Professor Ian Alexander
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Professor in Paediatrics & Molecular Medicine
C29 - Children's Hospital Westmead |
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Research interests
Dr Alexander's specific expertise and interests include virus-mediated gene transfer with a focus on target organs including the liver and bone marrow, both of which have immense promise as target organs for the treatment of genetic disease in children. His team became the first in Australia to treat a genetic disease (SCID-X1) by gene therapy and are recognised leaders in the establishment of this exciting field in Australia.
Current national competitive grants*
2012
Cellular therapy for genetic liver disease exploiting induced pluripotent stem cells and liver progenitor cells
Alexander I, Tam P, Russell D, Yeoh G
NHMRC Project Grants ($770,175 over 3 years)
Analysis and manipulation of the genome-wide integration signatures of gamma-retroviral and lentiviral vectors in human haematopoietic stem cells
Alexander I, Ranganathan S, Cavazzana-Calvo M
NHMRC Project Grants ($591,125 over 3 years)
2011
Novel therapeutic interventions for the orthopaedic complications of Neurofibromatosis type 1 (NF1)
Little D, Alexander I, Schindeler A
National Health and Medical Research Council Project Grant ($606,732 over 3 years)
In vivo gene transfer and phenotype correction of normal and urea-cycle deficient primary human hepatocytes in chimeric mouse-human livers: Towards gene therapy for metabolic liver disease
Alexander I, Braet F, Christodoulou J, Kuchel P, Carpenter K
National Health and Medical Research Council Project Grant ($476,706 over 3 years)
2010
Gene therapy, stress haematopoiesis and the risk of malignancy
Alexander I, Alexander S, McCormack M, Thrasher A, Ginn S
NHMRC Project Grant ($595,500 over 3 years)
* Grants administered through the University of Sydney