Dr Janet Martin

Senior Research Fellow
Medicine, Northern Clinical School
Kolling Institute of Medical Research

Telephone +61 2 9926 8486
Fax +61 2 9926 8484

Website Related website

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Selected grants

2015

  • Breast cancer therapies that target IGFBP-3 signalling; Baxter R, Boyle F, Martin J; Cancer Council New South Wales/Research Project Grants.

2012

  • Colleen Martin Donation; Martin J; Colleen Martin Donation/Research Donation.

2011

  • Targetting IGFBP-3 signalling pathways as a novel therapeutic approach in triple negative breast cancer; Baxter R, Martin J; Cancer Council New South Wales/Research Project Grants.

2006

  • FAXSCalibur 4 -colour Flow Cytometer; Baxter R, Firth S, Marsh D, Schedlich L, Scott C, Martin J, Robinson B; Cancer Institute New South Wales/Research Grants Program - Category 2.

2005

  • Cancer InstNSW Fell05- Martin; Martin J; Cancer Institute New South Wales/Research Grant.
  • Igfbp-3 As A Growth Inhibitor In Breast Cancer; Baxter R, Firth S, Martin J; Worldwide Cancer Research/Research Grants Scheme.

2004

  • Endocrine and autocrine regulation of breast cancer cell growth by IGF-binding protein-3; Martin J, Baxter R; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • The role of an insulin-like growth factor binding protein (IGFBP-2) in ovarian cancer.; Martin J; University of Sydney/Cancer Research Fund.

2000

  • IGF-binding protein proteolysis: a regulator of cell proliferation; Martin J, Baxter R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Insulin-like growth factor binding protein-3 (IGFBP-3) sensitivity and signalling in breast cancer; Martin J, Baxter R; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Martin, J., de Silva, H., Lin, Z., Scott, C., Baxter, R. (2014). Inhibition of insulin-like growth factor binding protein-3 signaling through sphingosine kinase 1 sensitizes triple-negative breast cancer cells to EGF receptor blockade. Molecular Cancer Therapeutics, 13(2), 316-328. [More Information]
  • Lin, Z., Marzec, K., Martin, J., Baxter, R. (2014). The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents. Oncogene, 33(1), 85-96. [More Information]
  • Caixeiro, N., Martin, J., Scott, C. (2013). Silencing the mannose 6-phosphate/IGF-II receptor differentially affects tumorigenic properties of normal breast epithelial cells. International Journal of Cancer, 133(11), 2542-2550. [More Information]
  • Lin, W., Martin, J., Marsh, D., Jack, M., Baxter, R. (2011). Involvement of insulin-like growth factor binding protein-3 in the effects of the histone deacetylase inhibitor MS-275 in hepatoma cells. Journal of Biological Chemistry, 286(34), 29540-29547. [More Information]
  • Martin, J., Baxter, R. (2011). Signalling pathways of insulin-like growth factors (IGFs) and IGF binding protein-3. Growth Factors, 29(6), 235-244. [More Information]
  • Martin, J., Lin, Z., McGowan, E., Baxter, R. (2009). Potentiation of growth factor signaling by insulin-like growth factor binding protein-3 in breast epithelial cells requires sphingosine kinase activity. Journal of Biological Chemistry, 284(38), 25542-25552. [More Information]
  • Marsh, D., Trahair, T., Martin, J., Chee, W., Walker, J., Kirk, E., Baxter, R., Marshall, G. (2008). Rapamycin treatment for a child with germline PTEN mutation. Nature Clinical Practice Oncology, 5(6), 357-361. [More Information]
  • Martin, J., Baxter, R. (2007). Expression of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway. Endocrinology, 148(5), 2532-2541. [More Information]
  • Martin, J., Jambazov, S. (2006). Insulin-Like Growth Factor Binding Protein-3 inExtracellular Matrix Stimulates Adhesion of BreastEpithelial Cells and Activation of p44/42 Mitogen-Activated Protein Kinase. Endocrinology, 147(9), 4400-4409. [More Information]
  • Butt, A., Martin, J., Dickson, K., McDougall, F., Firth, S., Baxter, R. (2004). Insulin-Like Growth Factor Binding Protein-3 Expression Is Associated With Growth Stimulation Of T47D Human Breast Cancer Cells: The Role Of Altered Epidermal Growth Factor Signaling. Journal of Clinical Endocrinology and Metabolism, 89(4), 1950-1956.
  • Lee, J., Weiss, J., Martin, J., Scott, C. (2003). Increased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo. International Journal of Cancer, 107(4), 564-570. [More Information]
  • Martin, J., Weenink, S., Baxter, R. (2003). Insulin-like growth factor-binding protein-3 potentiates epidermal growth factor action in MCF-10A mammary epithelial cells. Journal of Biological Chemistry, 278(5), 2969-2976.
  • Kodama, Y., Baxter, R., Martin, J. (2002). Insulin-like Growth Factor-I Inhibits Cell Growth in the A549 Non-Small Lung Cancer Cell Line. American Journal of Respiratory Cell and Molecular Biology, 27(3), 336-344.
  • Martin, J. (2001). IGFBPs down under. Trends in Endocrinology and Metabolism, 12, 142-144.

2014

  • Martin, J., de Silva, H., Lin, Z., Scott, C., Baxter, R. (2014). Inhibition of insulin-like growth factor binding protein-3 signaling through sphingosine kinase 1 sensitizes triple-negative breast cancer cells to EGF receptor blockade. Molecular Cancer Therapeutics, 13(2), 316-328. [More Information]
  • Lin, Z., Marzec, K., Martin, J., Baxter, R. (2014). The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents. Oncogene, 33(1), 85-96. [More Information]

2013

  • Caixeiro, N., Martin, J., Scott, C. (2013). Silencing the mannose 6-phosphate/IGF-II receptor differentially affects tumorigenic properties of normal breast epithelial cells. International Journal of Cancer, 133(11), 2542-2550. [More Information]

2011

  • Lin, W., Martin, J., Marsh, D., Jack, M., Baxter, R. (2011). Involvement of insulin-like growth factor binding protein-3 in the effects of the histone deacetylase inhibitor MS-275 in hepatoma cells. Journal of Biological Chemistry, 286(34), 29540-29547. [More Information]
  • Martin, J., Baxter, R. (2011). Signalling pathways of insulin-like growth factors (IGFs) and IGF binding protein-3. Growth Factors, 29(6), 235-244. [More Information]

2009

  • Martin, J., Lin, Z., McGowan, E., Baxter, R. (2009). Potentiation of growth factor signaling by insulin-like growth factor binding protein-3 in breast epithelial cells requires sphingosine kinase activity. Journal of Biological Chemistry, 284(38), 25542-25552. [More Information]

2008

  • Marsh, D., Trahair, T., Martin, J., Chee, W., Walker, J., Kirk, E., Baxter, R., Marshall, G. (2008). Rapamycin treatment for a child with germline PTEN mutation. Nature Clinical Practice Oncology, 5(6), 357-361. [More Information]

2007

  • Martin, J., Baxter, R. (2007). Expression of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway. Endocrinology, 148(5), 2532-2541. [More Information]

2006

  • Martin, J., Jambazov, S. (2006). Insulin-Like Growth Factor Binding Protein-3 inExtracellular Matrix Stimulates Adhesion of BreastEpithelial Cells and Activation of p44/42 Mitogen-Activated Protein Kinase. Endocrinology, 147(9), 4400-4409. [More Information]

2004

  • Butt, A., Martin, J., Dickson, K., McDougall, F., Firth, S., Baxter, R. (2004). Insulin-Like Growth Factor Binding Protein-3 Expression Is Associated With Growth Stimulation Of T47D Human Breast Cancer Cells: The Role Of Altered Epidermal Growth Factor Signaling. Journal of Clinical Endocrinology and Metabolism, 89(4), 1950-1956.

2003

  • Lee, J., Weiss, J., Martin, J., Scott, C. (2003). Increased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor in breast cancer cells alters tumorigenic properties in vitro and in vivo. International Journal of Cancer, 107(4), 564-570. [More Information]
  • Martin, J., Weenink, S., Baxter, R. (2003). Insulin-like growth factor-binding protein-3 potentiates epidermal growth factor action in MCF-10A mammary epithelial cells. Journal of Biological Chemistry, 278(5), 2969-2976.

2002

  • Kodama, Y., Baxter, R., Martin, J. (2002). Insulin-like Growth Factor-I Inhibits Cell Growth in the A549 Non-Small Lung Cancer Cell Line. American Journal of Respiratory Cell and Molecular Biology, 27(3), 336-344.

2001

  • Martin, J. (2001). IGFBPs down under. Trends in Endocrinology and Metabolism, 12, 142-144.

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