Dr Jiao Jiao Li

BEng(Hons)/BMedSci PhD Sydney
NHMRC Peter Doherty Biomedical Early Career Fellow
Kolling Institute of Medical Research
Northern Clinical School
Chief Investigator, Australian Research Council Training Centre for Innovative BioEngineering

Member of China Studies Centre

Member of The University of Sydney Nano Institute


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Biographical details

Dr Jiao Jiao Li is based at the Kolling Institute at Royal North Shore Hospital. Jiao Jiao completed her PhD in Biomedical Engineering at the University of Sydney in 2015. Before starting at the Kolling Institute in 2017 on her NHMRC Early Career Fellowship, Jiao Jiao worked on developing biomaterials-based solutions to regenerate bone and cartilage tissues. Her current research focuses on investigating the mechanisms underlying degeneration and regeneration following injury in bones and joints. Building on this, she is developing cell- and biomaterials-based solutions to combat chronic musculoskeletal diseases, using a combination of techniques in materials science, cell and molecular biology, and animal models.

Research interests

Biomaterials; Tissue engineering; Regenerative medicine; Stem cells; Joint degeneration; Orthopaedics

Teaching and supervision

BMET4971 / BMET9971 Tissue Engineering – Course Co-coordinator, Lecturer and Tutor (2018, 2017), Lecturer and Tutor (2016), Tutor (2015, 2014, 2013, 2010)

AMME1961 Biomedical Engineering 1B – Tutor and Laboratory Demonstrator (2016)

AMME1362 Materials 1 – Tutor (2015)

MECH3361 Mechanics of Solids 2 – Tutor (2010)

Current projects

Musculoskeletal disease is a major contributor to disability, frailty and unhealthy ageing, a common cause of which is bone or joint injury sustained during young adulthood.The satisfactory repair of damaged tissues (bone, cartilage, ligaments and synovium) arising from these injuries remains a significant clinical challenge, often resulting in chronic disease progression. This can culminate in a range of musculoskeletal diseases, such as impaired fracture healing and osteoarthritis, which have detrimental effects on the patients’ quality of life and incur significant healthcare costs. My research aims to develop novel, multidisciplinary strategies for treating musculoskeletal injuries that improves their prognosis.

1.Understanding the mechanisms of chronic joint disease

2.Developing a tissue engineered implant for treating chronic joint injury

3.Developing a tissue engineered solution for vascularised bone regeneration

Associations

International: Tissue Engineering & Regenerative Medicine International Society (TERMIS)

National: Australian Society for Medical Research (ASMR); Australian & New Zealand Orthopaedic Research Society (ANZORS); Matrix Biology Society of Australia and New Zealand (MBSANZ); Alliance for Design and Application in Tissue Engineering (ADATE)

Local: China Studies Centre (University of Sydney); Sydney Nano; Royal North Shore Hospital Scientific Staff Council; Sydney Musculoskeletal, Bone & Joint Health Alliance

Awards and honours

- Rebecca L. Cooper Medical Research Foundation Medal 2017 for the best research paper published by a postdoctoral researcher within the Bosch Institute, University of Sydney (Li JJ et al,Biomedical Materials2016).

- Member of Science Assessing Committee for the Health Research Council of New Zealand (2017).

- Appointment to the Young Investigator Council and Editorial Board of Tissue Engineering, Parts A, B, & C (most influential journal in the field of tissue engineering), selected from among 450 international applicants (2016).

- Award of Excellence by the Institute of Biomedical Engineering and Technology, University of Sydney for the recognition of excellence and dedication towards research cluster projects development and management (2016).

- Endeavour Research Fellowship, awarded by the Australian Government as a nationally competitive, merit-based program to undertake research as exchange scholar at Tufts University, USA for 6 months (2011).

- University Medal for Bachelor of Biomedical Engineering, University of Sydney (2010).

- Awards for conference presentations: Award for Research Excellence (ASMR NSW 2018), Early Career Researcher Award – Best Oral Presentation (New Horizons 2017 conference), First Prize for Best Presentation (Sydney Medical School ECR Showcase 2017), Student & Young Investigator Section Oral Award (TERMIS-AP 2016), Award for Best Doctoral Presentation (ADATE 2014, 2010), Award for Best PhD Presentation (ANZORS 2013), Prize for Best Postgraduate Poster (University of Sydney Research Conversazione 2014, 2013, 2012, 2010), Prizes for Best Student Presentation (University of Sydney Student Research Conference 2012), Award for Outstanding Oral Presentation (University of Sydney Bosch Young Investigators Symposium 2012).

- Travel grants: Ramsay Health Care Australasian Travel Fellowship (2018), Institute of Bone and Joint Research (IBJR) Travel Award (2018), Kolling Institute ECR Travelling Fellowship (2018), RNSH Scientific Staff Council New Horizons Travel Award (2017), ANZORS Travel Grant (2016, 2012), Biomed Link Travel Grant (2013), University of Sydney Postgraduate Research Support Scheme (2012, 2011, 2010).

- PhD scholarships: Australian Postgraduate Award (awarded by Australian Government) and Vice-Chancellor’s Research Scholarship (awarded by University of Sydney for being the top-ranked PhD commencing student in Engineering with a University Medal).

In the media

- Co-author on a magazine article published by the American Orthotic and Prosthetic Association (AOPA); “Osseointegration: The Australian Experience After 500 Surgeries”, O&P News, July 2018 issue, p. 12–15.

- Published research (Li JJ et al, Journal of Materials Chemistry B 2015) was featured as the subject of a Science Highlight article by the U.S. National Institute of Biomedical Imaging and Bioengineering (16 September, 2015).

Professional activities

Peer-review: Scientific Expert Peer Reviewer, NHMRC Development Grants (2018); Assessor for NHMRC Project Grants, ARC Discovery Projects, and ARC Discovery Early Career Researcher Awards (2018); Science Assessing Committee panel member for Project Grants, Health Research Council of New Zealand (2017); Grant Reviewer, Arthritis Research UK (2017); Scientific Committee for ANZORS conference (2018) and New Horizons conference (2018); Young Investigator Council and Editorial Board member of Tissue Engineering, Parts A, B, & C (2016); Outstanding Reviewer for Materials Science and Engineering: C; invited reviewer for multidisciplinary journals including Journal of Materials Chemistry B,ACS Applied Materials and Interfaces,Polymer, and Disability and Rehabilitation.

Conference and seminar organisation: Organising Committee member for New Horizons conference (2018), Kolling Institute Seminar Series (2017–present), and ADATE Tissue Engineering Symposia (2016, 2014, 2012); Chair for ANZORS conference session (2018);Young Investigator Co-chair for conference session (TERMIS-AP 2016).

Committees: Executive Committee Member, Royal North Shore Hospital Scientific Staff Council (2018); Judging Panel member, 2017 NSRHS Allied Health Symposium; Judging Panel member, 3 Minute Thesis Local Area Competitions 2017.

Community engagement: Mentor for NSW high school students, Science Extension Program (2018 –2019); Speaker (representing Biomedical Engineering, University of Sydney) for Careers Day at North Sydney Girls High School (2018); host and panel member for Kolling Institute School Partnership Program (2018); advisor and tour guide for Biomedical Engineering at the University of Sydney Open Day (annually since 2010).

Selected grants

2018

  • Australian Research Council Training Centre for Innovative BioEngineering; Zreiqat H, Suaning G, Feng D, Berndt C, Li Q, Dunstan C, Kim J, McEwan A, Whitchurch C, Chandrawati R, Roohaniesfahani S, Li J, Kumar A, Fulham M, Muderis M, Rutkove S, Smith W, Kappelt G, Sadeghpour A, Nisbet D, Williams R; Australian Research Council (ARC)/Industrial Transformation Training Centres (ITTC).
  • A novel strategy for treating chronic joint injury; Li J; Sydney Medical School/Kickstart Grant.

2017

  • A novel strategy for the treatment of chronic skeletal joint defects; Li J; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Book Chapters

  • Lu, Z., Li, J., Zreiqat, H. (2015). Bone-Biomimetic Biomaterial and Cell Fate Determination. In Hala Zreiqat, Colin R. Dunstan, Vicki Rosen (Eds.), A Tissue Regneration Approach to Bone and Cartilage Repair, (pp. 119-146). Cham: Springer. [More Information]

Journals

  • Al Muderis, M., Lu, W., Li, J., Kaufman, K., Orendurff, M., Highsmith, M., Lunseth, P., Kahle, J. (2018). Clinically Relevant Outcome Measures Following Limb Osseointegration; Systematic Review of the Literature. Journal of Orthopaedic Trauma, 32(2), e64-e75. [More Information]
  • Li, J., Ebeid, M., Xu, J., Zreiqat, H. (2018). Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering. Advanced Healthcare Materials, 7(6). [More Information]
  • Li, J., Akey, A., Dunstan, C., Vielreicher, M., Friedrich, O., Bell, D., Zreiqat, H. (2018). Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model. Advanced Healthcare Materials, 7(15), 1-9. [More Information]
  • Wang, L., Yang, Q., Chen, Y., Chai, Y., Li, J., Du, L., Tan, R., Yang, S., Tu, M., Yu, B. (2017). A reformative shear precipitation procedure for the fabrication of vancomycin-loaded poly(lactide-co-glycolide) microspheres. Journal of Biomaterials Applications, 31(7), 995-1009. [More Information]
  • No, Y., Li, J., Zreiqat, H. (2017). Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes. Materials, 10(2), 1-37. [More Information]
  • Al Muderis, M., Lu, W., Li, J. (2017). Osseointegrated Prosthetic Limb for the treatment of lower limb amputations: Experience and outcomes [Das Osseointegrated Prosthetic Limb zur Behandlung von Amputationen der unteren Extremit�ten: Erfahrungen und Ergebnisse]. Der Unfallchirurg, 120(4), 306-311. [More Information]
  • Atallah, R., Li, J., Lu, W., Leijendekkers, R., Frolke, J., Al Muderis, M. (2017). Osseointegrated Transtibial Implants in Patients with Peripheral Vascular Disease: A Multicenter Case Series of 5 Patients with 1-Year Follow-up. Journal of Bone and Joint Surgery: American Volume, 99(18), 1516-1523. [More Information]
  • Mills, N., Lu, W., Li, J., Al Muderis, M. (2017). Osseointegration as treatment for a knee disarticulation because of a congenital femoral deficiency: A case report. JBJS Case Connector, 7(4), 1-6. [More Information]
  • Li, J., Roohaniesfahani, S., Kim, K., Kaplan, D., Zreiqat, H. (2017). Silk coating on a bioactive ceramic scaffold for bone regeneration: Effective enhancement of mechanical and in vitro osteogenic properties towards load-bearing applications. Journal of Tissue Engineering and Regenerative Medicine, 11(6), 1741-1753. [More Information]
  • Al Muderis, M., Lu, W., Tetsworth, K., Bosley, B., Li, J. (2017). Single-stage osseointegrated reconstruction and rehabilitation of lower limb amputees: The Osseointegration Group of Australia Accelerated Protocol-2 (OGAAP-2) for a prospective cohort study. BMJ Open, 7(3), 1-10. [More Information]
  • Li, J., Roohaniesfahani, S., Dunstan, C., Quach, T., Steck, R., Saifzadeh, S., Pivonka, P., Zreiqat, H. (2016). Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiae. Biomedical Materials, 11(1), 1-12. [More Information]
  • Chen, Y., Zhou, Y., Yang, S., Li, J., Li, X., Ma, Y., Hou, Y., Jiang, N., Xu, C., Zhang, S., et al (2016). Novel bone substitute composed of chitosan and strontium-doped alpha-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility. Materials Science and Engineering C, 66, 84-91. [More Information]
  • Li, J., Kim, K., Roohani-Esfahani, S., Guo, J., Kaplan, D., Zreiqat, H. (2015). A biphasic scaffold based on silk and bioactive ceramic with stratified properties for osteochondral tissue regeneration. Journal of Materials Chemistry B, 3(26), 5361-5376. [More Information]
  • Lu, Z., Roohaniesfahani, S., Li, J., Zreiqat, H. (2015). Synergistic effect of nanomaterials and BMP-2 signalling in inducing osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(1), 219-228. [More Information]
  • Roohaniesfahani, S., Wong, K., Lu, Z., Chen, Y., Li, J., Gronthos, S., Menicanin, D., Shi, J., Dunstan, C., Zreiqat, H. (2014). Fabrication of a novel triphasic and bioactive ceramic and evaluation of its in vitro and in vivo cytocompatibility and osteogenesis. Journal of Materials Chemistry B, 2(13), 1866-1878. [More Information]
  • Li, J., Kaplan, D., Zreiqat, H. (2014). Scaffold-based regeneration of skeletal tissues to meet clinical challenges. Journal of Materials Chemistry B, 2(42), 7272-7306. [More Information]
  • Li, J., Gil, E., Hayden, R., Li, C., Roohaniesfahani, S., Kaplan, D., Zreiqat, H. (2013). Multiple Silk Coatings on Biphasic Calcium Phosphate Scaffolds: Effect on Physical and Mechanical Properties and In Vitro Osteogenic Response of Human Mesenchymal Stem Cells. Biomacromolecules, 14(7), 2179-2188. [More Information]
  • Roohaniesfahani, S., Dunstan, C., Li, J., Lu, Z., Davies, B., Pearce, S., Field, J., Williams, R., Zreiqat, H. (2013). Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomaterialia, 9(6), 7014-7024. [More Information]
  • Roohaniesfahani, S., Lu, Z., Li, J., Ellis-Behnke, R., Kaplan, D., Zreiqat, H. (2012). Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds. Acta Biomaterialia, 8(1), 302-312. [More Information]

Conferences

  • Roohaniesfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Introducing Magnesium Silicate Based Scaffolds. International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration, China: Zhejiang University.
  • Roohaniesfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Magnesium Silicate Scaffolds: a New Candidate Biomaterial for Bone Regeneration (ID:3072). 9th World Biomaterials Congress, China: World Biomaterials Congress.
  • Roohaniesfahani, S., Lu, Z., Li, J., Appleyard, R., Zreiqat, H. (2010). Enhancing Mechanical and Biological Behavior of Strontium-Doped Hardystonite Scaffolds with Nanocomposite Coating. TERMIS 2010, Orlando, Florida, United States of America.
  • Li, J., Roohaniesfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Novel Silk-Modified Strontium-Hardystonite Composite Scaffolds for Skeletal Regeneration. TERMIS - North America 2010 Conference on Tissue Engineering & Regenerative Medicine International Society, USA: Tissue Engineering & Regenerative Medicine International Society.
  • Li, J., Roohaniesfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Silk-Modified Strontium-Hardystonite Scaffolds for Bone Tissue Engineering. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.

Patents

  • Zreiqat, H., Roohaniesfahani, S., Dunstan, C., Li, J. (2015). [Sr-Gahnite] Alumina Calcium Silicate Composite Scaffold. Patent No. 9220806.

2018

  • Al Muderis, M., Lu, W., Li, J., Kaufman, K., Orendurff, M., Highsmith, M., Lunseth, P., Kahle, J. (2018). Clinically Relevant Outcome Measures Following Limb Osseointegration; Systematic Review of the Literature. Journal of Orthopaedic Trauma, 32(2), e64-e75. [More Information]
  • Li, J., Ebeid, M., Xu, J., Zreiqat, H. (2018). Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering. Advanced Healthcare Materials, 7(6). [More Information]
  • Li, J., Akey, A., Dunstan, C., Vielreicher, M., Friedrich, O., Bell, D., Zreiqat, H. (2018). Effects of Material-Tissue Interactions on Bone Regeneration Outcomes Using Baghdadite Implants in a Large Animal Model. Advanced Healthcare Materials, 7(15), 1-9. [More Information]

2017

  • Wang, L., Yang, Q., Chen, Y., Chai, Y., Li, J., Du, L., Tan, R., Yang, S., Tu, M., Yu, B. (2017). A reformative shear precipitation procedure for the fabrication of vancomycin-loaded poly(lactide-co-glycolide) microspheres. Journal of Biomaterials Applications, 31(7), 995-1009. [More Information]
  • No, Y., Li, J., Zreiqat, H. (2017). Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes. Materials, 10(2), 1-37. [More Information]
  • Al Muderis, M., Lu, W., Li, J. (2017). Osseointegrated Prosthetic Limb for the treatment of lower limb amputations: Experience and outcomes [Das Osseointegrated Prosthetic Limb zur Behandlung von Amputationen der unteren Extremit�ten: Erfahrungen und Ergebnisse]. Der Unfallchirurg, 120(4), 306-311. [More Information]
  • Atallah, R., Li, J., Lu, W., Leijendekkers, R., Frolke, J., Al Muderis, M. (2017). Osseointegrated Transtibial Implants in Patients with Peripheral Vascular Disease: A Multicenter Case Series of 5 Patients with 1-Year Follow-up. Journal of Bone and Joint Surgery: American Volume, 99(18), 1516-1523. [More Information]
  • Mills, N., Lu, W., Li, J., Al Muderis, M. (2017). Osseointegration as treatment for a knee disarticulation because of a congenital femoral deficiency: A case report. JBJS Case Connector, 7(4), 1-6. [More Information]
  • Li, J., Roohaniesfahani, S., Kim, K., Kaplan, D., Zreiqat, H. (2017). Silk coating on a bioactive ceramic scaffold for bone regeneration: Effective enhancement of mechanical and in vitro osteogenic properties towards load-bearing applications. Journal of Tissue Engineering and Regenerative Medicine, 11(6), 1741-1753. [More Information]
  • Al Muderis, M., Lu, W., Tetsworth, K., Bosley, B., Li, J. (2017). Single-stage osseointegrated reconstruction and rehabilitation of lower limb amputees: The Osseointegration Group of Australia Accelerated Protocol-2 (OGAAP-2) for a prospective cohort study. BMJ Open, 7(3), 1-10. [More Information]

2016

  • Li, J., Roohaniesfahani, S., Dunstan, C., Quach, T., Steck, R., Saifzadeh, S., Pivonka, P., Zreiqat, H. (2016). Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiae. Biomedical Materials, 11(1), 1-12. [More Information]
  • Chen, Y., Zhou, Y., Yang, S., Li, J., Li, X., Ma, Y., Hou, Y., Jiang, N., Xu, C., Zhang, S., et al (2016). Novel bone substitute composed of chitosan and strontium-doped alpha-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility. Materials Science and Engineering C, 66, 84-91. [More Information]

2015

  • Zreiqat, H., Roohaniesfahani, S., Dunstan, C., Li, J. (2015). [Sr-Gahnite] Alumina Calcium Silicate Composite Scaffold. Patent No. 9220806.
  • Li, J., Kim, K., Roohani-Esfahani, S., Guo, J., Kaplan, D., Zreiqat, H. (2015). A biphasic scaffold based on silk and bioactive ceramic with stratified properties for osteochondral tissue regeneration. Journal of Materials Chemistry B, 3(26), 5361-5376. [More Information]
  • Lu, Z., Li, J., Zreiqat, H. (2015). Bone-Biomimetic Biomaterial and Cell Fate Determination. In Hala Zreiqat, Colin R. Dunstan, Vicki Rosen (Eds.), A Tissue Regneration Approach to Bone and Cartilage Repair, (pp. 119-146). Cham: Springer. [More Information]
  • Lu, Z., Roohaniesfahani, S., Li, J., Zreiqat, H. (2015). Synergistic effect of nanomaterials and BMP-2 signalling in inducing osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(1), 219-228. [More Information]

2014

  • Roohaniesfahani, S., Wong, K., Lu, Z., Chen, Y., Li, J., Gronthos, S., Menicanin, D., Shi, J., Dunstan, C., Zreiqat, H. (2014). Fabrication of a novel triphasic and bioactive ceramic and evaluation of its in vitro and in vivo cytocompatibility and osteogenesis. Journal of Materials Chemistry B, 2(13), 1866-1878. [More Information]
  • Li, J., Kaplan, D., Zreiqat, H. (2014). Scaffold-based regeneration of skeletal tissues to meet clinical challenges. Journal of Materials Chemistry B, 2(42), 7272-7306. [More Information]

2013

  • Li, J., Gil, E., Hayden, R., Li, C., Roohaniesfahani, S., Kaplan, D., Zreiqat, H. (2013). Multiple Silk Coatings on Biphasic Calcium Phosphate Scaffolds: Effect on Physical and Mechanical Properties and In Vitro Osteogenic Response of Human Mesenchymal Stem Cells. Biomacromolecules, 14(7), 2179-2188. [More Information]
  • Roohaniesfahani, S., Dunstan, C., Li, J., Lu, Z., Davies, B., Pearce, S., Field, J., Williams, R., Zreiqat, H. (2013). Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomaterialia, 9(6), 7014-7024. [More Information]

2012

  • Roohaniesfahani, S., Lu, Z., Li, J., Ellis-Behnke, R., Kaplan, D., Zreiqat, H. (2012). Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds. Acta Biomaterialia, 8(1), 302-312. [More Information]
  • Roohaniesfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Introducing Magnesium Silicate Based Scaffolds. International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration, China: Zhejiang University.
  • Roohaniesfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Magnesium Silicate Scaffolds: a New Candidate Biomaterial for Bone Regeneration (ID:3072). 9th World Biomaterials Congress, China: World Biomaterials Congress.

2010

  • Roohaniesfahani, S., Lu, Z., Li, J., Appleyard, R., Zreiqat, H. (2010). Enhancing Mechanical and Biological Behavior of Strontium-Doped Hardystonite Scaffolds with Nanocomposite Coating. TERMIS 2010, Orlando, Florida, United States of America.
  • Li, J., Roohaniesfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Novel Silk-Modified Strontium-Hardystonite Composite Scaffolds for Skeletal Regeneration. TERMIS - North America 2010 Conference on Tissue Engineering & Regenerative Medicine International Society, USA: Tissue Engineering & Regenerative Medicine International Society.
  • Li, J., Roohaniesfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Silk-Modified Strontium-Hardystonite Scaffolds for Bone Tissue Engineering. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.

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