Professor John McAvoy

Sydney Medical Research Foundation Professor of Experimental Ophthalmology
Clinical Ophthalmology & Eye Health, Central Clinical School
Save Sight Institute

Telephone +61 2 9382 7369
Fax +61 2 9382 7318

Website Save Sight Institute

Map

Biographical details

Research interests

How a particular tissue or organ develops its characteristic size and three-dimensional cellular architecture is often a poorly understood part of its developmental program; yet, as is clearly the case for the eye lens, precise regulation of these features can be critical for function. During lens morphogenesis cells become organized into a polarized, spheroidal structure with a monolayer of epithelial cells overlying the apical tips of highly elongated fibre cells. Epithelial cells proliferate and progeny that shift below the lens equator differentiate into new fibres that become precisely aligned and oriented towards the poles of the lens as they progressively add to the fibre mass. Research in our laboratory has shown that FGF induces epithelial to fibre differentiation; however, it is not fully understood how the proliferation and differentiation compartments are regulated to ensure appropriate growth and at the same time maintain the highly ordered and polarized three-dimensional lens structure. In recent studies we have shown that planar cell polarity (PCP) operates in the lens and Wnt-Frizzled signalling plays a role in regulating the polarized cell behaviour that is critical for normal lens morphogenesis and growth. We believe that the lens will be a useful model system to study Wnt-Frizzled/PCP in general and gain insights into mechanisms that generate high-level cellular order during development.

Selected grants

2013

  • Zeiss Confocal Microscope, LSM700; McAvoy J, Martin P, Gillies M, Grunert U, Watson S, Lovicu F; DVC Research/Equipment Grant.
  • The contribution of aberrant Wnt signalling to neuronal and vascular pathology in retinal disease; Gillies M, Shen W, McAvoy J, Zhu L; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • MACSQuant Analyzer (FL8); McAvoy J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Preventing Blindness: Blocking TGF-induced EMT and Cataract Development; Lovicu F, McAvoy J; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Ciliogenesis is a key feature of FGF -induced lens fibre differentiation that is required for coordinating fibre cell alignment and orientation.; McAvoy J, Lovicu F; Ophthalmic Research Institute of Australia (ORIA)/Research Grant.
  • Support for a 12 month Postdoctoral Fellowship ($106,745) for Dr Lucy Dawes to supplement her Endeavour Postdoctoral award from the Department of Education, Science and Training; McAvoy J, Dawes L; Sydney Eye Hospital Foundation/Research Support.
  • Role of primary cilia and PCP proteins in lens development: implication for lens regeneration after cataract surgery; McAvoy J, Lovicu F; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Blocking cataract development by promoting the maintenance of the lens epithelium.; Lovicu F, McAvoy J; DVC Research/Bridging Support Grant.
  • Bio-Rad CFX384 Real-Time PCR Detection System; McAvoy J, Truscott R, Gillies M, Lovicu F, Martin P, Grunert U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Growth factor regulation of lens development: implications for understanding cataract; McAvoy J, Lovicu F; Sydney Foundation for Medical Research/Research Support.

2009

  • Zeiss Axio Imager.M1 microscope.; Lovicu F, McAvoy J; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Mechanisms of Lithiumss Promotion of Lens Epithelial Phenotype; McAvoy J; Ophthalmic Research Institute of Australia (ORIA)/Research Support.
  • Roles for MAPK/ERK1/2, B-catenin/TCF and Smad3 mediated signalling pathways in TGFB-induced cataract; McAvoy J, Lovicu F; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Tecan Infinite M200 monochromator microplate reader and detector plus software; McAvoy J, Lovicu F; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Presbyopia: CLEC 2 - Controlling Lens Epithelial Cells: Stream II (CLEC II); Hopkins P, Miller S, Davis A, McAvoy J; Vision CRC/Research Grant (USyd non-Participant).
  • Receptor Tyrosine Kinase Antagonists, Sef and Sprouty, Regulate Eye Lens Cell Behaviour; Lovicu F, McAvoy J; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Growth factor regulation of lens epithelial growth and differentiation: Implications for understanding normal development and cataract; McAvoy J, Baker C, Collins L, Klapsch V, Bryant D; Sydney Foundation for Medical Research/Research Grants.
  • Understanding lens aging: the molecular basis of presbyopia; Truscott R, McAvoy J, Aquilina J, Aquilina J; Australian Research Council (ARC)/Discovery Projects (DP).
  • Advanced Imaging Flow Cytometry Facility for NSW; King N, Campbell I, Cook D, Black J, Halliday G, McAvoy J, Gunning P, Pollard J, Murray M, Britton W, Dawes I, Khachigian L, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Growth factor indction of lens epithelial differentiation: implications for controlling posterior capsular pacification; McAvoy J; ORIA/Research Grants in Ophthalmology.

2005

  • Gradient HPLC system; McAvoy J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • FACS Aria for the University of Sydney Flow Cytometry Facility; King N, Pollard J, Rasko J, Lovicu F, Bishop A, Bertolino P, Briscoe H, Gillies M, Madigan M, McAvoy J, Murphy C, Balcar V, Armour C, Hughes M, Reeve V, Christopherson R, Halliday G, Christie M, Pollock C, McCaughan G, Gorrell M, Dong Q, Abendroth A, Menzies S, Barnetson R, Byrne S, Hunt N, Hambly B, Cook D, Mason R, Day M, Black J; University of Sydney/Equipment Grant.

2004

  • Honda Foundation funding for the purchase of a Zeiss Axiovision and Axiocam Digital Documentation System; McAvoy J; Honda Foundation/Research Grant.
  • Leica tissue processor and embedding centre; McAvoy J; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
  • Inverted flourescence microscope workstation, including:; McAvoy J, Lovicu F, Truscott R, Madigan M, Provis J, Gillies M, McClellan K; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • Inductive interactions between lens and optic cup specify cell fates; McAvoy J, Lovicu F; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Leica TCS confocal microscope; McAvoy J; Clive & Vera Ramaciotti Foundation/Research Grants.
  • HM355S rotary motorised microtome; HM340E manual rotary microtome; McAvoy J, Provis J, Gillies M, Madigan M, Lovicu F; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Expression and role of integrins during lens development and cataractogenesis; McAvoy J, de Iongh R; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Normal & pathological lens development in relation to cataract; McAvoy J; Sydney Foundation for Medical Research/Research Grant.
  • The role of Crim-1 in lens development and eye disease; McAvoy J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Luminometer; Mason R, McAvoy J; Clive & Vera Ramaciotti Foundation/Project Support.
  • Equipment for research into the molecular basis of changes in gene activity in major blinding diseases; McAvoy J; Lions NSW-ACT Save Sight Foundation/Research Grant.

2000

  • Induction of cataract by TGF-Beta: effect of other growth factors and the ocular media; Chamberlain C, McAvoy J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Roles of FGF and TGF-beta in lens development; McAvoy J, Lovicu F; Australian Research Council (ARC)/Small Grants.
  • Lens differentiation and cataract: role of TGFB; De Iongh R, Hales A, Lovicu F, McAvoy J; National Institutes of Health/National Eye Institute Project Support.
  • Capsule production in lens explants: Role of TGF-BETA and FGF (1994); McAvoy J, Chamberlain C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Analysis of FGF receptor signalling involved in lens cell proliferation and differentiation; Lovicu F, McAvoy J; National Health and Medical Research Council (NHMRC)/Project Grants.

1999

  • Functional genomics equipment; Morris B, McAvoy J; Clive & Vera Ramaciotti Foundation/Research Grants.

1998

  • Lens differentiation and cataract: role of FGF and WNT; McAvoy J, Lovicu F, De Iongh R, Hales A; National Institutes of Health (USA)/Research Grant.

Selected publications

Download citations: PDF RTF Endnote

Books

  • Pandey, S., Apple, D., Werner, L., McAvoy, J., Maloof, A., Milverton, E. (2005). Posterior Capsule Opacification. India: Jaypee Brothers Medical Publishers.

Book Chapters

  • Sugiyama, Y., McAvoy, J. (2012). Analysis of PCP defects in mammalian eye lens. In Kursad Turksen (Eds.), Methods in Microbiology: Planar Cell Polarity, (pp. 100-120). New York: Humana Press.
  • Lovicu, F., McAvoy, J. (2008). Epithelial explants and their application to study developmental processes in the lens. In P A Tsonis (Eds.), Animal Models in Eye Research, (pp. 134-147). United States: Academic Press Elsevier.
  • Lang, R., McAvoy, J. (2004). Growth Factors In Lens Development. In Frank Lovicu, Michael Robinson (Eds.), Development of the Ocular Lens, (pp. 261-289). Canada: Cambridge University Press.

Journals

  • Dawes, L., Sugiyama, Y., Lovicu, F., Harris, C., Shelley, E., McAvoy, J. (2014). Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism. Developmental Biology, 385(2), 291-303. [More Information]
  • Wang, C., Dawes, L., Liu, Y., Wen, L., Lovicu, F., McAvoy, J. (2013). Dexamethasone influences fgf-induced responses in lens epithelial explants and promotes the posterior capsule coverage that is a feature of glucocorticoid-induced cataract. Experimental Eye Research, 111, 79-87. [More Information]
  • Sugiyama, Y., Shelley, E., Wen, L., Stump, R., Shimono, A., Lovicu, F., McAvoy, J. (2013). Sfrp1 and Sfrp2 are not involved in Wnt/β-catenin signal silencing during lens induction but are required for maintenance of Wnt/β-catenin signaling in lens epithelial cells. Developmental Biology, 384(2), 181-193. [More Information]
  • You, J., Hodge, C., Wen, L., McAvoy, J., Madigan, M., Sutton, G. (2013). Tear levels of SFRP1 are significantly reduced in keratoconus patients. Molecular Vision, 19, 509-515. [More Information]
  • Dawes, L., Sugiyama, Y., Tanedo, A., Lovicu, F., McAvoy, J. (2013). Wnt-Frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Investigative Ophthalmology and Visual Science, 54(3), 1582-1590. [More Information]
  • Madigan, M., You, J., Wen, L., Hodges, C., Roufas, A., McAvoy, J., Sutton, G. (2012). Secreted frizzled proteins in control and keratoconus (KC) tears and corneas. Acta Ophthalmologica, 90(Supplement s249). [More Information]
  • Shin, E., Basson, M., Robinson, M., McAvoy, J., Lovicu, F. (2012). Sprouty Is a Negative Regulator of Transforming Growth Factor B-induced Epithelial-to-Mesenchymal Transition and Cataract. Molecular Medicine, 18, 861-873. [More Information]
  • You, J., Hodge, C., Wen, L., McAvoy, J., Madigan, M., Sutton, G. (2012). Using soybean trypsin inhibitor as an external loading control for Western blot analysis of tear proteins: Application to corneal disease. Experimental Eye Research, 99(1), 55-62. [More Information]
  • Sugiyama, Y., Lovicu, F., McAvoy, J. (2011). Planar cell polarity in the mammalian eye lens. Organogenesis, 7(3), 191-201. [More Information]
  • Kallifatidis, G., Boros, J., Shin, E., McAvoy, J., Lovicu, F. (2011). The fate of dividing cells during lens morphogenesis, differentiation and growth. Experimental Eye Research, 92(6), 502-511. [More Information]
  • Lovicu, F., McAvoy, J., de Iongh, R. (2011). Understanding the role of growth factors in embryonic development: insights from the lens. Philosophical Transactions of the Royal Society B. Biological Sciences, 366(1568), 1204-1218. [More Information]
  • Wang, Q., McAvoy, J., Lovicu, F. (2010). Growth Factor Signaling in Vitreous Humor–Induced Lens Fiber Differentiation. Investigative Ophthalmology and Visual Science, 51(7), 3599-3610. [More Information]
  • Sutton, G., Madigan, M., Roufas, A., McAvoy, J. (2010). Secreted frizzled-related protein 1 (SFRP1) is highly upregulated in keratoconus epithelium: a novel finding highlighting a new potential focus for keratoconus research and treatment. Clinical and Experimental Ophthalmology, 38(1), 43-48. [More Information]
  • Sugiyama, Y., Stump, R., Nguyen, A., Wen, L., Chen, Y., Murdoch, J., Lovicu, F., McAvoy, J. (2010). Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia. Developmental Biology, 338(2), 193-201. [More Information]
  • Newitt, P., Boros, J., Madakashira, B., Robinson, M., Reneker, L., McAvoy, J., Lovicu, F. (2010). Sef is a negative regulator of fiber cell differentiation in the ocular lens. Differentiation: ontogeny, neoplasia and differentiation therapy, 80(1), 53-67. [More Information]
  • Iyengar, L., Patkunanathan, B., McAvoy, J., Lovicu, F. (2009). Growth factors involved in aqueous humour-induced lens cell proliferation. Growth Factors, 27(1), 50-62. [More Information]
  • Wang, Q., Stump, R., McAvoy, J., Lovicu, F. (2009). MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation. Experimental Eye Research, 88(2), 293-306. [More Information]
  • Sharma, S., Koh, K., Collin, C., Dave, A., mcMellon, A., Sugiyama, Y., McAvoy, J., Voss, A., Gecz, J., Craig, J. (2009). NHS-A isoform of the NHS gene is a novel interactor of ZO-1. Experimental Cell Research: emphasizing molecular approaches to cell biology, 315(14), 2358-2372. [More Information]
  • Chong, C., Stump, R., Lovicu, F., McAvoy, J. (2009). TGF{beta} promotes Wnt expression during cataract development. Experimental Eye Research, 88(2), 307-313. [More Information]
  • O'Connor, M., Wederell, E., de Iongh, R., Lovicu, F., McAvoy, J. (2008). Generation of transparency and cellular organization in lens explants. Experimental Eye Research, 86(5), 734-745. [More Information]
  • Chen, Y., Stump, R., Lovicu, F., Shimono, A., McAvoy, J. (2008). Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Developmental Biology, 324(1), 161-176. [More Information]
  • Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al (2007). Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More Information]
  • Pennisi, D., Wilkinson, L., Kolle, G., Sohaskey, M., Gillinder, K., Piper, M., McAvoy, J., Lovicu, F., Little, M. (2007). Crim1(KST264/KST264) mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Developmental Dynamics, 236(2), 502-511. [More Information]
  • Iyengar, L., Wang, Q., Rasko, J., McAvoy, J., Lovicu, F. (2007). Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate. Differentiation: ontogeny, neoplasia and differentiation therapy, 75(7), 662-668. [More Information]
  • O'Connor, M., McAvoy, J. (2007). In vitro generation of functional lens-like structures with relevance to age-related nuclear cataract. Investigative Ophthalmology and Visual Science, 48(3), 1245-1252. [More Information]
  • Chen, Y., Stump, R., Lovicu, F., McAvoy, J. (2006). A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation? Seminars in Cell and Developmental Biology, 17(6), 712-725. [More Information]
  • Iyengar, L., Patkunanathan, B., Lynch, O., McAvoy, J., Rasko, J., Lovicu, F. (2006). Aqueous humour- and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Experimental Eye Research, 83(3), 667-678. [More Information]
  • Stump, R., Lovicu, F., Ang, S., Pandey, S., McAvoy, J. (2006). Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. Journal of Pathology, 210(2), 249-257. [More Information]
  • Sharma, S., Ang, S., Shaw, M., Mackey, D., Gecz, J., McAvoy, J., Craig, J. (2006). Nance-Horan syndrome protein, NHS, associates with epithelial cell junctions. Human Molecular Genetics, 15(12), 1972-1983.
  • Boros, J., Newitt, P., Wang, Q., McAvoy, J., Lovicu, F. (2006). Sef and Sprouty expression in the developing ocular lens: Implications for regulating lens cell proliferation and differentiation. Seminars in Cell and Developmental Biology, 17(6), 741-752. [More Information]
  • Taliana, L., Evans, M., Ang, S., McAvoy, J. (2006). Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants. Molecular Vision, 12, 1233-1242. [More Information]
  • Lovicu, F., McAvoy, J. (2005). Growth factor regulation of lens development. Developmental Biology, 280(1), 1-14. [More Information]
  • Wederell, E., Brown, H., O'Connor, M., Chamberlain, C., McAvoy, J., de Iongh, R. (2005). Laminin-binding integrins in rat lens morphogenesis and their regulation during fibre differentiation. Experimental Eye Research, 81(3), 326-39. [More Information]
  • de Iongh, R., Wederell, E., Lovicu, F., McAvoy, J. (2005). Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs, 179(1-2), 43-55. [More Information]
  • Lovicu, F., Steven, P., Saika, S., McAvoy, J. (2004). Aberrant Lens Fiber Differentiation In Anterior Subcapsular Cataract Formation: A Process Dependent On Reduced Levels Of Pax6. Investigative Ophthalmology and Visual Science, 45(6), 1946-1953.
  • de Iongh, R., Chen, Y., Kokkinos, M., McAvoy, J. (2004). Bmp And Activin Receptor Expression In Lens Development. Molecular Vision, 10(69), 566-576.
  • Lovicu, F., Ang, S., Chorazyczewska, M., McAvoy, J. (2004). Deregulation Of Lens Epithelial Cell Proliferation And Differentiation During The Development Of Tgf?-Induced Anterior Subcapsular Cataract. Developmental Neuroscience, 26(5-6), 446-455.
  • Chen, Y., Stump, R., Lovicu, F., McAvoy, J. (2004). Expression Of Frizzleds And Secreted Frizzled-Related Proteins (Sfrps) During Mammalian Lens Development. International Journal of Developmental Biology, 48(8-9), 867-877.
  • Tanaka, T., Saika, S., Ohinishi, Y., Ooshima, A., McAvoy, J., Liu, C., Azhar, M., Doetschman, T., Whei-Yang Kao, W. (2004). Fibroblast Growth Factor 2: Roles Of Regulation Of Lens Cell Proliferation and Epithelial-Mesenchymal Transition In Response To Injury. Molecular Vision, 10(59), 462-467.
  • Ang, S., Stump, R., Lovicu, F., McAvoy, J. (2004). Spatial And Temporal Expression Of Wnt And Dickkopf Genes During Murine Lens Development. Gene Expression Patterns, 4(3), 289-295.
  • Stump, R., Ang, S., Chen, Y., von Bahr, T., Lovicu, F., Pinson, K., De Iongh, R., Yamaguchi, T., Sassoon, D., McAvoy, J. (2003). A role for Wnt/Beta-catenin signaling in lens epithelial differentiation. Developmental Biology, 259(1), 48-61.
  • Maruno, K., Lovicu, F., Chamberlain, C., McAvoy, J. (2002). Apoptosis is a feature of TGFb-induced cataract. Clinical and Experimental Optometry, 85(2), 76-82.
  • Kok, A., Lovicu, F., Chamberlain, C., McAvoy, J. (2002). Influence of platelet-derived growth factor on lens epithelial cell proliferation and differentiation. Growth Factors, , 27-34.
  • Saika, S., Miyamoto, T., Ishida, I., Shirai, K., Ohnishi, Y., Ooshima, A., McAvoy, J. (2002). TGF-Smad signalling in postoperative human lens epithelial cells. British Journal of Ophthalmology, 86(12), 1428-1433.
  • Lovicu, F., Schulz, M., Hales, A., Vincent, L., Overbeek, P., Chamberlain, C., McAvoy, J. (2002). TGFB induces morphological and molecular changes similar to human anterior subcapsular cataract. British Journal of Ophthalmology, 86(2), 220-226.
  • Lovicu, F., McAvoy, J. (2001). FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/1) signalling. Development (Cambridge), 128 (24), 5075-5084.
  • De Iongh, R., Lovicu, F., Hardeman, E., McAvoy, J., Overbeek, P., Schneider, M., Joya, J. (2001). Requirement for TGFb receptor signalling during terminal lens fiber differentiation. Development (Cambridge), 128, 3995-4010.
  • McAvoy, J., Saika, S., Okada,, Y., Miyamoto, T., Ohnishi, Y., Ooshima,, A. (2001). Smad translocation & growth suppression in lens epithelial cells by endogenous TGFB2 during wound repair. Experimental Eye Research, 72 (6), 679-686.
  • McAvoy, J., Saika, S., Okada,, Y., Miyamoto, T., Ohnishi, Y., Ooshima,, A. (2001). Smad translocation and growth suppression in lens epithelial cells by endogenous TGFb2 during wound repair. Experimental Eye Research, 72, 679-686.
  • De Iongh, R., Chamberlain, C., Hales, A., McAvoy, J., Gordon-Thomson, C. (2001). TGFB receptor expression in lens: Implications for differentiation and cataractogenesis. Experimental Eye Research, 72 (5), 649-659.

Patents

  • McAvoy, J., Chamberlain, C. (2006). A Method For Preventing Or Controlling Cataract. Patent No. 735895. Austria, Belgium, Denmark, France, Germany, Greece, Ireland, Italy, Liechtenstein, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom.

2014

  • Dawes, L., Sugiyama, Y., Lovicu, F., Harris, C., Shelley, E., McAvoy, J. (2014). Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism. Developmental Biology, 385(2), 291-303. [More Information]

2013

  • Wang, C., Dawes, L., Liu, Y., Wen, L., Lovicu, F., McAvoy, J. (2013). Dexamethasone influences fgf-induced responses in lens epithelial explants and promotes the posterior capsule coverage that is a feature of glucocorticoid-induced cataract. Experimental Eye Research, 111, 79-87. [More Information]
  • Sugiyama, Y., Shelley, E., Wen, L., Stump, R., Shimono, A., Lovicu, F., McAvoy, J. (2013). Sfrp1 and Sfrp2 are not involved in Wnt/β-catenin signal silencing during lens induction but are required for maintenance of Wnt/β-catenin signaling in lens epithelial cells. Developmental Biology, 384(2), 181-193. [More Information]
  • You, J., Hodge, C., Wen, L., McAvoy, J., Madigan, M., Sutton, G. (2013). Tear levels of SFRP1 are significantly reduced in keratoconus patients. Molecular Vision, 19, 509-515. [More Information]
  • Dawes, L., Sugiyama, Y., Tanedo, A., Lovicu, F., McAvoy, J. (2013). Wnt-Frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Investigative Ophthalmology and Visual Science, 54(3), 1582-1590. [More Information]

2012

  • Sugiyama, Y., McAvoy, J. (2012). Analysis of PCP defects in mammalian eye lens. In Kursad Turksen (Eds.), Methods in Microbiology: Planar Cell Polarity, (pp. 100-120). New York: Humana Press.
  • Madigan, M., You, J., Wen, L., Hodges, C., Roufas, A., McAvoy, J., Sutton, G. (2012). Secreted frizzled proteins in control and keratoconus (KC) tears and corneas. Acta Ophthalmologica, 90(Supplement s249). [More Information]
  • Shin, E., Basson, M., Robinson, M., McAvoy, J., Lovicu, F. (2012). Sprouty Is a Negative Regulator of Transforming Growth Factor B-induced Epithelial-to-Mesenchymal Transition and Cataract. Molecular Medicine, 18, 861-873. [More Information]
  • You, J., Hodge, C., Wen, L., McAvoy, J., Madigan, M., Sutton, G. (2012). Using soybean trypsin inhibitor as an external loading control for Western blot analysis of tear proteins: Application to corneal disease. Experimental Eye Research, 99(1), 55-62. [More Information]

2011

  • Sugiyama, Y., Lovicu, F., McAvoy, J. (2011). Planar cell polarity in the mammalian eye lens. Organogenesis, 7(3), 191-201. [More Information]
  • Kallifatidis, G., Boros, J., Shin, E., McAvoy, J., Lovicu, F. (2011). The fate of dividing cells during lens morphogenesis, differentiation and growth. Experimental Eye Research, 92(6), 502-511. [More Information]
  • Lovicu, F., McAvoy, J., de Iongh, R. (2011). Understanding the role of growth factors in embryonic development: insights from the lens. Philosophical Transactions of the Royal Society B. Biological Sciences, 366(1568), 1204-1218. [More Information]

2010

  • Wang, Q., McAvoy, J., Lovicu, F. (2010). Growth Factor Signaling in Vitreous Humor–Induced Lens Fiber Differentiation. Investigative Ophthalmology and Visual Science, 51(7), 3599-3610. [More Information]
  • Sutton, G., Madigan, M., Roufas, A., McAvoy, J. (2010). Secreted frizzled-related protein 1 (SFRP1) is highly upregulated in keratoconus epithelium: a novel finding highlighting a new potential focus for keratoconus research and treatment. Clinical and Experimental Ophthalmology, 38(1), 43-48. [More Information]
  • Sugiyama, Y., Stump, R., Nguyen, A., Wen, L., Chen, Y., Murdoch, J., Lovicu, F., McAvoy, J. (2010). Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia. Developmental Biology, 338(2), 193-201. [More Information]
  • Newitt, P., Boros, J., Madakashira, B., Robinson, M., Reneker, L., McAvoy, J., Lovicu, F. (2010). Sef is a negative regulator of fiber cell differentiation in the ocular lens. Differentiation: ontogeny, neoplasia and differentiation therapy, 80(1), 53-67. [More Information]

2009

  • Iyengar, L., Patkunanathan, B., McAvoy, J., Lovicu, F. (2009). Growth factors involved in aqueous humour-induced lens cell proliferation. Growth Factors, 27(1), 50-62. [More Information]
  • Wang, Q., Stump, R., McAvoy, J., Lovicu, F. (2009). MAPK/ERK1/2 and PI3-kinase signalling pathways are required for vitreous-induced lens fibre cell differentiation. Experimental Eye Research, 88(2), 293-306. [More Information]
  • Sharma, S., Koh, K., Collin, C., Dave, A., mcMellon, A., Sugiyama, Y., McAvoy, J., Voss, A., Gecz, J., Craig, J. (2009). NHS-A isoform of the NHS gene is a novel interactor of ZO-1. Experimental Cell Research: emphasizing molecular approaches to cell biology, 315(14), 2358-2372. [More Information]
  • Chong, C., Stump, R., Lovicu, F., McAvoy, J. (2009). TGF{beta} promotes Wnt expression during cataract development. Experimental Eye Research, 88(2), 307-313. [More Information]

2008

  • Lovicu, F., McAvoy, J. (2008). Epithelial explants and their application to study developmental processes in the lens. In P A Tsonis (Eds.), Animal Models in Eye Research, (pp. 134-147). United States: Academic Press Elsevier.
  • O'Connor, M., Wederell, E., de Iongh, R., Lovicu, F., McAvoy, J. (2008). Generation of transparency and cellular organization in lens explants. Experimental Eye Research, 86(5), 734-745. [More Information]
  • Chen, Y., Stump, R., Lovicu, F., Shimono, A., McAvoy, J. (2008). Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture. Developmental Biology, 324(1), 161-176. [More Information]

2007

  • Jamieson, R., Farrar, N., Stewart, K., Perveen, R., Mihelec, M., Carette, M., Grigg, J., McAvoy, J., Lovicu, F., Tam, P., et al (2007). Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation. Human Mutation, 28(10), 968-977. [More Information]
  • Pennisi, D., Wilkinson, L., Kolle, G., Sohaskey, M., Gillinder, K., Piper, M., McAvoy, J., Lovicu, F., Little, M. (2007). Crim1(KST264/KST264) mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Developmental Dynamics, 236(2), 502-511. [More Information]
  • Iyengar, L., Wang, Q., Rasko, J., McAvoy, J., Lovicu, F. (2007). Duration of ERK1/2 phosphorylation induced by FGF or ocular media determines lens cell fate. Differentiation: ontogeny, neoplasia and differentiation therapy, 75(7), 662-668. [More Information]
  • O'Connor, M., McAvoy, J. (2007). In vitro generation of functional lens-like structures with relevance to age-related nuclear cataract. Investigative Ophthalmology and Visual Science, 48(3), 1245-1252. [More Information]

2006

  • McAvoy, J., Chamberlain, C. (2006). A Method For Preventing Or Controlling Cataract. Patent No. 735895. Austria, Belgium, Denmark, France, Germany, Greece, Ireland, Italy, Liechtenstein, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom.
  • Chen, Y., Stump, R., Lovicu, F., McAvoy, J. (2006). A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation? Seminars in Cell and Developmental Biology, 17(6), 712-725. [More Information]
  • Iyengar, L., Patkunanathan, B., Lynch, O., McAvoy, J., Rasko, J., Lovicu, F. (2006). Aqueous humour- and growth factor-induced lens cell proliferation is dependent on MAPK/ERK1/2 and Akt/PI3-K signalling. Experimental Eye Research, 83(3), 667-678. [More Information]
  • Stump, R., Lovicu, F., Ang, S., Pandey, S., McAvoy, J. (2006). Lithium stabilizes the polarized lens epithelial phenotype and inhibits proliferation, migration, and epithelial mesenchymal transition. Journal of Pathology, 210(2), 249-257. [More Information]
  • Sharma, S., Ang, S., Shaw, M., Mackey, D., Gecz, J., McAvoy, J., Craig, J. (2006). Nance-Horan syndrome protein, NHS, associates with epithelial cell junctions. Human Molecular Genetics, 15(12), 1972-1983.
  • Boros, J., Newitt, P., Wang, Q., McAvoy, J., Lovicu, F. (2006). Sef and Sprouty expression in the developing ocular lens: Implications for regulating lens cell proliferation and differentiation. Seminars in Cell and Developmental Biology, 17(6), 741-752. [More Information]
  • Taliana, L., Evans, M., Ang, S., McAvoy, J. (2006). Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants. Molecular Vision, 12, 1233-1242. [More Information]

2005

  • Lovicu, F., McAvoy, J. (2005). Growth factor regulation of lens development. Developmental Biology, 280(1), 1-14. [More Information]
  • Wederell, E., Brown, H., O'Connor, M., Chamberlain, C., McAvoy, J., de Iongh, R. (2005). Laminin-binding integrins in rat lens morphogenesis and their regulation during fibre differentiation. Experimental Eye Research, 81(3), 326-39. [More Information]
  • Pandey, S., Apple, D., Werner, L., McAvoy, J., Maloof, A., Milverton, E. (2005). Posterior Capsule Opacification. India: Jaypee Brothers Medical Publishers.
  • de Iongh, R., Wederell, E., Lovicu, F., McAvoy, J. (2005). Transforming growth factor-beta-induced epithelial-mesenchymal transition in the lens: a model for cataract formation. Cells Tissues Organs, 179(1-2), 43-55. [More Information]

2004

  • Lovicu, F., Steven, P., Saika, S., McAvoy, J. (2004). Aberrant Lens Fiber Differentiation In Anterior Subcapsular Cataract Formation: A Process Dependent On Reduced Levels Of Pax6. Investigative Ophthalmology and Visual Science, 45(6), 1946-1953.
  • de Iongh, R., Chen, Y., Kokkinos, M., McAvoy, J. (2004). Bmp And Activin Receptor Expression In Lens Development. Molecular Vision, 10(69), 566-576.
  • Lovicu, F., Ang, S., Chorazyczewska, M., McAvoy, J. (2004). Deregulation Of Lens Epithelial Cell Proliferation And Differentiation During The Development Of Tgf?-Induced Anterior Subcapsular Cataract. Developmental Neuroscience, 26(5-6), 446-455.
  • Chen, Y., Stump, R., Lovicu, F., McAvoy, J. (2004). Expression Of Frizzleds And Secreted Frizzled-Related Proteins (Sfrps) During Mammalian Lens Development. International Journal of Developmental Biology, 48(8-9), 867-877.
  • Tanaka, T., Saika, S., Ohinishi, Y., Ooshima, A., McAvoy, J., Liu, C., Azhar, M., Doetschman, T., Whei-Yang Kao, W. (2004). Fibroblast Growth Factor 2: Roles Of Regulation Of Lens Cell Proliferation and Epithelial-Mesenchymal Transition In Response To Injury. Molecular Vision, 10(59), 462-467.
  • Lang, R., McAvoy, J. (2004). Growth Factors In Lens Development. In Frank Lovicu, Michael Robinson (Eds.), Development of the Ocular Lens, (pp. 261-289). Canada: Cambridge University Press.
  • Ang, S., Stump, R., Lovicu, F., McAvoy, J. (2004). Spatial And Temporal Expression Of Wnt And Dickkopf Genes During Murine Lens Development. Gene Expression Patterns, 4(3), 289-295.

2003

  • Stump, R., Ang, S., Chen, Y., von Bahr, T., Lovicu, F., Pinson, K., De Iongh, R., Yamaguchi, T., Sassoon, D., McAvoy, J. (2003). A role for Wnt/Beta-catenin signaling in lens epithelial differentiation. Developmental Biology, 259(1), 48-61.

2002

  • Maruno, K., Lovicu, F., Chamberlain, C., McAvoy, J. (2002). Apoptosis is a feature of TGFb-induced cataract. Clinical and Experimental Optometry, 85(2), 76-82.
  • Kok, A., Lovicu, F., Chamberlain, C., McAvoy, J. (2002). Influence of platelet-derived growth factor on lens epithelial cell proliferation and differentiation. Growth Factors, , 27-34.
  • Saika, S., Miyamoto, T., Ishida, I., Shirai, K., Ohnishi, Y., Ooshima, A., McAvoy, J. (2002). TGF-Smad signalling in postoperative human lens epithelial cells. British Journal of Ophthalmology, 86(12), 1428-1433.
  • Lovicu, F., Schulz, M., Hales, A., Vincent, L., Overbeek, P., Chamberlain, C., McAvoy, J. (2002). TGFB induces morphological and molecular changes similar to human anterior subcapsular cataract. British Journal of Ophthalmology, 86(2), 220-226.

2001

  • Lovicu, F., McAvoy, J. (2001). FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/1) signalling. Development (Cambridge), 128 (24), 5075-5084.
  • De Iongh, R., Lovicu, F., Hardeman, E., McAvoy, J., Overbeek, P., Schneider, M., Joya, J. (2001). Requirement for TGFb receptor signalling during terminal lens fiber differentiation. Development (Cambridge), 128, 3995-4010.
  • McAvoy, J., Saika, S., Okada,, Y., Miyamoto, T., Ohnishi, Y., Ooshima,, A. (2001). Smad translocation & growth suppression in lens epithelial cells by endogenous TGFB2 during wound repair. Experimental Eye Research, 72 (6), 679-686.
  • McAvoy, J., Saika, S., Okada,, Y., Miyamoto, T., Ohnishi, Y., Ooshima,, A. (2001). Smad translocation and growth suppression in lens epithelial cells by endogenous TGFb2 during wound repair. Experimental Eye Research, 72, 679-686.
  • De Iongh, R., Chamberlain, C., Hales, A., McAvoy, J., Gordon-Thomson, C. (2001). TGFB receptor expression in lens: Implications for differentiation and cataractogenesis. Experimental Eye Research, 72 (5), 649-659.

To update your profile click here. For support on your academic profile contact .