Associate Professor Hilda Pickett

Associate Professor
Medicine, Children's Medical Research Institute

Telephone 9687 2800
Fax 9687 2120
Website Honours in Medical Sciences at Westmead

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Current research students

Project title Research student
Dynamics of Telomeric Recombination and Sumoylation in Alternative Lengthening of Telomeres Robert LU

PhD and master's project opportunities

Selected grants

2016

  • Developing treatment strategies to target telomere maintenance in cancer; Pickett H, Cosconati S; Cancer Council New South Wales/Research Project Grants.

2015

  • Molecular mechanisms of telomere length control; Pickett H; Cancer Institute New South Wales/Career Development Fellowship.

2014

  • Activation of TERT in breast cancer; Reddel R, Beesley J, French J, Pickett H, Huschtscha-Holliday L, Cloonan N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Altered teleomeric chromatin and its role in Laternative Lengthening of Telomeres; Pickett H; Cancer Council New South Wales/Research Project Grants.

2013

  • Molecular characterisation of telomere trimming and its role in cell proliferative capacity; Reddel R, Pickett H; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Telomere structural abnormalities in cells using alternative lengthening of teleomeres; Reddel R, Pickett H; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Telomere trimming: a novel mechanism for preventing unlimited cellular proliferation; Pickett H; Cancer Australia/Priority Driven Collaborative Cancer Research Scheme.

Selected publications

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Book Chapters

  • Pickett, H., Reddel, R. (2009). Alternative lengthening of telomeres in human cells. In Keiko Hiyama (Eds.), Telomeres and Telomerase in Cancer, (pp. 127-148). New York: Springer.

Journals

  • Killedar, A., Stutz, M., Sobinoff, A., Tomlinson, C., Bryan, T., Beesley, J., Chenevix-Trench, G., Reddel, R., Pickett, H. (2015). A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. PLoS Genetics, 11(6), 1-23. [More Information]
  • Udugama, M., Chang, F., Chan, F., Tang, M., Pickett, H., McGhie, J., Mayne, L., Collas, P., Mann, J., Wong, L. (2015). Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres. Nucleic Acids Research, 43(21), 10227-10237. [More Information]
  • Pickett, H., Reddel, R. (2015). Molecular mechanisms of activity and derepression of alternative lengthening of telomeres. Nature Structural and Molecular Biology, 22(11), 875-880. [More Information]
  • Bull, C., Mayrhofer, G., O'Callaghan, N., Au, A., Pickett, H., Low, G., Zeegers, D., Hande, M., Fenech, M. (2014). Folate Deficiency Induces Dysfunctional Long and Short Telomeres; Both States are Associated With Hypomethylation and DNA Damage in Human WIL2-NS Cells. Cancer Prevention Research, 7(1), 128-138. [More Information]
  • Guo, Y., Kartawinata, M., Li, J., Pickett, H., Teo, J., Kilo, T., Barbaro, P., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R., Christodoulou, J., Bryan, T., et al (2014). Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood, 124(18), 2767-2774. [More Information]
  • Conomos, D., Reddel, R., Pickett, H. (2014). NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nature Structural and Molecular Biology, 21(9), 760-770. [More Information]
  • Lee, M., Hills, M., Conomos, D., Stutz, M., Dagg, R., Lau, L., Reddel, R., Pickett, H. (2014). Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Research, 42(3), 1733-1746. [More Information]
  • Kojima, Y., Kaufman-Francis, K., Studdert, J., Steiner, K., Power, M., Loebel, D., Jones, V., Hor, A., de Alencastro, G., Logan, G., Alexander, I., Pickett, H., Tam, P., et al (2014). The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak. Cell Stem Cell, 14(1), 107-120. [More Information]
  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Devleopment, 27(1), 18-23. [More Information]
  • Conomos, D., Pickett, H., Reddel, R. (2013). Alternative lengthening of telomeres: remodeling the telomere architecture. Frontiers in Oncology, 3, 1-7. [More Information]
  • Bojesen, S., Pooley, K., Johnatty, S., Beesley, J., Michailidou, K., Tyrer, J., Edwards, S., Pickett, H., Shen, H., Smart, C., Stutz, M., Reddel, R., et al (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics, 45(4), 371-384. [More Information]
  • Bender, H., Murchison, E., Pickett, H., Deakin, J., Strong, M., Conlan, C., McMillan, D., Neumann, A., Greider, C., Hannon, G., Reddel, R., et al (2012). Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PloS One, 7(9), 1-10. [More Information]
  • Uringa, E., Lisaingo, K., Pickett, H., Brind'amour, J., Rohde, J., Zelensky, A., Essers, J., Lansdorp, P. (2012). RTEL1 contributes to DNA replication and repair and telomere maintenance. Molecular Biology of the Cell, 23(14), 2782-2792. [More Information]
  • Stern, J., Zyner, K., Pickett, H., Cohen, S., Bryan, T. (2012). Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently. Molecular and Cellular Biology, 32(13), 2384-2395. [More Information]
  • Pickett, H., Reddel, R. (2012). The role of telomere trimming in normal telomere length dynamics. Cell Cycle, 11(7), 1309-1315. [More Information]
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012). Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology, 199(6), 893-906. [More Information]
  • Beesley, J., Pickett, H., Johnatty, S., Dunning, A., Chen, X., Li, J., Michailidou, K., Lu, Y., Rider, D., Palmieri, R., Stutz, M., Reddel, R., et al (2011). Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PloS One, 6(9), 1-6. [More Information]
  • Pickett, H., Henson, J., Au, A., Neumann, A., Reddel, R. (2011). Normal mammalian cells negatively regulate telomere length by telomere trimming. Human Molecular Genetics, 20(23), 4684-4692. [More Information]
  • Pickett, H., Cesare, A., Johnston, R., Neumann, A., Reddel, R. (2009). Control of telomere length by a trimming mechanism that involves generation of t-circles. The EMBO Journal, 28(7), 799-809. [More Information]
  • Henson, J., Cao, Y., Huschtscha-Holliday, L., Chang, A., Au, A., Pickett, H., Reddel, R. (2009). DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nature Biotechnology, 27(12), 1181-1185. [More Information]
  • Cesare, A., Kaul, Z., Cohen, S., Napier, C., Pickett, H., Neumann, A., Reddel, R. (2009). Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nature Structural and Molecular Biology, 16(12), 1244-1251. [More Information]
  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008). Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels. Cancer Research, 68(9), 3115-3123. [More Information]

2015

  • Killedar, A., Stutz, M., Sobinoff, A., Tomlinson, C., Bryan, T., Beesley, J., Chenevix-Trench, G., Reddel, R., Pickett, H. (2015). A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. PLoS Genetics, 11(6), 1-23. [More Information]
  • Udugama, M., Chang, F., Chan, F., Tang, M., Pickett, H., McGhie, J., Mayne, L., Collas, P., Mann, J., Wong, L. (2015). Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres. Nucleic Acids Research, 43(21), 10227-10237. [More Information]
  • Pickett, H., Reddel, R. (2015). Molecular mechanisms of activity and derepression of alternative lengthening of telomeres. Nature Structural and Molecular Biology, 22(11), 875-880. [More Information]

2014

  • Bull, C., Mayrhofer, G., O'Callaghan, N., Au, A., Pickett, H., Low, G., Zeegers, D., Hande, M., Fenech, M. (2014). Folate Deficiency Induces Dysfunctional Long and Short Telomeres; Both States are Associated With Hypomethylation and DNA Damage in Human WIL2-NS Cells. Cancer Prevention Research, 7(1), 128-138. [More Information]
  • Guo, Y., Kartawinata, M., Li, J., Pickett, H., Teo, J., Kilo, T., Barbaro, P., Keating, B., Chen, Y., Tian, L., Al-Odaib, A., Reddel, R., Christodoulou, J., Bryan, T., et al (2014). Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. Blood, 124(18), 2767-2774. [More Information]
  • Conomos, D., Reddel, R., Pickett, H. (2014). NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination. Nature Structural and Molecular Biology, 21(9), 760-770. [More Information]
  • Lee, M., Hills, M., Conomos, D., Stutz, M., Dagg, R., Lau, L., Reddel, R., Pickett, H. (2014). Telomere extension by telomerase and ALT generates variant repeats by mechanistically distinct processes. Nucleic Acids Research, 42(3), 1733-1746. [More Information]
  • Kojima, Y., Kaufman-Francis, K., Studdert, J., Steiner, K., Power, M., Loebel, D., Jones, V., Hor, A., de Alencastro, G., Logan, G., Alexander, I., Pickett, H., Tam, P., et al (2014). The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak. Cell Stem Cell, 14(1), 107-120. [More Information]

2013

  • Neumann, A., Watson, C., Noble, J., Pickett, H., Tam, P., Reddel, R. (2013). Alternative lengthening of telomeres in normal mammalian somatic cells. Genes and Devleopment, 27(1), 18-23. [More Information]
  • Conomos, D., Pickett, H., Reddel, R. (2013). Alternative lengthening of telomeres: remodeling the telomere architecture. Frontiers in Oncology, 3, 1-7. [More Information]
  • Bojesen, S., Pooley, K., Johnatty, S., Beesley, J., Michailidou, K., Tyrer, J., Edwards, S., Pickett, H., Shen, H., Smart, C., Stutz, M., Reddel, R., et al (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nature Genetics, 45(4), 371-384. [More Information]

2012

  • Bender, H., Murchison, E., Pickett, H., Deakin, J., Strong, M., Conlan, C., McMillan, D., Neumann, A., Greider, C., Hannon, G., Reddel, R., et al (2012). Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PloS One, 7(9), 1-10. [More Information]
  • Uringa, E., Lisaingo, K., Pickett, H., Brind'amour, J., Rohde, J., Zelensky, A., Essers, J., Lansdorp, P. (2012). RTEL1 contributes to DNA replication and repair and telomere maintenance. Molecular Biology of the Cell, 23(14), 2782-2792. [More Information]
  • Stern, J., Zyner, K., Pickett, H., Cohen, S., Bryan, T. (2012). Telomerase Recruitment Requires both TCAB1 and Cajal Bodies Independently. Molecular and Cellular Biology, 32(13), 2384-2395. [More Information]
  • Pickett, H., Reddel, R. (2012). The role of telomere trimming in normal telomere length dynamics. Cell Cycle, 11(7), 1309-1315. [More Information]
  • Conomos, D., Stutz, M., Hills, M., Neumann, A., Bryan, T., Reddel, R., Pickett, H. (2012). Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells. The Journal of Cell Biology, 199(6), 893-906. [More Information]

2011

  • Beesley, J., Pickett, H., Johnatty, S., Dunning, A., Chen, X., Li, J., Michailidou, K., Lu, Y., Rider, D., Palmieri, R., Stutz, M., Reddel, R., et al (2011). Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PloS One, 6(9), 1-6. [More Information]
  • Pickett, H., Henson, J., Au, A., Neumann, A., Reddel, R. (2011). Normal mammalian cells negatively regulate telomere length by telomere trimming. Human Molecular Genetics, 20(23), 4684-4692. [More Information]

2009

  • Pickett, H., Reddel, R. (2009). Alternative lengthening of telomeres in human cells. In Keiko Hiyama (Eds.), Telomeres and Telomerase in Cancer, (pp. 127-148). New York: Springer.
  • Pickett, H., Cesare, A., Johnston, R., Neumann, A., Reddel, R. (2009). Control of telomere length by a trimming mechanism that involves generation of t-circles. The EMBO Journal, 28(7), 799-809. [More Information]
  • Henson, J., Cao, Y., Huschtscha-Holliday, L., Chang, A., Au, A., Pickett, H., Reddel, R. (2009). DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nature Biotechnology, 27(12), 1181-1185. [More Information]
  • Cesare, A., Kaul, Z., Cohen, S., Napier, C., Pickett, H., Neumann, A., Reddel, R. (2009). Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nature Structural and Molecular Biology, 16(12), 1244-1251. [More Information]

2008

  • Cao, Y., Huschtscha, L., Nouwens, A., Pickett, H., Neumann, A., Chang, A., Toouli, C., Bryan, T., Reddel, R. (2008). Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels. Cancer Research, 68(9), 3115-3123. [More Information]

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