Dr James Chong

PhD, FRACP, MBBS,
Senior Lecturer
Medicine, Westmead Clinical School
The Westmead Institute for Medical Research

Telephone +61 2 9845 6795
Fax +61 2 9845 8323

Curriculum vitae Curriculum vitae

Map

Biographical details

As a cardiologist at Sydney’s Westmead Hospital, I have seen first-hand the suffering of patients with severe heart failure and also how limited our current treatment options are. Although heart transplantation is a viable option for some, there will never be enough donor organs to supply the increasing demand of our ageing nation. This motivated me to set up my research group at the University of Sydney/Westmead Institute for Medical Research focusing on novel methods to achieve heart regeneration.

My research group is inspired by the patients who I treat daily. The aim is to create effective treatments for patients with injured hearts (after heart attack for example) so that much needed solutions to the growing epidemic of heart failure can save billions of dollars in health care costs and many future lives.

Our research draws upon the diverse skills that I developed over the past 15 years or so. After my specialist medical and cardiology training, I completed a National Heart Foundation supported PhD at the Victor Chang Cardiac Research Institute. Here, under the mentorship of Prof Richard Harvey, we identified a previously unknown population of stem cells in the adult mouse heart. During this doctoral training I learned powerful basic science skills including how to use genetic-mouse models to dissect the lineage origins cell populations. This work was subsequently published in Cell Stem Cell (the top journal in the stem cell field, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652240).

I then realised that there may be more power/utility in other forms of stem cells (including pluripotent stem cells) leading me to the University of Washington, Seattle, USA to work with Prof Charles Murry, one of the world leaders in cardiac stem cell translational science. This Fulbright and NHMRC fellowship supported period increased my skills further to include pluripotent stem cell culture and differentiation as well as multiple animal models of cardiac disease. During this period, I was the first to demonstrate that human Pluripotent Stem Cell Derived Cardiomyocytes (hPSC-CM) can be produced in a large enough scale to treat non-human primates and that hPSC-CM can electrically integrate after transplantation into the injured heart. This work was published (first author) in the prestigious journal Nature, and remains highly cited (http://www.ncbi.nlm.nih.gov/pubmed/24776797).

Research interests

Heart regeneration

Therapeutic application of stem cells

Coronary atherosclerosis and thrombosis

Current research students

Project title Research student
Molecular Mechanisms of Human Heart Disease Rebecca BAO
SOMATIC GENE TRANSFER OF HTBX18 TO INDUCE BIOLOGICAL PACEMAKER FUNCTIONALITY IN OVINE HEARTS WITH REDUCED PACEMAKING ABILITY Melad FARRAHA
Platelet Derived Growth Factor Mediated Activation and Rejuvenation of Endogenous Cardiac Stem Cells. Sujitha THAVAPALACHANDRAN

Current projects

Human Cardiac Stem Cells for Cardiac Regeneration and Repair

Improving Electrical Integration of Pluripotent Stem Cell Derived Cardiomyocytes in the Injured Heart

Therapeutic Effects of Recombinant Human Platelet Derived Growth Factor in the Infarcted Swine Heart

Purification and Analaysis of Exosomes Derived from Human Cardiac Progenitor Cells

Associations

Australaian Society for Stem Cell Researchers

Stem Cells Australia

Cardiac Society of Australia and New Zealand

Awards and honours

2016 Metcalf Prize (National Stem Cell Foundation)

2014 Ministerial Award for Rising Stars in Cardiovascular Research (NSW Govt/Heart Foundation)

2014 Sydney Medical Foundation Chapman Fellowship

2013 Ludwig Engel Fellowship, Westmead Millennium Institute/Westmead Hospital.

2011 National Health and Medical Research Council Overseas Biomedical Training (CJ Martin) Fellowship.

2011 Australian-American Fulbright Commision Scholarship.

2009 Ralph Reader Prize (Basic Science) Finalist - Cardiac Society of Australia and New Zealand Annual Scientific Meeting 2009. Young Investigator Award.

2009 Cardiac Society of Australia and New Zealand Travelling Fellowship to American Heart Association Scientific Sessions.

2009 Network in Genes and Environment in Development, Travel Grant Award.

2009 University of New South Wales Post Graduate Support Scheme Grant.2008 National Heart Foundation Postgraduate Research Scholarship.

2007 Australian Stem Cell Centre Student Bursary.

2007 Australian Postgraduate Award (Australian Government).

2007 Mc Caughey Trust Research Scholarship Royal Australasian College of Physicians

2007 Pfizer Cardiovascular Travel Grant 2007.

In the media

twitter: @jameschong_doc

Keywords

Cardiovascular diseases; Atherosclerosis; Stem cells

Clinical Specialty

Cardiology

International links

United States

(University of Washington) Close collaborative relationship with Prof Charles (Chuck) Murry, Director of the Institute for Stem Cells and Regenerative Medicine.

Selected grants

2016

  • Investigation of Cardiac Stem Cell Regenerative Capabilities and their Enhancement by Manipulation of Telomerase Reverse Transcriptase; Chong J; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • Heart Stem Cells for Heart Regeneration; Chong J; University of Sydney/Internal Scheme.
  • Clinical Translation of Human Pluripotent Stem Cell Derived Cardiomyocytes; Chong J; National Heart Foundation/Future Leader Fellowship.
  • International Program Development Fund – 2015 Round; Chong J; University of Sydney/International Program Development Fund.
  • Clinical Translation of Human Pluripotent Stem Cells for Heart Failure (Catalyst funding for University of Washington Collaboration).; Chong J, Kizana E, Murry C; DVC International/IPDF Grant.
  • Activation and Rejuvenation of Endogenous Cardiac Stem Cells; Chong J; National Heart Foundation of Australia/NSW CVRN Research Development Project Grant.
  • Human cardiomyocyte and mesenchymal stem cell production for animal models of cardiac disease; Chong J; Agency for Science, Technology and Research/Bioprocessing Technology Institute, Biomedical Sciences Institutes.

2014

  • Sydney Medical School New Staff/Early Career Researcher Scheme 2014; Chong J; University of Sydney/Early Career Researcher.
  • Human Cardiac Stem Cells for Heart Regeneration; Chong J; Royal Australasian College of Physicians/Vincent Fairfax Family Foundation Research Establishment Fellowship.

2013

  • Improving Survival and Function of Stem Cell Derived Human Heart Muscle Grafts; Chong J; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.
  • Ludwig Engel Memorial Fellowship; Chong J, Chong J; Westmead Millennium Institute for Medical Research/Ludwig Engel Memorial Fellowship.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Zheng, S., Chong, J., Chong, B. (2016). Pharmacodynamics, pharmacokinetics and clinical efficacy of apixaban in the treatment of thrombosis. Expert Opinion on Drug Metabolism and Toxicology, 12(5), 575-580. [More Information]
  • Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]
  • Fernandes, S., Chong, J., Paige, S., Iwata, M., Torok-Storb, B., Keller, G., Reinecke, H., Murry, C. (2015). Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair. Stem cell reports, 5(5), 753-762. [More Information]
  • Ding, D., Chong, J., Jalaludin, B., Comino, E., Bauman, A. (2015). Risk factors of incident type 2-diabetes mellitus over a 3-year follow-up: Results from a large Australian sample. Diabetes Research and Clinical Practice, 108(2), 306-315. [More Information]
  • Chong, J., Murry, C. (2014). Cardiac regeneration using pluripotent stem cells-Progression to large animal models. Stem Cell Research, 13(3), 654-665. [More Information]
  • Chong, J., Forte, E., Harvey, R. (2014). Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells. Stem Cell Research, 13(3), 592-614. [More Information]
  • Al Raisi, S., Pouliopoulos, J., Barry, M., Swinnen, J., Thiagalingam, A., Thomas, S., Sivagangabalan, G., Chow, C., Chong, J., Kizana, E., Kovoor, P. (2014). Evaluation of lesion and thermodynamic characteristics of Symplicity and EnligHTN renal denervation systems in a phantom renal artery model. EuroIntervention, 10(2), 277-284. [More Information]
  • Chong, J., Yang, X., Don, C., Minami, E., Liu, Y., Weyers, J., Mahoney, W., Van Biber, B., Cook, S., et al (2014). Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature, 510(7504), 273-277. [More Information]
  • Murry, C., Chong, J., Laflamme, M. (2014). Letter by Murry et al Regarding Article, “Embryonic Stem Cell–Derived Cardiac Myocytes Are Not Ready for Human Trials�? Circulation Research, 115(10), e28-e29. [More Information]
  • Matar, A., Chong, J. (2014). Stem cell therapy for cardiac dysfunction. SpringerPlus, 3(1), 1-14. [More Information]
  • Chong, J., Chong, B. (2013). HIT: nucleic acid masquerading as heparin. Blood, 122(2), 156-158. [More Information]
  • Chong, J., Reinecke, H., Iwata, M., Torok-Storb, B., Stempien-Otero, A., Murry, C. (2013). Progenitor Cells Identi�?ed by PDGFR-Alpha Expression in the Developing and Diseased Human Heart. Stem Cells and Development, 22(13), 1932-1943. [More Information]
  • Chong, J. (2012). Cell therapy for left ventricular dysfunction: an overview for cardiac clinicians. Heart, Lung and Circulation, 21(9), 532-542. [More Information]
  • Chong, J., Chandrakanthan, V., Xaymardan, M., Asli, N., Li, J., Ahmed, I., Heffernan, C., Menon, M., Scarlett, C., Rashidianfar, A., Zoellner, H., et al (2011). Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin. Cell Stem Cell, 9(6), 527-540. [More Information]
  • Chong, B., Chong, J. (2010). IVIg immune inhibitory activity: APC is key. Blood, 115(9), 1663-1164. [More Information]
  • Chong, J., Ganesan, A., Eipper, V., Kovoor, P. (2008). Comparison of left ventricular ejection fraction and inducible ventricular tachycardia in ST-elevation myocardial infarction treated by primary angioplasty versus thrombolysis. The American Journal of Cardiology, 101(2), 153-157. [More Information]
  • Chong, J., Chard, R., McKay, T., Thomas, L. (2008). Two-dimensional and three-dimensional transthoracic echocardiography in surgical planning for right atrial metastatic melanoma. European Journal of Echocardiography, 9. [More Information]

2016

  • Zheng, S., Chong, J., Chong, B. (2016). Pharmacodynamics, pharmacokinetics and clinical efficacy of apixaban in the treatment of thrombosis. Expert Opinion on Drug Metabolism and Toxicology, 12(5), 575-580. [More Information]

2015

  • Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]
  • Fernandes, S., Chong, J., Paige, S., Iwata, M., Torok-Storb, B., Keller, G., Reinecke, H., Murry, C. (2015). Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair. Stem cell reports, 5(5), 753-762. [More Information]
  • Ding, D., Chong, J., Jalaludin, B., Comino, E., Bauman, A. (2015). Risk factors of incident type 2-diabetes mellitus over a 3-year follow-up: Results from a large Australian sample. Diabetes Research and Clinical Practice, 108(2), 306-315. [More Information]

2014

  • Chong, J., Murry, C. (2014). Cardiac regeneration using pluripotent stem cells-Progression to large animal models. Stem Cell Research, 13(3), 654-665. [More Information]
  • Chong, J., Forte, E., Harvey, R. (2014). Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells. Stem Cell Research, 13(3), 592-614. [More Information]
  • Al Raisi, S., Pouliopoulos, J., Barry, M., Swinnen, J., Thiagalingam, A., Thomas, S., Sivagangabalan, G., Chow, C., Chong, J., Kizana, E., Kovoor, P. (2014). Evaluation of lesion and thermodynamic characteristics of Symplicity and EnligHTN renal denervation systems in a phantom renal artery model. EuroIntervention, 10(2), 277-284. [More Information]
  • Chong, J., Yang, X., Don, C., Minami, E., Liu, Y., Weyers, J., Mahoney, W., Van Biber, B., Cook, S., et al (2014). Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature, 510(7504), 273-277. [More Information]
  • Murry, C., Chong, J., Laflamme, M. (2014). Letter by Murry et al Regarding Article, “Embryonic Stem Cell–Derived Cardiac Myocytes Are Not Ready for Human Trials�? Circulation Research, 115(10), e28-e29. [More Information]
  • Matar, A., Chong, J. (2014). Stem cell therapy for cardiac dysfunction. SpringerPlus, 3(1), 1-14. [More Information]

2013

  • Chong, J., Chong, B. (2013). HIT: nucleic acid masquerading as heparin. Blood, 122(2), 156-158. [More Information]
  • Chong, J., Reinecke, H., Iwata, M., Torok-Storb, B., Stempien-Otero, A., Murry, C. (2013). Progenitor Cells Identi�?ed by PDGFR-Alpha Expression in the Developing and Diseased Human Heart. Stem Cells and Development, 22(13), 1932-1943. [More Information]

2012

  • Chong, J. (2012). Cell therapy for left ventricular dysfunction: an overview for cardiac clinicians. Heart, Lung and Circulation, 21(9), 532-542. [More Information]

2011

  • Chong, J., Chandrakanthan, V., Xaymardan, M., Asli, N., Li, J., Ahmed, I., Heffernan, C., Menon, M., Scarlett, C., Rashidianfar, A., Zoellner, H., et al (2011). Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin. Cell Stem Cell, 9(6), 527-540. [More Information]

2010

  • Chong, B., Chong, J. (2010). IVIg immune inhibitory activity: APC is key. Blood, 115(9), 1663-1164. [More Information]

2008

  • Chong, J., Ganesan, A., Eipper, V., Kovoor, P. (2008). Comparison of left ventricular ejection fraction and inducible ventricular tachycardia in ST-elevation myocardial infarction treated by primary angioplasty versus thrombolysis. The American Journal of Cardiology, 101(2), 153-157. [More Information]
  • Chong, J., Chard, R., McKay, T., Thomas, L. (2008). Two-dimensional and three-dimensional transthoracic echocardiography in surgical planning for right atrial metastatic melanoma. European Journal of Echocardiography, 9. [More Information]

To update your profile click here. For support on your academic profile contact .