Associate Professor Jeff Holst

Faculty, Centenary Institute
Conjoint Associate Professor, School of Medicine, Central Clinical School

Telephone +61 2 9565 6172
Fax +61 2 9565 6101

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Current research students

Project title Research student
Targeting ASCT2/SLC1A5 for inhibition of cellular growth and metabolism in triple-negative breast cancer Michelle Anne SIMMONS

PhD and master's project opportunities

+ indicates the opportunity is full and unavailable.

Selected grants

2016

  • Targeting Glutamine metabolism to starve triple-negative breast cancer; Holst J, Beith J, Hoy A, Quek L; University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding.

2015

  • Adaptive Response to Targeting the Androgen Axis: A Strategic Offensive on Resistance; Nelson C, Lehman M, Williams E, Holst J, Chopin L, Dinger M, Hutmacher D, O'Leary J, Herington A, Clements J, Quinn R; Prostate Cancer Foundation of Australia/Movember Revolutionary Team Awards.
  • Starving cancer cells: Developing nutrient uptake inhibitors as prostate cancer therapeutics; Holst J, Quinn R; Cancer Council New South Wales/Research Project Grants.

2014

  • Nutrient transporters: elucidating and targeting their functions in cancer; Holst J; DVC Research/HMR+ Implementation Fund - MRI.

2013

  • WITEC Alpha 300R High Throughput Microscope - Confocal Raman Microscope; Traini D, Young P, Murray M, Dehghani F, Chan K, Oliver B, Holst J; DVC Research/Equipment Grant.
  • Activation and suppression of oncogenic translocation by uracil-DNA glycosylases; Jolly C, Holst J, Franklin A; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Micronutrient uptake in breast cancer progression.; Holst J; National Breast Cancer Foundation/Early Career Fellowship.

2011

  • The small animal bioimager; Halliday G, Hambley T, Zreiqat H, Richardson D, Holst J, Rasko J, Byrne S, Dong Q, Hong A, Lyons G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Structural analysysis of amino acid transporters that regulate the mTOR pathway; Jormakka M, Bailey C, Holst J; Prostate Cancer Foundation of Australia/Project Grants.
  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Dissecting BORIS function in neoplasia; Rasko J, Holst J; Cancer Council New South Wales/Research Project Grants.
  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas de St Groth B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • The Role of Nutrient Amino Acids in Prostate Cancer; Holst J; Prostate Cancer Foundation of Australia/Young Investigator Grants.
  • Dissecting BORIS Function in Neoplasia; Rasko J, Holst J; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Dissecting the role of cancer/testis antigen transcription factors in neoplasia; Holst J; Cancer Institute New South Wales/Early Career Fellowship.
  • Analysis of the Wnt signalling pathway in cancer; Rasko J, Holst J; Cancer Institute New South Wales/Research Grant.

Selected publications

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Journals

  • Wibowo, M., Levrier, C., Sadowski, M., Nelson, C., Wang, Q., Holst, J., Healy, P., Hofmann, A., Davis, R. (2016). Bioactive Dihydro-β-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis. Journal of Natural Products, 79(5), 1445-1453. [More Information]
  • Xi, Z., Yao, M., Li, Y., Holst, J., Liu, T., Cai, S., Lao, Y., Tan, H., Xu, H., Dong, Q. (2016). Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation. Cell Death and Disease, 7(6), 1-13. [More Information]
  • Wong, J., Au, A., Gao, D., Pinello, N., Kwok, C., Thoeng, A., Lau, K., Gordon, J., Schmitz, U., Feng, Y., Nguyen, T., Middleton, R., Bailey, C., Holst, J., Rasko, J., Ritchie, W. (2016). RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever. Nucleic Acids Research, 44(6), 2888-2897. [More Information]
  • Wang, K., Holst, J. (2015). L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. American Journal of Cancer Research, 5(4), 1281-1294.
  • Grkovic, T., Pouwer, R., Wang, K., Guymer, G., Holst, J., Quinn, R. (2015). LAT Transport Inhibitors from Pittosporum venulosum Identified by NMR Fingerprint Analysis. Journal of Natural Products, 78(6), 1215-1220. [More Information]
  • Colas, C., Grewer, C., Otte, N., Gameiro, A., Albers, T., Singh, K., Shere, H., Bonomi, M., Holst, J., Schlessinger, A. (2015). Ligand Discovery for the Alanine-SerineCysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening. PLoS Computational Biology, 11(10), 1-22. [More Information]
  • Hnit, S., Xie, C., Yao, M., Holst, J., Bensoussan, A., de Souza, P., Li, Z., Dong, Q. (2015). p27(Kip1) signaling: Transcriptional and post-translational regulation. The International Journal of Biochemistry and Cell Biology, 68, 9-14. [More Information]
  • Leach, D., Need, E., Toivanen, R., Trotta, A., Palenthorpe, H., Tamblyn, D., Kopsaftis, T., England, G., Smith, E., Drew, P., Holst, J., et al (2015). Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome. Oncotarget, 6(18), 16135-16150.
  • Wang, K., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]
  • Yao, M., Xie, C., Kiang, M., Teng, Y., Harman, D., Tiffen, J., Wang, K., Sved, P., Bao, B., Witting, P., Holst, J., Dong, Q. (2015). Targeting of cytosolic phospholipase A2a impedes cell cycle re-entry of quiescent prostate cancer cells. Oncotarget, 6(33), 34458-34474. [More Information]
  • Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology & Oncology, 7(1), 1-15. [More Information]
  • Wang, K., Grkovic, T., Font Sadurni, J., Bonham, S., Pouwer, R., Bailey, C., Moran, A., Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al (2014). Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth. ACS Chemical Biology, 9(6), 1369-1376. [More Information]
  • Wang, K., Beaumont, K., Otte, N., Font Sadurni, J., Bailey, C., van Geldermalsen, M., Sharp, D., Tiffen, J., Ryan, R., Jormakka, M., Haass, N., Rasko, J., Holst, J. (2014). Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer, 135(5), 1060-1071. [More Information]
  • Holst, J. (2013). Letter to the Editor. International Journal of Pharmaceutics, 455(1-2), 393-393. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
  • Khoo, T., Xiros, N., Guan, F., Orellana, D., Holst, J., Joshua, D., Rasko, J. (2013). Performance evaluation of the Abbott CELL-DYN Emerald for use as a bench-top analyzer in a research setting. International Journal of Laboratory Hematology, 35(4), 447-456. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. Journal of the National Cancer Institute, 105(19), 1463-1473. [More Information]
  • Tiffen, J., Bailey, C., Marshall, A., Metierre, C., Feng, Y., Wang, K., Watson, S., Holst, J., Rasko, J. (2013). The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells. International Journal of Cancer, 133(7), 1603-1614. [More Information]
  • de Bock, C., Ardjmand, A., Molloy, T., Bone, S., Johnstone, D., Campbell, D., Shipman, K., Yeadon, T., Holst, J., Spanevello, M., Catchpoole, D., et al (2012). The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. Leukemia, 26(5), 918-926. [More Information]
  • Wang, Q., Bailey, C., Ng, C., Tiffen, J., Thoeng, A., Minhas, V., Lehman, M., Hendy, S., Buchanan, G., Nelson, C., Rasko, J., Holst, J. (2011). Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression. Cancer Research, 71(24), 7525-7536. [More Information]
  • Broer, A., Juelich, T., Vanslambrouck, J., Tietze, N., Solomon, P., Holst, J., Bailey, C., Rasko, J., Broer, S. (2011). Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse. Journal of Biological Chemistry, 286(30), 26638-26651. [More Information]
  • Tiffen, J., Bailey, C., Ng, C., Rasko, J., Holst, J. (2010). Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo. Molecular Cancer, 9, 299-1-299-8. [More Information]
  • Flamant, S., Ritchie, W., Guilhot, J., Holst, J., Bonnet, M., Chomel, J., Guilhot, F., Turhan, A., Rasko, J. (2010). Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. Haematologica, 95(8), 1325-1333. [More Information]
  • Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]
  • Kranias, G., Watt, L., Carpenter, H., Holst, J., Ludowyke, R., Strack, S., Sim, A., Verrills, N. (2010). Protein Phosphatase 2A Carboxymethylation and Regulatory B Subunits Differentially Regulate Mast Cell Degranulation. Cellular Signalling, 22(12), 1882-1890. [More Information]
  • Broer, A., Vanslambrouck, J., Thavyogarajah, T., Holst, J., Bailey, C., Broer, S., Rasko, J. (2010). Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria. Biochemical Journal, 428(3), 397-407. [More Information]
  • Holst, J., Watson, S., Lord, M., Eamegdool, S., Bax, D., Nivison-Smith, L., Kondyurin, A., Ma, L., Oberhauser, A., Weiss, A., Rasko, J. (2010). Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Nature Biotechnology, 28(10), 1123-1128. [More Information]
  • Wang, H., Holst, J., Woo, S., Guy, C., Bettini, M., Wang, Y., Shafer, A., Naramura, M., Mingueneau, M., Dragone, L., et al (2010). Tonic Ubiquitylation Controls T-cell Receptor:CD3 Complex Expression During T-cell Development. The EMBO Journal, 29(7), 1285-1298. [More Information]
  • Holst, J., Wang, H., Eder, K., Workman, C., Boyd, K., Baquet, Z., Singh, H., Forbes, K., Chruscinski, A., Smeyne, R., et al (2008). Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nature Immunology, 9(6), 658-666. [More Information]
  • El Kasmi, K., Holst, J., Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., Smith, A., Rutschman, R., Kaushal, D., Shen, Y., et al (2007). General nature of the STAT3-activated anti-inflammatory response. The Journal of Immunology, 177(11), 7880-7888. [More Information]
  • Holst, J., Szymczak-Workman, A., Vignali, K., Burton, A., Workman, C., Vignali, D. (2007). Generation of T-cell receptor retrogenic mice. Nature Protocols, 1(1), 406-417. [More Information]
  • Holst, J., Vignali, K., Burton, A., Vignali, D. (2006). Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Nature Methods, 3(3), 191-197. [More Information]
  • Holst, J., Rasko, J. (2006). The Use of Retroviral Vectors for Gene Transfer into Hematopoietic Stem Cells. Methods in Enzymology, 420, 82-100. [More Information]
  • Holst, J., Rasko, J. (2006). The use of retroviral vectors for gene transfer into hematopoietic stem cells. Methods in Enzymology, 420, 82-100. [More Information]

2016

  • Wibowo, M., Levrier, C., Sadowski, M., Nelson, C., Wang, Q., Holst, J., Healy, P., Hofmann, A., Davis, R. (2016). Bioactive Dihydro-β-agarofuran Sesquiterpenoids from the Australian Rainforest Plant Maytenus bilocularis. Journal of Natural Products, 79(5), 1445-1453. [More Information]
  • Xi, Z., Yao, M., Li, Y., Holst, J., Liu, T., Cai, S., Lao, Y., Tan, H., Xu, H., Dong, Q. (2016). Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation. Cell Death and Disease, 7(6), 1-13. [More Information]
  • Wong, J., Au, A., Gao, D., Pinello, N., Kwok, C., Thoeng, A., Lau, K., Gordon, J., Schmitz, U., Feng, Y., Nguyen, T., Middleton, R., Bailey, C., Holst, J., Rasko, J., Ritchie, W. (2016). RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever. Nucleic Acids Research, 44(6), 2888-2897. [More Information]

2015

  • Wang, K., Holst, J. (2015). L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. American Journal of Cancer Research, 5(4), 1281-1294.
  • Grkovic, T., Pouwer, R., Wang, K., Guymer, G., Holst, J., Quinn, R. (2015). LAT Transport Inhibitors from Pittosporum venulosum Identified by NMR Fingerprint Analysis. Journal of Natural Products, 78(6), 1215-1220. [More Information]
  • Colas, C., Grewer, C., Otte, N., Gameiro, A., Albers, T., Singh, K., Shere, H., Bonomi, M., Holst, J., Schlessinger, A. (2015). Ligand Discovery for the Alanine-SerineCysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening. PLoS Computational Biology, 11(10), 1-22. [More Information]
  • Hnit, S., Xie, C., Yao, M., Holst, J., Bensoussan, A., de Souza, P., Li, Z., Dong, Q. (2015). p27(Kip1) signaling: Transcriptional and post-translational regulation. The International Journal of Biochemistry and Cell Biology, 68, 9-14. [More Information]
  • Leach, D., Need, E., Toivanen, R., Trotta, A., Palenthorpe, H., Tamblyn, D., Kopsaftis, T., England, G., Smith, E., Drew, P., Holst, J., et al (2015). Stromal androgen receptor regulates the composition of the microenvironment to influence prostate cancer outcome. Oncotarget, 6(18), 16135-16150.
  • Wang, K., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]
  • Yao, M., Xie, C., Kiang, M., Teng, Y., Harman, D., Tiffen, J., Wang, K., Sved, P., Bao, B., Witting, P., Holst, J., Dong, Q. (2015). Targeting of cytosolic phospholipase A2a impedes cell cycle re-entry of quiescent prostate cancer cells. Oncotarget, 6(33), 34458-34474. [More Information]

2014

  • Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology & Oncology, 7(1), 1-15. [More Information]
  • Wang, K., Grkovic, T., Font Sadurni, J., Bonham, S., Pouwer, R., Bailey, C., Moran, A., Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al (2014). Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth. ACS Chemical Biology, 9(6), 1369-1376. [More Information]
  • Wang, K., Beaumont, K., Otte, N., Font Sadurni, J., Bailey, C., van Geldermalsen, M., Sharp, D., Tiffen, J., Ryan, R., Jormakka, M., Haass, N., Rasko, J., Holst, J. (2014). Targeting glutamine transport to suppress melanoma cell growth. International Journal of Cancer, 135(5), 1060-1071. [More Information]

2013

  • Holst, J. (2013). Letter to the Editor. International Journal of Pharmaceutics, 455(1-2), 393-393. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
  • Khoo, T., Xiros, N., Guan, F., Orellana, D., Holst, J., Joshua, D., Rasko, J. (2013). Performance evaluation of the Abbott CELL-DYN Emerald for use as a bench-top analyzer in a research setting. International Journal of Laboratory Hematology, 35(4), 447-456. [More Information]
  • Wang, K., Tiffen, J., Bailey, C., Lehman, M., Ritchie, W., Fazli, L., Metierre, C., Feng, Y., Li, E., Gleave, M., Rasko, J., Holst, J., et al (2013). Targeting Amino Acid Transport in Metastatic Castration-Resistant Prostate Cancer: Effects on Cell Cycle, Cell Growth, and Tumor Development. Journal of the National Cancer Institute, 105(19), 1463-1473. [More Information]
  • Tiffen, J., Bailey, C., Marshall, A., Metierre, C., Feng, Y., Wang, K., Watson, S., Holst, J., Rasko, J. (2013). The cancer-testis antigen BORIS phenocopies the tumor suppressor CTCF in normal and neoplastic cells. International Journal of Cancer, 133(7), 1603-1614. [More Information]

2012

  • de Bock, C., Ardjmand, A., Molloy, T., Bone, S., Johnstone, D., Campbell, D., Shipman, K., Yeadon, T., Holst, J., Spanevello, M., Catchpoole, D., et al (2012). The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. Leukemia, 26(5), 918-926. [More Information]

2011

  • Wang, Q., Bailey, C., Ng, C., Tiffen, J., Thoeng, A., Minhas, V., Lehman, M., Hendy, S., Buchanan, G., Nelson, C., Rasko, J., Holst, J. (2011). Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression. Cancer Research, 71(24), 7525-7536. [More Information]
  • Broer, A., Juelich, T., Vanslambrouck, J., Tietze, N., Solomon, P., Holst, J., Bailey, C., Rasko, J., Broer, S. (2011). Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse. Journal of Biological Chemistry, 286(30), 26638-26651. [More Information]

2010

  • Tiffen, J., Bailey, C., Ng, C., Rasko, J., Holst, J. (2010). Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo. Molecular Cancer, 9, 299-1-299-8. [More Information]
  • Flamant, S., Ritchie, W., Guilhot, J., Holst, J., Bonnet, M., Chomel, J., Guilhot, F., Turhan, A., Rasko, J. (2010). Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia. Haematologica, 95(8), 1325-1333. [More Information]
  • Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]
  • Kranias, G., Watt, L., Carpenter, H., Holst, J., Ludowyke, R., Strack, S., Sim, A., Verrills, N. (2010). Protein Phosphatase 2A Carboxymethylation and Regulatory B Subunits Differentially Regulate Mast Cell Degranulation. Cellular Signalling, 22(12), 1882-1890. [More Information]
  • Broer, A., Vanslambrouck, J., Thavyogarajah, T., Holst, J., Bailey, C., Broer, S., Rasko, J. (2010). Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria. Biochemical Journal, 428(3), 397-407. [More Information]
  • Holst, J., Watson, S., Lord, M., Eamegdool, S., Bax, D., Nivison-Smith, L., Kondyurin, A., Ma, L., Oberhauser, A., Weiss, A., Rasko, J. (2010). Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells. Nature Biotechnology, 28(10), 1123-1128. [More Information]
  • Wang, H., Holst, J., Woo, S., Guy, C., Bettini, M., Wang, Y., Shafer, A., Naramura, M., Mingueneau, M., Dragone, L., et al (2010). Tonic Ubiquitylation Controls T-cell Receptor:CD3 Complex Expression During T-cell Development. The EMBO Journal, 29(7), 1285-1298. [More Information]

2008

  • Holst, J., Wang, H., Eder, K., Workman, C., Boyd, K., Baquet, Z., Singh, H., Forbes, K., Chruscinski, A., Smeyne, R., et al (2008). Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nature Immunology, 9(6), 658-666. [More Information]

2007

  • El Kasmi, K., Holst, J., Coffre, M., Mielke, L., de Pauw, A., Lhocine, N., Smith, A., Rutschman, R., Kaushal, D., Shen, Y., et al (2007). General nature of the STAT3-activated anti-inflammatory response. The Journal of Immunology, 177(11), 7880-7888. [More Information]
  • Holst, J., Szymczak-Workman, A., Vignali, K., Burton, A., Workman, C., Vignali, D. (2007). Generation of T-cell receptor retrogenic mice. Nature Protocols, 1(1), 406-417. [More Information]

2006

  • Holst, J., Vignali, K., Burton, A., Vignali, D. (2006). Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Nature Methods, 3(3), 191-197. [More Information]
  • Holst, J., Rasko, J. (2006). The Use of Retroviral Vectors for Gene Transfer into Hematopoietic Stem Cells. Methods in Enzymology, 420, 82-100. [More Information]
  • Holst, J., Rasko, J. (2006). The use of retroviral vectors for gene transfer into hematopoietic stem cells. Methods in Enzymology, 420, 82-100. [More Information]

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