Associate Professor James Triccas

Level D (Research Only) Academic
Medicine (Immunology & Infectious Diseases), Central Clinical School

Telephone +61 2 9036 6582
Fax +61 2 9351 5319

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Research interests

Our research program is focused on determining how virulent micro-organisms promote disease, and developing novel strategies to prevent infection. A particular emphasis of the research is determining which components of the immune response are targeted by pathogenic mycobacteria during infection, and using this information to aid the rational development of more effective anti-tuberculosis vaccines.

Selected grants

2015

  • A new class of inhibitors for the treatment of tuberculosis; Triccas J, Rutledge P, West N, Todd M; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Formulation of novel tuberculosis (TB) subunit vaccines for human delivery; Triccas J, Britton W; Aeras/Research Support.
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Latent Tuberculosis Infection; West N, Triccas J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • New candidate vaccines to prevent tuberculosis: preclinical assessment of efficacy, safety and mechanism of protection; Triccas J, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Tuberculosis control: from discovery to public health practice and policy; Britton W, Marais B, Marks G, Sintchenko V, Graham S, Triccas J, Saunders B, Kerridge I, Bennett B, Gilbert G; National Health and Medical Research Council (NHMRC)/Centres of Research Excellence.
  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • Impact of Influenza A infection on T cell-mediated immunity to pulmonary tuberculosis.; Britton W, Triccas J, Florido M, Stambas J; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Identifying new compounds to treat infection with the major lung pathogen Mcyobacterium tuberculosis; Triccas J; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Visualising gamma-delta T cell responses in cutaneous inflammation; Weninger W, Triccas J; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Identification and validation of novel drug targets to combat tuberculosis; Triccas J; National Health and Medical Research Council (NHMRC)/Travelling Award for Research Training.
  • Chronic bacterial infection and thye generation of T cell memory: implication for vaccination against tuberculosis; Triccas J, Britton W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • autoMACS Pro Separator; Abendroth A, Britton W, Richardson D, King N, Halliday G, Pollard J, McMinn P, Bishop A, Triccas J, Wang M, Byrne S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Identifying virulence strategies and developing new vaccines for the major lung pathogens Pseudomonas aeruginosa and Mycobacterium tuberculosis; Triccas J; Rebecca L Cooper Medical Research Foundation/Research Support.
  • Regulation of pulmonary immune responses to subunit vaccines against tuberculosis; Britton W, Triccas J, West N; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Identifying new target of the human immune response to Mycobacterium tuberculosis.; Triccas J; University of Sydney/Newly Appointed Staff.

2006

  • Manipulating immunity to Mycobacterium tuberculosis with novel vaccines and immunotherapeutics; Triccas J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Advanced Bioinformatics Teaching Facility; Arthur J, Triccas J, Jermiin L, Charleston M, Yang J, Britton W; DVC Research/Teaching Equipment Grant (Sesqui).
  • Identifying Determinants Of Mycobacterial Pathogenesis And Understanding Host Immunity For The Development Of Novel Anti-Tb Vaccines; Triccas J; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

1999

  • Identification of genes expressed by cobacterium tuberculosis to enhance intracellular survival; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Book Chapters

  • Triccas, J., Ryan, A. (2009). Heterologous Expression of Genes in Mycobacteria. In arish, Tanya; Brown, Amanda Claire (Eds.), Methods in Molecular Biology: Mycobacteria Protocols, (pp. 243-253). Springer.
  • Britton, W., Triccas, J. (2008). The constituents of the cell envelope and their impact on the host immune system. In Daffe M; Reyrat J-M (Eds.), The Mycobacterial Cell Envelope, (pp. 249-270). Washington DC: ASM Press.

Journals

  • Yu, M., Ryan, T., Ellis, S., Bush, A., Triccas, J., Rutledge, P., Todd, M. (2014). Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta. Metallomics, 6(10), 1931-1940. [More Information]
  • Ellis, S., Kalinowski, D., Leotta, L., Huang, M., Jelfs, P., Sintchenko, V., Richardson, D., Triccas, J. (2014). Potent Anti-Mycobacterial Activity of the Pyridoxal Isonicotinoyl Hydrazone Analogue, 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone: A Lipophilic Transport Vehicle for Isonicotinic Acid Hydrazide. Molecular Pharmacology, 85(2), 269-278. [More Information]
  • Burke, C., Liu, M., Britton, W., Triccas, J., Thomas, T., Smith, A., Allen, S., Salomon, R., Harry, E. (2013). Harnessing single cell sorting to identify cell division genes and regulators in bacteria. PLoS One, 8(4), 1-13. [More Information]
  • Pinto, R., Leotta, L., Shanahan, E., West, N., Leyh, T., Britton, W., Triccas, J. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. The Journal of Infectious Diseases, 207(5), 778-785. [More Information]
  • Yu, M., Lim, N., Ellis, S., Nagase, H., Triccas, J., Rutledge, P., Todd, M. (2013). Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity. ChemistryOpen, 2(3), 99-105. [More Information]
  • Florido, M., Grima, M., Gillis, C., Xia, Y., Turner, S., Triccas, J., Stambas, J., Britton, W. (2013). Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Coinfection. The Journal of Immunology, 191(1), 302-311. [More Information]
  • Harmer, C., Alnassafi, K., Hu, H., Elkins, M., Bye, P., Rose, B., Cordwell, S., Triccas, J., Harbour, C., Manos, J. (2013). Modulation of gene expression by Pseudomonas aeruginosa during chronic infection in the adult cystic fibrosis lung. Microbiology, 159(11), 2354-2363. [More Information]
  • Nambiar, J., Pinto, R., Aguilo, J., Takatsu, K., Martin, C., Britton, W., Triccas, J. (2012). Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4+ T-cell memory. European Journal of Immunology, 42(2), 385-392. [More Information]
  • Harmer, C., Triccas, J., Hu, H., Rose, B., Bye, P., Elkins, M., Manos, J. (2012). Pseudomonas aeruginosa strains from the chronically infected cystic fibrosis lung display increased invasiveness of A549 epithelial cells over time. Microbial Pathogenesis, 53(1), 37-43. [More Information]
  • Kao, F., Mahmuda, S., Pinto, R., Triccas, J., West, N., Britton, W. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PLoS One, 7(5), 1-12. [More Information]
  • Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012). Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology, 57(2), 352-358. [More Information]
  • Sumaria, N., Roediger, B., Ng, L., Qin, J., Pinto, R., Cavanagh, L., Shklovskaya, E., Fazekas de St Groth, B., Triccas, J., Weninger, W. (2011). Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells. The Journal of Experimental Medicine, 208(3), 505-518. [More Information]
  • West, N., Thomson, S., Triccas, J., Medveczky, C., Ramshaw, I., Britton, W. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29(44), 7759-7765. [More Information]
  • Triccas, J., Winter, N., Feng, C., West, N. (2011). Immunity to Mycobacterium tuberculosis. Clinical & Developmental Immunology, 2011, 406549-406549. [More Information]
  • Kong, C., Ng, L., Nambiar, J., Spratt, J., Weninger, W., Triccas, J. (2011). Targeted induction of antigen expression within dendritic cells modulates antigen-specific immunity afforded by recombinant BCG. Vaccine, 29(7), 1374-1381. [More Information]
  • Shanahan, E., Pinto (Pinto-Nadanachandran), R., Triccas, J., Britton, W., West, N. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28(5), 1341-1346. [More Information]
  • Spratt, J., Britton, W., Triccas, J. (2010). In vivo persistence and protective efficacy of the bacille Calmette Guerin vaccine overexpressing the HspX latency antigen. Bioengineered Bugs, 1(1), 61-65. [More Information]
  • Magnet, S., Hartkoorn, R., Szekely, R., Pato, J., Triccas, J., Schneider, P., Szantai-Kis, C., Orfi, L., Chambon, M., Banfi, D., et al (2010). Leads for antitubercular compounds from kinase inhibitor library screens. Tuberculosis, 90(6), 354-360. [More Information]
  • Nambiar, J., Ryan, A., Kong, C., Britton, W., Triccas, J. (2010). Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection. European Journal of Immunology, 40(1), 153-161. [More Information]
  • Triccas, J. (2010). Recombinant BCG as a vaccine vehicle to protect against tuberculosis. Bioengineered Bugs, 1(2), 110-115. [More Information]
  • Hulseberg, P., Zozulya, A., Chu, H., Triccas, J., Fabry, Z., Sandor, M. (2010). The same well-characterized T cell epitope SIINFEKL expressed in the context of a cytoplasmic or secreted protein in BCG induces different CD8(+) T cell responses. Immunology Letters, 130, 36-42. [More Information]
  • Ryan, A., Nambiar, J., Wozniak, T., Roediger, B., Shklovskaya, E., Britton, W., Fazekas de St Groth, B., Triccas, J. (2009). Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection. The Journal of Immunology, 182(11), 7172-7177. [More Information]
  • Scandurra, G., Britton, W., Triccas, J. (2008). Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice. Microbes and Infection, 10, 38-44. [More Information]
  • Ng, L., Hsu, A., Mandell, M., Roediger, B., Hoeller, C., Mrass, P., Iparraguirre, A., Cavanagh, L., Triccas, J., Beverley, S., Weninger, W., et al (2008). Migratory dermal dendritic cells act as rapid sensors of protozoan parasites. P L o S Pathogens, 4(11), 1-13. [More Information]
  • Triccas, J., Shklovskaya, E., Spratt, J., Ryan, A., Palindera, U., Fazekas de St Groth, B., Britton, W. (2007). Effects of DNA- and Mycobacterium bovis BCG-based delivery of Flt3 ligand on protective immunity to Mycobacterium tuberculosis. Infection and Immunity, 75(11), 5368-5375. [More Information]
  • Ryan, A., Wozniak, T., Shklovskaya, E., O’Donnell, M., Fazekas de St Groth, B., Britton, W., Triccas, J. (2007). Improved protection against disseminated tuberculosis by Mycobacterium bovis bacillus Calmette-Guerin secreting murine GM-CSF Is associated with expansion and activation of APCs. Journal of Immunology, 179(12), 8418-8424. [More Information]
  • Scandurra, G., Ryan, A., Pinto (Pinto-Nadanachandran), R., Britton, W., Triccas, J. (2006). Contribution of L-Alanine Dehydrogenase to In Vivo Persistence and Protective Efficacy of the BCG Vaccine. Microbiology and immunology, 50(10), 805-810. [More Information]
  • Scandurra, G., Williams, R., Triccas, J., Pinto (Pinto-Nadanachandran), R., Gicquel, B., Slobedman, B., Cunningham, A., Britton, W. (2006). Effect of phthiocerol dimycocerosate deficiency on the transcriptional response of human macrophages to Mycobacterium tuberculosis. Microbes and Infection, 9(1), 87-95. [More Information]
  • Wozniak, T., Ryan, A., Triccas, J., Britton, W. (2006). Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection. Infection and Immunity, 74(1), 557-565. [More Information]
  • Ryan, A., Spratt, J., Britton, W., Triccas, J. (2006). Secretion of functional Monocyte Chemotactic Protein-3 by recombinant Mycobacterium bovis BCG attenuates vaccine virulence and maintains protective efficacy against M. tuberculosis infection. Infection and Immunity, 75(1), 523-526. [More Information]
  • Spratt, J., Ryan, A., Britton, W., Triccas, J. (2005). Epitope-tagging vectors for the expression and detection of recombinant proteins in mycobacteria. Plasmid, 53(3), 269-273. [More Information]
  • Palendira, U., Spratt, D., Britton, W., Triccas, J. (2005). Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection. Vaccine, 23(14), 1680-1685. [More Information]
  • Sun, M., Andreassi, J., Liu, S., Pinto (Pinto-Nadanachandran), R., Triccas, J., Leyh, T. (2005). The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis. Journal of Biological Chemistry, 280(9), 7861-7866.
  • Pinto (Pinto-Nadanachandran), R., Saunders, B., Britton, W., Camacho, L., Gicquel, B., Triccas, J. (2004). Mycobacterium Tuberculosis Defective In Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity Against Tuberculosis Than The Existing Bacille Calmette-Gu?Rin Vaccine. The Journal of Infectious Diseases, 189(1), 105-112.
  • Luo, Y., Yamada, H., Chen, X., Ryan, A., Evanoff, D., Triccas, J., O'Donnell, M. (2004). Recombinant Mycobacterium bovis bacillus Calmette-Guerin (BCG) expressing mouse IL-18 augments Th1 immunity and macrophage cytotoxicity. Clinical and Experimental Immunology, 137(1), 24-34.
  • Pinto (Pinto-Nadanachandran), R., Tang, Q., Britton, W., Leyh, T., Triccas, J. (2004). The Mycobacterium Tuberculosis Cysd And Cysnc Genes Form A Stress-Induced Operon That Encodes A Tri-Functional Sulfate-Activating Complex. Microbiology, 150(6), 1681-1686.
  • Spratt, J., Britton, W., Triccas, J. (2003). Identification of strong promoter elements of Mycobacterium smegmatis and their utility for foreign gene expression in mycobacteria. FEMS Microbiology Letters, 224(1), 139-142.

2014

  • Yu, M., Ryan, T., Ellis, S., Bush, A., Triccas, J., Rutledge, P., Todd, M. (2014). Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta. Metallomics, 6(10), 1931-1940. [More Information]
  • Ellis, S., Kalinowski, D., Leotta, L., Huang, M., Jelfs, P., Sintchenko, V., Richardson, D., Triccas, J. (2014). Potent Anti-Mycobacterial Activity of the Pyridoxal Isonicotinoyl Hydrazone Analogue, 2-Pyridylcarboxaldehyde Isonicotinoyl Hydrazone: A Lipophilic Transport Vehicle for Isonicotinic Acid Hydrazide. Molecular Pharmacology, 85(2), 269-278. [More Information]

2013

  • Burke, C., Liu, M., Britton, W., Triccas, J., Thomas, T., Smith, A., Allen, S., Salomon, R., Harry, E. (2013). Harnessing single cell sorting to identify cell division genes and regulators in bacteria. PLoS One, 8(4), 1-13. [More Information]
  • Pinto, R., Leotta, L., Shanahan, E., West, N., Leyh, T., Britton, W., Triccas, J. (2013). Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis. The Journal of Infectious Diseases, 207(5), 778-785. [More Information]
  • Yu, M., Lim, N., Ellis, S., Nagase, H., Triccas, J., Rutledge, P., Todd, M. (2013). Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity. ChemistryOpen, 2(3), 99-105. [More Information]
  • Florido, M., Grima, M., Gillis, C., Xia, Y., Turner, S., Triccas, J., Stambas, J., Britton, W. (2013). Influenza A Virus Infection Impairs Mycobacteria-Specific T Cell Responses and Mycobacterial Clearance in the Lung during Pulmonary Coinfection. The Journal of Immunology, 191(1), 302-311. [More Information]
  • Harmer, C., Alnassafi, K., Hu, H., Elkins, M., Bye, P., Rose, B., Cordwell, S., Triccas, J., Harbour, C., Manos, J. (2013). Modulation of gene expression by Pseudomonas aeruginosa during chronic infection in the adult cystic fibrosis lung. Microbiology, 159(11), 2354-2363. [More Information]

2012

  • Nambiar, J., Pinto, R., Aguilo, J., Takatsu, K., Martin, C., Britton, W., Triccas, J. (2012). Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4+ T-cell memory. European Journal of Immunology, 42(2), 385-392. [More Information]
  • Harmer, C., Triccas, J., Hu, H., Rose, B., Bye, P., Elkins, M., Manos, J. (2012). Pseudomonas aeruginosa strains from the chronically infected cystic fibrosis lung display increased invasiveness of A549 epithelial cells over time. Microbial Pathogenesis, 53(1), 37-43. [More Information]
  • Kao, F., Mahmuda, S., Pinto, R., Triccas, J., West, N., Britton, W. (2012). The Secreted Lipoprotein, MPT83, of Mycobacterium tuberculosis Is Recognized during Human Tuberculosis and Stimulates Protective Immunity in Mice. PLoS One, 7(5), 1-12. [More Information]
  • Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012). Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology, 57(2), 352-358. [More Information]

2011

  • Sumaria, N., Roediger, B., Ng, L., Qin, J., Pinto, R., Cavanagh, L., Shklovskaya, E., Fazekas de St Groth, B., Triccas, J., Weninger, W. (2011). Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells. The Journal of Experimental Medicine, 208(3), 505-518. [More Information]
  • West, N., Thomson, S., Triccas, J., Medveczky, C., Ramshaw, I., Britton, W. (2011). Delivery of a multivalent scrambled antigen vaccine induces broad spectrum immunity and protection against tuberculosis. Vaccine, 29(44), 7759-7765. [More Information]
  • Triccas, J., Winter, N., Feng, C., West, N. (2011). Immunity to Mycobacterium tuberculosis. Clinical & Developmental Immunology, 2011, 406549-406549. [More Information]
  • Kong, C., Ng, L., Nambiar, J., Spratt, J., Weninger, W., Triccas, J. (2011). Targeted induction of antigen expression within dendritic cells modulates antigen-specific immunity afforded by recombinant BCG. Vaccine, 29(7), 1374-1381. [More Information]

2010

  • Shanahan, E., Pinto (Pinto-Nadanachandran), R., Triccas, J., Britton, W., West, N. (2010). Cutinase-like protein-6 of Mycobacterium tuberculosis is recognised in tuberculosis patients and protects mice against pulmonary infection as a single and fusion protein vaccine. Vaccine, 28(5), 1341-1346. [More Information]
  • Spratt, J., Britton, W., Triccas, J. (2010). In vivo persistence and protective efficacy of the bacille Calmette Guerin vaccine overexpressing the HspX latency antigen. Bioengineered Bugs, 1(1), 61-65. [More Information]
  • Magnet, S., Hartkoorn, R., Szekely, R., Pato, J., Triccas, J., Schneider, P., Szantai-Kis, C., Orfi, L., Chambon, M., Banfi, D., et al (2010). Leads for antitubercular compounds from kinase inhibitor library screens. Tuberculosis, 90(6), 354-360. [More Information]
  • Nambiar, J., Ryan, A., Kong, C., Britton, W., Triccas, J. (2010). Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection. European Journal of Immunology, 40(1), 153-161. [More Information]
  • Triccas, J. (2010). Recombinant BCG as a vaccine vehicle to protect against tuberculosis. Bioengineered Bugs, 1(2), 110-115. [More Information]
  • Hulseberg, P., Zozulya, A., Chu, H., Triccas, J., Fabry, Z., Sandor, M. (2010). The same well-characterized T cell epitope SIINFEKL expressed in the context of a cytoplasmic or secreted protein in BCG induces different CD8(+) T cell responses. Immunology Letters, 130, 36-42. [More Information]

2009

  • Ryan, A., Nambiar, J., Wozniak, T., Roediger, B., Shklovskaya, E., Britton, W., Fazekas de St Groth, B., Triccas, J. (2009). Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection. The Journal of Immunology, 182(11), 7172-7177. [More Information]
  • Triccas, J., Ryan, A. (2009). Heterologous Expression of Genes in Mycobacteria. In arish, Tanya; Brown, Amanda Claire (Eds.), Methods in Molecular Biology: Mycobacteria Protocols, (pp. 243-253). Springer.

2008

  • Scandurra, G., Britton, W., Triccas, J. (2008). Inactivation of the Mycobacterium tuberculosis fadB4 gene results in increased virulence in host cell and mice. Microbes and Infection, 10, 38-44. [More Information]
  • Ng, L., Hsu, A., Mandell, M., Roediger, B., Hoeller, C., Mrass, P., Iparraguirre, A., Cavanagh, L., Triccas, J., Beverley, S., Weninger, W., et al (2008). Migratory dermal dendritic cells act as rapid sensors of protozoan parasites. P L o S Pathogens, 4(11), 1-13. [More Information]
  • Britton, W., Triccas, J. (2008). The constituents of the cell envelope and their impact on the host immune system. In Daffe M; Reyrat J-M (Eds.), The Mycobacterial Cell Envelope, (pp. 249-270). Washington DC: ASM Press.

2007

  • Triccas, J., Shklovskaya, E., Spratt, J., Ryan, A., Palindera, U., Fazekas de St Groth, B., Britton, W. (2007). Effects of DNA- and Mycobacterium bovis BCG-based delivery of Flt3 ligand on protective immunity to Mycobacterium tuberculosis. Infection and Immunity, 75(11), 5368-5375. [More Information]
  • Ryan, A., Wozniak, T., Shklovskaya, E., O’Donnell, M., Fazekas de St Groth, B., Britton, W., Triccas, J. (2007). Improved protection against disseminated tuberculosis by Mycobacterium bovis bacillus Calmette-Guerin secreting murine GM-CSF Is associated with expansion and activation of APCs. Journal of Immunology, 179(12), 8418-8424. [More Information]

2006

  • Scandurra, G., Ryan, A., Pinto (Pinto-Nadanachandran), R., Britton, W., Triccas, J. (2006). Contribution of L-Alanine Dehydrogenase to In Vivo Persistence and Protective Efficacy of the BCG Vaccine. Microbiology and immunology, 50(10), 805-810. [More Information]
  • Scandurra, G., Williams, R., Triccas, J., Pinto (Pinto-Nadanachandran), R., Gicquel, B., Slobedman, B., Cunningham, A., Britton, W. (2006). Effect of phthiocerol dimycocerosate deficiency on the transcriptional response of human macrophages to Mycobacterium tuberculosis. Microbes and Infection, 9(1), 87-95. [More Information]
  • Wozniak, T., Ryan, A., Triccas, J., Britton, W. (2006). Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection. Infection and Immunity, 74(1), 557-565. [More Information]
  • Ryan, A., Spratt, J., Britton, W., Triccas, J. (2006). Secretion of functional Monocyte Chemotactic Protein-3 by recombinant Mycobacterium bovis BCG attenuates vaccine virulence and maintains protective efficacy against M. tuberculosis infection. Infection and Immunity, 75(1), 523-526. [More Information]

2005

  • Spratt, J., Ryan, A., Britton, W., Triccas, J. (2005). Epitope-tagging vectors for the expression and detection of recombinant proteins in mycobacteria. Plasmid, 53(3), 269-273. [More Information]
  • Palendira, U., Spratt, D., Britton, W., Triccas, J. (2005). Expanding the antigenic repertoire of BCG improves protective efficacy against aerosol Mycobacterium tuberculosis infection. Vaccine, 23(14), 1680-1685. [More Information]
  • Sun, M., Andreassi, J., Liu, S., Pinto (Pinto-Nadanachandran), R., Triccas, J., Leyh, T. (2005). The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis. Journal of Biological Chemistry, 280(9), 7861-7866.

2004

  • Pinto (Pinto-Nadanachandran), R., Saunders, B., Britton, W., Camacho, L., Gicquel, B., Triccas, J. (2004). Mycobacterium Tuberculosis Defective In Phthiocerol Dimycocerosate Translocation Provides Greater Protective Immunity Against Tuberculosis Than The Existing Bacille Calmette-Gu?Rin Vaccine. The Journal of Infectious Diseases, 189(1), 105-112.
  • Luo, Y., Yamada, H., Chen, X., Ryan, A., Evanoff, D., Triccas, J., O'Donnell, M. (2004). Recombinant Mycobacterium bovis bacillus Calmette-Guerin (BCG) expressing mouse IL-18 augments Th1 immunity and macrophage cytotoxicity. Clinical and Experimental Immunology, 137(1), 24-34.
  • Pinto (Pinto-Nadanachandran), R., Tang, Q., Britton, W., Leyh, T., Triccas, J. (2004). The Mycobacterium Tuberculosis Cysd And Cysnc Genes Form A Stress-Induced Operon That Encodes A Tri-Functional Sulfate-Activating Complex. Microbiology, 150(6), 1681-1686.

2003

  • Spratt, J., Britton, W., Triccas, J. (2003). Identification of strong promoter elements of Mycobacterium smegmatis and their utility for foreign gene expression in mycobacteria. FEMS Microbiology Letters, 224(1), 139-142.

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