Dr James (Tim) Howells

Bill Gole MND Research Fellow
Sydney Medical School


Map

Selected grants

2018

  • Hyperexcitability of motor neurons in Motor Neurone Disease; Howells J; Brain Foundation of Australia/Dawn Wallace Fellowship.

2015

  • Hyperexcitability of the lower motor neuron in ALS; Howells J; Motor Neurone Disease Research Institute of Australia/Postdoctoral Fellowship.

Selected publications

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Book Chapters

  • Burke, D., Howells, J. (2017). The motor unit. In Kerry R. Mills (Eds.), Oxford Textbook of Clinical Neurophysiology, (pp. 9-17). Oxford: Oxford University Press. [More Information]

Journals

  • Farrar, M., Lee, M., Howells, J., Andrews, P., Lin, C. (2017). Burning pain: axonal dysfunction in erythromelalgia. Pain, 158(5), 900-911. [More Information]
  • Matamala, J., Geevasinga, N., Huynh, W., Dharmadasa, T., Howells, J., Simon, N., Menon, P., Vucic, S., Kiernan, M. (2017). Cortical function and corticomotoneuronal adaptation in monomelic amyotrophy. Clinical Neurophysiology, 128(8), 1488-1495. [More Information]
  • Garg, N., Park, S., Vucic, S., Yiannikas, C., Spies, J., Howells, J., Huynh, W., Matamala, J., Krishnan, A., Pollard, J., Kiernan, M., et al (2017). Differentiating lower motor neuron syndromes. Journal of Neurology, Neurosurgery and Psychiatry, 88(6), 474-483. [More Information]
  • Kanagaratnam, M., Pendleton, C., Souza, D., Pettit, J., Howells, J., Baker, M. (2017). Diuretic-sensitive electroneutral Na(+) movement and temperature effects on central axons. The Journal of Physiology, 595(11), 3471-3482. [More Information]
  • Shibuya, K., Park, S., Howells, J., Huynh, W., Noto, Y., Shahrizaila, N., Matamala, J., Vucic, S., Kiernan, M. (2017). Laterality of motor cortical function measured by transcranial magnetic stimulation threshold tracking. Muscle and Nerve, 55(3), 424-427. [More Information]
  • Simon, N., Lagopoulos, J., Paling, S., Pfluger, C., Park, S., Howells, J., Gallagher, T., Kliot, M., Henderson, R., Vucic, S., Kiernan, M. (2017). Peripheral nerve diffusion tensor imaging as a measure of disease progression in ALS. Journal of Neurology, 264(5), 882-890. [More Information]
  • Burke, D., Howells, J., Kiernan, M. (2017). Sensory and motor axons are different: implications for neurological disease. Annals of Clinical Neurophysiology, 19(1), 3-12. [More Information]
  • Shibuya, K., Simon, N., Geevasinga, N., Menon, P., Howells, J., Park, S., Huynh, W., Noto, Y., Vucic, S., Kiernan, M. (2017). The evolution of motor cortical dysfunction in amyotrophic lateral sclerosis. Clinical Neurophysiology, 128, 1075-1082. [More Information]
  • Howells, J., Bostock, H., Burke, D. (2016). Accommodation to hyperpolarization of human axons assessed in the frequency domain. Journal of Neurophysiology, 116(2), 322-335. [More Information]
  • Huynh, W., Pickering, H., Howells, J., Murray, J., Cormack, C., Lin, C., Vucic, S., Kiernan, M., Krishnan, A. (2016). Effect of fampridine on axonal excitability in multiple sclerosis. Clinical Neurophysiology, 127(7), 2636-2642. [More Information]
  • Kwai, N., Arnold, R., Poynten, A., Howells, J., Kiernan, M., Lin, C., Krishnan, A. (2016). In vivo evidence of reduced nodal and paranodal conductances in type 1 diabetes. Clinical Neurophysiology, 127(2), 1700-1706. [More Information]
  • Shibuya, K., Park, S., Geevasinga, N., Menon, P., Howells, J., Simon, N., Huynh, W., Noto, Y., Gotz, J., Kril, J., Vucic, S., Kiernan, M., et al (2016). Motor cortical function determines prognosis in sporadic ALS. Neurology, 87(5), 513-520. [More Information]
  • Shibuya, K., Park, S., Geevasinga, N., Huynh, W., Simon, N., Menon, P., Howells, J., Vucic, S., Kiernan, M. (2016). Threshold tracking transcranial magnetic stimulation: Effects of age and gender on motor cortical function. Clinical Neurophysiology, 127(6), 2355-2361. [More Information]
  • Geevasinga, N., Menon, P., Howells, J., Nicholson, G., Kiernan, M., Vucic, S. (2015). Axonal Ion Channel Dysfunction in C9orf72 Familial Amyotrophic Lateral Sclerosis. JAMA Neurology, 72(1), 49-57. [More Information]
  • Geevasinga, N., Menon, P., Nicholson, G., Ng, K., Howells, J., Kril, J., Yannikas, C., Kiernan, M., Vucic, S. (2015). Cortical Function in Asymptomatic Carriers and Patients With C9orf72 Amyotrophic Lateral Sclerosis. JAMA Neurology, 72(11), 1268-1274. [More Information]
  • Czesnik, D., Howells, J., Negro, F., Wagenknecht, M., Hanner, S., Farina, D., Burke, D., Paulus, W. (2015). Increased HCN channel driven inward rectification in benign cramp fasciculation syndrome. Brain, 138(11), 3168-3179. [More Information]
  • Simon, N., Lin, C., Lee, M., Howells, J., Vucic, S., Burke, D., Kiernan, M. (2015). Segmental motoneuronal dysfunction is a feature of amyotrophic lateral sclerosis. Clinical Neurophysiology, 126(4), 828-836. [More Information]
  • Menon, P., Geevasinga, N., Yiannikas, K., Howells, J., Kiernan, M., Vucic, S. (2015). Sensitivity and specificity of threshold tracking transcranial magnetic stimulation for diagnosis of amyotrophic lateral sclerosis: A prospective study. The Lancet Neurology, 14(5), 478-484. [More Information]
  • Liang, C., Howells, J., Kennerson, M., Nicholson, G., Burke, D., Ng, K. (2014). Axonal excitability in X-linked dominant Charcot Marie Tooth disease. Clinical Neurophysiology, 125(6), 1261-1269. [More Information]
  • Arnold, R., Pussell, B., Howells, J., Grinius, V., Kiernan, M., Lin, C., Krishnan, A. (2014). Evidence for a causal relationship between hyperkalaemia and axonal dysfunction in end-stage kidney disease. Clinical Neurophysiology, 125(1), 179-185. [More Information]
  • Ng, K., Howells, J., Pollard, J., Burke, D. (2013). Different mechanisms underlying changes in excitability of peripheral nerve sensory and motor axons in multiple sclerosis. Muscle and Nerve, 47(1), 53-60. [More Information]
  • Arnold, R., Pussell, B., Pianta, T., Grinius, V., Lin, C., Kiernan, M., Howells, J., Jardine, M., Krishnan, A. (2013). Effects of hemodiafiltration and high flux hemodialysis on nerve excitability in end-stage kidney disease. PloS One, 8(3), 1-8. [More Information]
  • Howells, J., Czesnik, D., Trevillion, L., Burke, D. (2013). Excitability and the safety margin in human axons during hyperthermia. The Journal of Physiology, 591(12), 3063-3080. [More Information]
  • Burke, D., Howells, J., Tomlinson, S. (2013). HCN Channels: Function and clinical implications. Neurology, 81(5), 513-514. [More Information]
  • Howells, J., Trevillion, L., Bostock, H., Burke, D. (2012). The voltage dependence of Ih in human myelinated axons. The Journal of Physiology, 590(7), 1625-1640. [More Information]
  • Trevillion, L., Howells, J., Tomlinson, S., Bostock, H., Burke, D. (2011). What makes some axons more excitable than others. Physiology News, 82, 32-35.
  • Trevillion, L., Howells, J., Bostock, H., Burke, D. (2010). Properties of Low-Threshold Motor Axons in the Human Median Nerve. The Journal of Physiology, 288(13), 2503-2515. [More Information]
  • Burke, D., Howells, J., Trevillion, L., McNulty, P., Jankelowitz, S., Kiernan, M. (2009). Threshold behaviour of human axons explored using subthreshold perturbations to membrane potential. The Journal of Physiology, 587(2), 491-504. [More Information]
  • Ng, K., Howells, J., Pollard, J., Burke, D. (2008). Up-regulation of slow K+ channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosis. Brain, 131(11), 3062-3071. [More Information]
  • Burke, D., Howells, J., Trevillion, L., Kiernan, M., Bostock, H. (2007). Inflections in threshold electrotonus to depolarizing currents in sensory axons. Muscle and Nerve, 36(6), 849-852. [More Information]
  • Trevillion, L., Howells, J., Burke, D. (2007). Outwardly rectifying deflections in threshold electrotonus due to K+ conductances. The Journal of Physiology, 580(2), 685-696. [More Information]
  • Jankelowitz, S., Howells, J., Burke, D. (2007). Plasticity of inwardly rectifying conductances following a corticospinal lesion in human subjects. The Journal of Physiology, 581(3), 927-940. [More Information]
  • Vucic, S., Howells, J., Trevillion, L., Kiernan, M. (2006). Assessment of cortical excitability using threshold tracking techniques. Muscle and Nerve, 33(4), 477-486. [More Information]
  • Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2006). Augmentation of the contraction force of human thenar muscles by and during brief discharge trains. Muscle and Nerve, 33(3), 384-392. [More Information]
  • Bostock, H., Lin, C., Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2005). After-effects of near-threshold stimulation in single human motor axons. The Journal of Physiology, 564(3), 931-940. [More Information]
  • Trevillion, L., Howells, J., Jankelowitz, S., Burke, D. (2004). Axonal Excitability Measured By Tracking Twitch Contraction Force. Muscle and Nerve, 30(4), 437-443. [More Information]

Conferences

  • Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2006). The Catch-Like property of human thenar muscles studied during brief trains of discharges. XIth International Congress on Neuromuscular Diseases, United Kingdom: Elsevier.

2017

  • Farrar, M., Lee, M., Howells, J., Andrews, P., Lin, C. (2017). Burning pain: axonal dysfunction in erythromelalgia. Pain, 158(5), 900-911. [More Information]
  • Matamala, J., Geevasinga, N., Huynh, W., Dharmadasa, T., Howells, J., Simon, N., Menon, P., Vucic, S., Kiernan, M. (2017). Cortical function and corticomotoneuronal adaptation in monomelic amyotrophy. Clinical Neurophysiology, 128(8), 1488-1495. [More Information]
  • Garg, N., Park, S., Vucic, S., Yiannikas, C., Spies, J., Howells, J., Huynh, W., Matamala, J., Krishnan, A., Pollard, J., Kiernan, M., et al (2017). Differentiating lower motor neuron syndromes. Journal of Neurology, Neurosurgery and Psychiatry, 88(6), 474-483. [More Information]
  • Kanagaratnam, M., Pendleton, C., Souza, D., Pettit, J., Howells, J., Baker, M. (2017). Diuretic-sensitive electroneutral Na(+) movement and temperature effects on central axons. The Journal of Physiology, 595(11), 3471-3482. [More Information]
  • Shibuya, K., Park, S., Howells, J., Huynh, W., Noto, Y., Shahrizaila, N., Matamala, J., Vucic, S., Kiernan, M. (2017). Laterality of motor cortical function measured by transcranial magnetic stimulation threshold tracking. Muscle and Nerve, 55(3), 424-427. [More Information]
  • Simon, N., Lagopoulos, J., Paling, S., Pfluger, C., Park, S., Howells, J., Gallagher, T., Kliot, M., Henderson, R., Vucic, S., Kiernan, M. (2017). Peripheral nerve diffusion tensor imaging as a measure of disease progression in ALS. Journal of Neurology, 264(5), 882-890. [More Information]
  • Burke, D., Howells, J., Kiernan, M. (2017). Sensory and motor axons are different: implications for neurological disease. Annals of Clinical Neurophysiology, 19(1), 3-12. [More Information]
  • Shibuya, K., Simon, N., Geevasinga, N., Menon, P., Howells, J., Park, S., Huynh, W., Noto, Y., Vucic, S., Kiernan, M. (2017). The evolution of motor cortical dysfunction in amyotrophic lateral sclerosis. Clinical Neurophysiology, 128, 1075-1082. [More Information]
  • Burke, D., Howells, J. (2017). The motor unit. In Kerry R. Mills (Eds.), Oxford Textbook of Clinical Neurophysiology, (pp. 9-17). Oxford: Oxford University Press. [More Information]

2016

  • Howells, J., Bostock, H., Burke, D. (2016). Accommodation to hyperpolarization of human axons assessed in the frequency domain. Journal of Neurophysiology, 116(2), 322-335. [More Information]
  • Huynh, W., Pickering, H., Howells, J., Murray, J., Cormack, C., Lin, C., Vucic, S., Kiernan, M., Krishnan, A. (2016). Effect of fampridine on axonal excitability in multiple sclerosis. Clinical Neurophysiology, 127(7), 2636-2642. [More Information]
  • Kwai, N., Arnold, R., Poynten, A., Howells, J., Kiernan, M., Lin, C., Krishnan, A. (2016). In vivo evidence of reduced nodal and paranodal conductances in type 1 diabetes. Clinical Neurophysiology, 127(2), 1700-1706. [More Information]
  • Shibuya, K., Park, S., Geevasinga, N., Menon, P., Howells, J., Simon, N., Huynh, W., Noto, Y., Gotz, J., Kril, J., Vucic, S., Kiernan, M., et al (2016). Motor cortical function determines prognosis in sporadic ALS. Neurology, 87(5), 513-520. [More Information]
  • Shibuya, K., Park, S., Geevasinga, N., Huynh, W., Simon, N., Menon, P., Howells, J., Vucic, S., Kiernan, M. (2016). Threshold tracking transcranial magnetic stimulation: Effects of age and gender on motor cortical function. Clinical Neurophysiology, 127(6), 2355-2361. [More Information]

2015

  • Geevasinga, N., Menon, P., Howells, J., Nicholson, G., Kiernan, M., Vucic, S. (2015). Axonal Ion Channel Dysfunction in C9orf72 Familial Amyotrophic Lateral Sclerosis. JAMA Neurology, 72(1), 49-57. [More Information]
  • Geevasinga, N., Menon, P., Nicholson, G., Ng, K., Howells, J., Kril, J., Yannikas, C., Kiernan, M., Vucic, S. (2015). Cortical Function in Asymptomatic Carriers and Patients With C9orf72 Amyotrophic Lateral Sclerosis. JAMA Neurology, 72(11), 1268-1274. [More Information]
  • Czesnik, D., Howells, J., Negro, F., Wagenknecht, M., Hanner, S., Farina, D., Burke, D., Paulus, W. (2015). Increased HCN channel driven inward rectification in benign cramp fasciculation syndrome. Brain, 138(11), 3168-3179. [More Information]
  • Simon, N., Lin, C., Lee, M., Howells, J., Vucic, S., Burke, D., Kiernan, M. (2015). Segmental motoneuronal dysfunction is a feature of amyotrophic lateral sclerosis. Clinical Neurophysiology, 126(4), 828-836. [More Information]
  • Menon, P., Geevasinga, N., Yiannikas, K., Howells, J., Kiernan, M., Vucic, S. (2015). Sensitivity and specificity of threshold tracking transcranial magnetic stimulation for diagnosis of amyotrophic lateral sclerosis: A prospective study. The Lancet Neurology, 14(5), 478-484. [More Information]

2014

  • Liang, C., Howells, J., Kennerson, M., Nicholson, G., Burke, D., Ng, K. (2014). Axonal excitability in X-linked dominant Charcot Marie Tooth disease. Clinical Neurophysiology, 125(6), 1261-1269. [More Information]
  • Arnold, R., Pussell, B., Howells, J., Grinius, V., Kiernan, M., Lin, C., Krishnan, A. (2014). Evidence for a causal relationship between hyperkalaemia and axonal dysfunction in end-stage kidney disease. Clinical Neurophysiology, 125(1), 179-185. [More Information]

2013

  • Ng, K., Howells, J., Pollard, J., Burke, D. (2013). Different mechanisms underlying changes in excitability of peripheral nerve sensory and motor axons in multiple sclerosis. Muscle and Nerve, 47(1), 53-60. [More Information]
  • Arnold, R., Pussell, B., Pianta, T., Grinius, V., Lin, C., Kiernan, M., Howells, J., Jardine, M., Krishnan, A. (2013). Effects of hemodiafiltration and high flux hemodialysis on nerve excitability in end-stage kidney disease. PloS One, 8(3), 1-8. [More Information]
  • Howells, J., Czesnik, D., Trevillion, L., Burke, D. (2013). Excitability and the safety margin in human axons during hyperthermia. The Journal of Physiology, 591(12), 3063-3080. [More Information]
  • Burke, D., Howells, J., Tomlinson, S. (2013). HCN Channels: Function and clinical implications. Neurology, 81(5), 513-514. [More Information]

2012

  • Howells, J., Trevillion, L., Bostock, H., Burke, D. (2012). The voltage dependence of Ih in human myelinated axons. The Journal of Physiology, 590(7), 1625-1640. [More Information]

2011

  • Trevillion, L., Howells, J., Tomlinson, S., Bostock, H., Burke, D. (2011). What makes some axons more excitable than others. Physiology News, 82, 32-35.

2010

  • Trevillion, L., Howells, J., Bostock, H., Burke, D. (2010). Properties of Low-Threshold Motor Axons in the Human Median Nerve. The Journal of Physiology, 288(13), 2503-2515. [More Information]

2009

  • Burke, D., Howells, J., Trevillion, L., McNulty, P., Jankelowitz, S., Kiernan, M. (2009). Threshold behaviour of human axons explored using subthreshold perturbations to membrane potential. The Journal of Physiology, 587(2), 491-504. [More Information]

2008

  • Ng, K., Howells, J., Pollard, J., Burke, D. (2008). Up-regulation of slow K+ channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosis. Brain, 131(11), 3062-3071. [More Information]

2007

  • Burke, D., Howells, J., Trevillion, L., Kiernan, M., Bostock, H. (2007). Inflections in threshold electrotonus to depolarizing currents in sensory axons. Muscle and Nerve, 36(6), 849-852. [More Information]
  • Trevillion, L., Howells, J., Burke, D. (2007). Outwardly rectifying deflections in threshold electrotonus due to K+ conductances. The Journal of Physiology, 580(2), 685-696. [More Information]
  • Jankelowitz, S., Howells, J., Burke, D. (2007). Plasticity of inwardly rectifying conductances following a corticospinal lesion in human subjects. The Journal of Physiology, 581(3), 927-940. [More Information]

2006

  • Vucic, S., Howells, J., Trevillion, L., Kiernan, M. (2006). Assessment of cortical excitability using threshold tracking techniques. Muscle and Nerve, 33(4), 477-486. [More Information]
  • Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2006). Augmentation of the contraction force of human thenar muscles by and during brief discharge trains. Muscle and Nerve, 33(3), 384-392. [More Information]
  • Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2006). The Catch-Like property of human thenar muscles studied during brief trains of discharges. XIth International Congress on Neuromuscular Diseases, United Kingdom: Elsevier.

2005

  • Bostock, H., Lin, C., Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2005). After-effects of near-threshold stimulation in single human motor axons. The Journal of Physiology, 564(3), 931-940. [More Information]

2004

  • Trevillion, L., Howells, J., Jankelowitz, S., Burke, D. (2004). Axonal Excitability Measured By Tracking Twitch Contraction Force. Muscle and Nerve, 30(4), 437-443. [More Information]

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