Mr Tim Howells

Research Officer
Sydney Medical School


Map

Selected grants

2015

  • Hyperexcitability of the lower motor neuron in ALS; Howells J; Motor Neurone Disease Research Institute of Australia/Postdoctoral Fellowship.

Selected publications

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Journals

  • Liang, C., Howells, J., Kennerson, M., Nicholson, G., Burke, D., Ng, K. (2014). Axonal excitability in X-linked dominant Charcot Marie Tooth disease. Clinical Neurophysiology, 125(6), 1261-1269. [More Information]
  • Arnold, R., Pussell, B., Howells, J., Grinius, V., Kiernan, M., Lin, C., Krishnan, A. (2014). Evidence for a causal relationship between hyperkalaemia and axonal dysfunction in end-stage kidney disease. Clinical Neurophysiology, 125(1), 179-185. [More Information]
  • Ng, K., Howells, J., Pollard, J., Burke, D. (2013). Different mechanisms underlying changes in excitability of peripheral nerve sensory and motor axons in multiple sclerosis. Muscle and Nerve, 47(1), 53-60. [More Information]
  • Arnold, R., Pussell, B., Pianta, T., Grinius, V., Lin, C., Kiernan, M., Howells, J., Jardine, M., Krishnan, A. (2013). Effects of hemodiafiltration and high flux hemodialysis on nerve excitability in end-stage kidney disease. PloS One, 8(3), 1-8. [More Information]
  • Howells, J., Czesnik, D., Trevillion, L., Burke, D. (2013). Excitability and the safety margin in human axons during hyperthermia. The Journal of Physiology, 591(12), 3063-3080. [More Information]
  • Burke, D., Howells, J., Tomlinson, S. (2013). HCN Channels: Function and clinical implications. Neurology, 81(5), 513-514. [More Information]
  • Howells, J., Trevillion, L., Bostock, H., Burke, D. (2012). The voltage dependence of Ih in human myelinated axons. The Journal of Physiology, 590(7), 1625-1640. [More Information]
  • Trevillion, L., Howells, J., Tomlinson, S., Bostock, H., Burke, D. (2011). What makes some axons more excitable than others. Physiology News, 82, 32-35.
  • Trevillion, L., Howells, J., Bostock, H., Burke, D. (2010). Properties of Low-Threshold Motor Axons in the Human Median Nerve. The Journal of Physiology, 288(13), 2503-2515. [More Information]
  • Burke, D., Howells, J., Trevillion, L., McNulty, P., Jankelowitz, S., Kiernan, M. (2009). Threshold behaviour of human axons explored using subthreshold perturbations to membrane potential. The Journal of Physiology, 587(2), 491-504. [More Information]
  • Ng, K., Howells, J., Pollard, J., Burke, D. (2008). Up-regulation of slow K+ channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosis. Brain, 131(11), 3062-3071. [More Information]
  • Burke, D., Howells, J., Trevillion, L., Kiernan, M., Bostock, H. (2007). Inflections in threshold electrotonus to depolarizing currents in sensory axons. Muscle and Nerve, 36(6), 849-852. [More Information]
  • Trevillion, L., Howells, J., Burke, D. (2007). Outwardly rectifying deflections in threshold electrotonus due to K+ conductances. The Journal of Physiology, 580(2), 685-696. [More Information]
  • Jankelowitz, S., Howells, J., Burke, D. (2007). Plasticity of inwardly rectifying conductances following a corticospinal lesion in human subjects. The Journal of Physiology, 581(3), 927-940. [More Information]
  • Vucic, S., Howells, J., Trevillion, L., Kiernan, M. (2006). Assessment of cortical excitability using threshold tracking techniques. Muscle and Nerve, 33(4), 477-486. [More Information]
  • Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2006). Augmentation of the contraction force of human thenar muscles by and during brief discharge trains. Muscle and Nerve, 33(3), 384-392. [More Information]
  • Bostock, H., Lin, C., Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2005). After-effects of near-threshold stimulation in single human motor axons. The Journal of Physiology, 564(3), 931-940. [More Information]
  • Trevillion, L., Howells, J., Jankelowitz, S., Burke, D. (2004). Axonal Excitability Measured By Tracking Twitch Contraction Force. Muscle and Nerve, 30(4), 437-443. [More Information]

Conferences

  • Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2006). The Catch-Like property of human thenar muscles studied during brief trains of discharges. XIth International Congress on Neuromuscular Diseases, United Kingdom: Elsevier.

2014

  • Liang, C., Howells, J., Kennerson, M., Nicholson, G., Burke, D., Ng, K. (2014). Axonal excitability in X-linked dominant Charcot Marie Tooth disease. Clinical Neurophysiology, 125(6), 1261-1269. [More Information]
  • Arnold, R., Pussell, B., Howells, J., Grinius, V., Kiernan, M., Lin, C., Krishnan, A. (2014). Evidence for a causal relationship between hyperkalaemia and axonal dysfunction in end-stage kidney disease. Clinical Neurophysiology, 125(1), 179-185. [More Information]

2013

  • Ng, K., Howells, J., Pollard, J., Burke, D. (2013). Different mechanisms underlying changes in excitability of peripheral nerve sensory and motor axons in multiple sclerosis. Muscle and Nerve, 47(1), 53-60. [More Information]
  • Arnold, R., Pussell, B., Pianta, T., Grinius, V., Lin, C., Kiernan, M., Howells, J., Jardine, M., Krishnan, A. (2013). Effects of hemodiafiltration and high flux hemodialysis on nerve excitability in end-stage kidney disease. PloS One, 8(3), 1-8. [More Information]
  • Howells, J., Czesnik, D., Trevillion, L., Burke, D. (2013). Excitability and the safety margin in human axons during hyperthermia. The Journal of Physiology, 591(12), 3063-3080. [More Information]
  • Burke, D., Howells, J., Tomlinson, S. (2013). HCN Channels: Function and clinical implications. Neurology, 81(5), 513-514. [More Information]

2012

  • Howells, J., Trevillion, L., Bostock, H., Burke, D. (2012). The voltage dependence of Ih in human myelinated axons. The Journal of Physiology, 590(7), 1625-1640. [More Information]

2011

  • Trevillion, L., Howells, J., Tomlinson, S., Bostock, H., Burke, D. (2011). What makes some axons more excitable than others. Physiology News, 82, 32-35.

2010

  • Trevillion, L., Howells, J., Bostock, H., Burke, D. (2010). Properties of Low-Threshold Motor Axons in the Human Median Nerve. The Journal of Physiology, 288(13), 2503-2515. [More Information]

2009

  • Burke, D., Howells, J., Trevillion, L., McNulty, P., Jankelowitz, S., Kiernan, M. (2009). Threshold behaviour of human axons explored using subthreshold perturbations to membrane potential. The Journal of Physiology, 587(2), 491-504. [More Information]

2008

  • Ng, K., Howells, J., Pollard, J., Burke, D. (2008). Up-regulation of slow K+ channels in peripheral motor axons: a transcriptional channelopathy in multiple sclerosis. Brain, 131(11), 3062-3071. [More Information]

2007

  • Burke, D., Howells, J., Trevillion, L., Kiernan, M., Bostock, H. (2007). Inflections in threshold electrotonus to depolarizing currents in sensory axons. Muscle and Nerve, 36(6), 849-852. [More Information]
  • Trevillion, L., Howells, J., Burke, D. (2007). Outwardly rectifying deflections in threshold electrotonus due to K+ conductances. The Journal of Physiology, 580(2), 685-696. [More Information]
  • Jankelowitz, S., Howells, J., Burke, D. (2007). Plasticity of inwardly rectifying conductances following a corticospinal lesion in human subjects. The Journal of Physiology, 581(3), 927-940. [More Information]

2006

  • Vucic, S., Howells, J., Trevillion, L., Kiernan, M. (2006). Assessment of cortical excitability using threshold tracking techniques. Muscle and Nerve, 33(4), 477-486. [More Information]
  • Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2006). Augmentation of the contraction force of human thenar muscles by and during brief discharge trains. Muscle and Nerve, 33(3), 384-392. [More Information]
  • Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2006). The Catch-Like property of human thenar muscles studied during brief trains of discharges. XIth International Congress on Neuromuscular Diseases, United Kingdom: Elsevier.

2005

  • Bostock, H., Lin, C., Howells, J., Trevillion, L., Jankelowitz, S., Burke, D. (2005). After-effects of near-threshold stimulation in single human motor axons. The Journal of Physiology, 564(3), 931-940. [More Information]

2004

  • Trevillion, L., Howells, J., Jankelowitz, S., Burke, D. (2004). Axonal Excitability Measured By Tracking Twitch Contraction Force. Muscle and Nerve, 30(4), 437-443. [More Information]

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