Dr John Allen

Senior Research Fellow (Cancer Institute NSW), Senior Research Fellow (Central Clinical School, University of Sydney) & Head, Cancer Drug Resistance Group
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6192
Fax +61 2 9565 6101

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Research interests

Drug resistance mechanisms in chemotherapy: multidrug transporters, apoptosis pathways, the unfolded protein response. New anticancer drugs, anticancer drug pharmacokinetics and toxicity. Animal models of tumorigenesis and drug resistance. Melanoma, myeloma and other common recalcitrant cancers.

Selected grants

2009

  • Multi-photon microscope for intravital imaging; Weninger W, Vadas M, Hogg P, Norris M, Fazekas de St Groth B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D; Cancer Institute New South Wales/Equipment Grant.

2008

  • Predicting response to proteasome inhibitors; Allen J, Ling S; Cure Cancer Australia Foundation/Research Support.

2006

  • Cancer Institute NSW - Research Grants Program; Allen J; Cancer Institute New South Wales/Research Support.

2003

  • Interaction of new kinase inhibitor drugs with multi-drug resistance (MDR) transporter proteins; Haber M, Allen J, Rivory L; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Osborne, B., Yao, T., Wang, X., Chen, Y., Kotan, L., Nadvi, N., Herdem, M., McCaughan, G., Allen, J., Yu, M., Gorrell, M., et al (2014). A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1844 (7), 1248-1259. [More Information]
  • Kota, B., Abdul, M., Allen, J., Kalagara, M., Roufogalis, B. (2012). Effect of vitamin D3 supplementation on the pharmacokinetics of digoxin - a pilot study. Fundamental and Clinical Pharmacology, 26(4), 543-548. [More Information]
  • Ling, S., Lau, K., Al-Shabeeb, A., Nikolic, A., Catalano, A., Iland, H., Horvath, N., Ho, J., Harrison, S., Fleming, S., Joshua, D., Allen, J. (2012). Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1. Haematologica: the hematology journal, 97(1), 64-72. [More Information]
  • McGowan, E., Alling, N., Jackson, E., Yagoub, D., Haass, N., Allen, J., Martinello-Wilks, R. (2011). Evaluation of Cell Cycle Arrest in Estrogen Responsive MCF-7 Breast Cancer Cells: Pitfalls of the MTS Assay. PLoS One, 6(6), 1-8. [More Information]
  • Kota, B., Allen, J., Roufogalis, B. (2011). The Effect of Vitamin D3 and Ketoconazole Combination on VDR-mediated P-gp Expression and Function in Human Colon Adenocarcinoma Cells: Implications in Drug Disposition and Resistance. Basic and Clinical Pharmacology and Toxicology, 109(2), 97-102. [More Information]
  • Kota, B., Tran, V., Allen, J., Bebawy, M., Roufogalis, B. (2010). Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells. Pharmacological Research, 62(5), 426-431. [More Information]
  • Dilda, P., Decollogne, S., Weerakoon, L., Norris, M., Haber, M., Allen, J., Hogg, P. (2009). Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol. Journal of Medicinal Chemistry, 52(20), 6209-6216. [More Information]
  • Ho, L., Kench, J., Handelsman, D., Scheffer, G., Stricker, P., Grygiel, J., Sutherland, R., Henshall, S., Allen, J., Horvath, L. (2008). Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer. The Prostate, 68(13), 1421-1429. [More Information]
  • Holland, M., Allen, J., Arnold, J. (2008). Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). European Journal of Pharmacology, 591, 128-131. [More Information]
  • Jiang, C., Lucas, K., Avery-Kiejda, K., Wade, M., deBock, C., Thorne, R., Allen, J., Hersey, P., Zhang, X. (2008). Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. Cancer Research, 68(16), 6708-6717. [More Information]
  • Mhaidat, N., Zhang, X., Allen, J., Avery-Kiejda, K., Scott, R., Hersey, P. (2007). Temozolomide induces senescence but not apoptosis in human melanoma cells. British Journal of Cancer, 97(9), 1225-1233. [More Information]
  • Holland, M., Lau, D., Allen, J., Arnold, J. (2007). The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. British Journal of Pharmacology, 152(5), 815-824. [More Information]
  • Holland, M., Panetta, J., Hoskins, J., Bebawy, M., Roufogalis, B., Allen, J., Arnold, J. (2006). The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochemical Pharmacology, 71(8), 1146-1154. [More Information]
  • Norris, M., Smith, J., Tanabe, K., Tobin, P., Flemming, C., Scheffer, G., Wielinga, P., Cohn, S., London, W., Marshall, G., Allen, J., et al (2005). Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro. Molecular Cancer Therapeutics, 4(4), 547-553. [More Information]
  • Allen, J., Zhou, Y., Scott, C., Boyle, G., Hersey, P., Strasser, A. (2005). Is Apaf-1 expression frequently abrogated in melanoma? Cell Death and Differentiation, 12(6), 680-681.
  • Allen, J., van Dort, S., Buitelaar, M., van Tellingen, O., Schinkel, A. (2003). Mouse Breast Cancer Resistance Protein (Bcrp1/Abcg2) Mediates Etoposide Resistance and Transport, but Etoposide Oral Availability Is Limited Primarily by P-glycoprotein. Cancer Research, 63(6), 1339-1344.

Conferences

  • Cabot, M., Yu, J., Kelly, G., Brown, D., Lucas, K., Tanabe, K., Allen, J. (2005). Phenoxodiol, a synthetic analog of genistein, generates ceramide and is equipotent in wild-type and multidrug-resistant human tumor cells. 2005 American Society of Clinical Oncology (ASCO) Annual Meeting, United States: American Society of Clinical Oncology.

2014

  • Osborne, B., Yao, T., Wang, X., Chen, Y., Kotan, L., Nadvi, N., Herdem, M., McCaughan, G., Allen, J., Yu, M., Gorrell, M., et al (2014). A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids), 1844 (7), 1248-1259. [More Information]

2012

  • Kota, B., Abdul, M., Allen, J., Kalagara, M., Roufogalis, B. (2012). Effect of vitamin D3 supplementation on the pharmacokinetics of digoxin - a pilot study. Fundamental and Clinical Pharmacology, 26(4), 543-548. [More Information]
  • Ling, S., Lau, K., Al-Shabeeb, A., Nikolic, A., Catalano, A., Iland, H., Horvath, N., Ho, J., Harrison, S., Fleming, S., Joshua, D., Allen, J. (2012). Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1. Haematologica: the hematology journal, 97(1), 64-72. [More Information]

2011

  • McGowan, E., Alling, N., Jackson, E., Yagoub, D., Haass, N., Allen, J., Martinello-Wilks, R. (2011). Evaluation of Cell Cycle Arrest in Estrogen Responsive MCF-7 Breast Cancer Cells: Pitfalls of the MTS Assay. PLoS One, 6(6), 1-8. [More Information]
  • Kota, B., Allen, J., Roufogalis, B. (2011). The Effect of Vitamin D3 and Ketoconazole Combination on VDR-mediated P-gp Expression and Function in Human Colon Adenocarcinoma Cells: Implications in Drug Disposition and Resistance. Basic and Clinical Pharmacology and Toxicology, 109(2), 97-102. [More Information]

2010

  • Kota, B., Tran, V., Allen, J., Bebawy, M., Roufogalis, B. (2010). Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells. Pharmacological Research, 62(5), 426-431. [More Information]

2009

  • Dilda, P., Decollogne, S., Weerakoon, L., Norris, M., Haber, M., Allen, J., Hogg, P. (2009). Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol. Journal of Medicinal Chemistry, 52(20), 6209-6216. [More Information]

2008

  • Ho, L., Kench, J., Handelsman, D., Scheffer, G., Stricker, P., Grygiel, J., Sutherland, R., Henshall, S., Allen, J., Horvath, L. (2008). Androgen regulation of multidrug resistance-associated protein 4 (MRP4/ABCC4) in prostate cancer. The Prostate, 68(13), 1421-1429. [More Information]
  • Holland, M., Allen, J., Arnold, J. (2008). Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1). European Journal of Pharmacology, 591, 128-131. [More Information]
  • Jiang, C., Lucas, K., Avery-Kiejda, K., Wade, M., deBock, C., Thorne, R., Allen, J., Hersey, P., Zhang, X. (2008). Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. Cancer Research, 68(16), 6708-6717. [More Information]

2007

  • Mhaidat, N., Zhang, X., Allen, J., Avery-Kiejda, K., Scott, R., Hersey, P. (2007). Temozolomide induces senescence but not apoptosis in human melanoma cells. British Journal of Cancer, 97(9), 1225-1233. [More Information]
  • Holland, M., Lau, D., Allen, J., Arnold, J. (2007). The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids. British Journal of Pharmacology, 152(5), 815-824. [More Information]

2006

  • Holland, M., Panetta, J., Hoskins, J., Bebawy, M., Roufogalis, B., Allen, J., Arnold, J. (2006). The effects of cannabinoids on P-glycoprotein transport and expression in multidrug resistant cells. Biochemical Pharmacology, 71(8), 1146-1154. [More Information]

2005

  • Norris, M., Smith, J., Tanabe, K., Tobin, P., Flemming, C., Scheffer, G., Wielinga, P., Cohn, S., London, W., Marshall, G., Allen, J., et al (2005). Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro. Molecular Cancer Therapeutics, 4(4), 547-553. [More Information]
  • Allen, J., Zhou, Y., Scott, C., Boyle, G., Hersey, P., Strasser, A. (2005). Is Apaf-1 expression frequently abrogated in melanoma? Cell Death and Differentiation, 12(6), 680-681.
  • Cabot, M., Yu, J., Kelly, G., Brown, D., Lucas, K., Tanabe, K., Allen, J. (2005). Phenoxodiol, a synthetic analog of genistein, generates ceramide and is equipotent in wild-type and multidrug-resistant human tumor cells. 2005 American Society of Clinical Oncology (ASCO) Annual Meeting, United States: American Society of Clinical Oncology.

2003

  • Allen, J., van Dort, S., Buitelaar, M., van Tellingen, O., Schinkel, A. (2003). Mouse Breast Cancer Resistance Protein (Bcrp1/Abcg2) Mediates Etoposide Resistance and Transport, but Etoposide Oral Availability Is Limited Primarily by P-glycoprotein. Cancer Research, 63(6), 1339-1344.

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