), 414-418. [More Information]
  • White, C., Hamilton, E., Garcia, A., Rasmussen, H. (2006). PKA inhibits the Na+-K+ pump in cadiac myocytes via superoxide. 30th Annual Meeting of the Australiasian Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press.

2005

  • Hamilton, E., Garcia, A., William, M., White, C., Franzin, C., Marassi, F., Rasmussen, H. (2005). Phospholemman enhances the sensitivity of the rabbit ventricular myocyte Na+-K+ pump to intracellular Na+. Biophysical Society 49th Annual Meeting, Bethesda, MD: Biophysical Society.
  • William, M., Vien, J., Hamilton, E., Garcia, A., Bundgaard, H., Clarke, R., Rasmussen, H. (2005). The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes. The Journal of Physiology, 565.3(3), 815-825. [More Information]
  • Lozzi, L., Carstensen, S., Rasmussen, H., Nelson, G. (2005). Why do acute myocardial infarction patients not call an ambulance? An interview with patients presenting to hospital with acute myocardial infarction symptoms. Internal Medicine Journal, 35(11), 668-671. [More Information]

2004

  • Buhagiar, K., Hansen, P., Kong, B., Clarke, R., Fernandes, C., Rasmussen, H. (2004). Dietary Cholesterol Alters Na+/K+ Selectivity At Intracellular Na+/K+ Pump Sites In Cardiac Myocytes. American Journal of Physiology: Cell Physiology, 286(2), C398-C405.

2003

  • Pitt, A., Fernandes, C., Bewick, N., Hemsworth, P., Buhagiar, K., Hansen, P., Rasmussen, H., Delbridge, L., Whalley, D. (2003). Chronic amiodarone-induced inhibition of the Na+ -K+ pump in rabbit cardiac myocytes is thryoid-dependent: comparison with dronedarone. Cardiovascular Research, 57(1), 101-108.

2002

  • Hansen, P., Buhagiar, K., Kong, B., Clarke, R., Gray, D., Rasmussen, H. (2002). Dependence of Na+-K+ pump current-voltage relationship on intracellular Na+, K+, and Cs+ in rabbit cardiac myocytes. American Journal of Physiology: Cell Physiology, 283(5), 1511-1521.
  • Hanratty, C., Koyama, Y., Rasmussen, H., Hansen, P., Nelson, G., Ward, M. (2002). Exaggeration of Nonculprit Stenosis Severity During Acute Myocardial Infarction: Implications for Immediate Multivessel Revascularization. Journal of the American College of Cardiology, 40(5), 911-916.
  • Koyama, Y., Hansen, P., Hanratty, C., Nelson, G., Rasmussen, H. (2002). Prevalance of Coronary Occlusion and Outcome of an Immediate Invasive Strategy in Suspected Acute Myocardial Infarction with and without ST-Segment Elevation. The American Journal of Cardiology, 90(6), 579-584.

2001

  • Mardini, M., Rasmussen, H., Mihailidou, A., Wong, A. (2001). Cyclosporine and FK506 differentially regulate the sarcolemmal Na+-K+ pump. Journal of Pharmacology and Experimental Therapeutics, 297, 804-810.
  • Buhagiar, K., Hansen, P., Rasmussen, H., Bewick, N. (2001). Protein kinase C-omega contributes to regulation of the sarcolemmal Na+-K+ pump. American Journal of Physiology: Cell Physiology, 50.
  • Rasmussen, H., Hansen, P., Koyama, Y., Adelstein, B., O'Connell,, A., Nelson, G. (2001). Trial of a trial by media. Medical Journal of Australia, 175, 625-628.

2000

  • Mihailidou, A., Bundgaard, H., Mardini, M., Hansen, P., Kjeldsen, H., Rasmussen, H. (2000). Hyperaldosteronemia in rabbits inhibits the cardiac sarcolemmal Na+-K+ pump. Circulation Research, 86, 37-42.

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