Dr Jeff Holst

Associate Faculty
Centenary Institute
Medicine, Central Clinical School

Telephone +61 2 9565 6172
Fax +61 2 9565 6101

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PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

Selected grants

2013

  • Activation and suppression of oncogenic translocation by uracil-DNA glycosylases; Jolly C, Holst J, Franklin A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • WITEC Alpha 300R High Throughput Microscope - Confocal Raman Microscope; Traini D, Young P, Murray M, Dehghani F, Chan K, Oliver B, Holst J; DVC Research/Equipment Grant.

2012

  • Micronutrient uptake in breast cancer progression.; Holst J; National Breast Cancer Foundation/Early Career Fellowship.

2011

  • Structural analysysis of amino acid transporters that regulate the mTOR pathway; Jormakka M, Bailey C, Holst J; Prostate Cancer Foundation of Australia/Project Grants.
  • The small animal bioimager; Halliday G, Hambley T, Zreiqat H, Richardson D, Holst J, Rasko J, Byrne S, Dong Q, Hong A, Lyons G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Next-generation high-speed flow cytometric cell sorter; Fazekas B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Dissecting BORIS function in neoplasia; Rasko J, Holst J; Cancer Council New South Wales/Research Project Grants.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Dissecting BORIS Function in Neoplasia; Rasko J, Holst J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Role of Nutrient Amino Acids in Prostate Cancer; Holst J; Prostate Cancer Foundation of Australia/Young Investigator Grants.

2007

  • Analysis of the Wnt signalling pathway in cancer; Rasko J, Holst J; Cancer Institute New South Wales/Research Grant.
  • Dissecting the role of cancer/testis antigen transcription factors in neoplasia; Holst J; Cancer Institute New South Wales/Early Career Development Fellowship.

Selected publications

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Journals

  • Holst, J. (2013). Letter to the Editor. International Journal of Pharmaceutics, 455(1-2), 393-393. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
  • Khoo, T., Xiros, N., Guan, F., Orellana, D., Holst, J., Joshua, D., Rasko, J. (2013). Performance evaluation of the Abbott CELL-DYN Emerald for use as a bench-top analyzer in a research setting. International Journal of Laboratory Hematology, 35(4), 447-456. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. National Cancer Institute. Journal, 105(19), 1463-1473. [More Information]
  • Tiffen, J., Bailey, C., Marshall, A., Metierre, C., Feng, Y., Wang, K., Watson, S., Holst, J., Rasko, J. (2013). The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells. International Journal of Cancer, 133(7), 1603-1614. [More Information]
  • de Bock, C., Ardjmand, A., Molloy, T., Bone, S., Johnstone, D., Campbell, D., Shipman, K., Yeadon, T., Holst, J., Spanevello, M., Catchpoole, D., et al (2012). The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. Leukemia, 26(5), 918-926. [More Information]
  • Wang, Q., Bailey, C., Ng, C., Tiffen, J., Thoeng, A., Minhas, V., Lehman, M., Hendy, S., Buchanan, G., Nelson, C., Rasko, J., Holst, J. (2011). Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression. Cancer Research, 71(24), 7525-7536. [More Information]
  • Broer, A., Juelich, T., Vanslambrouck, J., Tietze, N., Solomon, P., Holst, J., Bailey, C., Rasko, J., Broer, S. (2011). Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse. Journal of Biological Chemistry, 286(30), 26638-26651. [More Information]
  • Holst, J., Rasko, J. (2011). The use of retroviral vectors for gene transfer into hematopoietic stem cells. Methods in Enzymology, 420, 82-100. [More Information]
  • Tiffen, J., Bailey, C., Ng, C., Rasko, J., Holst, J. (2010). Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo. Molecular Cancer, 9, 299-1-299-8. [More Information]
  • Flamant, S., Ritchie, W., Guilhot, J., Holst, J., Bonnet, M., Chomel, J., Guilhot, F., Turhan, A., Rasko, J. (2010). Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. Haematologica: the hematology journal, 95(8), 1325-1333. [More Information]
  • Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]
  • Kranias, G., Watt, L., Carpenter, H., Holst, J., Ludowyke, R., Strack, S., Sim, A., Verrills, N. (2010). Protein Phosphatase 2A Carboxymethylation and Regulatory B Subunits Differentially Regulate Mast Cell Degranulation. Cellular Signalling, 22(12), 1882-1890. [More Information]
  • Broer, A., Vanslambrouck, J., Thavyogarajah, T., Holst, J., Bailey, C., Broer, S., Rasko, J. (2010). Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria. Biochemical Journal, 428(3), 397-407. [More Information]
  • Holst, J., Watson, S., Lord, M., Eamegdool, S., Bax, D., Nivison-Smith, L., Kondyurin, A., Ma, L., Oberhauser, A., Weiss, A., Rasko, J. (2010). Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Nature Biotechnology, 28(10), 1123-1128. [More Information]
  • Wang, H., Holst, J., Woo, S., Guy, C., Bettini, M., Wang, Y., Shafer, A., Naramura, M., Mingueneau, M., Dragone, L., et al (2010). Tonic Ubiquitylation Controls T-cell Receptor:CD3 Complex Expression During T-cell Development. The EMBO Journal, 29(7), 1285-1298. [More Information]
  • Holst, J., Wang, H., Eder, K., Workman, C., Boyd, K., Baquet, Z., Singh, H., Forbes, K., Chruscinski, A., Smeyne, R., et al (2008). Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nature Immunology, 9(6), 658-666. [More Information]
  • El Kasmi, K., Holst, J., Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., Smith, A., Rutschman, R., Kaushal, D., Shen, Y., et al (2007). General nature of the STAT3-activated anti-inflammatory response. Journal of Immunology, 177(11), 7880-7888. [More Information]
  • Holst, J., Szymczak-Workman, A., Vignali, K., Burton, A., Workman, C., Vignali, D. (2007). Generation of T-cell receptor retrogenic mice. Nature Protocols (Print), 1(1), 406-417. [More Information]
  • Holst, J., Vignali, K., Burton, A., Vignali, D. (2006). Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Nature Methods, 3(3), 191-197. [More Information]
  • Holst, J., Rasko, J. (2006). The Use of Retroviral Vectors for Gene Transfer into Hematopoietic Stem Cells. Methods in Enzymology, 420, 82-100. [More Information]

2013

  • Holst, J. (2013). Letter to the Editor. International Journal of Pharmaceutics, 455(1-2), 393-393. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
  • Khoo, T., Xiros, N., Guan, F., Orellana, D., Holst, J., Joshua, D., Rasko, J. (2013). Performance evaluation of the Abbott CELL-DYN Emerald for use as a bench-top analyzer in a research setting. International Journal of Laboratory Hematology, 35(4), 447-456. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. National Cancer Institute. Journal, 105(19), 1463-1473. [More Information]
  • Tiffen, J., Bailey, C., Marshall, A., Metierre, C., Feng, Y., Wang, K., Watson, S., Holst, J., Rasko, J. (2013). The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells. International Journal of Cancer, 133(7), 1603-1614. [More Information]

2012

  • de Bock, C., Ardjmand, A., Molloy, T., Bone, S., Johnstone, D., Campbell, D., Shipman, K., Yeadon, T., Holst, J., Spanevello, M., Catchpoole, D., et al (2012). The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. Leukemia, 26(5), 918-926. [More Information]

2011

  • Wang, Q., Bailey, C., Ng, C., Tiffen, J., Thoeng, A., Minhas, V., Lehman, M., Hendy, S., Buchanan, G., Nelson, C., Rasko, J., Holst, J. (2011). Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression. Cancer Research, 71(24), 7525-7536. [More Information]
  • Broer, A., Juelich, T., Vanslambrouck, J., Tietze, N., Solomon, P., Holst, J., Bailey, C., Rasko, J., Broer, S. (2011). Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse. Journal of Biological Chemistry, 286(30), 26638-26651. [More Information]
  • Holst, J., Rasko, J. (2011). The use of retroviral vectors for gene transfer into hematopoietic stem cells. Methods in Enzymology, 420, 82-100. [More Information]

2010

  • Tiffen, J., Bailey, C., Ng, C., Rasko, J., Holst, J. (2010). Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo. Molecular Cancer, 9, 299-1-299-8. [More Information]
  • Flamant, S., Ritchie, W., Guilhot, J., Holst, J., Bonnet, M., Chomel, J., Guilhot, F., Turhan, A., Rasko, J. (2010). Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. Haematologica: the hematology journal, 95(8), 1325-1333. [More Information]
  • Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]
  • Kranias, G., Watt, L., Carpenter, H., Holst, J., Ludowyke, R., Strack, S., Sim, A., Verrills, N. (2010). Protein Phosphatase 2A Carboxymethylation and Regulatory B Subunits Differentially Regulate Mast Cell Degranulation. Cellular Signalling, 22(12), 1882-1890. [More Information]
  • Broer, A., Vanslambrouck, J., Thavyogarajah, T., Holst, J., Bailey, C., Broer, S., Rasko, J. (2010). Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria. Biochemical Journal, 428(3), 397-407. [More Information]
  • Holst, J., Watson, S., Lord, M., Eamegdool, S., Bax, D., Nivison-Smith, L., Kondyurin, A., Ma, L., Oberhauser, A., Weiss, A., Rasko, J. (2010). Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Nature Biotechnology, 28(10), 1123-1128. [More Information]
  • Wang, H., Holst, J., Woo, S., Guy, C., Bettini, M., Wang, Y., Shafer, A., Naramura, M., Mingueneau, M., Dragone, L., et al (2010). Tonic Ubiquitylation Controls T-cell Receptor:CD3 Complex Expression During T-cell Development. The EMBO Journal, 29(7), 1285-1298. [More Information]

2008

  • Holst, J., Wang, H., Eder, K., Workman, C., Boyd, K., Baquet, Z., Singh, H., Forbes, K., Chruscinski, A., Smeyne, R., et al (2008). Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nature Immunology, 9(6), 658-666. [More Information]

2007

  • El Kasmi, K., Holst, J., Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., Smith, A., Rutschman, R., Kaushal, D., Shen, Y., et al (2007). General nature of the STAT3-activated anti-inflammatory response. Journal of Immunology, 177(11), 7880-7888. [More Information]
  • Holst, J., Szymczak-Workman, A., Vignali, K., Burton, A., Workman, C., Vignali, D. (2007). Generation of T-cell receptor retrogenic mice. Nature Protocols (Print), 1(1), 406-417. [More Information]

2006

  • Holst, J., Vignali, K., Burton, A., Vignali, D. (2006). Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Nature Methods, 3(3), 191-197. [More Information]
  • Holst, J., Rasko, J. (2006). The Use of Retroviral Vectors for Gene Transfer into Hematopoietic Stem Cells. Methods in Enzymology, 420, 82-100. [More Information]

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