Professor Jennifer Gamble

Wenkart Chair of Endothelium
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6100

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Research interests

Professor Jennifer Gamble is an internationally recognized research leader in the field of endothelial cell function and holds the Inaugural Wenkart Chair of the Endothelium.

Her interests lie in understanding endothelial cell function particularly in the area of inflammation, and how dysfunction can influence disease. Her initial publication in this area established the endothelium as a dynamic organ, central to the control of inflammatory processes.

Diseases being investigated include cancer, atherosclerosis, metabolic disease, oedema and thoracic aortic aneurysms.

The current studies in the Vascular Biology Program are under four broad areas:

1.understanding ageing of the endothelium and its impact on vascular function. Age is the greatest risk factor for the development of many diseases such as cardiovascular disease and cancer. Understanding the consequences of the ageing process to endothelial cell function will influence our ability to help us "age better".

2. novel regulators of angiogenesis. Our genetic screens have identified genes that control endothelial cell function. One such gene impacts on tumour progression, metabolism and liver fibrosis. We are studying the mechanism of action of this gene, at the structural and functional levels

3.microRNA regulation of oedema and angiogenesis. MicroRNAs are small non-coding RNA, that control more than 30% of our protein coding genes. Thus they are known as regulators of major biological systems. Further they are often dysregulated in disease. Oedema is a critical feature in pathologies such as stroke and myocardial infarcts and angiogenic vessels in tumours are highly leaky. Limiting oedema can result in improved outcomes. We have identified a suite of microRNAs than influence vascular oedema and these are being studied as possible therapeutic candidates. Some of these microRNAs also regulate angiogenesis.

4.diseases of the Aorta. This is within the newly established Agnes Ginges, Diseases of the Aorta Laboratory, headed by Dr Renjing Liu and was established in collaboration with Prof Richmond Jeremy, Royal Prince Alfred Hospital. Initially we are focussing on thoracic aortic aneurysms which affect 1:500 to 1:1000 people and which can result in sudden death. Our aim is to identify the molecular determinants of disease progression, using animal models and extensive archival human material, which will expose opportunities to influence disease outcome.

Selected grants

2013

  • Normalisation of tumour angiogenic vessels by a novel miRNA inhibitor; Gamble J, Vadas M; Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding.
  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • miRNAs and Cardiovascular Disease; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.

2011

  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Senescence and Cardiovascular Disease; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.

2010

  • High speed 3D live cell imaging of cancer genesis, growth, metastasis and death.; Weninger W, Vadas M, Richardson D, Fazekas de St Groth B, Gamble J, McCaughan G, Rasko J, Shackel N, Haass N; Cancer Institute New South Wales/Equipment Grant.
  • New Surfaces for the Control of Endothelial Cell Function: Application in the Design of Biocompatible Stents; Neto C, Gamble J; Australian Research Council (ARC)/Discovery Projects (DP).
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inflammation, Angiogenesis and Cancer; Vadas M, McCaughan G, Gamble J, Bertolino P, Xia P; National Health and Medical Research Council (NHMRC)/Program Grants.

2009

  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas de St Groth B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.
  • How Age Influences Blood Vessel Function; Gamble J, Vadas M; Heart Foundation of Australia/Grants-in-Aid.

2008

  • Development of Inhibitors of PKCzeta for Targeting Vascular Leak; Parker M, Gamble J, Vadas M, Parker M; National Health and Medical Research Council (NHMRC)/Career Development Awards.
  • Sphingosine Kinase as a Key Regulator of Endothelial Permeability; Gamble J; National Heart Foundation/Grants-in-Aid.

Selected publications

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Journals

  • Tay, S., Wong, Y., McDonald, D., Wood, N., Roediger, B., Sierro, F., McGuffog, C., Alexander, I., Bishop, A., Gamble, J., Weninger, W., McCaughan, G., Bertolino, P., Bowen, D. (2014). Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 111(25), E2540-E2549. [More Information]
  • Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]
  • Lichtenstein, I., Charleston, M., Caetano, T., Gamble, J., Vadas, M. (2013). Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies. BMC Bioinformatics, 14, 1-22. [More Information]
  • Coleman, P., Chang, G., Hutas Attila, G., Grimshaw, M., Vadas, M., Gamble, J. (2013). Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging, 5(12), 913-924.
  • Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]
  • Thickett, S., Moses, J., Gamble, J., Neto, C. (2012). Micropatterned substrates made by polymer bilayer dewetting and collagen nanoscale assembly support endothelial cell adhesion. Soft Matter, 8(39), 9996-10007. [More Information]
  • Nguyen, L., Jolly, L., Shoubridge, C., Chan, W., Huang, L., Laumonnier, F., Raynaud, M., Hackett, A., Field, M., Rodriguez, J., Gamble, J., et al (2012). Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Molecular Psychiatry, 17(11), 1103-1115. [More Information]
  • Gamble, J., Vadas, M., McCaughan, G. (2011). Sinusoidal endothelium is essential for liver regeneration. Hepatology, 54(2), 731-733. [More Information]
  • Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., Khew-Goodall, Y. (2010). A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration. Journal of Immunology, 185(5), 3057-3063. [More Information]
  • Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., Beck, K., Stocker, R., Vadas, M., Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. [More Information]
  • Zhang, X., Cairns, M., Rose, B., O'Brien, C., Shannon, K., Clark, J., Gamble, J., Tran, N. (2009). Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland. International Journal of Cancer, 124, 2855-2863. [More Information]
  • Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 424-441. [More Information]
  • Wu, B., Midwinter, R., Cassano, C., Beck, K., Wang, Y., Changsirivathanathamrong, D., Gamble, J., Stocker, R. (2009). Heme Oxygenase-1 Increases Endothelial Progenitor Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(Online DOI: 10.1161/ATVBAHA.109.184713 - 1), 1-6. [More Information]
  • Gamble, J., Vadas, M. (2009). Insights into defibrotide as therapy for veno-occlusive disease. Hepatology, 49(2), 689-690. [More Information]
  • Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., Imhof, B., Vadas, M., Gamble, J. (2009). JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of beta 3 Integrins. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(8), 1200-1206. [More Information]
  • Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., Pitson, S., Lopez, A., Coates, P., Proia, R., Vadas, M., Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. [More Information]
  • Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., Bonder, C. (2009). Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. The American Journal of Pathology: cellular and molecular biology of disease, 175(5), 2217-2225. [More Information]
  • Limaye, V., Vadas, M., Pitson, S., Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 411-423. [More Information]
  • Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., Xia, P., Proia, R., Vadas, M., Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497.
  • Vadas, M., Xia, P., McCaughan, G., Gamble, J. (2008). The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction? BBA - Bioenergetics, 1781 (9), 442-447. [More Information]
  • Young, N., Hahn, C., Poh, A., Dong, C., Wilhelm, D., Olsson, J., Muscat, G., Parsons, P., Gamble, J., Koopman, P. (2006). Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. Journal of the National Cancer Institute, 98(15), 1060-1067. [More Information]
  • Cook-Johnson, R., Demasi, M., Cleland, L., Gamble, J., Saint, D., James, M. (2006). Endothelial cell COX-2 expression and activity in hypoxia. BBA - Bioenergetics, 1761 (12), 1443-1449. [More Information]
  • Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. [More Information]
  • Wang, L., Xing, X., Holmes, A., Wadham, C., Gamble, J., Vadas, M., Xia, P. (2005). Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells. Circulation Research, 97, 891-899. [More Information]
  • Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., Yu, S., Kremmidiotis, G., Gardner, A., Solomon, P., Vadas, M., Gamble, J., et al (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(-), 57-69. [More Information]
  • Zannettino, A., Holding, C., Diamond, P., Atkins, G., Kostakis, P., Farrugia, A., Gamble, J., To, L., Findlay, D., Haynes, D. (2005). Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. Journal of Cellular Physiology, 204(2), 714-723. [More Information]
  • Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. [More Information]
  • Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., Kremmidiotis, G., Vadas, M., Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 101(33), 12212-12217.
  • Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., Chatterjee, V., Vadas, M., Xia, P. (2004). PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase. Circulation Research, 94(11), 1515-1522.
  • Li, X., Hahn, C., Parsons, M., Drew, J., Vadas, M., Gamble, J. (2004). Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood, 104(6), 1716-1724.
  • Stein, B., Gamble, J., Pitson, S., Vadas, M., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. Journal of Immunology, 171(11), 6097-6104.
  • Carr, J., Hocking, H., Bunting, K., Wright, P., Davidson, A., Gamble, J., Burrell, C., Li, P. (2003). Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers. Journal of Medical Virology, 69(4), 521-528. [More Information]
  • Wadham, C., Gamble, J., Vadas, M., Khew-Goodall, Y. (2003). The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates β-catenin. Molecular Biology of the Cell, 14(6), 2520-2529.

2014

  • Tay, S., Wong, Y., McDonald, D., Wood, N., Roediger, B., Sierro, F., McGuffog, C., Alexander, I., Bishop, A., Gamble, J., Weninger, W., McCaughan, G., Bertolino, P., Bowen, D. (2014). Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 111(25), E2540-E2549. [More Information]
  • Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]

2013

  • Lichtenstein, I., Charleston, M., Caetano, T., Gamble, J., Vadas, M. (2013). Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies. BMC Bioinformatics, 14, 1-22. [More Information]
  • Coleman, P., Chang, G., Hutas Attila, G., Grimshaw, M., Vadas, M., Gamble, J. (2013). Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging, 5(12), 913-924.
  • Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]

2012

  • Thickett, S., Moses, J., Gamble, J., Neto, C. (2012). Micropatterned substrates made by polymer bilayer dewetting and collagen nanoscale assembly support endothelial cell adhesion. Soft Matter, 8(39), 9996-10007. [More Information]
  • Nguyen, L., Jolly, L., Shoubridge, C., Chan, W., Huang, L., Laumonnier, F., Raynaud, M., Hackett, A., Field, M., Rodriguez, J., Gamble, J., et al (2012). Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Molecular Psychiatry, 17(11), 1103-1115. [More Information]

2011

  • Gamble, J., Vadas, M., McCaughan, G. (2011). Sinusoidal endothelium is essential for liver regeneration. Hepatology, 54(2), 731-733. [More Information]

2010

  • Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., Khew-Goodall, Y. (2010). A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration. Journal of Immunology, 185(5), 3057-3063. [More Information]
  • Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., Beck, K., Stocker, R., Vadas, M., Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. [More Information]

2009

  • Zhang, X., Cairns, M., Rose, B., O'Brien, C., Shannon, K., Clark, J., Gamble, J., Tran, N. (2009). Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland. International Journal of Cancer, 124, 2855-2863. [More Information]
  • Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 424-441. [More Information]
  • Wu, B., Midwinter, R., Cassano, C., Beck, K., Wang, Y., Changsirivathanathamrong, D., Gamble, J., Stocker, R. (2009). Heme Oxygenase-1 Increases Endothelial Progenitor Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(Online DOI: 10.1161/ATVBAHA.109.184713 - 1), 1-6. [More Information]
  • Gamble, J., Vadas, M. (2009). Insights into defibrotide as therapy for veno-occlusive disease. Hepatology, 49(2), 689-690. [More Information]
  • Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., Imhof, B., Vadas, M., Gamble, J. (2009). JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of beta 3 Integrins. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(8), 1200-1206. [More Information]
  • Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., Pitson, S., Lopez, A., Coates, P., Proia, R., Vadas, M., Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. [More Information]
  • Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., Bonder, C. (2009). Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. The American Journal of Pathology: cellular and molecular biology of disease, 175(5), 2217-2225. [More Information]
  • Limaye, V., Vadas, M., Pitson, S., Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 411-423. [More Information]

2008

  • Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., Xia, P., Proia, R., Vadas, M., Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497.
  • Vadas, M., Xia, P., McCaughan, G., Gamble, J. (2008). The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction? BBA - Bioenergetics, 1781 (9), 442-447. [More Information]

2006

  • Young, N., Hahn, C., Poh, A., Dong, C., Wilhelm, D., Olsson, J., Muscat, G., Parsons, P., Gamble, J., Koopman, P. (2006). Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. Journal of the National Cancer Institute, 98(15), 1060-1067. [More Information]
  • Cook-Johnson, R., Demasi, M., Cleland, L., Gamble, J., Saint, D., James, M. (2006). Endothelial cell COX-2 expression and activity in hypoxia. BBA - Bioenergetics, 1761 (12), 1443-1449. [More Information]
  • Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. [More Information]

2005

  • Wang, L., Xing, X., Holmes, A., Wadham, C., Gamble, J., Vadas, M., Xia, P. (2005). Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells. Circulation Research, 97, 891-899. [More Information]
  • Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., Yu, S., Kremmidiotis, G., Gardner, A., Solomon, P., Vadas, M., Gamble, J., et al (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(-), 57-69. [More Information]
  • Zannettino, A., Holding, C., Diamond, P., Atkins, G., Kostakis, P., Farrugia, A., Gamble, J., To, L., Findlay, D., Haynes, D. (2005). Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. Journal of Cellular Physiology, 204(2), 714-723. [More Information]
  • Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. [More Information]

2004

  • Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., Kremmidiotis, G., Vadas, M., Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 101(33), 12212-12217.
  • Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., Chatterjee, V., Vadas, M., Xia, P. (2004). PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase. Circulation Research, 94(11), 1515-1522.
  • Li, X., Hahn, C., Parsons, M., Drew, J., Vadas, M., Gamble, J. (2004). Role of protein kinase Cζ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood, 104(6), 1716-1724.

2003

  • Stein, B., Gamble, J., Pitson, S., Vadas, M., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. Journal of Immunology, 171(11), 6097-6104.
  • Carr, J., Hocking, H., Bunting, K., Wright, P., Davidson, A., Gamble, J., Burrell, C., Li, P. (2003). Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers. Journal of Medical Virology, 69(4), 521-528. [More Information]
  • Wadham, C., Gamble, J., Vadas, M., Khew-Goodall, Y. (2003). The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates β-catenin. Molecular Biology of the Cell, 14(6), 2520-2529.

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