Dr Jin Sung Park

Senior Research Fellow
Medicine, Northern Clinical School

Telephone +61 2 9926 4867
Fax 0434 260 314

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Biographical details

Dr Jin-Sung Park is currently working as a senior research fellow at the University of Sydney and is Leader of the Parkinson’s disease unit in the Department of Neurogenetics, Kolling Institute of Medical Research. He completed a Bachelor’s degree in Veterinary Medicine (Doctor of Veterinary Medicine) with a Chancellor’s award for outstanding scholastic achievement and a Master’s degree in Veterinary Medical Science (Laboratory animal science/Toxicological pathology) with main research topics on preclinical testing of drugs and toxicopathology of endocrine discruptors at Seoul National University, South Korea. Then, he moved to Japan for PhD degree course and obtained a PhD degree majoring in Veterinary Medical Science (Neuroscience) with main research topics on the molecular mechanisms associated with cerebellum-depedent learning and memory in mice models at the University of Tokyo/RIKEN Brain Science Institute, Japan in 2005. After one year's postdoctoral training in RIKEN Brain Science Institute, Dr Park moved to Sydney and took up a postdoctoral position on adult neurogenesis in Garvan Institute of Medical Research. In 2007, he moved his position to Kolling Intitute and started research on Parkinson's disease using patient-derived cell lines including fibroblasts and olfactory neurosphere culture . Until now, Dr Park successfully completed numerous research projects with high quality research articles impacting the related biomedical fields as demonstrated in his publication list.

[Selected research articles published before 2009]

Jin-Sung Park, Takashi Onodera, Shin-ichi Nishimura, Richard F. Thompson, Shigeyoshi Itohara (2006), Molecular evidence for the two-stage learning and partial laterality in the eyeblink conditioning of mice, Proc. Natl. Acad. Sci. U.S.A., 103(14):5549-5554

Keiichi Inoue, Yuko Mikuni-Takagaki, Kaoru Oikawa, Takeshi Itoh, Masaki Inada, Takanori Noguchi, Jin-Sung Park, Takashi Onodera, Stephen M. Krane, Masaki Noda, and Shigeyoshi Itohara (2006), A crucial role for MMP-2 in osteocytic canalicular formation and bone metabolism, J. Biol. Chem., 281(44):33814-33824

Nam-Shik Ahn*, Hongbo Hu*, Jin-Sung Park, Joon-Suk Park, Jong-Sik Kim, Sungwhan An, Gu Kong, Okezei I. Aruoma, Yong-Soon Lee, Kyung-Sun Kang (2005), Molecular mechanism of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced inverted U-shaped dose responsiveness in anchorage independent growth and cell proliferation of human breast epithelial cells with stem cell characteristics, Mutat. Res.- Fund. Mol. M., 579(1-2):189-99.

Jin-Sung Park, Beom-Jun Lee, Kyung-Sun Kang, Joo-Ho Tai, Jae-Jin Cho, Myung-Haing Cho, Tohru Inoue, and Yong-Soon Lee (2000), Hormonal effects of several chemicals using recombinant yeast, MCF-7 cells and uterotrophic assay in mice, J. Microbiol. Biotechnol., 10(3): 293-299

Research interests

Since the appointment as Leader of Parkinson's diease unit in the Department of Neurogenetics, Dr Park has been successfully establishing a national/international reputation for high quality research on mitochondrial dysfunction in Parkinson’s disease (PD). Of particular note, his unit is a world leader in research on ATP13A2 (PARK9)-associated PD since becoming the first Australian group to report novel pathogenic ATP13A2 mutations in 2011. Recently, Dr Park’s unit reported a ground-breaking discovery in PD research, which demonstrated that ATP13A2 regulates zinc metabolism and thereby mitochondrial function, two known aetiological factors that contribute to PD development. Another main research focus is about mechanisms involved in mitochondrial quality control in PD. PINK1 and Parkin are two PD-associated molecules which ensure normal mitochondrial function by mediating degradation of (dys)functional mitochondria via autophagy, the process also known as mitophagy. Loss of these molecules by mutations causes PD by impairing mitophagy and thereby mitochondrial function. Dr Park’s unit identified an individual who is clinically asymptomatic and has normal mitochondrial function, but surprisingly lacks functional Parkin. These findings suggest the existence of compensatory pathway(s) which may have prevented the development of PD in the individual. Recently, his unit has made a great progress in isolating the responsible pathway, which is currently under extensive investigation to validate its therapeutic potential for PD.

[Naional/International collaborators]

1) A/Prof Antony A. Cooper, Garvan Institute, Australia (ATP13A2 project)

2) Prof Dimitri Krainc, Northwestern University, USA (ATP13A2, autophagy and iPS cells projects)

3) Prof Christine Klein, University of Lübeck, Germany (ATP13A2 and TUBB4a projects)

4) Dr. Shigeyoshi Itohara, RIKEN Brain Science, Japan (Development of transgenic mouse models)

5) A/Prof Byeong-Cheol Kang, Seoul National University, South Korea (Adult stem cells project)

Teaching and supervision

Dr Park is an experienced postgraduate supervisor for the Faculty of Medicine, Sydney Medical School. In Australia, he started supervising postgraduate students in 2009 and has since supervised one research student as the primary supervisor and a PhD student under the joint supervision with Prof. Carolyn Sue to the successful completion. Dr Park also has been supervising another PhD student with Prof. Carolyn Sue who has her thesis under review. In addition, he has been involved in mentoring two postdoctoral scientists as well as supervising four other PhD students in the Department of Neurogenetics.

Selected grants

2014

  • Understanding the role of ATP13A2 (PARK9) in the pathogenesis of Parkinson’s disease; Park J; Parkinson's New South Wales Incorporated/Research Grants.

Selected publications

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Journals

  • Park, J., Koentjoro, B., Veivers, D., Mackay-Sim, A., Sue, C. (2014). Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction. Human Molecular Genetics, 23(11). [More Information]
  • Kong, S., Chan, B., Park, J., Hill, K., Aitken, J., Cottle, L., Farghaian, H., Cole, A., Lay, P., Sue, C., et al (2014). Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes alpha-Synuclein externalization via exosomes. Human Molecular Genetics, 23(11), 2816-2833. [More Information]
  • Lohmann, K., Wilcox, R., Winkler, S., Ramirez, A., Rakovic, A., Park, J., Arns, B., Lohnau, T., Groen, J., Kasten, M., Kumar, K., Sue, C., et al (2013). Whispering Dysphonia (DYT4 dystonia) Is Caused by a Mutation in the TUBB4 Gene. Annals of Neurology, 73(4), 537-545. [More Information]
  • Koentjoro, B., Park, J., Ha, A., Sue, C. (2012). Phenotypic variability of parkin mutations in single kindred. Movement Disorders, 27(10), 1299-1303. [More Information]
  • Park, J., Mehta, P., Cooper, A., Veivers, D., Heimbach, A., Stiller, B., Kubisch, C., Fung, V., Krainc, D., Mackay-Sim, A., Sue, C. (2011). Pathogenic Effects of Novel Mutations in the P-Type ATPase ATP13A2 (PARK9) Causing Kufor-Rakeb Syndrome, a Form of Early-Onset Parkinsonism. Human Mutation, 32(8), 956-964. [More Information]
  • Abdipranoto-Cowley, A., Park, J., Croucher, D., Daniel, J., Henshall, S., Galbraith, S., Mervin, K., Vissel, B. (2009). Activin A is essential for neurogenesis following neurodegeneration. Stem Cells, 27(6), 1330-1346. [More Information]
  • Inoue, K., Mikuni-Takagaki, Y., Oikawa, K., Itoh, T., Inada, M., Noguchi, T., Park, J., Onodera, T., Krane, S., Noda, M., et al (2006). A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. Journal of Biological Chemistry, 281(44), 33814-33824. [More Information]
  • Park, J., Onodera, T., Nishimura, S., Thompson, R., Itohara, S. (2006). Molecular evidence for two-stage learning and partial laterality in eyeblink conditioning of mice. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 103(14), 5549-5554. [More Information]
  • Park, J., Ahn, N., Hu, H., Park, J., Kim, J., An, S., Kong, G., Aruoma, O., Lee, Y., Kang, K. (2005). Molecular mechanisms of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced inverted U-shaped dose responsiveness in anchorage independent growth and cell proliferation of human breast epithelial cells with stem cell characteristics. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 579(1/2), 189-199. [More Information]

2014

  • Park, J., Koentjoro, B., Veivers, D., Mackay-Sim, A., Sue, C. (2014). Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction. Human Molecular Genetics, 23(11). [More Information]
  • Kong, S., Chan, B., Park, J., Hill, K., Aitken, J., Cottle, L., Farghaian, H., Cole, A., Lay, P., Sue, C., et al (2014). Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes alpha-Synuclein externalization via exosomes. Human Molecular Genetics, 23(11), 2816-2833. [More Information]

2013

  • Lohmann, K., Wilcox, R., Winkler, S., Ramirez, A., Rakovic, A., Park, J., Arns, B., Lohnau, T., Groen, J., Kasten, M., Kumar, K., Sue, C., et al (2013). Whispering Dysphonia (DYT4 dystonia) Is Caused by a Mutation in the TUBB4 Gene. Annals of Neurology, 73(4), 537-545. [More Information]

2012

  • Koentjoro, B., Park, J., Ha, A., Sue, C. (2012). Phenotypic variability of parkin mutations in single kindred. Movement Disorders, 27(10), 1299-1303. [More Information]

2011

  • Park, J., Mehta, P., Cooper, A., Veivers, D., Heimbach, A., Stiller, B., Kubisch, C., Fung, V., Krainc, D., Mackay-Sim, A., Sue, C. (2011). Pathogenic Effects of Novel Mutations in the P-Type ATPase ATP13A2 (PARK9) Causing Kufor-Rakeb Syndrome, a Form of Early-Onset Parkinsonism. Human Mutation, 32(8), 956-964. [More Information]

2009

  • Abdipranoto-Cowley, A., Park, J., Croucher, D., Daniel, J., Henshall, S., Galbraith, S., Mervin, K., Vissel, B. (2009). Activin A is essential for neurogenesis following neurodegeneration. Stem Cells, 27(6), 1330-1346. [More Information]

2006

  • Inoue, K., Mikuni-Takagaki, Y., Oikawa, K., Itoh, T., Inada, M., Noguchi, T., Park, J., Onodera, T., Krane, S., Noda, M., et al (2006). A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. Journal of Biological Chemistry, 281(44), 33814-33824. [More Information]
  • Park, J., Onodera, T., Nishimura, S., Thompson, R., Itohara, S. (2006). Molecular evidence for two-stage learning and partial laterality in eyeblink conditioning of mice. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 103(14), 5549-5554. [More Information]

2005

  • Park, J., Ahn, N., Hu, H., Park, J., Kim, J., An, S., Kong, G., Aruoma, O., Lee, Y., Kang, K. (2005). Molecular mechanisms of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced inverted U-shaped dose responsiveness in anchorage independent growth and cell proliferation of human breast epithelial cells with stem cell characteristics. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 579(1/2), 189-199. [More Information]

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