Dr Jin Huang

Lecturer
Biomedical Sciences, School of Medical Sciences

Telephone 9351 9065

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Research interests

Glaucoma is the leading cause of irreversible blindness worldwide. It is a group of eye diseases where raised intraocular pressure (IOP) occurs over time, leading to visual impairment, and eventually blindness. This raised IOP causes the progressive death of the output nerve cells (neurons) of the eye called retinal ganglion cells. Despite substantial research on this disease, the pathophysiology of glaucoma is not fully understood.

The retina is made up of light sensitive tissue located at the back of the eye. It contains neurons that are important in the first stage of visual perception and visual processing. One of these neurons is called ganglion cells. They project from the retina to other regions within the brain (such as the lateral geniculate nucleus), and are important in the modification of complex visual signals.

To understand the pathophysiological changes in the properties of ganglion cells in glaucoma, we are using a mouse model. Techniques involved are intracellular recording techniques such as patch clamp and confocal microscopy. We will examine the properties of ganglion cells at different time points to allow comparisons before the development of glaucoma and during glaucoma with peak IOP. We will focus on the large alpha ganglion cells and characterise their basic physiological responses, which provide information about their health and behaviour such as spontaneous activity, contrast sensitivity and receptive field organisation. Thus, this project will contribute to our understanding of the effects of raised IOP characteristic of glaucoma on ganglion cell properties that ultimately leads to their death.

We published a video article which provides an overview of the techniques used and some of the projects we are working on.

For full access of the video and paper, click on the link below and type in your Unikey and password:

http://www.jove.com.ezproxy1.library.usyd.edu.au/video/50400/implementing-dynamic-clamp-with-synaptic-artificial-conductances

For full access of the video and partial access of the paper, click the link below:

http://www.jove.com/video/50400/implementing-dynamic-clamp-with-synaptic-artificial-conductances

This research is done in collaboration with Dr Dario Protti in the Discipline of Physiology.

Teaching and supervision

Dr Huang teaches Neuroanatomy, Neurophysiology and Anatomy to undergraduate and postgraduate students. Dr Huang has extensive teaching experience. She has taught Medical, Medical Science and Science students, Health Sciences, Speech Science, Medical Radiation Sciences, Nursing and Paramedic students. Modes of delivery include lectures, practicals, tutorials, problem based learning, distance education and residential schools.

Current research students

Project title Research student
Cannabinoid effects on the visual system. Xiaohui LIN

Associations

A partner of the Scientists and Mathematicians in Schools program. http://www.scientistsinschools.edu.au

A member of:

  • Glaucoma Australia Sustainability Liaison Committee.
  • RAMP Research Ambassador & Mentoring Programme (DAAD Australia and AAvHF). https://www.ramp-australia.info

Awards and honours

Australian Postgraduate Award

Service:

  • Subject/unit co-ordinator for Neuroscience (BIOS1171, Semester 1) and Clinically Based Neuroscience (BIOS5091).
  • A member of the Learning and Teaching Committee of Discipline of Biomedical Science.
  • School of Medical Sciences APR interviewer.
  • Sydney Medical Program PPD and MMI interviewer.

Volunteering:

  • University Information day (January) and Open day (August) faculty advisor.
  • Volunteer for Glaucoma Australia (http://www.glaucoma.org.au).
  • Run outreach activities in high schools (see below).

Dr Huang leads a team of Scientists and actively promotes Brain Awareness to high school students and the public. Outreach activities tend to occur March (Brain Awareness Week) and August (Science Week). If you have studied Neuroscience, love to talk to kids and are willing to volunteer, please email Jin. If you are interested in organising a similar event, fell free to contact Jin. She is happy to forward you the program and lend some equipment. Student feedback scores for outreach activities have been very positive:

  • Sydney International Grammar School - 4.7/5 for 2016; 4.6/5 for 2015
  • Condell Park High School - 4.7/5 for 2016; 4.6/5 for 2015

Dr Huang was invited by the Australian Museum to perform outreach activities with kids on 23-24 September 2015 (Scientist For a Day: Lose Your Senses: http://australianmuseum.net.au/event/school-holiday-program) and with adults on 30 October 2015 (Jurassic Lounge Halloween: http://www.jurassiclounge.com/).

Selected grants

2014

  • Understanding retinal ganglion cell function in glaucoma; Protti D, Huang J; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

Selected publications

Download citations: PDF RTF Endnote

Journals

  • Huang, J., Protti, D. (2016). The impact of inhibitory mechanisms in the inner retina on spatial tuning of RGCs. Scientific Reports, 6, 1-13. [More Information]
  • Protti, D., Di Marco, S., Huang, J., Vonhoff, C., Nguyen, V., Solomon, S. (2014). Inner retinal inhibition shapes the receptive field of retinal ganglion cells in primate. The Journal of Physiology, 592(1), 49-65. [More Information]
  • Huang, J., Stiefel, K., Protti, D. (2013). Implementing dynamic clamp with synaptic and artificial conductances in mouse retinal ganglion cells. Journal of Visualized Experiments, 75, 1-7. [More Information]
  • Wang, C., Huang, J., Bardy, C., Fitzgibbon, T., Dreher, B. (2010). Influence of 'feedback' signals on spatial integration in receptive fields of cat area 17 neurons. Brain Research, 1328, 34-48. [More Information]
  • Bardy, C., Huang, J., Wang, C., Fitzgibbon, T., Dreher, B. (2009). 'Top-down' influences of ipsilateral or contralateral postero-temporal visual cortices on the extra-classical receptive fields of neurons in cat's striate cortex. Neuroscience, 158(2), 951-968. [More Information]
  • Wang, C., Bardy, C., Huang, J., Fitzgibbon, T., Dreher, B. (2009). Contrast dependence of center and surround integration in primary visual cortex of the cat. Journal of Vision, 9(20), 1-15. [More Information]
  • Huang, J., Wang, C., Dreher, B. (2007). The effects of reversible inactivation of postero-temporal visual cortex on neuronal activities in cat's area 17. Brain Research, 1138, 111-128. [More Information]
  • Bardy, C., Huang, J., Wang, C., Fitzgibbon, T., Dreher, B. (2006). 'Simplification' of responses of complex cells in cat striate cortex: suppressive surrounds and 'feedback' inactivation. The Journal of Physiology, 574(3), 731-750. [More Information]

2016

  • Huang, J., Protti, D. (2016). The impact of inhibitory mechanisms in the inner retina on spatial tuning of RGCs. Scientific Reports, 6, 1-13. [More Information]

2014

  • Protti, D., Di Marco, S., Huang, J., Vonhoff, C., Nguyen, V., Solomon, S. (2014). Inner retinal inhibition shapes the receptive field of retinal ganglion cells in primate. The Journal of Physiology, 592(1), 49-65. [More Information]

2013

  • Huang, J., Stiefel, K., Protti, D. (2013). Implementing dynamic clamp with synaptic and artificial conductances in mouse retinal ganglion cells. Journal of Visualized Experiments, 75, 1-7. [More Information]

2010

  • Wang, C., Huang, J., Bardy, C., Fitzgibbon, T., Dreher, B. (2010). Influence of 'feedback' signals on spatial integration in receptive fields of cat area 17 neurons. Brain Research, 1328, 34-48. [More Information]

2009

  • Bardy, C., Huang, J., Wang, C., Fitzgibbon, T., Dreher, B. (2009). 'Top-down' influences of ipsilateral or contralateral postero-temporal visual cortices on the extra-classical receptive fields of neurons in cat's striate cortex. Neuroscience, 158(2), 951-968. [More Information]
  • Wang, C., Bardy, C., Huang, J., Fitzgibbon, T., Dreher, B. (2009). Contrast dependence of center and surround integration in primary visual cortex of the cat. Journal of Vision, 9(20), 1-15. [More Information]

2007

  • Huang, J., Wang, C., Dreher, B. (2007). The effects of reversible inactivation of postero-temporal visual cortex on neuronal activities in cat's area 17. Brain Research, 1138, 111-128. [More Information]

2006

  • Bardy, C., Huang, J., Wang, C., Fitzgibbon, T., Dreher, B. (2006). 'Simplification' of responses of complex cells in cat striate cortex: suppressive surrounds and 'feedback' inactivation. The Journal of Physiology, 574(3), 731-750. [More Information]

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